4383
成果及论文
- Hai Y, Fan R, Zhao T, Lin R, Zhuang J, Deng A, Meng S*, Hou Z*, Wei G*, A novel mitochondria-targeting DHODH inhibitor induces robust ferroptosis and alleviates immune suppression. Pharmacological Research 2024, 202, 107115.
- Fan R, Lin R, Zhang S, Deng A, Hai Y, Zhuang J, Liu Y*, Cheng M, Wei G*, Novel Pt(IV) complex OAP2 induces STING activation and pyroptosis via mitochondrial membrane remodeling for synergistic Chemo-Immunotherapy, Acta Pharmaceutica Sinica B 2023, DOI: 10.1016/j.apsb.2023.11.032.
- Sang R, Fan R, Deng A, Gou J, Lin R, Zhao T, Hai Y, Song J*, Liu Y*, Qi B, Du G, Cheng M, Wei G*, Degradation of Hexokinase 2 (HK2) Blocks Glycolysis and Induces GSDME-Dependent Pyroptosis to Amplify Immunogenic Cell Death for Breast Cancer Therapy, Journal of Medicinal Chemistry 2023, 66 (13), 8464−8483.
- Fan R, Deng A, Qi B, Zhang S, Sang R, Luo L, Gou J, Liu Y, Lin R, Zhao M, Liu Y*, Yang L*, Cheng M, Wei G*, CJ(2): A Novel Potent Platinum(IV) Prodrug Enhances Chemo-Immunotherapy by Facilitating PD-L1 Degradation in the Cytoplasm and Cytomembrane, Journal of Medicinal Chemistry 2023, 66 (1), 875-889.
- Tang X, Luo X, Su Q, Wei G*, Meng S*, Chan A*, Chemoselective Dual Functionalization of Phenols via Relay Catalysis of Borane with Different Forms, CCS Chemistry 2021, 3 (8), 2245-2258.
- Wei G*, Sun J, Luan W, Hou Z, Wang S, Cui S, Cheng M*, Liu Y*, Natural Product Albiziabioside A Conjugated with Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate To Induce Apoptosis-Ferroptosis-M2-TAMs Polarization for Combined Cancer Therapy, Journal of Medicinal Chemistry 2019, 62 (19), 8760-8772.
- Wei G, Huang L, Shen Y, Huang Z, Xu X, Zhao C*, Porphyrin‐Based Porous Organic Frameworks as Oxygen Reservoirs to Overcome Tumor Hypoxia for Enhanced Photodynamic Therapy, Advanced Therapeutics 2019, 2 (8), 1900059.
- Wei G*, Huang L, Jiang Y, Shen Y, Huang Z, Huang Y, Sun X, Zhao C*, Lenvatinib-zinc phthalocyanine conjugates as potential agents for enhancing synergistic therapy of multidrug-resistant cancer by glutathione depletion, European Journal of Medicinal Chemistry 2019, 169, 53-64.
- Huang Z, Wei G, Zeng Z, Huang Y, Huang L, Shen Y, Sun X, Xu C, Zhao C*, Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor, Theranostics 2019, 9 (19), 5542-5557.
- Wei G, Sun J, Hou Z, Luan W, Wang S, Cui S, Cheng M, Liu Y*, Novel antitumor compound optimized from natural saponin Albiziabioside A induced caspase-dependent apoptosis and ferroptosis as a p53 activator through the mitochondrial pathway, European Journal of Medicinal Chemistry 2018, 157, 759-772.
- Huang L, Wei G*, Sun X, Jiang Y, Huang Z, Huang Y, Shen Y, Xu X, Liao Y, Zhao C*, A tumor-targeted Ganetespib-zinc phthalocyanine conjugate for synergistic chemo-photodynamic therapy, European Journal of Medicinal Chemistry 2018, 151, 294-303.
- Wei G, Cui S, Luan W, Wang S, Hou Z, Liu Y, Liu Y*, Cheng M*, Natural product-based design, synthesis and biological evaluation of Albiziabioside A derivatives that selectively induce HCT116 cell death, European Journal of Medicinal Chemistry 2016, 113, 92-101.
- Wei G, Luan W, Wang S, Cui S, Li F, Liu Y, Liu Y*, Cheng M*, A library of 1,2,3-triazole-substituted oleanolic acid derivatives as anticancer agents: design, synthesis, and biological evaluation, Organic & Biomolecular Chemistry 2015, 13 (5), 1507-1514.
- Wei G, Wang S, Cui S, Guo J, Liu Y, Liu Y*, Cheng M*, Synthesis and evaluation of the anticancer activity of albiziabioside A and its analogues as apoptosis inducers against human melanoma cells, Organic & Biomolecular Chemistry 2014, 12 (31), 5928-5935.
