39. Iridium-Catalyzed Direct and Site-Selective C–H Heteroarylation, Alkenylation, and Alkylation of Indoles 

Tian Cao,# Wanqi Hu,# Linlu Hao,# Liting Guo,# Li Wu, Lei Xu, Zhaobing Gao, Jia Li*, Fuyun Tian*, and Xiaowei Wu*. J. Org. Chem. 2025, https://doi.org/10.1021/acs.joc.5c02429

38. Divergent Synthesis of Homoallylic and Allenic Sulfides, Selenides, and S,C-Sulfonium Ylides by Ruthenium Catalysis

Zhiyue He,# Li Wu,# Yanli Ma, Liting Wen, Xueqing Liu, Wenqian Ding, Wanqi Hu, and Xiaowei Wu*. Precis. Chem. 2025, https://doi.org/10.1021/prechem.5c00098

37. Rhodium-Catalyzed C–H Heteroarylation and Alkenylation of N-Phenoxyacetamides Using Iodonium Ylides

Wenqian Ding,# Wanqi Hu,# Weiqi Liu, and Xiaowei Wu*. J. Org. Chem. 2025, 90, 14373-14382. 

36. A general rhodium-catalyzed regioselective C–H functionalization: accessing heteroarylated and alkenylated arenes

Tian Cao,# Yan Wang,# Shiping Zhan, Wenqian Ding, and Xiaowei Wu*. Org. Chem. Front., 2025, 12, 5868-5874.

35. Site-Selective α-Alkoxylation of Iodonium Ylides with Alcohols via Ruthenium Catalysis

Sijia Shi,# Yaxi Liu,# Tian Cao, Yong Nian,* and Xiaowei Wu*. Organic Letters, 2025, 27, 7253-7260. 

34. Rhodium-Catalyzed C(sp²)-H Activation and [3+3] Annulation: Accessing Pyrano[3,2-c]chromene-2,5-diones as TASK-3 Activators

Xueqing Liu,# Shuoshuo Zheng,# Qionglin Ge,# Tian Cao, Fengmei Zeng, Fuyun Tian, Zhiyue He, Zhaobing Gao,* and Xiaowei Wu*. J. Org. Chem., 2025, 90, 4646–4651.  

33. Enantioselective Synthesis of Indole-Fused Polycycles Bearing Four Consecutive Stereocenters via Rhodium Catalysis

Ting Yu,# Weiqi Liu,# Beijing Chen,# Zhiyue He, Wenqian Ding, Lei Xu, Hong Liu,* Jia Li,* Yu Zhou,* and Xiaowei Wu,*. Organic Letters, 2025, 27, 1459-1464.              

32. Direct C-H Difluoroallylation of α,β-Unsaturated Amides and Aryl Amides by Rhodium catalysis

Wenqian Ding,# Wanqi Hu,# Xingyu Chen, Yan Wang, Xueqing Liu, Weiqi Liu, and Xiaowei Wu*. Chemical Communications, 2024, 60, 13036-13039.

31. Discovery of Imidazo[1,2-a]pyrazine Derivatives as Potent ENPP1 Inhibitors

Shiping Zhan,# Yingying Zhang,# Tian Cao,# Ruirui Yang,# Qiang Wang, Lin Huang, Rongrong Cui, Jie Yu, Haifang Meng, Yitian Wang, Sulin Zhang,* Mingyue Zheng,* Xiaowei Wu*. Journal of Medicinal Chemistry, 2024, 67, 18317-18333.

30. Accessing 7,8-Dihydroquinoline-2,5-diones via Rh-Catalyzed Olefinic C-H Activation/[4+2] Cyclization

Xueqing Liu,# Sijia Shi,# Wenqian Ding, Zhiyue He, Yu Shen, Yong Nian,* and Xiaowei Wu*. Organic Letters, 2024, 26, 5136-5140.

29. Rhodium-catalyzed diastereoselective C-H activation/[4+2] annulation of a,b-unsaturated amides with bicyclic alkenes

Yan Wang,# Sijia Shi,# Wei Zhang, Yong Nian,* and Xiaowei Wu*. Organic Letters, 2024, 26, 483-487.

28. The Synthesis of Spirocyclopropane Skeletons Enabled by Rh(III)-Catalyzed Enantioselective C-H Activation/[4+2] Annulation

Hao Wang,# Yidi Li,# Lin Huang,# Huiying Xu,# Yukun Jiao,# Zhi Zhou, Zhenhao Tang, Feifei Fang, Xiaoxue Zhang, Kan Ding, Wei Yi,* Hong Liu,* Xiaowei Wu,* and Yu Zhou*. Chem Catalysis, 2023, 3, 100822.

27. Discovery, Structure-Activity Relationship and Antitumor Activity of Small-Molecule Inhibitors of the Protein-Protein Interactions between AF9/ENL and AF4 or DOT1L

Xin Li,# Xiaowei Wu,# Shenyou Nie, Jidong Zhao, Yuan Yao, Fangrui Wu, Chandra B Bhushan, Md Ashraf Uz-Zaman, Bala Krishna Moku, Yongcheng Song*. Cancers, 2023, 15, 5283.

26. An unusual four-step cascade reaction for accessing furo[3,4-c]pyridine-1,4-diones via rhodium catalysis

Yidi Li,# Huiying Xu,# Zhi Zhou,* Lin Huang, Zhenhao Tang, Wei Yi* and Xiaowei Wu*. Organic Chemistry Frontiers, 2023, 10, 4658-4664.

25. Rhodium-catalyzed Regioselective C-H Activation/Lossen Rearrangement/Annulation for the Green Synthesis of Trisubstituted 2-Pyridones

Yidi Li,# Huiying Xu,# Lin Huang,# Zhi Zhou,* Zhenhao Tang, Haifang Meng, Wei Zhang, Wei Yi* and Xiaowei Wu*. Organic Chemistry Frontiers, 2023, 10, 3000-3009.

Haifang Meng,# Huiying Xu,# Zhi Zhou,# Zhenhao Tang, Yidi Li, Yu Zhou,* Wei Yi*, and Xiaowei Wu*. Green Chemistry, 2022, 24, 7012-7021.

Fei Zhao,*# Zhi Zhou,# Yangbin Lu,# Jin Qiao, Xiaoning Zhang, Xin Gong, Siyu Liu, Shuang Lin, Xiaowei Wu*, Wei Yi*. ACS Catalysis, 2021, 11, 13921-13934.

22. Design, Synthesis and pharmacological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors

Xiaowei Wu,# Mengdi Dai,# Jihui Zhao, Yulan Wang, Chunpu Li, Xia Peng, Rongrong Cui, Bao Wang, Yang Dai, Dan Feng, Hualiang Jiang, Meiyu Geng, Jing Ai*, Mingyue Zheng*, Hong Liu*. Acta Pharmaceutica Sinica B. 2021, 11, 781-794.

21. Additive-Controlled Divergent Synthesis of Tetrasubstituted 1,3-Enynes and Alkynylated 3H-pyrrolo[1,2-a]indol-3-ones via Rhodium Catalysis

Fei Zhao,* Xin Gong, Yangbin Lu, Jin Qiao, Xiuwen Jia, Hangcheng Ni, Xiaowei Wu*, Xiaoning Zhang*. Organic Letters, 2021, 23, 727-733.

20. Synthesis, structure-activity relationship and antiviral activity of indole-containing inhibitors of Flavivirus NS2B-NS3 protease

Shenyou Nie,# Jidong Zhao,# Xiaowei Wu,# Yuan Yao, Fangrui Wu, Yi-Lun Lin, Xin Li, Alexander R. Kneubehl, Megan B. Vogt, Rebecca Rico-Hesse, Yongcheng Song*. Eur. J. Med. Chem. 2021, 225, 113767.

19. Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth

Fangrui Wu,# Shenyou Nie,# Yuan Yao,# Tong Huo,# Xin Li, Xiaowei Wu, Jidong Zhao, Yi-Lun Lin, Yinjie Zhang, Qianxing Mo, Yongcheng Song*. Theranostics 2021, 11, 8172-8184.

18. Chemo- and Regioselective Synthesis of Functionalized 1H-imidazo[1,5-a]indol-3(2H)-ones via a Redox-Neutral Rhodium(III)-Catalyzed [4+1] Annulation between Indoles and Alkynes

Fei Zhao,* Jing Chen, Jin Qiao, Yangbin Lu, Xiaoning Zhang, Hui Mao,* Shiyao Lu, Xin Gong, Siyu Liu, Xiaowei Wu, Long Dai*. Adv. Synth. Catal. 2021, 363, 4380.

17. Temperature-Controlled Divergent Synthesis of Tetrasubstituted Alkenes and Pyrrolo[1,2-a]indole Derivatives via Iridium Catalysis

Siyu Liu, Hui Mao, Jin Qiao, Xiaoning Zhang, Yangbin Lu, Xin Gong, Aiqiong Jia, Linghui Gu*, Xiaowei Wu*, Fei Zhao*. Asian J. Org. Chem. 2021, 10, 3308-3320.

16. Synthesis, Structure-Activity Relationships, and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease

Shenyou Nie,# Yuan Yao,# Fangrui Wu,# Xiaowei Wu, Jidong Zhao, Yuanda Hua, Jingyu Wu, Tong Huo, Yi-Lun Lin, Alexander R. Kneubehl, Megan B Vogt, Josephine Ferreon, Rebecca Rico-Hesse, Yongcheng Song*. J. Med. Chem. 2021, 64, 5, 2777-2800.

15. Redox-Neutral Rhodium(III)-Catalyzed Chemospecific and Regiospecific [4+1] Annulation between Indoles and Alkenes for the Synthesis of Functionalized Imidazo[1,5-a]indoles

Fei Zhao,* Jin Qiao, Yangbin Lu, Xiaoning Zhang, Long Dai, Siyu Liu, Hangcheng Ni,* Xiuwen Jia, Xiaowei Wu, Shiyao Lu*. J. Org. Chem. 2021, 86, 10591–10607.

14. Rh(III)-Catalyzed Divergent Synthesis of Alkynylated Imidazo[1,5-a]indoles and α,α-Difluoromethylene Tetrasubstituted Alkenes

Fei Zhao,* Jin Qiao, Yangbin Lu, Xiaoning Zhang, Long Dai, Xin Gong, Hui Mao*, Shiyao Lu, Xiaowei Wu, Siyu Liu*. Organic Letters, 2021, 23, 5766–5771.

13. Discovery, Structure−Activity Relationship, and Biological Activityof Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP

Fangrui Wu,# Yuanda Hua,# Salma Kaochar, Shenyou Nie, Yi-Lun Lin, Yuan Yao, Jingyu Wu, Xiaowei Wu, Xiaoyong Fu, Rachel Schiff, Christel M Davis, Matthew Robertson, Erik A Ehli, Cristian Coarfa, Nicholas Mitsiades, Yongcheng Song*. J. Med. Chem. 2020, 63, 9, 4716-4731.

12. Rhodium(III)-Catalyzed C–H Alkenylation/Directing Group Migration for the Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes

Xiaowei Wu, Yangbin Lu, Jin Qiao, Wenhao Dai, Xiuwen Jia, Hangcheng Ni, Xiaoning Zhang, Hong Liu*, and Fei Zhao*. Organic Letters, 2020, 22, 9163-9168.

11. Synthesis of Indole-Fused Polyheterocycles via Rh(III)-Catalyzed Regioselective [4+2] Annulation/Lactonization of Indoles with 4-Hydroxy-2-Alkynoates

Xiaowei Wu, Pinyi Li, Jin Qiao, Yangbin Lu, Jingwei Zhao, Xiuwen Jia, Hangcheng Ni, Xiaoning Zhang, Fei Zhao*. Advanced Synthesis & Catalysis, 2020, 362, 2953.

Yulan Wang,# Yang Dai,# Xiaowei Wu,# Fei Li, Bo Liu, Chunpu Li, Qiufeng Liu, Yuanyang Zhou, Bao Wang, Mingrui Zhu, Rongrong Cui, Xiaoqin Tan, Zhaoping Xiong, Jia Liu, Minjia Tan, Yechun Xu, Mei-Yu Geng, Hualiang Jiang, Hong Liu*, Jing Ai*, Mingyue Zheng*. J. Med. Chem. 2019, 62, 7473-7488.

9. Ruthenium(II)-Catalyzed Regio- and Stereoselective C−H Allylation of Indoles with Allyl Alcohols

Xiaowei Wu, Haitao Ji*. Organic Letters, 2018, 20, 2224-2227. Highlighted by Synfacts and ChemistryViews.

8. Ruthenium-Catalyzed C–H Allylation of Alkenes with Allyl Alcohols via C–H Bond Activation in Aqueous Solution

Xiaowei Wu, Haitao Ji*. J. Org. Chem. 2018, 83, 12094-12102.

7. Rhodium-Catalyzed [4 + 1] Cyclization via C-H Activation for Divergent Heterocycle Bearing a Quaternary Carbon Synthesis

Xiaowei Wu, Haitao Ji*. J. Org. Chem. 2018, 83, 4650-4656.

6. Rhodium(III)-catalyzed C–H allylation of indoles with allyl alcohols via β-hydroxide elimination

Xiaowei Wu, Haitao Ji*. Org. Biomol. Chem. 2018, 16, 5691-5698.

5. Regio-selective and stereo-selective hydrosilylation of internal alkynes catalyzed by ruthenium complexes

Wenhao Dai,# Xiaowei Wu,# Chunpu Li, Rui Zhang, Jiang Wang, Hong Liu*. RSC Adv. 2018, 8, 28261-28265.

Xiaowei Wu, Bao Wang, Shengbin Zhou, Yu Zhou*, Hong Liu*. ACS Catalysis, 2017, 7, 2494-2499.

3. Propargyl alcohols as one-carbon synthons: redox-neutral Rh(III)-catalyzed C-H bond activation for the synthesis of isoindolinones bearing a quaternary carbon

Xiaowei Wu, Bao Wang, Yu Zhou, Hong Liu*. Organic Letters, 2017, 19, 1294-1297.

2. Ruthenium(II)-catalyzed redox-neutral [3+2] Annulation of indoles with internal alkynes via C−H bond activation: accessing to Pyrroloindolone scaffold

Yanan Xie,# Xiaowei Wu,# Chunpu Li, Jian Li, Hong Liu*. J. Org. Chem. 2017, 82, 5263–5273.

1. Site-specific indolation of proline-based peptides via copper(II)-catalyzed oxidative coupling of tertiary amine N-oxides

Xiaowei Wu,# Dengyou Zhang,# Shengbin Zhou, Feng Gao, Hong Liu*.  Chemical Communications , 2015, 51, 12571-12573.