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成果及论文


  • 52.
  • Huihui LiuJie GuoWangjing YinHehua XiongLing ChenYiling RuanKai FengDan Su*Yi Liu*Xiaolian Sun*. Dual  Locked Nanophotosensitizer Harnessing Cerenkov Radiation for Deep Tumor Therapy[J]. Journal of Medicinal Chemistry, 2025. https://doi.org/10.1021/acs.jmedchem.5c02387   
     

51.Yuyang Tian  , Lian Wang , Ruifang Chen , Yinxin Miao  , Yili Liu  , Weijing Huang  , Leyi Fang , Shaohai Liu , Jiewei Luo , Xiaolian Sun  , Yan Zhang  , Deju Ye l. Self‐Assembled Triple‐Targeted Radiosensitizer Enhances Hypoxic Tumor Targeting and Radio‐Immunotherapy Efficacy[J]. Angewandte Chemie, 2025, 137(18): e202500645.

Details are in the caption following the image

50.Yiling RuanHongxiang HuangHuihui LiuJinglang GongChangjun LiXiaolian Sun,"X-ray controlled release strategy in cancer therapyBMEMat (2025): e12136.  https://doi.org/10.1002/bmm2.12136.

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49.Haolin Zhang , Kai Feng , Guisen Li , Weijiao Chen , Yuan Shao , Jiayu Ding , Mingming Zheng , Kai Yuan , Xiaolian Sun , Peng Yang, "Carbonic anhydrase IX-targeted SMDCs for cancer precision treatment." Chinese Chemical Letters (2025). https://doi.org/10.1016/j.cclet.2025.111047

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48、Yiling Ruan, Yang Liu, Guojun Lei, Yuan Shao, Yaxuan Zhao, Jinglang Gong, Keying Li, Xiaojiang Xie, Shouju Wang, Xiaolian Sun. Fluoroalkane Engineered Magnetic Vectors Unlock the Potential of Gasdermin in Vivo Delivery for Pyroptosis Induced Cancer Therapy. A Advanced Healthcare Materials, (2025). https://doi.org/10.1002/adhm.202500801

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47.Wang Qiuyang, Kai Feng, Guangsheng Wan, Wei Liao, jing Jin, Peng Wang, aolian Sun, Weijun Wang, and Qing Jiang. "A ROS-responsive hydrogel encapsulated with matrix metalloproteinase-13 siRNA nanocarriers to attenuate osteoarthritis progression." Journal of Nanobiotechnology.(2025). https://doi.org/10.1186/s12951-024-03046-7

46.Yun Chai ,Minxia Xu , Ye Sun , Yanyan Zhu , Tianyou Du , Bingjian Zhu , Hui Yu , Xiaolian Sun ,Yi Pan ,Yi Liu. "Hydrogen sulfide-responsive and depleting NIR-II nanoplatform synergistic photodynamic therapy for colorectal cancer." Chemical Engineering Journal ,2025.(IF:13.3) https://doi.org/10.1016/j.cej.2025.161711.

45.Jingjing Shen , Kai Feng, Jing Yu, Yaxuan Zhao, Ruifang Chen, Hehua Xiong, Yiling Ruan, Zhengtao Xu, Tao Zhang, Xiaolian Sun,Responsive and traceless assembly of iron nanoparticles and 131I labeled radiopharmaceuticals for ferroptosis enhanced radio-immunotherapy. Biomaterials, 2025. ( IF 12.8 ) https://doi.org/10.1016/j.biomaterials.2024.122795

Scheme 1


44.Ruifang Chen, Jinglang Gong, Ziyi Yu, Xiyao Wu, Changjun Li, Yiling Ruan, Shouju Wang, Xiaolian Sun, X-ray triggered bimetallic nanoassemblies as radiosensitizers and STING agonists for a CDT/radio-immunotherapy strategy.Acta Biomaterialia ,2024IF 9.4 ). https://doi.org/10.1016/j.actbio.2024.12.030

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43.Wen Zhao , Juan Liu , Guangtao Wang , Xintian Wang , Chuanju Yang , Jian Li , Yuting Wang , Xiaolian Sun , Richen Lin , Gancheng Zuo , Wenlei Zhu. Copper-based catalysts for carbon monoxide electroreduction to multicarbon products. Science China Materials,2024 (IF 6.8https://doi.org/10.1007/s40843-023-2884-8

42. Naijie Wei  , Xiaoyang Chen  , Danchen Liu 1, Xiangchao Bu  , Guangji Wang  , Xiaolian Sun , Jingwei Zhang . A multi-modality imaging strategy to determine the multiple in vivo fates of human umbilical cord mesenchymal stem cells at different periods of acute liver injury treatment. Journal of Materials Chemistry B, 2024.( IF 6.1)  DOI: 10.1039/d4tb00914b

image file: d4tb00914b-f1.tif

41.Yiling Ruan, Xiaojing Wu, Keying Li, Jingjing Shen, Jinglang Gong, Kai Feng , Shouheng Sun, Xiaolian Sun ,FeAu Bimetallic Nanoparticle as Fe (0) Reservoir for Near Infrared Laser Enhanced Ferroptosis/Pyroptosis‐Based Tumor Immunotherapy( IF 18.5 ).Advanced Functional Materials, 2024. ( IF 18.5 ) https://doi.org/10.1002/adfm.202409335

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40.H. LiuH. XiongC. LiM. XuY. YunY. RuanL. TangT. ZhangD. SuX. Sun131I Induced In Vivo Proteolysis by Photoswitchable azoPROTAC Reinforces Internal RadiotherapySmall 2024, 2310865. ( IF 13.0 ) https://doi.org/10.1002/smll.202310865

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39.Xu, M., Yun, Y., Li, C., Ruan, Y., Muraoka, O., Xie, W., & Sun, X.  Radiation responsive PROTAC nanoparticles for tumor-specific proteolysis enhanced radiotherapy. Journal of materials chemistry. B2024.(IF 7.0 )https://doi.org/10.1039/d3tb03046f

38.Kai Feng  , Yiling Ruan , Xinmiao Zhang  , Xiaojing Wu  , Zixuan Liu  , Xiaolian Sun ,Photothermal-Ionic-Pharmacotherapy of Myocardial Infarction with Enhanced Angiogenesis and Antiapoptosis,ACS Applied Materials & Interfaces ( IF 9.5 ) Pub Date : 2023-11-29 , DOI: 10.1021/acsami.3c14109

37.Huihui Liu, Qing Wang, Jingru Guo, Kai Feng, Yiling Ruan, Zhihao Zhang, Xin Ji, Jigang Wang, Tao Zhang, Xiaolian Sun,Prodrug-based strategy with a two-in-one liposome for Cerenkov-induced photodynamic therapy and chemotherapy,

Journal of Controlled Release. 2023. IF 10.8 ) https://doi.org/10.1016/j.jconrel.2023.10.036.


36.Jingru Guo, Hehua Xiong, Huihui Liu, Tao Zhang, Xiaolian Sun.Radioiodine based biomedical carriers for cancer theranostics

Coordination Chemistry Reviews .2023.( IF 20.6 ) https://doi.org/10.1016/j.ccr.2023.215430


35.Yaxuan Zhao, Kai Feng, Guojun Lei, Jingjing Shen, Yang Liu, Yiling Ruan, Xiaolian Sun. Smart magnetic nanosystem sequentially extracellular and intracellular release proteins for cancer therapy. Nanoscale. 2023IF 8.307 ) https://doi.org/10.1039/D3NR01794J


34.Gao M, Feng K, Zhang X, et al. Nanoassembly with self-regulated magnetic thermal therapy and controlled immuno-modulating agent release for improved immune response. J Control Release2023.(IF  11.467) https://doi.org/10.1016/j.jconrel.2023.03.035


33.Yu H, Wang Q, Zhang X, Tiemuer A, Wang J, Zhang Y, Sun X, Liu Y. Hot-band absorption assisted single-photon frequency upconversion luminescent nanophotosensitizer for 808 nm light triggered photodynamic immunotherapy of cancer. Biomater Sci. 2023.(IF  15.304) https://doi.org/10.1039/d2bm01700h

Graphical abstract: Hot-band absorption assisted single-photon frequency upconversion luminescent nanophotosensitizer for 808 nm light triggered photodynamic immunotherapy of cancer


32.Feng K, Xu Z, Wang Y, et al. Renal-clearable porous hollow copper iron oxide nanoparticles for trimodal chemodynamic-photothermal-chemo anti-tumor therapy. Nanoscale2023.(IF 8.307 ) . https://doi.org/10.1039/d2nr06224k




31.Liu N, Su X, Sun X. Cerenkov radiation-activated probes for deep cancer theranostics: a review. Theranostics. 2022. ( IF 11.600 ).

https://doi.org/10.7150/thno.75279

Graphic abstract


30.Zhang, JXu, ZLi, Y, et al. Theranostic mesoporous platinum nanoplatform delivers halofuginone to remodel extracellular matrix of breast cancer without systematic toxicityBioeng Transl Med2022IF 10.684 ) https://doi.org/10.1002/btm2.10427


29. H Liang, XY Wu, GZ Zhao, K Feng, KY Ni, XL Sun*. Renal Clearable Ultrasmall Single-Crystal Fe Nanoparticles for Highly Selective and Effective Ferroptosis Therapy and Immunotherapy. J. Am. Chem. Soc. 2021. (IF 15.419)  https://pubs.acs.org/doi/10.1021/jacs.1c07471

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28. Guo J ,  K  Feng,  Wu W , et al. Smart 131I labeled self-illuminating photosensitizers for deep tumor imaging guided therapy[J]. Angewandte Chemie International Edition, 2021. (IF 15.336)  https://doi.org/10.1002/anie.202107231


27. H Liang, JR Guo, YY Shi, GZ Zhao, SH Sun*, XL Sun*. Porous yolk-shell Fe/Fe3O4 nanoparticles with controlled exposure of highly active Fe(0) for cancer therapy. Biomaterials 2021, 268, 120530. (IF 12.479)  https://doi.org/10.1016/j.biomaterials.2020.120530

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26. Wang Q, Wei N, Guo J, et al. Hemin-lipid assembly as an artemisinin oral delivery system for enhanced cancer chemotherapy and immunotherapy[J]. Nanoscale, 2021, 13(31): 13231-13240. (IF 7.79)  DOI:10.1039/D1NR01302E

https://pubs.rsc.org/en/content/articlelanding/2021/nr/d1nr01302e/unauth      

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25. Liu, Nian; Shi, Junpeng; Wang, Qiang; Guo, Jingru; Hou, Zhenyu; Su Xinhui*; Zhang, Hongwu*; XL Sun *. In vivo repeatedly activated persistent luminescence nanoparticles by radiopharmaceuticals for long-lasting tumor optical imaging. Small 2020, 16 (26)2001494. (IF 10.856) https://doi.org/10.1002/smll.202001494


24. Wang, Qiang; Liu, Nian; Hou, Zhenyu; Shi, Junpeng; Su, Xinhui*; XL Sun*. Radioiodinated persistent luminescence nanoplatform for radiation-induced photodynamic therapy and radiotherapy. Adv. Healthcare Mater. 20202000802. (IF 7.367)


23. Yu, Fei#; Zhang, Fuwu#; Tang, Longguang#; Ma, Jingwen; Ling, Daishun; Chen, Xiaoyuan*; XL Sun*. Redox-responsive dual chemophotothermal therapeutic nanomedicine for imaging-guided combinational therapy. J Mater Chem B20186(33), 5362-5367. (IF 6.331)


22. YL Dai, C Xu, XL Sun*, XY Chen*. Nanoparticle design strategies for enhanced  anticancer therapy by exploiting the tumour microenvironment. Chem. Soc. Rev. 2017, 46: 3830-3852. (IF 38.618) https://pubs.rsc.org/en/content/articlepdf/2017/cs/c6cs00592f


21. XL Sun, XF Yan, O Jacobson, WJ Sun, ZT Wang, X Tong, YQ Xia, DS Ling, XY Chen*. Improved tumor uptake by optimizing liposome based RES blockade strategy. Theranostics 2017, 7: 319-328. (IF 8.712)


20. LG Tang, FW Zhang, F Yu, WJ Sun, ML Song, XY Chen, XZ Zhang*, XL Sun*. Croconaine nanoparticles with enhanced tumor accumulation for multimodality cancer theranostics. Biomaterials 2017, 129: 28-36. (IF 7.886)


19. XL Sun*, YS Li, T Liu, ZJ Li, XZ Zhang*, XY Chen*. Peptide-based imaging agents for cancer detection. Adv. Drug Deliv. Rev. 2016, 110-111: 38-51. (IF 15.606) https://doi.org/10.1016/j.addr.2016.06.007


18. X Tong, ZT Wang, XL Sun, JB Song, O Jacobson, G Niu, DO Kiesewetter, XY Chen*. Size dependent kinetics of gold nanorods in EPR mediated tumor delivery. Theranostics. 2016, 6 (12): 2039-2051. (IF 8.712)


17. XL Sun*, WB Cai*, XY Chen*. Positron emission tomography imaging using radiolabeled inorganic nanomaterials. Acc. Chem. Res. 2015, 48: 286-294. (IF 20.268) https://pubs.acs.org/doi/10.1021/ar500362y


16. XL Sun*, DG Li, SJ Guo, WL Zhu, SH Sun*. Controlling core/shell Au/FePt nanoparticle electrocatalysis via changing the core size and shell thickness. Nanoscale 2015, 8: 2626-2631. (IF 7.760)


15. WS Guo, XL Sun*, O Jacobson, XF Yan, K Min, S Avinash, G Niu, D Kiesewetter, J Chang*, X Chen*. Intrinsically radioactive [64Cu]CuInS/ZnS quantum dots for PET and optical imaging: improved radiochemical stability and controllable Cerenkov luminescence. ACS nano 2014, 9:488-495. (IF 13.942)


14. XL Sun*, XL Huang, XF Yan, Y Wang, JX Guo, O Jacobson, DB Liu, LP Szajek, WL Zhu, G Niu, DO Kiesewetter, SH Sun, XY Chen*. Chelator-free 64Cu coated Au nanorod for PET imaging guided photothermal cancer therapy, ACS Nano 2014, 8(8): 8438-8446. (IF 13.942) https://pubs.acs.org/doi/pdf/10.1021/nn502950t


13. XL Sun, XL Huang, JX Guo, WL Zhu, Y Ding, G Niu, A Wang, DO Kiesewetter, ZL Wang, SH Su, XY Chen*. Self-illuminating 64Cu-doped CdSe/ZnS nanocrystals for in vivo tumor imaging, J. Am. Chem. Soc. 2014, 136(5): 1706-1709. (IF 13.858) DOI:10.1021/ja410438n  https://pubs.acs.org/doi/10.1021/ja410438n


12. XL Sun, DG Li, Y Ding, WL Zhu, SJ Guo, ZL Wang, SH Sun*. Core/shell Au/CuPt nanoparticles and their dual electrocatalysis for both reduction and oxidation reaction. J. Am. Chem. Soc. 2014, 136(15): 5745-5749. (IF 13.858) DOI:10.1021/ja500590 https://pubs.acs.org/doi/10.1021/ja500590n


11. YS Yu, WW Yang, XL Sun, WL Zhu, XZ Li, DJ Sellmyer, SH Sun*. Monodisperse MPt (M = Fe, Co, Ni, Cu, Zn) nanoparticles prepared from a facile oleylamine reduction of metal salts. Nano Lett. 2014, 14(5): 2778-2782. (IF 12.712)


10. XL Huang, F Zhang, XL Sun, KY Choi, G Niu, GF Zhang, JX Guo, S Lee, XY Chen*. The genotype-dependent influence of functionalized multiwalled carbon nanotubes on fetal development. Biomaterials. 2014, 35(2): 856-865. (IF 8.402)


9. XL Sun, SJ Guo, C Chung, WL Zhu, SH Sun*. A sensitive H2O2 assay based on dumbbell-like PtPd-Fe3O4 nanoparticles. Adv. Mater. 2013, 25(1): 132-136. (IF 19.791) https://doi.org/10.1002/adma.201203218


8. O Metin#, XL Sun#, SH Sun*. Monodisperse gold-palladium alloy nanoparticles and their composition-controlled catalysis in formic acid dehydrogenation under mild conditions. Nanoscale. 2013, 7: 5(3): 910-2. (# equally contributed) (IF 7.760)


7. XL Sun, SJ Guo, Y Liu, SH Sun*. Dumbbell-like PtPd-Fe3O4 nanoparticles for enhanced electrochemical detection of H2O2. Nano Lett. 2012, 12; 12(9): 4859-4863. (IF 12.712) 10.1021/nl302358e https://pubs.acs.org/doi/10.1021/nl302358e


6. XL Sun, NF Huls, A Sigdel, SH Sun*. Tuning exchange bias in core/shell FeO/Fe3O4 nanoparticles. Nano Lett. 2012, 12(1): 246-251. (IF 12.712) DOI:10.1021/nl2034514  https://pubs.acs.org/doi/10.1021/nl2034514


5. Y Ding, XL Sun, ZL Wang, SH Sun*. Misfit dislocations in multimetallic core-shelled nanoparticles. Appl. Phys. Lett. 2012, 100(11): 111603. (IF 3.411)


4. XL Sun, D Ho, LM Lacroix, JQ Xiao, SH Sun*. Magnetic nanoparticles for magnetoresistance-based biodetection. IEEE T. Nanobiosci. 2012, 11(1): 46-53. (IF 2.771)


3. D Ho, XL Sun, SH Sun*. Monodisperse magnetic nanoparticles for theranostic applications. Acc. Chem. Res. 2011, 44(10): 875-82. (IF 20.268) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184307/pdf/nihms303381.pdf


2. SJ Guo, S Zhang, XL Sun, SH Sun*. Synthesis of ultrathin FePtPd nanowires and their use as catalysts for methanol oxidation reaction. J. Am. Chem. Soc. 2011, 133(39): 15354-7. (IF 13.858)


1. LM Lacroix, NF Huls, D Ho, XL Sun, K Cheng, SH Sun*. Stable single-crystalline body centered cubic Fe nanoparticles. Nano Lett. 2011, 11(4): 1641-5. (IF 12.712)