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成果及论文

22. Development of Ts-Protected Selenocysteine for Sec-Conjugate Arylation via a Reductive Coupling Approach. Qinshuo Zhang, Shiang Zhai, Qingqing Lu, Shuai Cheng, Shiping Wang*, Ruo Wang*, Ying Liu, Chunfa Xu*. Org. Lett. 2025, 27, 12543-12548. doi.org/10.1021/acs.orglett.5c03945.

Figure 1


21. Photoactivatable Electrophilic Glycosylselenosulfonates for Ultrafast Modification of Alkynes and Thiols. Weitao Yan, Wenchao Liu, Qinshuo Zhang, Wentao Lin, Yujie Liao, Yiqun Geng, Ruo Wang, Chunfa Xu. ACS Central Sci. 2025, 11, 1400-1407. https://pubs.acs.org/doi/10.1021/acscentsci.5c00650


20. Mild Lewis-Acid-Promoted Cysteine−Tryptophan Conjugation Involving a Radical Process. Qingqing Lu, Hongyan Wen, Qinshuo Zhang, Zhou Zhang, Shiping Wang, Ruo Wang, Chunfa Xu. Org. Lett. 2025, 27, 6192-6197. https://pubs.acs.org/doi/10.1021/acs.orglett.5c01845

Figure 1


19. Copper-promoted late-stage glycosylsulfonylation of aryl iodide and bromide to access glycosyl aryl sulfones. Linyitian Wang (本科生), Huize Guo (本科生), Jiaxin Luo, Wenxu Zhen, Shiping Wang, Zailai Xie and Chunfa Xu. Org. Biomol. Chem. 2025, 23, 9922-9927. https://doi.org/10.1039/D5OB00509D


18. Photoinduced Diastereoselective and Stereodivergent Synthesis of C-Styryl Glycosides. Jialu Ma, Weitao Yan, Xinyu Chen, Wenxu Zhen, Jin Yu, Ruo Wang, Chunfa Xu. Org. Lett. 2025, 27, 5458-5463. https://doi.org/10.1021/acs.orglett.5c01437


17. Modular synthesis of glycosyl sulfonamide via reductive coupling of glycosyl sulfinate and nitroarene. Wenxu Zhen, Jialu Ma, Zhaohui Ni, Jiaxin Luo, Xiaomin Shen, Yusheng Xie, Hao Qiu and Chunfa Xu. New J. Chem. 2025, 49, 3416-3421. https://doi.org/10.1039/D4NJ04911J


16. Cu-catalyzed alkynylation of thiosulfonate-based peptide: an efficient approach to S-alkynyl-containing cyclic peptides. Zhou Zhang, Junjie Ying, Qingqing Lu, Qinshuo Zhanga and Chunfa Xu. Org. Chem. Front. 2025, 12, 2752-2758.  https://doi.org/10.1039/D5QO00152H



15. Radical Strategy Towards N-glycosides: Current Advances and Future Prospects. Chunfa Xu, Qinshuo Zhang, Yimuran Yusupu. ChemBioChem 2023, 26, e202400864. https://doi.org/10.1002/cbic.202400864


14. A stereoselective organocatalyzed C-glycosylation of indole: implications of acceptor–catalyst–donor interactions. Lihuang Xie, Wenchao Liu, Zhenbo Guo, Qinbo Jiao, Xiaomin Shen, Tianfei Liu and Chunfa Xu, Org. Chem. Front. 2025, 12, 509-515. https://doi.org/10.1039/D4QO01873G  

 


13. A radical activation strategy for versatile and stereoselective N-glycosylation. Wenyan Ding, Xinyu Chen, Zuyao Sun, Jiaxin Luo, Shiping Wang, Qingqing Lu, Jialu Ma, Chongxin Zhao, Fen-Er Chen, Chunfa Xu, Angew. Chem. Int. Ed. 2024, e20249004, doi.org/10.1002/anie.202409004https://doi.org/10.1002/anie.202409004 



12. 协同芳香亲核取代反应,林文涛(本科生),王文峰,袁耀锋,徐春发 ,大学化学


11. Transition-metal-free glycosyl sulfonation of diaryliodonium salt with sodium glycosyl sulfinate: an efficient approach to access glycosyl aryl sulfones, Jiaxin Luo, Xinyu Chen (Bachelor), Wenyan  Ding, Jialu Ma,  Zhaohui Ni, Lihuang Xie, Chunfa Xu, New J. Chem. 2024, 48, 4218-4223. 

   


10. Anion-Bridged Dual Hydrogen Bond Enabled Concerted Addition of Phenol to Glycal. Qinbo Jiao, Zhenbo Guo, Mingwen Zheng, Wentao Lin, Yujie Liao, Weitao Yan, Tianfei Liu, Chunfa Xu, Adv. Sci. 2024, 11, 2308513. https://doi.org/10.1002/advs.202308513 

 


9. Cu-catalyzed arylation of S-tosyl peptides with arylboronic acids. Junjie Ying, Jingrong Huang, Chenguan Liu, Fa-Jie Chen, Chunfa Xu, Fen-Er Chen, Org. Chem. Front. 2024, 11, 53-59. https://doi.org/10.1039/D3QO01534C  

       

DOI


8. A Robust Copper-Catalyzed Cross-Coupling of Glycosyl Thiosulfonate and Boronic Acids Enables the Construction of Thioglycosides. Zuyao Sun, Weitao Yan, Lihuang Xie, Wenchao Liu, Chunfa Xu, Fen-Er Chen, Org. Lett. 2023, 25, 5714-5718. https://doi.org/10.1021/acs.orglett.3c01798 


7. Synergistic Pd/Cu catalysis enabled cross-coupling of glycosyl stannanes with sulfonium salts to access C-aryl/alkenyl glycals. Weitao Yan, Mingwen Zheng, Peihsuan Chuang, Hao Sun, Shiping Wang, Chunfa Xu, Fen-er Chen. Chin. Chem. Lett. 2023, 34, 108021. https://doi.org/10.1016/j.cclet.2022.108021 


6. Recent Progress on Trifluoromethylthiolation of (Hetero)Aryl C–H Bonds with Electrophilic Trifluoromethylthiolating Reagents. Chunfa Xu, Shiping Wang, Qilong Shen, ACS Sustainable Chem. Eng. 2022, 10, 6889-6899. doi.org/10.1021/acssuschemeng.2c01006https://doi.org/10.1021/acssuschemeng.2c01006 


5. Dinitrogen extrusion of diazene in organic synthesis.  Chunngai Hui, Shiping Wang, Chunfa Xu.  Chin. Chem. Lett202233, 3695-3700. doi.org/10.1016/j.cclet.2022.03.073.  


4. Molecular editing in natural product synthesis. Chunngai Hui, Zhuo Wang, Shiping Wang, Chunfa Xu. Org. Chem. Front. 2022, 9, 1451-1457. DOI: 10.1039/d2qo00043a 


3.  Skeletal contraction: A novel strategy to access multisubstituted cyclobutane. Chunfa, Xu. V. U. Bhaskara Rao, Fen-Er Chen. Green Synth. Catal. 20223, 1-3. https://doi.org/10.1016/j.gresc.2021.12.001 

          Image 1


2. 三氯蔗糖简介及其在有机化学授课中的探索. 徐春发,陈萍(本科生),袁耀峰. 大学化学,202136(X), 2110040.


1.  Harnessing noncovalent interaction of chalcogen bond in organocatalysis: From the catalyst point of view. Weitao, Yan#, Mingwen Zheng#, Chunfa Xu*, Fen-Er Chen. Green Synth. Catal. 2021, 2, 329-336. doi.org/10.1016/j.gresc.2021.08.002https://doi.org/10.1016/j.gresc.2021.08.002 

Image 1

Before FZU

1. Chunfa Xu, V. U. Bhaskara Rao, Julia Weigen, Charles C. J. Loh A robust and tunable halogen bond organocatalyzed 2-deoxyglycosylation involving quantum tunneling. Nature Communications 2020, 11, 4911.

2. Chunfa Xu, Charles C. J. Loh A multi-stage halogen bond catalyzed strain-release glycosylation unravels new hedgehog signaling inhibitors. Journal of the American Chemical Society 2019, 141, 5381.

3. Chunfa Xu, Charles C. J. Loh An ultra-low thiourea catalyzed strain-release glycosylation and a multicatalytic diversification strategy. Nature Communications 2018, 9, 4057.

4. Chunfa Xu, Bingqing Ma, Qilong Shen N-Trifluoromethylthiosaccharin: an easily accessible, shelf-stable, broadly applicable trifluoromethylthiolating reagent. Angewandte Chemie International Edition 2014, 53, 9316.

5. Xinxin Shao#, Chunfa Xu#, Qilong Shen Shelft-stable electrophilic reagents for trifluoromethylthiolation. Accounts of Chemical Research 2015, 48, 1227. (#Contribute equally)

6. Chunfa Xu, Qingyun Chen, Qilong Shen Nucleophilic trifluoromethylthiolation of alkyl chlorides, bromides and tosylates. Chinese Journal of Chemistry 2016, 34, 495.

7. Chunfa Xu, Qilong Shen Lewis acid mediated trifluoromethylthio lactonization/lactamization Organic Letters 2015, 17, 4561.

8. Chunfa Xu, Qilong Shen Palladium-catalyzed trifluoromethylthiolation of aryl C-H bonds. Organic Letters 201416, 2046.

9. Chunfa Xu, Sheng Chen, Long Lu, Qilong Shen Preparation of trifluorostyrenes via palladium-catalyzed coupling of arylboronic acids with chloro- and bromotrifluoroethylene. Journal of Organic Chemistry 2012, 77, 10314. 

10. Jiansheng Zhu, Chunhui Xu, Chunfa Xu, Qilong Shen Organic Synthesis 2017, 94, 217.

11. Panpan Zhang, Man Li, Xiaosong Xue, Chunfa Xu, Qunchao Zhao, Yafei Liu, Haoyang Wang, Yilong Guo, Long Lu, Qilong Shen N-Trifluoromethylthio-dibenzenesulfonimide: A shelf-stable, broadly applicable electrophilic trifluoromethylthiolating reagent. Journal of Organic Chemistry 2016, 81, 7486. 

12. Xinxin Shao, Chunfa Xu, Long Lu, Qilong Shen Structure-reactivity relationship of trifluoromethanesulfenates: discovery of an electrophilic trifluoromethylthiolating reagent. Journal of Organic Chemistry 2015, 80, 3012. 

13. Kaikang, Chunfa Xu, Qilong Shen Copper-catalyzed trifluoromethylthiolation of aryl and vinyl boronic acids with a shelf-stable electrophilic trifluoromethylthiolating reagent. Organic Chemistry Frontiers 2014, 1, 294.

14. Sheng Chen, Chunfa Xu, Long Lu, Qilong Shen Palladium-catalyzed cross-coupling of fluorinated vinyl chlorides with terminal alkynes: a general protocol to fluorinated enynes. Chinese Journal of Chemistry 2013, 31, 901.

15. Qianyi Zhao, Lei Gong, Chunfa Xu, Jun Zhu, Xumin He, Haiping Xia Angewandte Chemie International Edition 2011, 50, 1354.