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李亚东 研究员，博士生导师    

教育经历

2015-2018 复旦大学，药理学博士

2012-2015 皖南医学院、复旦大学联合培养，药理学硕士

2008-2012 皖南医学院，药学学士

工作经历

2023-至今 上海交通大学医学院松江研究院，研究员

2018-2023 美国北卡罗来纳大学教堂山分校药理学系，博士后

发表论文

  1. Li YD, et al. (2024), Anterior cingulate cortex projections to the dorsal medial striatum underlie insomnia associated with chronic pain, Neuron, 2024.
  2. Ya-Dong Li#, Yan-Jia Luo#, Ling Xie, Dalton S. Tart, Ryan N. Sheehy, Libo Zhang, Leon G. Coleman, Jr, Xian Chen, and Juan Song* (2023). Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer's disease. Cell Stem Cell, 30,415-432.
  3. Li, Y. D., Luo, Y. J., & Song, J. (2023). Optimizing memory performance and emotional states: multi-level enhancement of adult hippocampal neurogenesis. Current opinion in neurobiology, 79, 102693.
  4. Luo, Y. J., Ge, J., Chen, Z. K., Liu, Z. L., Lazarus, M., Qu, W. M., Huang, Z. L., & Li, Y. D. (2023). Ventral pallidal glutamatergic neurons regulate wakefulness and emotion through separated projections. iScience, 26(8), 107385.
  5. Li Y#, Luo Y#, Chen Z, Quintanilla L, Cherasse Y, Lazarus M, Huang Z, Song J* (2022). Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-likebehavior. Nat Neurosci, 25:630-645.
  6. Li Y#, Luo Y#, Xu W, Ge J, Cherasse Y, Wang Y, Lazarus M, Qu W* & Huang Z* (2021). Ventral pallidal GABAergic neurons control wakefulness associated with motivation through the ventral tegmental pathway. Mol Psychiatry, 26:2912-28.
  7. Li YD, Bao H, Luo Y, Sullivan Y, Quintanilla L, Wickersham I, Lazarus M, Shin Y, Song J*(2020). Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release. eLife, 9:e53129.
  8. Li, Y. D., Ge, J., Luo, Y. J., Xu, W., Wang, J., Lazarus, M., Hong, Z. Y., Qu, W. M., & Huang, Z. L. (2020). High cortical delta power correlates with aggravated allodynia by activating anterior cingulate cortex GABAergic neurons in neuropathic pain mice. Pain, 161(2), 288–299.
  9. Luo Y#, Li Y#, Wang L#, Yang S, Yuan X, Wang J, Cherasse Y, Lazarus M, Chen J, Qu W*, Huang Z* (2018). Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D1 receptors. Nat Commun, 9:1576.
  10. Chen, Z. K., Quintanilla, L., Su, Y., Sheehy, R. N., Simon, J. M., Luo, Y. J., Li, Y. D., Chen, Z., Asrican, B., Tart, D. S., Farmer, W. T., Ming, G. L., Song, H., & Song, J. (2024). Septo-dentate gyrus cholinergic circuits modulate function and morphogenesis of adult neural stem cells through granule cell intermediaries. Proceedings of the National Academy of Sciences of the United States of America, 121(40), e2405117121.
  11. Luo, Y. J., Bao, H., Crowther, A., Li, Y. D., Chen, Z. K., Tart, D. S., Asrican, B., Zhang, L., & Song, J. (2024). Sex-specific expression of distinct serotonin receptors mediates stress vulnerability of adult hippocampal neural stem cells in mice. Cell reports, 43(5), 114140.
  12. Chen, Z. K., Dong, H., Liu, C. W., Liu, W. Y., Zhao, Y. N., Xu, W., Sun, X., Xiong, Y. Y., Liu, Y. Y., Yuan, X. S., Wang, B., Lazarus, M., Chérasse, Y., Li, Y. D., Han, F., Qu, W. M., Ding, F. F., & Huang, Z. L. (2022). A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy. Cell discovery, 8(1), 115.
  13. Wander, C. M., Li, Y. D., Bao, H., Asrican, B., Luo, Y. J., Sullivan, H. A., Chao, T. H., Zhang, W. T., Chéry, S. L., Tart, D. S., Chen, Z. K., Shih, Y. I., Wickersham, I. R., Cohen, T. J., & Song, J. (2023). Compensatory remodeling of a septo-hippocampal GABAergic network in the triple transgenic Alzheimer's mouse model. Journal of translational medicine, 21(1), 258.
  14. Chen, X., Xie, L., Sheehy, R., Xiong, Y., Muneer, A., Wrobel, J., Park, K. S., Liu, J., Velez, J., Luo, Y., Li, Y. D., Quintanilla, L., Li, Y., Xu, C., Wen, Z., Song, J., Jin, J., & Deshmukh, M. (2023). Novel brain-penetrant inhibitor of G9a methylase blocks Alzheimer's disease proteopathology for precision medication. Research square, rs.3.rs-2743792.
  15. Asrican, B., Wooten, J., Li, Y. D., Quintanilla, L., Zhang, F., Wander, C., Bao, H., Yeh, C. Y., Luo, Y. J., Olsen, R., Lim, S. A., Hu, J., Jin, P., & Song, J. (2020). Neuropeptides Modulate Local Astrocytes to Regulate Adult Hippocampal Neural Stem Cells. Neuron, 108(2), 349–366.e6.
  16. Wang, T. X., Yin, D., Guo, W., Liu, Y. Y., Li, Y. D., Qu, W. M., Han, W. J., Hong, Z. Y., & Huang, Z. L. (2015). Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice. Pharmacology, biochemistry, and behavior, 135, 31–39.
  17. Wu, Y. E., Li, Y. D., Luo, Y. J., Wang, T. X., Wang, H. J., Chen, S. N., Qu, W. M., & Huang, Z. L. (2015). Gelsemine alleviates both neuropathic pain and sleep disturbance in partial sciatic nerve ligation mice. Acta pharmacologica Sinica, 36(11), 1308–1317.