主持科研项目:
1. 道地药材品质保障与资源持续利用全国重点实验室开放课题(2023)
2. 国家自然科学基金面上项目 (2019)
3. 温州市重大科技创新攻关医疗卫生项目 (2019)
4. 浙江省自然科学基金面上项目 (2018)
5. 温州市科技计划项目 (2018)
6. 中国博士后科学基金第61批面上资助一等 (2017)
7. 国家自然科学基金青年项目 (2014)
8. 吉林省科技厅重点科技攻关项目 (2014)
9. 吉林省科技厅青年基金 (2012)
10. 吉林省教育厅“吉林省高校科研春苗人才”项目 (2012)
获奖情况:
1. 吉林省青年科技奖,2016
2. 中国商业联合会科学技术奖,三等奖,2020 (第一完成人)
3. 吉林市科技进步奖,三等奖,2017 (第一完成人)
4. 浙江省药学会科学技术奖,二等奖,2020(第一完成人)
5. 吉林省自然科学奖,二等奖,2019(第二完成人)
6. 吉林省自然科学奖,二等奖,2015(第二完成人)
7. 吉林省科技进步奖,二等奖,2013(第二完成人)
近五年发表论文(#同等贡献;*通讯作者):
1. Zhang, Y.#, Cheng, Y.#, Liu, J.#, Zuo, JH., Yan, L.P., Thring, W.R., Ba, X.Q., Qi, D.K., Wu, M.J., Gao, Y.T.*, Tong, H.B.* Tauroursodeoxycholic acid functions as a critical effector mediating insulin sensitization of metformin in obese mice. Redox Biology, 2022, 57, 102481(IF:10.787,1区 Top)
2. Zuo, J.H.#, Zhang, Y.#, Wu, Y.#, Liu, J., Wu, Q.F., Shen, Y.Z., Jin, L., Wu, M.J.*, Ma, Z.L.*, Tong, H.B.* Sargassum fusiforme fucoidan ameliorates diet-induced obesity through enhancing thermogenesis of adipose tissues and modulating gut microbiota. International Journal of Biological Macromolecules, 2022, 216, 728–740(IF:8.025,1区Top)
3. Zhang, Y.#, Wu, Q.F.#, Liu, J., Zhang, Z.S., Ma, X.J., Zhang, Y.Y., Zhu, J.W., Thring, W.R., Wu, M.J., Gao, Y.T.*, Tong, H.B.* Sulforaphane alleviates high fat diet-induced insulin resistance via AMPK/Nrf2/GPx4 axis. Biomedicine & Pharmacotherapy, 2022, 152, 113273(IF:7.419,2区 Top)
4. Wu, S.Y.#, Liu, J.#, Zhang, Y.#, Song, J.X., Zhang, Z.S., Yang, Y., Wu, M.J.*, Tong, H.B.* Structural characterization and antagonistic effect against P-selectin-mediated function of SFF-32, a fucoidan fraction from Sargassum fusiforme. Journal of Ethnopharmacology, 2022, 295, 115408(IF:5.195,2区 Top)
5. He, D.#, Wu, Q.F.#, Lu, C.Y., Wu, J.L., Chen, P.C., Wu, M.J.*, Choi, J.I.*, Tong, H.B.* Pyropia yezoensis porphyran alleviates metabolic disorders via modulating gut microbiota in high sucrose-fed Drosophila melanogaster. Journal of The Science of Food and Agriculture, 2022, 102, 4802-4812(IF:4.125,2区 Top)
6. Qin, Z.Y., Yuan, X.Y., Liu, J., Shi, Z.Q., Cao, L.P., Yang, L.X., Wu, K., Lou, Y.L, Tong, H.B.*, Jiang, L.*, Du, J.M.* Albuca Bracteata polysaccharides attenuate AOM/DSS induced colon tumorigenesis via regulating oxidative stress, inflammation and gut microbiota in mice. Frontiers in Pharmacology, 2022, 13:833077(IF:5.988,2区Top)
7. Yang, Y., Mao, R., Yang, L.C. Liu, J., Wu, S.Y., Wu, M.J.*, Zhang, X., Tong, H.B.*, Ji, X.L.* Rapid and comprehensive quality assessment of Bupleuri Radix through near-infrared spectroscopy combined with chemometrics. Infrared Physics & Technology, 2022, 104051(IF:2.997,2区)
8. Wei, S.W., Zhao, Y.J., Zhou, R.M., Lin, J.W., Su, T.T., Tong, H.B.*, Wang, Z.Y. Biodegradation of polybutylene adipate-co-terephthalate by Priestia megaterium, Pseudomonas mendocina, and Pseudomonas pseudoalcaligenes following incubation in the soil. Chemosphere, 2022, 307, 135700(IF:8.943,2区Top)
9. Yang, Y., She, X.T., Cao, X.Q., Yang, L.C. Huang, J.M., Zhang, X., Su, L.J., Wu, M.J.*, Tong, H.B.*, Ji, X.L.* Comprehensive evaluation of Dendrobium officinale from different geographical origins using near-infrared spectroscopy and chemometrics. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 277:121249(IF:4.831,2区)
10. Zhang, Y.#, Liu, J.#, Mao, G.X.#, Zuo, J.H. Li, S.J., Yang, Y., Thring, R., Wu, M.J.*, Tong, H.B.* Sargassum fusiforme fucoidan alleviates diet-induced insulin resistance by inhibiting colon-derived ceramide biosynthesis. Food & Function, 2021, 12, 8440–8453.(IF:5.396,1区Top)
11. Liu, J.#, Wu, S.Y.#, Cheng, Y.#, Liu, Q., Su, L.J., Yang, Y., Zhang, X., Wu, M.J., Choi, J.-i.*, Tong, H.B.* Sargassum fusiforme alginate relieves hyperglycemia and modulates intestinal microbiota and metabolites in type 2 diabetic mice. Nutrients, 2021, 13, 2887.(IF:5.717,2区Top)
12. Gao, S.B., Gao, H.X., Dai, L.P., Han, Y.J., Lei, Z., Wang, X.Z., Chang, H.B., Liu, S.S., Wang, Z.T., Tong, H.B.*, Wu, H.* miR-126 regulates angiogenesis in myocardial ischemia by targeting HIF-1α. Experimental Cell Research, 2021, 409, 112925(IF:3.905,3区)
13. He, D., Yan L.P., Zhang, J.Q., Li, F., Wu, Y., Su, L.J., Chen, P.C., Wu, Q.F., Wu, M.J.*, Choi, J.I.*, Tong, H.B.* Sargassum fusiforme polysaccharide attenuates high-sugar-induced lipid accumulation in HepG2 cells and Drosophila melanogaster larvae. Food Science & Nutrition, 2021, 9:5590–5599.(IF:2.863,3区)
14. Wu, Q.F., Du, X.T., Feng, X.C., Cheng, H.M., Chen, Y.J., Lu, C.Y., Wu, M.J., Tong, H.B.* Chlordane exposure causes developmental delay and metabolic disorders in Drosophila melanogaster. Ecotoxicology and Environmental Safety, 2021, 225, 112739.(IF:6.291,2区Top)
15. Wu, S.Y.#, Zuo, J.H.#, Cheng, Y.#, Zhang, Y., Zhang, Z.S., Wu, M.J.*, Yang, Y.*, Tong, H.B.* Ethanol extract of Sargarsum fusiforme alleviates HFD/STZ-induced hyperglycemia in association with modulation of gut microbiota and intestinal metabolites in type 2 diabetic mice. Food Research International, 2021, 147, 110550.(IF:6.475,1区Top)
16. Wu, Q.F. #, Wu, S.Y. #, Cheng, Y. #, Zhang, Z.S., Mao, G.X., Li, S.J., Yang, Y., Zhang, X., Wu, M.J.*, Tong, H.B.* Sargassum fusiforme fucoidan modifies gut microbiota and intestinal metabolites during alleviation of hyperglycemia in type 2 diabetic mice. Food & Function, 2021, 12, 3572–3585.(IF:5.396,1区Top)
17. He, D., Yan L.P., Hu, Y.X., Wu, Q.F., Wu, M.J.*, Choi, J.I.*, Tong, H.B.* Optimization of Pyropia yezoensis porphyran by response surface methodology and its lipid-lowering effect. Marine Drugs, 2021, 19, E53.(IF:5.118,2区)
18. Zhang, Y.#, Zuo, J.H.#, Yan, L.P.#, Cheng, Y., Li, Q.J., Wu, S.Y., Chen, L., Thring, R., Yang, Y., Gao, Y.T.*, Wu, M.J.*, Tong, H.B.* Sargassum fusiforme fucoidan alleviates high-fat diet-induced obesity and insulin resistance associated with the improvement of hepatic oxidative stress and gut microbiota profile. Journal of Agricultural and Food Chemistry, 2020, 68, 10626–10638.(IF:4.192,1区Top)
19. Liu, J., Luthuli, S., Wu, Q.F., Wu, M.J.*, Choi, L.I.*, Tong, H.B.* Pharmaceutical and nutraceutical potential applications of Sargassum fulvellum. BioMed Research International, 2020, e2417410.(IF:2.276,3区)
20. Liu, J., Luthuli, S., Yang, Y., Cheng, Y., Zhang, Y., Wu, M.J.*, Choi, L.I.*, Tong, H.B.* Therapeutic and nutraceutical potentials of a brown seaweed Sargassum fusiforme. Food Science & Nutrition, 2020, 8:5195-5205.(SCI,IF:1.797,3区)
21. He, D.#, Yan L.P.#, Ma, X.J., Cheng, Y., Wu, S.Y., Zuo, J.H., Park, E.J., Liu, J., Wu, M.J., Choi, J.I.*, Tong, H.B.* Gamma-irradiation degradation of sulfated polysaccharide from a new red alga strain Pyropia yezoensis Sookwawon 104 and their in vitro antitumor bioactivity. Oncology Letters, 2020, 20(4): e91.(IF:2.311,4区)
22. Song, J.X., Wu, Y., Ma, X.J., Feng, L.J., Wang, Z.G., Jiang, G.Q.*, Tong, H.B.* Structural characterization and α-glycosidase inhibitory activity of a novel polysaccharide fraction from Aconitum coreanum. Carbohydrate Polymers, 2020, 230, 115586.(IF:7.182,1区Top)
23. Liu, J.#, Wu, S.Y.#, Chen, L., Li, Q.J., Shen, Y.Z., Jin, L., Zhang, X., Chen, P.C., Wu, M.J.*, Choi, J.I*, Tong, H.B.* Different extraction methods bring about distinct physicochemical properties and antioxidant activities of Sargassum fusiforme fucoidans. International Journal of Biological Macromolecules, 2020, 155, 1385–1392.(IF:5.162,2区Top)
24. Luthuli, S.#, Wu, S.Y.#, Cheng, Y., Zheng, X.L., Wu, M.J.*, Tong, H.B.* Therapeutic effects of fucoidan: A review on recent studies. Marine Drugs, 2019, 17, E487.(IF:3.772,2区,入选高被引论文)
25. Song, J.X., Wu, Y., Jiang, G.Q., Feng, L.J., Wang, Z.G., Yuan, G.X.*, Tong, H.B.* Sulfated polysaccharides from Rhodiola sachalinensis reduce D-gal-induced oxidative stress in NIH 3T3 cells. International Journal of Biological Macromolecules, 2019, 140, 288–293.(IF:4.784,2区)
26. He, D.#, Wu, S.Y.#, Yan, L.P., Zuo, J.H., Cheng, Y., Wang, H.F., Liu, J., Zhang, X., Choi, J.I., Wu, M.J.*, Tong, H.B.* Antitumor bioactivity of porphyran extracted from Pyropia yezoensis Chonsoo2 on human cancer cell lines. Journal of the Science of Food and Agriculture, 2019, 99: 6722–6730.(IF:2.422,2区 Top)
27. Cheng, Y.#, Sibusiso, L.#, Hou, L.F., Jiang, H.J., Chen, P.C., Zhang, X., Wu, M.J.*, Tong, H.B.* Sargassum fusiforme fucoidan modifies the gut microbiota during alleviation of streptozotocin-induced hyperglycemia in mice. International Journal of Biological Macromolecules, 2019, 131: 1162-1170. (IF:4.784,2区)
28. Wu, S.Y., Zhang, X., Liu, J., Song, J.X., Yu, P., Chen, P.C., Liao, Z.Y., Wu, M.J.*, Tong, H.B.* Physicochemical characterization of Sargassum fusiforme fucoidan fractions and their antagonistic effect against P-selectin-mediated cell adhesion. International Journal of Biological Macromolecules, 2019, 133: 656-662. (IF:4.784,2区)