Lu J, Liu J, Guo Y, Zhang Y, Xu Y, Wang X*. CRISPR-Cas9: A method for establishing rat models of drug metabolism and pharmacokinetics. Acta Pharmaceutica Sinica B 2021 January 7, doi.org/10.1016/j.apsb.2021.01.007
Zhang Y, Huang S, Zhong W, Chen W, Yao B, Wang X*. 3D organoids derived from the small intestine: An emerging tool for drug transport research. Acta Pharmaceutica Sinica B 2021, 11(7): 1697-1707. December 13, doi.org/10.1016/j.apsb.2020.12.002
Sun D, Lu J, Zhang Y, Liu J, Liu Z, Yao B, Guo Y, Wang X*. Characterization of a novel CYP1A2 knockout rat model constructed by CRISPR/Cas9. Drug Metabolism and Disposition 2021, doi: 10.1124/dmd.121.000403
Huang S, Zhang Y, Zhang Y, Liu J, Liu Z, Wang X*. Establishment of LC-MS/MS method for determination of aloperine in rat plasma and its application in preclinical pharmacokinetics. Journal of Chromatography B 2021, 1173(2):122671. doi.org/10.1016/j.jchromb.2021.122671
Lu J, Chen A, Ma X, Shang X, Zhang Y, Guo Y, Liu M, Wang X*. Generation and Characterization of Cytochrome P450 2J3/10 CRISPR/Cas9 Knockout Rat Model. Drug Metabolism and Disposition 2020, 48(11): 1129-1136. （Cover Story)
About the cover: New CYP2J3/10 knockout rat model for drug metabolism and cardiovascular disease. See the article by Lu et al. (dx.doi.org/10.1124/dmd.120.000114).
Lu J, Shang X, Zhong W, Xu Y, Shi R, Wang X*. New insights of CYP1A in endogenous metabolism：a focus on single nucleotide polymorphisms and diseases. Acta Pharmaceutica Sinica B 2020, 10: 91-104. doi:10.1016/j.apsb.2019.11.016
Luo H, Xu Y, Sun D, Cheng Y, Sun Z, Gao J, Zhang Y, Wang X*. Assessment of the inhibition risk of paris saponins, bioactive compounds from Paris polyphylla, on CYP and UGT enzymes via cocktail inhibition assays. Regulatory Toxicology and Pharmacology 2020, 113: 104637. doi:10.1016/j.yrtph.2020.104637
Ma X, Shang X, Qin X, Lu J, Liu M, Wang X*. Characterization of organic anion transporting polypeptide 1b2 knockout rats generated by CRISPR/Cas9: A novel model for drug transport and hyperbilirubinemia disease. Acta Pharmaceutica Sinica B 2020, 10: 850-860. doi:10.1016/j.apsb.2019.11.007
Li Y, Meng Q, Yang M, Liu D, Hou X, Tang L, Wang X#, Lyu Y, Chen X, Liu K, Yu A, Zuo Z, Bi H. Current Trends in Drug Metabolism and Pharmacokinetics. Acta Pharmaceutica Sinica B 2019, 9, 1113-1144. doi:10.1016/j.apsb.2019.10.001
Ma X, Qin X, Shang X, Liu M, Wang X*. Organic anion transport polypeptide 1b2 selectively affects the pharmacokinetic interaction between paclitaxel and sorafenib in rats. Biochemical Pharmacology 2019, 169: 113612. doi:10.1016/j.bcp.2019.08.014
Qin X, Wang X*. Role of vitamin D receptor in the regulation of CYP3A gene expression. Acta Pharmaceutica Sinica B 2019, 9, 1087-1098. doi:10.1016/j.apsb.2019.03.005
Zhang L, Liang C, Xu P, Liu M, Xu F, Wang X*. Characterization of in vitro Mrp2 transporter model based on intestinal organoids. Regulatory Toxicology and Pharmacology 2019, 108: 104449. doi:10.1016/j.yrtph.2019.104449
Zhang L, Xu P, Cheng Y, Wang P, Ma X, Liu M, Wang X*, Xu F*. Diet-induced obese alters the expression and function of hepatic drug-metabolizing enzymes and transporters in rats. Biochemical Pharmacology 2019, 164, 368-376. doi:10.1016/j.bcp.2019.05.002
Liang C, Zhao J, Lu J, Zhang Y, Ma X, Shang X, Li Y, Ma X, Liu M, Wang X*. Development and characterization of MDR1 (Mdr1a/b) CRISPR/Cas9 knockout rat model. Drug Metabolism and Disposition 2019 Feb;47(2):71-79. doi: 10.1124/dmd.118.084277. Epub 2018 Nov 26
Cheng Y, Tang S, Chen A, Zhang Y, Liu M, Wang X*. Evaluation of the inhibition risk of shikonin on human and rat UDP-glucuronosyltransferases (UGT) through the cocktail approach. Toxicology Letters 2019, 312, 214-221. doi: 10.1016/j.toxlet.2019.05.017
Tang S, Ma X, Lu J, Zhang Y, Liu M, Wang X*. Preclinical toxicology and toxicokinetic evaluation of ailanthone, a natural product against castration-resistant prostate cancer, in mice. Fitoterapia 2019,136: 104161.doi:10.1016/j.fitote.2019.04.016
He Y, Peng S, Wang J, Chen H, Cong X, Chen A, Hu M, Qin M, Wu H, Gao S, Wang L, Wang X*, Yi Z*, Liu M*. Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer. Nature Communications 2016, 7:13122.
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Wang P, Qin X, Liu M, Wang X*.The burgeoning role of cytochrome P450-mediated vitamin D metabolites against colorectal cancer. Pharmacological Research 2018, 133, 9-20. doi:10.1016/j.phrs.2018.04.022
Qin X, Wang X*. Quantification of nucleotides and their sugar conjugates in biological samples: Purposes, instruments and applications. Journal of Pharmaceutical and Biomedical Analysis 2018, 158, 280-287. doi:10.1016/j.jpba.2018.06.013 (The invited review)
Lu J, Liu D, Zhou X, Chen A, Jiang Z, Ye X, Liu M, Wang X*.Plant natural product plumbagin presents potent inhibitory effect on human cytochrome P450 2J2 enzyme. Phytomedicine 2018, 39, 137-145. doi: 10.1016/j.phymed.2017.12.026
Chen A, Zhou X, Cheng Y, Tang S, Liu M, Wang X*. Design and optimization of thecocktail assay for rapid assessment of the activity of UGT enzymes in human and rat liver microsomes. Toxicology Letters 2018, 295, 379-389. doi: 10.1016/j.toxlet.2018.07.021
Li J, Li L, Qin X, Degrace P, Demizieux L, Limbu S, Wang X, Zhang M, Li D, Du Z. Inhibited carnitine synthesis causes systemic alteration of nutrient metabolism in zebrafish. Frontiers in Physiology2018, 9, 509. doi:10.3389/fphys.2018.00509
Su L, Li J, Zhou Z, Huang D, Zhang Y, Pei H, Guo W, Wu H, Wang X, Liu M, Yang CG, Chen Y. Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents. European Journal of Medicinal Chemistry 2018 Nov 8;162:203-211. doi: 10.1016/j.ejmech.2018.11.016.
Zhang L, Zhao J, Liang C, Liu M, Xu F*, Wang X*. A novel biosensor based on intestinal 3D organoids for detecting the function of BCRP. Drug Delivery 2017, 24, 1453-1459. doi:10.1080/10717544.2017.1381199
Tang S, Chen A, Zhou X, Zeng L, Liu M, Wang X*. Assessment of the inhibition risk of shikonin on cytochrome P450 via cocktail inhibition assay. Toxicology Letters 2017, 281, 74-83. doi: 10.1016/j.toxlet.2017.09.014
Qin X, Lu J, Wang P, Xu P, Liu M, Wang X*. Cytochrome P450 3A selectively affects the pharmacokinetic interaction between erlotinib and docetaxel in rats. Biochemical Pharmacology 2017, 143,129-139. doi:10.1016/j.bcp.2017.07.013
Lu J, Zhang Y, Sun M, Liu M, Wang X*. Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein. Phytomedicine 2017, 26, 1-10.
Lu J, Shao Y, Qin X, Liu D, Chen A, Li D*, Liu M*, Wang X*. CRISPR knockout rat cytochrome P450 3A1/2 model for advancing drug metabolism and pharmacokinetics research. Scientific Reports 2017, 7，42922.
Li JM, Li LY, Qin X, Ning LJ, Lu DL, Li DL, Zhang ML, Wang X*, Du ZY*. Systemic regulation of L-carnitine in nutritional metabolism in zebrafish, Danio rerio. Scientific Reports 2017, 7, 40815.
Qin X, Chen A, Lu J, Zhang YJ, Liu MY, Wang X*. Evaluation of plasma stability and pharmacokinetics of parthenolide in rats with LC-MS/MS analysis. Acta Pharmaceutica Sinica 2017, 52, 609-614. doi:10.16438/j.0513-4870.2016-1006
Wang X*, Tang Y, Lu J, Shao Y, Qin X, Li Y, Wang L, Li D, Liu M. Characterization of novel cytochrome P450 2E1 knockout rat model generated by CRISPR/Cas9. Biochemical Pharmacology 2016, 105, 80-90.
Qin X, Liu M, Wang X*. New insights into the androgen biotransformation in prostate cancer: a regulatory network among androgen, androgen receptors and UGTs .Pharmacological Research 2016, 106, 114-22.
Zhao J, Zeng Z, Sun J, Zhang Y, Li D, Zhang X, Liu M, Wang X*. A Novel Model of P-Glycoprotein Inhibitor Screening Using Human Small Intestinal Organoids. Basic & Clinical Pharmacology & Toxicology 2017, 120, 250-255.
Chen A, Zhou X, Tang S, Liu M, Wang X*. Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach. Scientific Reports 2016, 6, 28482.
Zhang Y, Zeng Z, Zhao J, Li D, Liu M, Wang X*. Measurement of Rhodamine 123 in Three-Dimensional Organoids: A Novel Model for P-Glycoprotein Inhibitor Screening. Basic & Clinical Pharmacology & Toxicology 2016, 119, 349-352.
Qin M, Peng S, Liu N, Hu M, He Y, Li G, Chen H, He Y, Chen A, Wang X, Liu M, Chen Y, Yi Z. LG308, a novel synthetic compound with anti-microtubule activity in prostate cancer cells, exerts effective antitumor activity. J Pharmacol Exp Ther.2015, 355, 473-483.
Lu J, Ding T, Qin X, Liu M, Wang X*. In vitro and in vivo evaluation of cucurbitacin E on rat hepatic CYP2C11 expression and activity using LC-MS/MS. Sci China Life Sci. 2017，60, 215-224. doi：10.1007/s11427-015-4911-7.
Zheng C, Zhou W, Wang T, You P, Zhao Y, Yang Y, Wang X, Luo J, Chen Y, Liu M, Chen H. A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic β-Cells in Type 2 Diabetic Mice. PLoS One 2015 Jul 24;10(7):e0134051. doi: 10.1371/journal.pone.0134051.
Chen A, Qin X, Lu J, Yi Z, Liu M, Wang X*. Development of a validated LC-MS/MS method for the determination of ailanthone in rat plasma with application to pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis 2015, 102, 514-518.
Sun M, Tang Y, Ding T, Liu M,Wang X*. Investigation of cytochrome P450 inhibitory properties of maslinic acid, a bioactive compound from Olea europaea L., and its structure-activity relationship. Phytomedicine 2015, 22, 56-65.
Ding T, Zhang Y, Chen A, Tang Y, Liu M, Wang X*(Corresponding author). Effects of Cucurbitacin E, a Tetracyclic Triterpene Compound from Cucurbitaceae, on the Pharmacokinetics and Pharmacodynamics of Warfarin in Rats. Basic & Clinical Pharmacology & Toxicology 2015, 116, 385-389. DOI: 10.1111/bcpt.12329
Yang F, Zhang T, Wu H, Yang Y, Liu N, Chen A, Li Q, Li J, Qin L, Jiang B, Wang X, Pang X, Yi Z, Liu M, Chen Y. Design and Optimization of Novel Hydroxamate-Based Histone Deacetylase Inhibitors of Bis-Substituted Aromatic Amides Bearing Potent Activities against Tumor Growth and Metastasis. Journal of Medicinal Chemistry 2014, 57, 9357-9369. DOI: 10.1021/jm5012148
Chen A, Qin X, Tang Y, Liu M, Wang X*. Evaluation of enzyme inhibition kinetics in drug-drug interactions. Chemico-Biological Interactions 2014, 222, 133-134.
Lu J, Qin X, Liu M, Wang X*. A note on CYP2J2-mediated terfenadine hydroxylation in human liver microsomes. Food and Chemical Toxicology 2014, 71, 284-285.
Sun M, Tang Y, Ding T, Liu M, Wang X*. Inhibitory effects of celastrol on rat liver cytochrome P450 1A2, 2C11, 2D6, 2E1 and 3A2 activity. Fitoterapia 2014, 92, 1-8.
