2025
55. Rongcui Zhong,1 Lingqing Xu,1 Jiaxuan Wu, Mengyi He, Suhua Wu, Zhaozu Luo, Nuotong Han, Yongyi Yao, Jing Zhou, Zhixiong Ruan,* Shouping Liu,* Shuimu Lin.* Rational design of ivacaftor-derived antimicrobial peptidomimetics: Membrane-targeting strategy enhances broad-spectrum antimicrobial efficacy against MDR pathogens. Eur. J. Med. Chem. 2026, 302, 118290. https://www.sciencedirect.com/science/article/pii/S0223523425010554?via%3Dihub
54. Xinwei Hu,1 Yong Zeng,1 Jiongdong Ma,1 Han Diao,1 Fei-Xiao Chen, Mu Chen, Shou-Kun Zhang, Chengzhi Jin,* Shao-Fei Ni,* Zhixiong Ruan.* Electrochemical selenylation of tyrosine oligopeptides to benzo[b]furan-functionalized peptides. Chin. Chem. Lett. 2025, https://doi.org/10.1016/j.cclet.2025.111928
53. Xinwei Hu,+ Zaimu Cao,+ Mu Chen,+ Chun-Dong Huang, Shao-Fei Ni, Shou-Kun Zhang, and Zhixiong Ruan.* Electrochemical Late-Stage Stitching of Tryptophan Peptides via N─S Bond Formation. Angew. Chem. Int. Ed. 2025, e202517101. https://onlinelibrary.wiley.com/doi/10.1002/anie.202517101
52. Suhua Wu, Venkatesh Mayandi, Eunice Tze Leng Goh, Wenyi Wang, Nuotong Han, Rongcui Zhong, Zhaozu Luo, Yue Wang, Mu Chen, Rajamani Lakshminarayanan,* Zhixiong Ruan,* Shouping Liu,* Shuimu Lin.* Boronic acid derivatives inhibit Candida albicans growth by compromising energy metabolism. J. Adv. Res. 2025, https://doi.org/10.1016/j.jare.2025.07.044
51. Balati Hasimujiang, Wenyan Xu, Yongjie Yang, Jinghua Huang, Qingbin Yuan, Xinwei Hu, Mu Chen, Zhixiong Ruan.* Electrochemical Cascade Cyclization for Selenobenzothiophenes: Synthesis, Photochemistry, and Bioactivity. Adv. Synth. Catal. 2025, 67, e70014. https://advanced.onlinelibrary.wiley.com/doi/10.1002/adsc.70014
50. Jiamei Chen, Xinwei Hu, Yang Huang, Chengzhi Jin, Xujia Hong, Zhixiong Ruan*, Ning Gan*, Shengfeng Huang.* Zwitterionic Thiophene-Functionalized Sensing Interface Enables Robust Antifouling Electrochemical Analysis. Anal. Chem. 2025, 97, 14781–14791. https://pubs.acs.org/doi/10.1021/acs.analchem.5c02407
49. Xinwei Hu, Chengwei Zheng, Xiaotong Song, Balati Hasimujiang, Mu Chen, Zhixiong Ruan.* Manganese-Catalyzed Electrochemical Diazidation of Dehydroalanine Peptides. Adv. Sci. 2025, 12, 2502711. https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202502711
48. Yongjie Yang., Balati Hasimujiang., Zaimu Cao., Qingbin Yuan., Hu, Xinwei.,* Ruan, Zhixiong.* Nickel-Catalyzed Electroreductive Heck Reaction: A Divergent Synthesis of C7- or C2-Arylindolines. Org. Lett. 2025, 27, 3838–3843. https://pubs.acs.org/doi/full/10.1021/acs.orglett.5c00495
47. Wenyan Xu,# Chengwei Zheng,# Mu Chen,# Xin Deng,# Lingmin Zhang, Xueping Lei, Lu Liang, Xi-Yong Yu, Xinwei Hu,* Juyun He,* Shuimu Lin,* Zhixiong Ruan.* Modular Synthesis of Bioactive Selenoheterocycles for Efficient Cancer Therapy via Electrochemical Selenylation/Cyclization. J. Med. Chem. 2025, 68, 6339–6360. https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c02724
Highlighted by Chin. Chem. Lett. Chin. Chem. Lett. 2025, 36, 111408. https://doi.org/10.1016/j.cclet.2025.111408
2024
46. Xinyue Fang,# Xinwei Hu,# Quan-Xin Li, Shao-Fei Ni,* Zhixiong Ruan,* Paired Electro-Synthesis of Remote Amino Alcohols with/in H2O. Angew. Chem. Int. Ed. 2024, e202418277. https://doi.org/10.1002/anie.202418277
Highlighted by Synfacts. Synfacts 2025, 21(06): 617. DOI: 10.1055/a-2588-1698. https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2588-1698
Highlighted by Chin. J. Org. Chem. Chin. J. Org. Chem. 2025, 45, 722–723. DOI: 10.6023/cjoc202500006. https://sioc-journal.cn/Jwk_yjhx/EN/10.6023/cjoc202500006
45. 哈斯木江·巴拉提; 胡彩凤（本科生）; 黄雅雯（本科生）; 陈沐; 胡新伟; 阮志雄*， 含硒吡喃酮和查尔酮的溶剂调控电化学合成综合实验设计. 大学化学 2024, 39, 273. https://www.dxhx.pku.edu.cn/CN/10.12461/PKU.DXHX202404040
Balati Hasimujiang, Caifeng Hu, Yawen Huang, Mu Chen, Xinwei Hu, Zhixiong Ruan. Comprehensive Experimental Design for Solvent-Controlled Electrochemical Synthesis of Selenium-Containing Pyranone and Chalcone[J]. University Chemistry, 2024, 39(12): 273-283.
44. Xinwei Hu and Zhixiong Ruan.* Electrochemical Oxidative Cross-Coupling and Annulation for Functionalized Heterocycles. In Construction and Functionalization of Heterocycles by Electrochemistry (Ed.: E. Nacsa), Topics in Heterocyclic Chemistry; Springer Berlin Heidelberg: Berlin, Heidelberg, 2024; pp. 1-17. (Book Chapter), In press.
43. Xinwei Hu,# Kaihui Zhong# and Zhixiong Ruan, Tunable Electrochemical Diverse Sulfurization of Sulfoxonium Ylides with Disulfides. Chem. Commun. 2024, doi:10.1039/D4CC02479F. (In press)
42. Xinyue Fang,# Yong Zeng,# Yawen Huang, Zile Zhu, Shengsheng Lin, Wenyan Xu, Chengwei Zheng, Xinwei Hu,* Youai Qiu* and Zhixiong Ruan,* Electrochemical synthesis of peptide aldehydes via C‒N bond cleavage of cyclic amines. Nat. Commun. 2024, 15, 5181, doi:10.1038/s41467-024-49223-y.
Highlighted by Synfacts. Synfacts 2025, 21(01): 95. DOI: 10.1055/a-2467-6245. https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2467-6245
41. Shaogao Zeng,# Yong Zeng,# Hui Wang,* Pinghua Sun* and Zhixiong Ruan,* Regio- and Stereoselective Synthesis of 3-Selenylazaflavanones and 3-Selenylflavanones via Electrochemically Facilitated Selenylation Cascade. J. Org. Chem. 2024, 89, 4074-4084, doi:10.1021/acs.joc.3c02934.
40. Fang Xinyue, Huang Yawen, Hu Xinwei,* Ruan Zhixiong,* Recent Progress in Electrochemical Modification of Amino acids and Peptides. Chin. J. Org. Chem., 2024, 44, 903-926, doi: 10.6023/cjoc202310024.
2023
39. Balati Hasimujiang and Zhixiong Ruan, Electrochemical Synthesis of Organoselenium Compounds：A Graphical Review. SynOpen 2023, doi:10.1055/a-2184-8411.
38. 胡新, 阮志雄,* 对乙基苯甲醚的电化学苄位唑胺化反应的探索. 大学化学 2023, 38, 263-271, https://www.dxhx.pku.edu.cn/CN/10.3866/PKU.DXHX202212027
Xinwei Hu, Zhixiong Ruan. Benzylic C―H Azolation of p-Ethyl Anisole by Electro-Oxidation. University Chemistry, 2023, 38(9): 263-271.
37. Songlin Fang,# Kaihui Zhong,# Shaogao Zeng, Xinwei Hu,* Pinghua Sun* and Zhixiong Ruan,* The electrochemically enabled α-C(sp3)–H azolation of ketones. Chem. Commun. 2023, 59, 11425-11428, http://dx.doi.org/10.1039/D3CC02852F
36. Wenyan Xu,# Lingran Du,# Lina Yu,# Huiyu Cen, Fangyu Lin, Siran Wang, Zhixiong Ruan, Zhongxiao Lin, Xin Zhang, Na Zhou, Jishuo Chang, Xiyong Yu,* Lingmin Zhang* and Lu Liang,* The mirrored cationic peptide as miRNA vehicle for efficient lung cancer therapy. MedComm 2023, 4, e273, https://doi.org/10.1002/mco2.273
35. Balati Hasimujiang,# Juyu Zhu,# Wenyan Xu, Hui Wang,* Xinwei Hu* and Zhixiong Ruan,* Solvent‐Regulated Electrochemical Selenylation and Deuteration of Alkynyl Aryl Ketones: Chemoselective Synthesis of 3‐Selenylated Chromones and Deutero‐Selenylated Chalcones. Adv. Synth. Catal. 2023, 365, 2929-2935, https://doi.org/10.1002/adsc.202300512
34. Balati Hasimujiang,# Yong Zeng,# Shifeng Zou, Kaihui Zhong, Lebin Su, Xinwei Hu and Zhixiong Ruan,* Direct Electrooxidative Selenylamination of Alkynes: Access to 3-Selenylindoles. Isr. J. Chem. 2023, e202300088, https://doi.org/10.1002/ijch.202300088
33. Zhongnan Xu,# Jiwen Yao,# Kaihui Zhong,# Shuimu Lin, Xinwei Hu* and Zhixiong Ruan,* Electrochemical Selenylation of Sulfoxonium Ylides for the Synthesis of gem-Diselenides as Antimicrobials against Fungi. J. Org. Chem. 2023, 88, 5572−5585, https://doi.org/10.1021/acs.joc.3c00091
32. Guangquan Mo,* Qiuxia Li, Liu Zhu, Zhixiong Ruan and Songqing Mei, Efficient direct electrocatalysis of nano-dodecahedron for the highly sensitive and selective detection of rutin, Microchem. J., 2023, 186, 108332. https://doi.org/10.1016/j.microc.2022.108332
31. Jia Qiu, Yougen Xu, Shimin Su, Yadong Gao, Peiyuan Yu, Zhixiong Ruan* and Kuangbiao Liao,* Auto Machine Learning Assisted Preparation of Carboxylic Acid by TEMPO-catalyzed Primary Alcohol Oxidation, Chin. J. Chem., 2023, 41, 143. doi:https://doi.org/10.1002/cjoc.202200555
2022
30. Li Xiong, Fengjuan Chen,* Yihang Wu, Xinwei Hu, Zhixiong Ruan, Huanfeng Jiang and Wei Zeng,* Cyclocarboamination of Alkynes with N-Aminopyridiniums by Photoredox Catalysis, Org. Lett., 2022, 24, 7856-7860. https://doi.org/10.1021/acs.orglett.2c03336
29. Balati Hasimujiang,# Shengsheng Lin,# Chengwei Zheng, Yong Zeng and Zhixiong Ruan,* Direct Electrooxidative Selenylation/Cyclization of Alkynes: Access to Functionalized Benzo[b]furans, Molecules, 2022, 27, 6314. https://doi.org/10.3390/molecules27196314
(#Contributed equally. Free charge, invited paper for the Special Issue Electrochemistry and Organometallic Catalysis: Themed Issue in Honor of the Great Contribution of Prof. Dr. Christian Amatore and Prof. Dr. Anny Jutand)
28. Shaogao Zeng, Songlin Fang, Haiping Cai, Dong Wang, Weiliang Liu, Xinwei Hu, Pinghua Sun* and Zhixiong Ruan,* Selenium-Electrocatalytic Cyclization of 2-Vinylanilides towards Indoles of Peptide Labeling, Chem. Asian J., 2022, 17, e202200762. doi:https://doi.org/10.1002/asia.202200762.
Highlighted by Synfacts. Synfacts 2023; 19(02): 0202, DOI: 10.1055/s-0042-1753219
27. Naifu Zhou, Jianchao Yu, Liyuan Hou, Xing Wu, Zhixiong Ruan* and Pengju Feng,* Electro-Oxidative Coupling of Azoles with 2- and 3-Haloindoles/Thiophenes Providing Access to 2/3-Halo(Azol-1-Yl)Indoles/Thiophenes, Adv. Synth. Catal., 2022, 364, 35-40. doi:https://doi.org/10.1002/adsc.202100958.
26. Shengsheng Lin,# Xiaomei Cheng,# Balati Hasimujiang, Zhongnan Xu, Fengtan Li and Zhixiong Ruan,* Electrochemical regioselective C–H selenylation of 2H-indazole derivatives, Org. Biomol. Chem., 2022, 20, 117-121. doi:10.1039/D1OB02108G. (#equal contribution)
2021
25. Naifu Zhou,# Junhao Zhao,# Chengbo Sun, Yuqin Lai, Zhixiong Ruan* and Pengju Feng,* Electro-Oxidative C–N Bond Formation through Azolation of Indole Derivatives: An Access to 3-Substituent-2-(Azol-1-yl)indoles, J. Org. Chem., 2021, 86, 16059-16067. doi:10.1021/acs.joc.1c01271. (#equal contribution)
24. Zhixiong Ruan, Zhixing Huang, Krzystof Kuciński and Lutz Ackermann, Electrochemical Fluoroalkylation, in Science of Synthesis: Electrochemistry in Organic Synthesis（Ed.: L. Ackermann）, Thieme, Stuttgart, 2021, DOI: 10.1055/sos-SD-236-00149, ch. 8, pp. 207-256. (Book Chapter)
23. Xichao Peng,# Junhao Zhao,# Guojian Ma, Yan Wu, Shiyu Hu, Zhixiong Ruan* and Pengju Feng,* Electro-oxidative C–H amination of heteroarenes with aniline derivatives via radical–radical cross coupling, Green Chem., 2021, 23, 8853-8858. doi:10.1039/D1GC02821A. (#equal contribution)
22. Xiaomei Cheng,# Balati Hasimujiang,# Zhongnan Xu, Haiping Cai, Guihong Chen, Guangquan Mo and Zhixiong Ruan,* Direct Electrochemical Selenylation/Cyclization of Alkenes: Access to Functionalized Benzheterocycles, J. Org. Chem., 2021, 86, 16045-16058. doi:10.1021/acs.joc.1c01267. (#equal contribution)
21. Zhixiong Ruan,#,* Zhixing Huang,# Zhongnan Xu, Shaogao Zeng, Pengju Feng* and Ping-Hua Sun,* Late-Stage Azolation of Benzylic C‒H Bonds Enabled by Electrooxidation, Sci. China Chem., 2021, 64, 800-807. doi:https://doi.org/10.1007/s11426-020-9938-9. (#equal contribution)
20. Guangquan Mo,* Xinru Zheng, Naobei Ye and Zhixiong Ruan,* Nitrogen-doped carbon dodecahedron embedded with cobalt nanoparticles for the direct electro-oxidation of glucose and efficient nonenzymatic glucose sensing, Talanta, 2021, 225, 121954. doi:https://doi.org/10.1016/j.talanta.2020.121954.
19. Yueheng Li, Zhixing Huang, Guangquan Mo, Wei Jiang, Chengwei Zheng, Pengju Feng* and Zhixiong Ruan,* Direct Electrochemical Synthesis of Sulfur-Containing Triazolium Inner Salts, Chin. J. Chem., 2021, 39, 942-946. doi:DOI: 10.1002/cjoc.202000586. (Selected as cover paper)
18. Xiaotong Cai, Yingqi Mo, Zhixiong Ruan and Guangquan Mo,* Highly active catalyst using zeolitic imidazolate framework derived nano-polyhedron for the electro-oxidation of l-cysteine and amperometric sensing, J. Colloid Interface Sci., 2021, 603, 822-833. doi:https://doi.org/10.1016/j.jcis.2021.06.154.
2020
17. Zhongnan Xu,# Yuqing Wang,# Yucheng Zheng, Zhixing Huang, Lutz Ackermann and Zhixiong Ruan,* Manganese- and rhenium-catalyzed C–H enaminylation: expedient access to novel indole–purine hybrids with anti-tumor bioactivities, Org. Chem. Front., 2020, 7, 3709-3714. doi:10.1039/d0qo01120g. (#equal contribution)
16. Zhongnan Xu,# Yueheng Li,# Guangquan Mo, Yucheng Zheng, Shaogao Zeng, Ping-Hua Sun* and Zhixiong Ruan,* Electrochemical Oxidative Phosphorylation of Aldehyde Hydrazones, Org. Lett., 2020, 22, 4016-4020. doi:10.1021/acs.orglett.0c01343. (#equal contribution)
15. Zhongnan Xu,# Zhixing Huang,# Yueheng Li, Rositha Kuniyil, Chao Zhang, Lutz Ackermann* and Zhixiong Ruan,* Catalyst-free, direct electrochemical synthesis of annulated medium-sized lactams through C–C bond cleavage, Green Chem., 2020, 22, 1099-1104. doi:10.1039/c9gc03901e. (#equal contribution) (Selected as cover paper)
14. Zhixiong Ruan,* Zhixing Huang, Zhongnan Xu, Guangquan Mo, Xu Tian, Xi-Yong Yu and Lutz Ackermann,* Catalyst-Free, Direct Electrochemical Tri- and Difluoroalkylation/Cyclization: Access to Functionalized Oxindoles and Quinolinones, Org. Lett., 2019, 21, 1237-1240. doi:10.1021/acs.orglett.9b00361. (ESI highly cited paper)
13. Jun-Shan Liu, Li-Juan Deng, Hai-Yan Tian, Zhi-Xiong Ruan, Hui-Hui Cao, Wen-Cai Ye, Dong-Mei Zhang* and Zhi-Ling Yu,* Anti-tumor effects and 3D-quantitative structure-activity relationship analysis of bufadienolides from toad venom, Fitoterapia, 2019, 134, 362-371. doi:https://doi.org/10.1016/j.fitote.2019.03.006.
Before GZMU
12. Z. Ruan, L. Ackermann and D. Stalke, C-H Alkylations and Alkynylations Using Ruthenium, Nickel and Manganese Complexes, Georg-August-Universität Göttingen, 2017. （PhD Thesis）
11. Zhixiong Ruan,# Shou-Kun Zhang,# Cuiju Zhu, Paul Niklas Ruth, Dietmar Stalke and Lutz Ackermann,* Ruthenium(II)-Catalyzed meta C-H Mono- and Difluoromethylations by Phosphine/Carboxylate Cooperation, Angew. Chem. Int. Ed., 2017, 56, 2045-2049. doi:10.1002/anie.201611595. (#equal contribution) (ESI highly cited paper)
10. Zhixiong Ruan,# Nicolas Sauermann,# Elisabetta Manoni and Lutz Ackermann,* Manganese-catalyzed C-H alkynylation: expedient peptide synthesis and modification, Angew. Chem. Int. Ed., 2017, 56, 3172-3176. doi:10.1002/anie.201611118. （#equal contribution）(ESI highly cited paper)
9. Zhixiong Ruan, Debasish Ghorai, Giuseppe Zanoni and Lutz Ackermann,* Nickel-catalyzed C-H activation of purine bases with alkyl halides, Chem. Commun., 2017, 53, 9113-9116. doi:10.1039/C7CC05011A.
8. Zhixiong Ruan, Sebastian Lackner and Lutz Ackermann,* Nickel-Catalyzed C-H Alkynylation of Anilines: Expedient Access to Functionalized Indoles and Purine Nucleobases, ACS Catal., 2016, 6, 4690-4693. doi:10.1021/acscatal.6b01120.
7. Zhixiong Ruan,# Sebastian Lackner# and Lutz Ackermann,* A General Strategy for the Nickel-Catalyzed C-H Alkylation of Anilines, Angew. Chem. Int. Ed., 2016, 55, 3153-3157. doi:10.1002/anie.201510743. （#equal contribution）(Hot paper, ESI highly cited paper)
6. Yan Chen,# Zhi-Xiong Ruan,# Fang Wang, De-Sheng Huangfu, Ping-Hua Sun, Jing Lin and Wei-Min Chen,* Novel Oxazolidinone Antibacterial Analogues with a Substituted Ligustrazine C-ring Unit, Chem. Biol. Drug Des., 2015, 86, 682-690. doi:10.1111/cbdd.12537.
5. Zhi-Xiong Ruan, De-Sheng Huangfu, Xing-Jun Xu, Ping-Hua Sun* and Wei-Min Chen,* 3D-QSAR and molecular docking for the discovery of ketolide derivatives, Expert Opin. Drug Discov., 2013, 8, 427-444.
4. Zhi-Xiong Ruan, De-Sheng Huangfu, Ping-Hua Sun* and Wei-Min Chen,* Molecular modeling studies on 3,4-dihydroquinazolines as trypanothione reductase inhibitors using 3D-QSAR and docking approaches, Med. Chem. Res., 2013, 22, 3541-3555. doi:10.1007/s00044-012-0335-0.
3. Dong-Mei Zhang,# Ying-Jie Li,# Chang Shu, Zhi-Xiong Ruan, Wei-Min Chen, Anita Yiu, Ying-Hui Peng, Jiao Wang, Ping Lan, Zhe Yao, Kwok-Pui Fung, Li-Wu Fu, Zhe-Sheng Chen* and Wen-Cai Ye,* Bipiperidinyl derivatives of 23-hydroxybetulinic acid reverse resistance of HepG2/ADM and MCF-7/ADR cells, Anti-Cancer Drugs, 2013, 24, 441-454. doi:10.1097/CAD.0b013e32835fcc77.（#equal contribution）
2. Junshan Liu,# Dongmei Zhang,# Yuan Li, Weimin Chen, Zhixiong Ruan, Lijuan Deng, Liwei Wang, Haiyan Tian, Anita Yiu, Chunlin Fan, Hai Luo, Shanwen Liu, Ying Wang, Gaokeng Xiao, Lixin Chen* and Wencai Ye,* Discovery of Bufadienolides as a Novel Class of ClC-3 Chloride Channel Activators with Antitumor Activities, J. Med. Chem., 2013, 56, 5734-5743. doi:10.1021/jm400881m. （#equal contribution）
1. Dong-Mei Zhang,# Chang Shu,# Jun-Jiang Chen,# Kamlesh Sodani, Jiao Wang, Jaya Bhatnagar, Ping Lan, Zhi-Xiong Ruan, Zhi-Jie Xiao, Suresh V. Ambudkar, Wei-Min Chen, Zhe-Sheng Chen* and Wen-Cai Ye,* BBA, a Derivative of 23-Hydroxybetulinic Acid, Potently Reverses ABCB1-Mediated Drug Resistance in Vitro and in Vivo, Mol. Pharmaceutics, 2012, 9, 3147-3159. doi:10.1021/mp300249s. （#equal contribution）