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成果及论文

代表性论文：

  1. Zhang, Lu+; Cheng, Ri+; He, Zuyang; Mei, Mei; Wu, Bin; Tan, Weimin*; Yan, Bo*; Wang, Shangfeng*; Zhang, Fan*, Excitation-encoded single-emission shortwave infrared lanthanide fluorophore palette for real-time in vivo multispectral imaging. Nat. Photon. 2025, 19 (11), 1209–1218.

  2. Wu, Bin+; Zhang, Lu+; Yan, Kui; Mei, Mei; Wu, Wenxiao; He, Zuyang; Wang, Shangfeng*; Zhang, Fan*, Electronic-Symmetry-Tuned Emission Beyond 1500 nm in Erbium(III)-Phthalocyanine Complexes for High-Resolution In Vivo Biosensing. J. Am. Chem. Soc. 2025. DOI: 10.1021/jacs.5c13688.

  3. Yan, Kui+; Hu, Zhubin+; Yu, Peng; He, Zuyang; Chen, Ying; Chen, Jiajian; Sun, Haitao*; Wang, Shangfeng*; Zhang, Fan*, Ultra-photostable small-molecule dyes facilitate near-infrared biophotonics. Nat. Commun. 2024, 15 (1), 2593.

  4. Wu, Wenxiao; Yan, Kui; He, Zuyang; Zhang, Lu; Dong, Yuyao; Wu, Bin; Liu, Hongyue; Wang, Shangfeng*; Zhang, Fan*, 2X-Rhodamine: A Bright and Fluorogenic Scaffold for Developing Near-Infrared Chemigenetic Indicators. J. Am. Chem. Soc. 2024, 146 (16), 11570–11576.

  5. Wang, Ting+; Wang, Shangfeng+*; Liu, Zhiyong; He, Zuyang; Yu, Peng; Zhao, Mengyao; Zhang, Hongxin; Lu, Lingfei; Wang, Zhengxin; Wang, Ziyu; Zhang, Weian*; Fan, Yong; Sun, Caixia; Zhao, Dongyuan; Liu, Weimin; Bünzli, Jean-Claude G.; Zhang, Fan*, A hybrid erbium(III)–bacteriochlorin near-infrared probe for multiplexed biomedical imaging. Nat. Mater. 2021, 20 (11), 1571–1578.

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发表论文：

2025

  1. Wu, Bin; Zhang, Lu; Yan, Kui; Mei, Mei; Wu, Wenxiao; He, Zuyang; Wang, Shangfeng; Zhang, Fan. Electronic-Symmetry-Tuned Emission Beyond 1500 nm in Erbium(III)-Phthalocyanine Complexes for High-Resolution In Vivo Biosensing. J. Am. Chem. Soc. 2025. DOI: 10.1021/jacs.5c13688.

  2. Zhang, Lu+; Cheng, Ri+; He, Zuyang; Mei, Mei; Wu, Bin; Tan, Weimin*; Yan, Bo*; Wang, Shangfeng*; Zhang, Fan*. Excitation-encoded single-emission shortwave infrared lanthanide fluorophore palette for real-time in vivo multispectral imaging. Nat. Photon. 2025, 19 (11), 1209–1218.

  3. Xiang, Bo+; Yan, Kui+; Zhang, Ying; Wu, Wenxiao; Zeng, Zhuo*; Zhang, Fan; Wang, Shangfeng*. Antiaromaticity-based general molecular design of activatable near-infrared photoacoustic probes with high acoustic loudness. Chem. & Biomed. Imaging (AIP).

2024

  1. Wu, Wenxiao; Yan, Kui; He, Zuyang; Zhang, Lu; Dong, Yuyao; Wu, Bin; Liu, Hongyue; Wang, Shangfeng*; Zhang, Fan*. 2X-Rhodamine: A Bright and Fluorogenic Scaffold for Developing Near-Infrared Chemigenetic Indicators. J. Am. Chem. Soc. 2024, 146 (16), 11570–11576.

  2. Shi, Ben+; Zhang, Lu+; Yan, Kui; Ming, Jiang; Chen, Zi-Han; Chen, Ying; He, Haisheng; Zhang, Hongxing; Wang, Lixin; Wang, Shangfeng*; Zhang, Fan*. Efficient and stable NIR-II phosphorescence of metallophilic molecular oligomers for in vivo single-cell tracking and time-resolved imaging. Angew. Chem. Int. Ed. 2024, e202410118.

  3. Yan, Kui+; Hu, Zubin+; Yu, Peng; He, Zuyang; Chen, Yin; Chen, Jiajian; Sun, Haitao*; Wang, Shangfeng*; Zhang, Fan*. Ultra-photostable small-molecule dyes facilitate near-infrared biophotonics. Nat. Commun. 2024, 15 (1), 2593. (ESI Highly Cited Paper)

  4. Ming, Jiang; Chen, Ying; Miao, Han; Fan, Yong; Wang, Shangfeng; Chen, Zihan; Guo, Zhenhao; Guo, Zhixiu; Qi, Luyin; Wang, Xusheng; Yun, Baofeng; Pei, Peng; He, Haisheng; Zhang, Hongxin; Tang, Yun; Zhao, Dongyuan; Wong, Gary Ka-Leung; Bünzli, Jean-Claude G.; Zhang, Fan*. High-brightness transition metal-sensitized lanthanide near-infrared luminescent nanoparticles. Nature Photonics 2024, 18 (12), 1254–1262.

  5. Mei, Mei; Wu, Bin; Wang, Shangfeng*; Zhang, Fan*. Lanthanide-dye hybrid luminophores for advanced NIR-II bioimaging. Curr. Opin. Chem. Biol. 2024, 80, 102469.

  6. Deng, Yu+; Yan, Kui+; Xu, Lingling; Liu, Xiaoyang; Zhao, Furong; Wang, Shangfeng; Zhang, Fan; Liang, Gaolin*; Wang, Rui*. “Turn-On” NIR-II Fluorescence of a Dually Quenched Probe for Sensitive Imaging of Cathepsin B In Vivo. Chem. Commun. 2024.

2023

  1. Chen, Ying; Wang, Shangfeng; Zhang, Fan*. Near-infrared luminescence high-contrast in vivo biomedical imaging. Nat. Rev. Bioeng. 2023, 1 (1), 60–78.

  2. Yang, Yiwei+; Chen, Ying+; Pei, Peng; Fan, Yong*; Wang, Shangfeng; Zhang, Hongxin; Zhao, Dongyuan; Qian, Bin-Zhi; Zhang, Fan*. Fluorescence-amplified nanocrystals in the second near-infrared window for in vivo real-time dynamic multiplexed imaging. Nat. Nano. 2023, 18 (10), 1195–1204.

  3. Zhao, Tiancong; Chen, Liang; Liu, Minchao; Lin, Runfeng; Cai, Weiluo; Hung, Chin-Te; Wang, Shangfeng; Duan, Linlin; Zhang, Fan; Elzatahry, Ahmed; Li, Xiaomin*; Zhao, Dongyuan*. Emulsion-oriented assembly for Janus double-spherical mesoporous nanoparticles as biological logic gates. Nat. Chem. 2023, 15 (6), 832–840.

  4. Wang, Ting; Chen, Ying; He, Zuyang; Wang, Xiaohan; Wang, Shangfeng; Zhang, Fan*. Molecular-Based FRET Nanosensor with Dynamic Ratiometric NIR-IIb Fluorescence for Real-Time In Vivo Imaging and Sensing. Nano Lett. 2023, 23 (10), 4548–4556.

2022

  1. Yang, Yang+; Sun, Caixia+; Wang, Shangfeng*; Yan, Kui; Zhao, Mengyao; Wu, Bin; Zhang, Fan*. Counterion-paired Bright Heptamethine Fluorophores with NIR-II Excitation and Emission Enable Multiplexed Biomedical Imaging. Angew. Chem. Int. Ed. 2022, 61 (24), e202117436. (Hot Paper)

  2. Yin, Dongrui+; Yao, Chenzhi+; Chen, Ying; He, Zuyang; Yu, Peng; Sun, Xingwen; Wang, Shangfeng*; Zhang, Fan*. HClO-activated Near-infrared Fluorogenic aza-BODIPY-Bisferrocene Triad with High Turn-on Ratio for in vivo Biosensing. Advanced Healthcare Materials 2022, e2201139.

  3. Yao, Chenzhi; Chen, Ying; Zhao, Mengyao; Wang, Shangfeng; Wu, Bin; Yin, Dongrui; Shi, Ben; Yang, Yang; Xu, Ge; Yu, Peng; Zhang, Hongxin; Zhang, Fan*. A Bright, Renal-Clearable NIR-II Brush Macromolecular Probe with Long Blood Circulation Time for Kidney Disease Bioimaging. Angew. Chem. Int. Ed. 2022, 61 (5), e202114273.

  4. Yu, Peng; Yan, Kui; Wang, Shangfeng*; Yao, Chenzhi; Lei, Zuhai; Tang, Yaohui; Zhang, Fan*. NIR-II Dyad-Doped Ratiometric Nanosensor with Enhanced Spectral Fidelity in Biological Media for In Vivo Biosensing. Nano Lett. 2022, 22 (23), 9732–9740.

  5. Pei, Peng; Hu, Hongxing; Chen, Ying; Wang, Shangfeng; Chen, Jing; Ming, Jiang; Yang, Yiwei; Sun, Caixia; Zhao, Shichang; Zhang, Fan*. NIR-II Ratiometric Lanthanide-Dye Hybrid Nanoprobes Doped Bioscaffolds for In Situ Bone Repair Monitoring. Nano Lett. 2022, 22 (2), 783–791.

2021

  1. Wang, Ting+; Wang, Shangfeng+; Liu, Zhiyong+; He, Zuyang; Yu, Peng; Zhao, Mengyao; Zhang, Hongxin; Lu, Lingfei; Wang, Zhengxin; Wang, Ziyu; Zhang, Weian; Fan, Yong; Sun, Caixia; Zhao, Dongyuan; Liu, Weimin; Bünzli, Jean-Claude G.; Zhang, Fan*. A hybrid erbium(III)–bacteriochlorin near-infrared probe for multiplexed biomedical imaging. Nat. Mater. 2021, 20 (11), 1571–1578. (ESI Highly Cited Paper)

  2. He, Yue+; Wang, Shangfeng+; Yu, Peng+; Yan, Kui; Ming, Jiang; Yao, Chenzhi; He, Zuyang; El-Toni, Ahmed Mohamed; Khan, Aslam; Zhu, Xinyan; Sun, Caixia; Lei, Zuhai; Zhang, Fan. NIR-II cell endocytosis-activated fluorescent probes for in vivo high-contrast bioimaging diagnostics. Chem. Sci. 2021, 10.1039/D1SC02763H.

  3. Wang, Shangfeng; Zhang, Fan*. Azo Pigments Make Raman Spectral Multiplexing More Sensitive. ACS Cent. Sci. 2021, 7 (5), 709–711.

  4. Zhao, Mengyao; Wang, Jianbo; Lei, Zuhai; Lu, Lingfei; Wang, Shangfeng; Zhang, Hongxin; Li, Benhao; Zhang, Fan*. NIR-II pH Sensor with a FRET Adjustable Transition Point for In Situ Dynamic Tumor Microenvironment Visualization. Angew. Chem. Int. Ed. 2021, 60 (10), 5091–5095.

  5. Zhang, Xin; Chen, Ying; He, Haisheng; Wang, Shangfeng; Lei, Zuhai; Zhang, Fan*. ROS/RNS and Base Dual Activatable Merocyanine-Based NIR-II Fluorescent Molecular Probe for in vivo Biosensing. Angew. Chem. Int. Ed. 2021, 60 (50), 26337–26341.

2020

  1. Wang, Shangfeng+; Li, Benhao+; Zhang, Fan*. Molecular Fluorophores for Deep-Tissue Bioimaging. ACS Cent. Sci. 2020, 6 (8), 1302–1316.

  2. Yang, Yanling; Wang, Shangfeng; Lu, Lingfei; Zhang, Qisong; Yu, Peng; Fan, Yong*; Zhang, Fan*. NIR-II chemiluminescence molecular sensor for in-vivo high contrast inflammation imaging. Angew. Chem. Int. Ed. 2020, 59 (42), 18380–18385. (Hot Paper)

  3. Lu, Lingfei; Li, Benhao; Ding, Suwan; Fan, Yong; Wang, Shangfeng; Sun, Caixia; Zhao, Mengyao; Zhao, Chun-Xia; Zhang, Fan*. NIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing. Nat. Commun. 2020, 11 (1), 4192.

2019

  1. Sun, Caixia; Li, Benhao; Zhao, Mengyao; Wang, Shangfeng; Lei, Zuhai; Lu, Lingfei; Zhang, Hongxin; Feng, Lishuai; Dou, Chaoran; Yin, Dongrui; Xu, Huixiong; Cheng, Yingsheng; Zhang, Fan*. J-aggregates of Cyanine Dye for NIR-II In-vivo Dynamic Vascular Imaging Beyond 1500 nm. J. Am. Chem. Soc. 2019, 141 (49), 19221–19225. (ESI Highly Cited Paper)

  2. Wang, Shangfeng; Fan, Yong; Li, Dandan; Sun, Caixia; Lei, Zuhai; Lu, Lingfei; Wang, Ting; Zhang, Fan*. Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing. Nat. Commun. 2019, 10 (1), 1058. (ESI Highly Cited Paper)

  3. Wang, Shangfeng; Liu, Lu; Fan, Yong; El-Toni, Ahmed Mohamed; Alhoshan, Mansour Saleh; Li, Dandan; Zhang, Fan*. In Vivo High-resolution Ratiometric Fluorescence Imaging of Inflammation Using NIR-II Nanoprobes with 1550 nm Emission. Nano Lett. 2019, 19 (4), 2418–2427. (ESI Highly Cited Paper)

  4. Li, Dandan; Wang, Shangfeng; Lei, Zuhai; Sun, Caixia; El-Toni, Ahmed Mohamed; Alhoshan, Mansour Saleh; Fan, Yong; Zhang, Fan*. Peroxynitrite Activatable NIR-II Fluorescent Molecular Probe for Drug-Induced Hepatotoxicity Monitoring. Anal. Chem. 2019, 91 (7), 4771–4779.

  5. Lei, Zuhai; Sun, Caixia; Pei, Peng; Wang, Shangfeng; Li, Dandan; Zhang, Xin; Zhang, Fan*. Stable, Wavelength-Tunable Fluorescent Dyes in the NIR-II Region for in-vivo High-Contrast Bioimaging and Multiplexed Biosensing. Angew. Chem. Int. Ed. 2019, 58 (24), 8166–8171.

  6. Fan, Yong; Wang, Shangfeng; Zhang, Fan*. Optical multiplexed bioassays improve biomedical diagnostics. Angew. Chem. Int. Ed. 2019, 58 (38), 13208–13219.

2018

  1. Liu, Lu; Wang, Shangfeng; Zhao, Baozhou; Pei, Peng; Fan, Yong; Li, Xiaomin*; Zhang, Fan*. Er3+ sensitized 1530 nm to 1180 nm second near-infrared window upconversion nanocrystals for in vivo biosensing. Angew. Chem. Int. Ed. 2018, 57 (25), 7518–7522. (ESI Highly Cited Paper)

  2. Zhao, Mengyao; Li, Benhao; Wang, Peiyuan; Lu, Lingfei; Zhang, Zhengcheng; Liu, Lu; Wang, Shangfeng; Li, Dandan; Wang, Rui; Zhang, Fan*. Supramolecularly Engineered NIR-II and Upconversion Nanoparticles In Vivo Assembly and Disassembly to Improve Bioimaging. Adv. Mater. 2018, 30 (52), 1804982.

2016

  1. Pan, Hang; Wang, Shangfeng; Xue, Yudong; Cao, Hongliang; Zhang, Weian*. Light-controllable toxicity recovery from selenium-based amphiphiles. Chem. Commun. 2016, 52 (99), 14208–14211.

2015

  1. Wang, Shangfeng; Wu, Bin; Liu, Feng; Gao, Yun; Zhang, Weian*. A well-defined alternating copolymer based on a salicylaldimine Schiff base for highly sensitive zinc(ii) detection and pH sensing in aqueous solution. Polym. Chem. 2015, 6 (7), 1127–1136.

  2. Wu, Bin; Xu, Lei; Wang, Shangfeng; Wang, Yong; Zhang, Weian*. A PEGylated colorimetric and turn-on fluorescent sensor based on BODIPY for Hg(ii) detection in water. Polymer Chemistry 2015, 6 (23), 4279–4289.

2014

  1. Cui, Jingjing; Wang, Shangfeng; Huang, Kai; Li, Yongsheng; Zhao, Wenru; Shi, Jianlin; Gu, Jinlou*. Conjugation-induced fluorescence labelling of mesoporous silica nanoparticles for the sensitive and selective detection of copper ions in aqueous solution. New J. Chem. 2014, 38 (12), 6017–6024.