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成果及论文

2022年

[24] Xinhui Hou , Shuo Li , Zhenguo Wang , Guoyang Zhang , Zhuo Wang*. Antifungal CoAl layered double hydroxide ultrathin nanosheets loaded with oregano essential oil for cereal preservation. Food Chemistry 397 (2022) 133809. (原文链接) 

ABSTRACT

Fungal infestation of cereals seriously affects human health and the economy. Protecting cereals from fungal infestation is meaningful. Therefore, safe and economical antifungal agents must be explored. Oregano essential oil (OEO) has broad-spectrum antifungal activity but is unstable and poorly water-dispersible. CoAl-LDH ultrathin nanosheets (CoAl-LDH UNs) are a biosafe carrier with peroxidase-like activity and good water dispersibility. A new nanocomposite was constructed by integrating OEO and CoAl-LDH UNs named OEO/CoAlLDH UNs. The antifungal activity of OEO was improved for the synergetic effect of OEO and CoAl-LDH UNs. OEO/CoAl-LDH UNs showed excellent antifungal activity against Fusarium moniliforme, Fusarium graminearum and Aspergillus flavus. A polyvinyl alcohol film containing OEO/CoAl-LDH UNs was prepared as a food package and effectively inhibited fungal infestation on cereals. This work can provide some insights for the exploration of other new antifungal materials. The good biosafety of this antifungal material can be effectively applied to food packaging. 


[23] Shuo Li, Yuzhi Chen, Peinan He, Yufan Ma, Yajie Cai, Xinhui Hou, Guoyang Zhang, Xin Zhang,* Zhuo Wang.*Aggregation-induced Emission (AIE) Photosensitizer Combined Polydopamine Nanomaterials for organelle-targeted Photodynamic and Photothermal Therapy by the Recognition of Sialic Acid. Advanced Healthcare Materials, 2022. (原文连接

ABSTRACT

The construction of organelle-targeted nanomaterials is an effective way to improve tumor imaging and treatment. Here, we have developed a new type of composite nanomaterial named as PTTPB. PTTPB is composed of organelle-targeted aggregation-induced emission (AIE) photosensitizer TTPB and polydopamine nanomaterials (PDA). With the functional modification of TTPB, PTTPB can recognize sialic acid (SA) on the cell membrane and present mitochondrial targeted capabilities. The intake of PTTPB in cancerous cells could be increased by the recognition process of cell membrane. PTTPB can generate singlet oxygen for photodynamic therapy (PDT), and present good photothermal conversion ability with irradiation. The PTTPB with organelle targeted -guided can realize the tumor ablation with the synergetic effect of PDT & PTT.

[22] Shuo Li, XinHui Hou, Yufan Ma, Zhuo Wang*. Phenylboronic acid-based functional chemical materials for fluorescence imaging and tumor therapy. ACS Omega 2022, 7, 3, 2520–2532. (原文链接

ABSTRACT

Various functional chemical materials have been widely used in imaging and tumor therapy. Targeted ligands such as antibodies, peptides, and small molecules have been combined with functional materials to enhance cellular uptake, which are used for active targeting of cancer cells and tumors. Among them, phenylboronic acid (PBA), as a small molecular ligand, has the characteristics of low cytotoxicity and being modified easily. PBA improves the cancer cell imaging and tumor treatment effect by binding to glycans on the surface of cancer cells. In the minireview, we introduced the modification strategy and targeting strategy of PBA. We focused on the applications of PBA-based functional materials in fluorescence imaging and tumor therapy. For fluorescence imaging, it proved the potential of PBA-based functional chemical materials in cancer diagnosis and tumor targeting by cell imaging and in vivo imaging. For tumor therapy, we mainly discussed the applications of PBA based functional chemical materials in chemotherapy, gene therapy, phototherapy and immunotherapy. PBA-based functional chemical materials provide a useful method for cancer diagnosis and treatment.

[21] Yujie Geng, Guoyang Zhang, Yuzhi Chen, Yanghan Peng, Xuefei Wang*, Zhuo Wang*. The Si-Rhodamine Derivatives for Brain Fluorescence Imaging and monitor of H2S in the brain of Schizophrenic Mice Before and After treatment. Anal. Chem. 2022. (原文链接

ABSTRACT

Schizophrenia is a common type of serious mental  illness with an unclear etiology. Recently, the excessive production  of hydrogen sulfide in the brain has been considered to be one of  the pathophysiological bases of schizophrenia. However, due to the  existence of the blood−brain barrier (BBB), almost no fluorescent  probe has been successfully used for the sensing and detection of  H2S in the brain. Herein, we designed and synthesized a series of  near-infrared fluorescent probes SiR-Bs based on a hemicyanine  and Si-rhodamine structure. Among them, Mindo-SiR presented a  good penetration ability of the BBB, a high brain uptake (transport:  4.95% ID/g at 5 min), and good response to H2S in vitro and in vivo. For the first time, a fluorescent probe was used to image the  changes of H2S in the brains of schizophrenic (SZ) mouse models,  and it was successfully proven that there was an abnormally high level of H2S in the brains of SZ mice. Moreover, the therapeutic effect of risperidone for the treatment of SZ could be evaluated by the changes of SiR-Bs’ fluorescence imaging.

2021

[20] Jiang Liu, Lijun Ma, Guoyang Zhang, Yuzhi Chen*, Zhuo Wang*. Recent Progress of Surface Modified Nanomaterials for Scavenging Reactive Oxygen Species in Organism. Bioconjugate chem. 2021, 32, 11, 2269–2289. (原文链接

ABSTRACT

Reactive oxygen species (ROS) are essential for normal physiological processes and play important roles in signal transduction, immunity, and tissue homeostasis. However, excess ROS may have a negative effect on the normal cells leading to various diseases. Nanomaterials are an attractive therapeutic alternative of antioxidants and possess an intrinsic ability to scavenge ROS. Surface modification for nanomaterials is a critical strategy to improve their comprehensive performances. Herein, we review the different surface modified strategies for nanomaterials to scavenge ROS and their inherent antioxidant capability, mechanisms of action, and biological applications. At last, the primary challenges and future perspectives in this emerging research frontier have also been highlighted. It is believed that this review paper will offer a top understanding and guidance on engineering future high-performance surface modified ROS scavenging nanomaterials for wide biomedical applications.

[19] Lijun Ma, Shu Yang, Yufan Ma, Yuzhi Chen, Zhenguo Wang, Tony D. James,* Xuefei Wang,* Zhuo Wang.* Benzothiazolium Derivatives Capped Silica Nanocompites for βamyloid Imaging in vivo. Anal. Chem. 2021, 93, 37, 12617–12627. 原文链接

ABSTRACT

Alzheimer’s disease (AD) is a neurodegenerative disease, and β-amyloid (Aβ) is believed to be a causative factor in AD pathology. The abnormal deposition of Aβ is believed to be responsible for progression of AD. In order to facilitate the imaging of Aβ in vivo, suitable probe molecules with a near-infrared emission wavelength that can penetrate the blood–brain barrier (BBB) were utilized. The commercial fluorescent probe thioflavin-T (ThT) is used to image Aβ; however, because of its short emission wavelength and poor BBB penetration, ThT can only be used in vitro. With this research, based on ThT, we design three fluorescent probes (SZIs) having a longer emission wavelength in order to image Aβ aggregates. SZIs with different numbers of double bonds respond to Aβ aggregates. The SZIs have a structure similar to ThT, and as such, the SZIs are also unable to penetrate the BBB. To deal with the problem, we develop nanocomposites (MSN-Lf@SZIs) to deliver SZIs into the brain of AD mouse and image Aβ successfully. These new nanocomposites are able to deliver the dyes into the brain and facilitate Aβ imaging in vivo.

2020


[18] Yuanyuan Zhang, Yufan Ma, Zhuo Wang*, Xueyan Zhang, Xin Chen, Shicong Hou * and Hongmei Wang *. A novel colorimetric and far-red emission ratiometric fluorescent probe for the highly selective and ultrafast detection of hypochlorite in water and its application in bioimaging. Analyst, 2020, 145, 939  (原文链接

ABSTRACT

Hypochlorous acid (HOCl)/hypochlorite (OCl), an important reactive oxygen species, plays a number of important roles in various physiological processes. However, abnormal levels of OCl can cause many serious diseases, such as atherosclerosis, rheumatoid arthritis, cardiovascular disease, and cancer. The development of efficient methods to monitor OCl in biological systems is therefore of particular importance. Thus, we herein report a novel isophorone-based fluorescent probe, i.e., DCOH-FR-OCl, for OCl detection. This probe was found to exhibit colorimetric and far-red ratiometric fluorescence response signals, excellent selectivity and sensitivity for OCl (detection limit, 88.06 nM), a remarkably large Stokes shift (158 nm), an ultrafast response (completed within 3 s), perfect photostability, and good water solubility (100% in aqueous media). DCOH-FR-OCl, as we know, is the first probe that can detect OCl by using two different response signals at an ultrafast speed with a large Stokes shift in fully aqueous media. Furthermore, DCOH-FR-OCl can be successfully employed in the real-time imaging of endogenous and exogenous OCl in living cells.

[17] Pan Guoyong, Li Yawen1, Ma Lijun1, Ma Yufan1, Ai Wenting1, Wang Zhenguo1, Hou Xinhui1, Grigory V·Zyryanov, Wang Zhuo. New Semiconducting Polymer Nanoparticles for Antibacterial Agent by the Synergetic Effect of Positive Charge and Photothermal Conversion. Chemical journal of Chinese Universities202041(4):670-681.

ABSTRACT

Because of the abuse of antibiotics and the emergence of bacterial resistance, the new antibacterial agents are required urgently. Herein, we prepared semiconducting polymer nanoparticles(SP-PPh3 NPs) with synergistic antibacterial activity due to photothermal properties and positive charge. SP-PPh3 NPs have broad-spectrum antibacterial properties against Gram-negative Escherichia coli(E. coli) and Gram-positive Staphylococcus aureus(S. aureus). The photothermal conversion efficiency of SP-PPh3 NPs is 43.8%. Moreover, the positive charge of SP-PPh3 NPs can adhere to bacteria, which is helpful to transmit heat to bacteria effectively. Under the synergistic effect of heat and positive charge, the antibacterial rates of E. coli and S. aureustreated with SP-PPh3 NPs are 99.9% and 98.6% in vitro, respectively. In addition, SP-PPh3 NPs have good biocompatibility and have almost no side effects on the major organs of mice. The bacteria-infected skin wounds on mice can completely heal after 12 d treated with SP-PPh3 NPs.



[16] Ruohao Zhang, Jie Yu, Kun Ma, Yufan Ma*, and Zhuo Wang*. Synergistic Chemo-Photothermal Antibacterial Effects of Polyelectrolyte-Functionalized Gold Nanomaterials. ACS Appl. Bio Mater. 2020. (原文链接

ABSTRACT

With the increasing threat of bacterial infection to human health, the development of different antimicrobial agents is essential. Therefore, based on the photothermal conversion properties of gold nanomaterials, the polyelectrolyte (PE)-coated gold nanorods (GNR@PE) and gold nanostars (GNS@PE) are designed and synthesized. Consequently, the chemo-photothermal synergistic antibacterial effect is achieved. GNR@PE effectively eliminates the high toxicity of cetyltrimethylammonium bromide (CTAB), and both GNR@PE and GNS@PE have good biocompatibility and stability. Because of the cation coating, GNR@PE and GNS@PE show high localized surface charge, which causes strong affinity to bacteria and destruction of bacterial cell walls and cell membranes. They have good chemical antibacterial effects, and the chemical antibacterial rates are above 50%. Under the irradiation of an 808 nm laser, for Gram-negative bacteria and Gram-positive bacteria, GNR@PE (50.00 μg/mL) and GNS@PE (55.00 μg/mL) can kill more than 99% of bacteria through chemo-photothermal effects. GNR@PE and GNS@PE can help eliminate inflammation caused by infection and promote wound healing in the mice model and have few side effects on the organs of mice.

 

[15] Xin Chen, Yufan Ma, Yuanyuan Zhang, Qing Chen, Hongmei Wang, Zhuo Wang*. A Selective and Reversible Fluorescent Probe for Zn2+ Detection in Living Cells. (原文链接

ABSTRACT

A newly 8aminoquioline based fluorescent probe (NQA) was designed and synthesized as a good turnon fluorescence sensor to reversibly detect Zn2+. The probe can detect Zn2+ in an aqueous solution with good selectivity without interference from other metal ions (Cd2+ in particular). And the limit of detection was calculated to be 2.15×10−9 M. The probe can efficiently monitor the change of concentration of Zn2+ in a broad pH range from 4.0 to 11.0. NQA can detection of Zn2+ reversibly based on the coordination interaction. NQA is biocompatibility and can be used to monitor the concentration of Zn2+ in living cells without the interference from other similar cations, especially Cd2+.

[14] Wenting Ai, Zhiqiang Yang, Yufan Ma, Xiaomin Han, Yuzhi Chen, Kui Zhu* and Zhuo Wang *. Combined tetraphenylethylene fluorogens with positive charge for imaging capsule-covered pathogens. Analyst, 2020,145, 6435-6440.原文链接

ABSTRACT

Capsule-covered pathogens can cause serious infectious diseases, and are highly pathogenic to humans. Herein, we developed four positively charged tetraphenylethylene derivatives (PC-TPEgens) that in certain combinations were applied to identify capsule-bearing pathogens using fluorescence imaging. The dual-charged probes were used to visualize the entire process of phagocytosis of pathogens into macrophages.

 

[13] Yufan Ma, Wenting Ai, Jia Huang, Lijun Ma, Yujie Geng, Xiaolei Liu, Xuefei Wang*, Zhiying Yang*, and Zhuo Wang*. Mitochondria-Targeted Sensor Array with Aggregation-Induced Emission Luminogens for Identification of Various Cells. Anal. Chem. 2020.  (原文链接

ABSTRACT

Accurate discrimination of cancerous cells is a good solution for early diagnosis of tumors. The mitochondrion plays an important role in cells. Herein, the five aggregation-induced emission luminogens (AIEgens) with various double positive charges are synthesized to image mitochondria. Tetraphenylethylene (TPE) molecules are modified by methoxy groups, conjugated donor–acceptor, and different positive charges to achieve multicolor emission. The five AIEgens form the PTx-Sa (positive mitochondria-target molecular sensor array) to perform cross-fluorescence response based on the mitochondria-targeted imaging to achieve the discrimination of various cells. Principal component analysis of the cross-response fluorescence data of PTx-Sa shows that 100% accurate identification of various cells, including cancer cells and normal cells, digestive tract cancer cells, gastric cancer cells, and mixed gastric cancer cells. By support vector machine to show the predictive ability of PTx-Sa to unknown cells by using blind samples. This is the first time to apply mitochondria-targeted sensor array to identification of various cells.


[12] Xiaomin Han,Yufan Ma,Yuzhi Chen,Xuefei Wang, Zhuo Wang.Hydrogen Bond Enhanced the Aggregation-induced Emission for Visualizing Hypochlorous Acid in Inflammation Model and Hepatocellular Carcinoma Model. Anal. Chem. 2020. (原文链接

ABSTRACT 

As an important reactive oxygen species, hypochlorous acid (HClO) is produced in various physiological processes. The ab-normal rise of HClO level is associated with a large number of inflammatory diseases. In this work, we develop a simple aqueous soluble AIE probe for sensing HClO with significant aggregation-induced fluorescence. (>1000 times) Two probes CH3O-TPE-Py+-N+ (COTN) and OH-TPE-Py+-N+ (HOTN) are synthesized for sensing HClO by the cleavage of Py+-N+ group. The reaction products are CH3O-TPE-CHO (COT) and OH-TPE-CHO (HOT) separately. The hydrophobicity of the probes is changed with the increased aggregation-induced emission. During the process, HOTN shows greatly better response than COTN. The slight different chemical structure of COTN and HOTN results the significant response to HClO. The theoretical calculation data support that the hydrogen bond is contributed to the excellent sensitivity for HClO. On the basis of the good response to HClO in vitro, HOTN is used to imaging inflammation and hepatocellular carcinoma in vivo, because these dis-eases always are accompanying with high HClO level.


 


2019

[11] Yufan Ma, Huiping Wang, Shan Su, Yuzhi Chen, Yawen Li, Xuefei Wang and Zhuo Wang , A red mitochondria-targeted AIEgen for visualizing H2S in living cells and tumours, Analyst, 2019,144, 3381-3385. (原文链接

ABSTRACT

Hydrogen sulfide (H2S) exists in the cytosol and mitochondria of mammalian cells as a signaling molecule. Scientists have explored many important physiological functions of H2S, such as regulating vasodilator relaxation, protecting living cells and avoiding damage. The measurement of H2S is therefore necessary for exploring the biological function of cells and tissues. Herein, we report the design and synthesis of a new aggregation-induced emission luminogen (AIEgen) with greater conjugation and more positive charges, based on previous research on mitochondrial-targeted luminogens. The Indo-TPE-Indo can enter cells rapidly, as compared with an AIEgen with only one indolium (TPE-indo), and can selectively recognize HS in mitochondria with the nucleophilic reaction of indolium and HS. The linear range (1–100 μM) of HS sensing can satisfy the requirement for HS concentration in living cells and tumors.

[10] Kun Ma, Yawen Li, Zhenguo Wang, Yuzhi Chen, Xin Zhang, Chunyuan Chen, Hao Yu, Jia Huang, Zhiying Yang, Xuefei Wang, and Zhuo Wang, CoreShell Gold Nanorod@Layered Double Hydroxide Nanomaterial with Highly Ecient Photothermal Conversion and Its Application in Antibacterial and Tumor Therap, ACS Applied Materials & Interfaces2019. (原文链接

ABSTRACT

Photothermal conversion efficiency (η) of gold nanorods (GNRs) can be tuned by enlarging the aspect ratio and forming the core–shell structure. Herein, an easy synthesis method is developed to construct the core–shell GNR@LDH nanostructure with GNRs and layered double hydroxides (LDHs). The interaction between Au and LDHs results some electron deficiency on the surface of Au and the more electrons induce more thermal energy conversion. The η value of GNR@LDH can reach up to 60% under the 808 nm laser irradiation, which is a significant enhanced conversion efficiency compared with the reported GNR-based photothermal therapy materials. CTAB (cetyltrimethyl ammonium bromide) can be replaced totally during the synthesis process, and GNRs maintain a good dispersion in LDHs. This core–shell composite GNR@LDH can be applied in photothermal, antibacterial, tumor therapy and biological imaging with low dosage and nontoxicity.

[9] Yawen Li  Zitong Liu  Yufan Ma  Yuzhi Chen  Kun Ma  Xuefei Wang  Deqing Zhang  Zhuo Wang. Semiconducting Nanocomposite with AIEgenTriggered Enhanced Photoluminescence and Photodegradation for DualModality Tumor Imaging and Therapy. Advanced Functional Materials, 2019. (原文链接

ABCTRACT

Semiconducting polymer nanoparticles (SPNs) have potential in biological applications. While some SPNs have significant photothermal conversion efficiencies (PCEs) as photothermal and photoacoustic agents, other SPNs offer high fluorescence yields as photoluminescent agents. However, the energy balance distribution in SPNs inhibits their successful applications in photoluminescence/photoacoustic (PL/PA) dualmodality imaging. Additionally, the ultrastability of SPNs in vivo may cause damage to organisms. This work reports nanocomposite semiconducting polymer and tetraphenylethene nanoparticles (STNPs) constructed by semiconducting polymers (SPs) and tetraphenylethene aggregationinduced emission luminogens (TPE AIEgens). The SP SPC10 endows good photothermal conversion ability, and the AIEgen TPBM supports enhanced photoluminescence of the STNPs. The results show that the STNPs can act as PL/PA dualmodality imaging agents. The signaltonoise (S/N) ratio in the PL modality reaches 8.7, and the imaging depth in the PA modality is 5.8 mm. The SPC10 in the STNPs can be decomposed under 90 mW cm2 white light irradiation in 6 h without any other additional agents. Furthermore, the STNPs are sufficient for the treatment of xenograft 4T1 tumorbearing mice based on photothermal therapy. The nanocomposite STNPs achieve optimized dualmodality PL/PA imaging and the AIEgentriggered in situ photodegradation of SPNs. These properties indicate the significant potential of STNPs in clinical diagnosis and noninvasive therapy.

2018

[8] Yuzhi Chen, Wenting Ai, Xuan Guo, Yawen Li, Yufan Ma, Lifang Chen, Hui Zhang, Tongxin Wang,* Xin Zhang,* and Zhuo Wang*. Mitochondria-Targeted Polydopamine Nanocomposite with AIE Photosensitizer for Image-Guided Photodynamic and Photothermal Tumor Ablation. Small, 2018. (原文链接

ABSTRACT

Photodynamic therapy (PDT) and photothermal therapy (PTT) are two kinds of treatment for tumors. Herein, a new aggregation-induced emission (AIE)gen  (MeO-TPE-indo, MTi) is synthesized with a D– π –A conjugated structure. MTi, which has an electron donor and an acceptor on a tetraphenylethene (TPE) conjugated skeleton, can induce the effective generation of reactive oxygen species (ROS) for PDT. With the guide of the indolium group, MTi can target and image mitochondrion selectively. In order to get good dispersion in water and long-time retention in tumors, MTi is modified on the surface of polydopamine nanoparticles (PDA NPs) to form the nanocomposite (PDA-MeO-TPEindo, PMTi) by π – π and hydrogen interactions. PMTi is a nanoscale composite for imaging-guided PDT and PTT in tumor treatment, which is constructed with AIEgens and PDA for the first time. The organic functional molecules are combined with nanomaterials for building a multifunctional diagnosis and treatment platform by utilizing the advantages of both sides.

[7] Li, Yawen,Chen, Yuzhi,Yu, Hao,Tian, Limei,Wang, Zhuo. Portable and Smart Devices for Monitoring Heavy Metal Ions Integrated with Nanomaterials. TrAC Trends in Analytical Chemistry, 2017:S0165993617303254. (原文链接

ABSTRACT

With increasing concerns of ecological environment, safe drinkable water and healthy food, the detection for heavy metal ions (HMIs) becomes an attractive research field. On the basis of optical, electrical and other signals from nanomaterials, many interesting methods and portable devices for detection of HMIs are growing flourishingly. In this review, we focus on the portable and smart devices integrated with nanomaterials for monitoring HMIs. The interesting design of the miniaturization, portability, and commercialization of HMIs detection devices are summarized and introduced comprehensively.

[6] YehuiWu, YuzhiChen, YawenLi, JiaHuang, HaoYu, ZhuoWang. Accelerating peroxidase-like activity of gold nanozymes using purine derivatives and its application for monitoring of occult blood in urine[J]. Sensors and Actuators B: Chemical, 2018, 270:443-451. (原文链接

ABSTRACT

Gold nanoparticles (AuNPs) is an important kind of nanozymes and a variety of its artificial enzymatic activities have been reported, such as oxidase, peroxidase, and superoxide dismutase. The DNA with poly purine-modified AuNPs shows an enhancement peroxidase activity compared with poly pyrimidine-modified AuNPs. In this work, purine derivatives are modified on the surface of AuNPs. The peroxidase-like activity of AuNPs is dependent on the chemical structure of the molecules capped on the surface. We find that ferric ions can accelerate the mimic enzymatic ability of 2, 6-diaminopurine (DAP) modified AuNPs. The enhanced catalytic activity comes from the synergistic reaction of AuNPs and ferric ions. The cooperative system can be applied to measure hemoglobin and red blood cells in urine with better sensitivity. Generally, there is no or few red blood cells in human urine. The presence of blood in the urine is closely related with serious diseases, for example chronic nephrotic syndrome and urinary system tumors. Compared the commercial urine test paper, the method based on DAP-AuNPs has a good sensitivity and wider quantitative range and will be helpful to do urine test at home.

[5] Zhuo Wang*, Hao Yu, Kun Ma, Yuzhi Chen, Xiuquan Zhang, Tongxin Wang, Sanbao Li, Xiaoqun Zhu, and Xuefei Wang*. Flower-like Surface of Three-Metal-Component Layered Double Hydroxide Composites for Improved Antibacterial Activity of Lysozyme. Bioconjugate Chemistry, 2018:acs.bioconjchem.8b00305-.(原文链接

ABSTRACT

Microbes play an important function in our lives, while some pathogenic bacteria are responsible for many infectious diseases, food safety, and ecological pollution. Layered double hydroxide (LDH) is a kind of natural two-dimensional material and has been applied in many fields. Lysozyme is a green natural antibacterial agent, while the antimicrobial activity of lysozyme is not as good as antibiotics. We use a different ratio of cations to tune the morphology of LDH covered with lysozyme to enhance the antibacterial ability of lysozyme. We synthesize MgAl-LDH, ZnAl-LDH, and ZnMgAl-LDH covered with lysozyme, characterize the structure and morphology, test the antibacterial in culture media, and evaluate the biotoxicity in vitro and in vivo. The flower-like structure of ZnMgAl-LDH has a rough surface, covered with lysozyme with a perfect ring, and presents good antibaterial properties and promotes wound healing of mice. The bloom flower structure of ZnMgAl-LDH can enhance the loading rate of lysozyme; meanwhile, the rougher surface can adhere more bacteria, so lyso@ZnMgAl-LDH presents better antibacterial activity than the binary LDHs.

[4] Zhuo Wang*, Yuzhi Chen, Hui Zhang, Yawen Li, Yufan Ma, Jia Huang, Xiaolei Liu, Fang Liu, Tongxin Wang, and Xin Zhang. Mitochondria-targeting Polydopamine Nanocomposites as Chemo-photothermal Therapeutics for Cancer. Bioconjugate Chemistry, 2018:acs.bioconjchem.8b00325-. (原文链接)

ABSTRACT

Mitochondria play a key role in a variety of physiological processes, and mitochondria-targeting drug delivery is helpful and effective in cancer therapy. Rhodamine123 (Rhod123) and Doxorubicin (Dox) are not new chemical molecules, and they both can inhibit the growth of cancerous cells. Here, we combine these two “old” chemicals with polydopamine nanoparticles (PDA NPs) to strengthen the antitumor effect with the aid of near-infrared irradiation. PDA NPs carry these two chemicals tightly by hydrogen bonds and π–π stacking besides chemical bonds. The better antitumor profile of PDA-Rhod-Dox comes from the mitochondria-targeting delivery, which decreases ATP in living cells, causing apoptosis of cancerous cells effectively and inhibiting the growth of tumors in mice. The synergistic effect of PDA, Rhod123, and Dox improves the treatment effect of conventional chemotherapy drugs.

[3] Yufan Ma, Yawen Li, Kun Ma, Zhuo WangOptical colorimetric sensor arrays for chemical and biological analysis[J]. Science China(Chemistry), 2018, v.61(06):15-27. (原文链接

ABSTRACT

In recent years, the sensor array has attracted much attention in the field of complex system analysis on the basis of its good selectivity and easy operation. Many optical colorimetric sensor arrays are designed to analyze multi-target analytes due to the good sensitivity of optical signal. In this review, we introduce the targeting analytes, sensing mechanisms and data processing methods of the optical colorimetric sensor array based on optical probes(including organic molecular probes, polymer materials and nanomaterials). The research progress in the detection of metal ions, anions, toxic gases, organic compounds, biomolecules and living organisms(such as DNA, amino acids, proteins, microbes and cells) and actual sample mixtures are summarized here.The review illustrates the types, application advantages and development prospects of the optical colorimetric sensor array to help broad readers to understand the research progress in the application of chemical sensor array.

2017

[2] Yuzhi Chen, Xiaomin Shi, Zhengliang Lu*, Xuefei Wang*, and Zhuo Wang*.  A Fluorescent Probe for Hydrogen Peroxide in Vivo Based on the Modulation of Intramolecular Charge Transfer. Anal.Chem., 2017:acs.analchem.6b04810. (原文链接

ABSTRACT

Endogenous hydrogen peroxide in vivo is related to many diseases, including cancer, diabetes, cardiovascular disease, and neurodegenerative disorders. Although many probes for detection of H2O2 have been explored, rapid response probes are still expected for in vivo application. Here, a new probe (PAM-BN-PB) was designed based on an intramolecular charge transfer (ICT) process with three parts: phenanthroimidazole, benzonitrile, and phenyl boronate. By modulation ICT process of PAM-BN-PB, H2O2 in solution systems can be detected with good selectivity. The exogenous and endogenous H2O2 in normal living cells, ischemia-reperfusion injury cells, and animals all can be imaged by PAM-BN-PB.

[1] 苏姗, 马宇帆, 田立枚, 王卓. 四苯乙烯聚集诱导发光探针在生物成像和药物递送中的应用研究进展. 中国科学:化学, 2017(09):37-46.