Publication List (^# Equal contribution; * Corresponding author)

2025

48.   Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis

Lanlan Zhang^#,*, Xuezhen Gui^#, Ruijie Hou^#, Liping Jia^#, Shu Xia^#, Xin Zhang, Yingyun Fu , Qian-Fang Meng, Qun Luo, Xing Shi, Bingxin Guo, Ruifang Liang, Ludan Yue, Xue Chen, Haizhao Xu, Pengbo Wang, Xia Tong, Lujie Liu, Lingwei Wang, Baicun Li, Zi Chen, Linfu Zhou, Linshu Zhang, Rongchang Chen, Changbin Sun, Wei Xu, Lang Rao*, Haibo Zhou*, Bi-Sen Ding*, & Shanze Chen*. Nature Communications, 2025, 16, in press. 

47.   Inhalable Macrophage Membrane-Camouflaged Hyperbranched Polymeric Nanoparticles for Acute Lung Injury Treatment

Xinyu Lin#, Qian-Fang Meng^#, Yuanwei Pan#, Xiao Hu, Zhuo Dong, Jihong Wang*, Xianzhu Yang, Lang Rao*, & Peng She*. Nano Letters, 2025, 25, 13003-13013. 

46.   Metal-Phenolic Outer Membrane Vesicles for Cancer Radioimmunotherapy

Chenchen Zhao^#, Yuanwei Pan^#, Lei Cao, Yuji Tang, Xiaoyuan Chen, Xingzhong Zhao, & Lang Rao*. Journal of the American Chemical Society, 2025, 147, 26195-26207. 

45.   Synergizing Ferroptosis and Immunotherapy via a PROTAC/PDT/HPK1 Inhibitor-Loaded Nanoplatform for Enhanced Antitumor Efficacy

Zhenjie Wang^#, Yuehua Wang^#, Yilan Dai, Chunmei Luo, Li Deng, Yuanwei Pan, Lang Rao*, Siyao Che*, & Zhiqiang Yu*. Advanced Functional Materials, 2025, 35, 2507906. 

44.   Yogurt-inspired hybrid membrane vesicles for the prevention and treatment of Helicobacter pylori infection

Lujie Liu, Yiming Guo, Baikui Wang, Yuanwei Pan, Chenchen Zhao, Zhiping Xiao, Yu Liu, Guocan Yu*, Xiaoyuan Chen*, & Lang Rao*. Cell Biomaterials, 2025, 1, 100072. 

43.   Engineering Cellular Vesicles for Immunotherapy

Xinyu Lin, Ludan Yue, Ke Cheng, & Lang Rao*. Accounts of Materials Research, 2025, 6, 327-339. 

42.   Antiviral covalent ACE2 vesicle spray

Qian-Fang Meng^#, Yu Han^#, Yu Liu^#, Pan Pan^#, Rong-Chang Chen, Heng Zhang*, & Lang Rao*. Cell Biomaterials, 2025, 1, 100017. 

41.   Biomimetic Targeted Co-Delivery System Engineered from Genomic Insights for Precision Treatment of Osteosarcoma

Tianqi Luo^#, Zhijin Fan^#, Anyu Zeng^#, Anqi Wang, Yuanwei Pan, Yanyang Xu, Hongmin Chen, Weiqing Chen, Dingmeng Nie, Jiaming Lin, Anfei Huang, Ming Gong, Yufeng Huang, Yun Ding, Xiaojun Zhu*, Lang Rao*, & Jin Wang*. Advanced Science, 2025, 12, 2410427. 

2024

40.   Designing nanotheranostics with machine learning

Lang Rao*, Yuan Yuan, Xi Shen, Guocan Yu & Xiaoyuan Chen*. Nature Nanotechnology, 2024, 19, 1769-1781. 

39.   Targeting Immunoproteasome in Polarized Macrophages Ameliorates Experimental Emphysema via Activating NRF1/2-P62 Axis and Suppressing IRF4 Transcription

Bingxin Guo^#, Xing Shi^#, Qiong Jiang^#, Yuanwei Pan, Yuqiong Yang, Yuanyuan Liu, Shuyu Chen, Wenjiao Zhu, Laibin Ren, Ruifang Liang, Xue Chen, Haizhao Xu, Laiyou Wei, Yongjian Lin, Jinyong Wang, Chen Qiu, Haibo Zhou, Lang Rao*, Lingwei Wang*, Rongchang Chen*, & Shanze Chen*. Advanced Science, 2024, 11, 2405318. 

38.   Engineered Cellular Vesicles Displaying Glycosylated Nanobodies for Cancer Immunotherapy 

Jicheng Wu^#, Hailin Lu^#, Ximing Xu, Lang Rao*, & Yun Ge*. Angewandte Chemie International Edition, 2024, 63, e202404889. 

37.   Genetically Edited Cascade Nanozymes for Cancer Immunotherapy 

Jing Zhang^#, Yuanwei Pan^#, Lujie Liu, Yangtao Xu, Chenchen Zhao, Wei Liu*, & Lang Rao*. ACS Nano, 2024, 18, 12295-12310. 

36.   Neutrophil Membrane-Camouflaged Polyprodrug Nanomedicine for Inflammation Suppression in Ischemic Stroke Therapy 

Ya Zhao^#, Qian Li^#,*, Jingyan Niu, Erliang Guo, Chenchen Zhao, Jian Zhang, Xue Liu, Lihua Wang, Lang Rao*, Xiaoyuan Chen*, & Kuikun Yang*. Advanced Materials, 2024, 36, 2311803. 

35.   3D-Printed Dendritic Cell Vaccines for Post-Surgery Cancer Immunotherapy

Yangtao Xu^#, Wenxiang Zhu^#, Jicheng Wu, Lujie Liu, Ludan Yue, Xueyang Zhang, Jiayi Li, Peng She, Jingjing Yang, Chengliang Sun, Ximing Xu*, & Lang Rao*. Advanced Functional Materials, 2024, 34, 2400507. 

34.   A Guanidinobenzol-Rich Polymer Overcoming Cascade Delivery Barriers for CRISPR-Cas9 Genome Editing 

Shuang Liang^#, Ning Ma^#, Xingang Li^#, Kaiqing Yun, Qian-Fang Meng, Kongshuo Ma, Ludan Yue, Lang Rao*, Xiaoyuan Chen*, & Zhaohui Wang*. Nano Letters, 2024, 45, 6872-6880. (Featured as Cover).

33.   Engineered Bio-Based Hydrogels for Cancer Immunotherapy 

Yuxuan Peng, Shuang Liang, Qian-Fang Meng, Dan Liu, Kongshuo Ma, Mengli Zhou, Kaiqing Yun, Lang Rao*, & Zhaohui Wang*. Advanced Materials, 2024, 36, 2313188. 

32.   Triple Hybrid Cellular Nanovesicles Promote Cardiac Repair after Ischemic Reperfusion 

Jialin Lai^#, Qi Pan^#, Guihao Chen^#, Yu Liu, Cheng Chen, Yuanwei Pan, Lujie Liu, Binglin Zeng, Ling Yu, Yunsheng Xu, Jinyao Tang, Yuejin Yang*, & Lang Rao*. ACS Nano, 2024, 18, 4443-4455. (Featured as Cover).

31.   Genetically engineered nanomodulators elicit potent immunity against cancer stem cells by checkpoint blockade and hypoxia relief 

Yuanwei Pan^#, Ling Yu^#, Lujie Liu, Jing Zhang, Shuang Liang, Badri Parshad, Jialin Lai, Li-Min Ma*, Zhaohui Wang*, & Lang Rao*. Bioactive Materials, 2024, 38, 31-44.  

30.   Tumor Microenvironment-Responsive Nanoparticles Amplifying STING Signaling Pathway for Cancer Immunotherapy 

Dan Liu, Shuang Liang, Kongshuo Ma, Qian-Fang Meng, Xingang Li, Jian Wei, Mengli Zhou, Kaiqing Yun, Yuanwei Pan, Lang Rao*, Xiaoyuan Chen*, & Zhaohui Wang*. Advanced Materials, 2024, 36, 2304845. 

2023

29.   Inhalation delivery of dexamethasone with iSEND nanoparticles attenuates the COVID-19 cytokine storm in mice and non-human primates 

Qian-Fang Meng^#, Wanbo Tai^#, Mingyao Tian^#, Xinyu Zhuang^#, Yuanwei Pan, Jialin Lai, Yangtao Xu, Zhiqiang Xu, Min Li, Guangyu Zhao, Guang-Tao Yu, Guocan Yu, Rongchang Chen, Ningyi Jin, Xiao Li*, Gong Cheng*, Xiaoyuan Chen*, & Lang Rao*. Science Advances, 2023, 9, eadg3277. 

28.   Macrophages in immunoregulation and therapeutics 

Shanze Chen^#, Abdullah F. Saeed^#, Quan Liu^#, Qiong Jiang, Haizhao Xu, Gary Guishan Xiao*, Lang Rao*, & Yanhong Duo*. Signal Transduction and Targeted Therapy, 2023, 8, 207. (Highly Cited Paper).

27.   Vesicular Antibodies: Shedding Light on Antibody Therapeutics with Cell Membrane Nanotechnology 

Chenchen Zhao, Yuanwei Pan, Guocan Yu*, Xing-Zhong Zhao, Xiaoyuan Chen*, & Lang Rao*. Advanced Materials, 2023, 35, 2207875. 

26.   Chromium Nanoparticles Improve Macrophage and T Cell Infiltration for Cancer Immunotherapy 

Quan Liu^#, Zhe Sun^#, Yanhong Duo^#, Lei Yin, Kong-Peng Lv, Ludan Yue, Qian-Fang Meng, Dingmeng Nie, Jiaojuan Chen, Dixian Luo*, Li-Ping Liu*, & Lang Rao*. ACS Materials Letters, 2023, 5, 1738-1751. (Featured as Supplementary Cover).

25.   Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy 

Shuang Liang, Jianjun Yao, Dan Liu, Lang Rao*, Xiaoyuan Chen*, & Zhaohui Wang*. Advanced Materials, 2023, 35, 2211130. 

24.   Boosting Checkpoint Immunotherapy with Biomaterials 

Lujie Liu^#, Yuanwei Pan^#, Chenchen Zhao, Peng Huang*, Xiaoyuan Chen*, & Lang Rao*. ACS Nano, 2023, 17, 3225-3258. 

23.   In situ formed scaffold with royal jelly-derived extracellular vesicles for wound healing 

Dehong Tan, Wenxiang Zhu, Lujie Liu, Yuanwei Pan, Yangtao Xu, Qinqin Huang, Lingling Li, & Lang Rao*. Theranostics, 2023, 13, 2811-2824. (Featured as Back Cover).

22.   Inhaled drug delivery: Past, present, and future 

Ludan Yue, Xueyang Zhang, Chenchen Zhao, Rongchang Chen, Xiaoyuan Chen*, & Lang Rao*. Nano Today, 2023, 52, 101942.

2022

21.   Metal-free bioorthogonal click chemistry in cancer theranostics  

Dan Wu^#,*, Kuikun Yang^#, Zhankui Zhang, Yunxuan Feng, Lang Rao*, Xiaoyuan Chen*, & Guocan Yu*. Chemical Society Reviews, 2022, 51, 1336-1376. (Featured as Inside Cover). 

20.   Nanomaterial-mediated ablation therapy for cancer stem cells  

Yuanwei Pan, Lujie Liu, Lang Rao*, & Xiaoyuan Chen*. Matter, 2022, 5, 1367-1390.

19.   Supramolecular engineering of cell membrane vesicles for cancer immunotherapy  

Shaolong Qi, Haiyan Zhang, Xueyan Zhang, Xinyang Yu, Yajun Wang, Qian-Fang Meng, Kai Yang, Bing Bai, Rui Tian, Shoujun Zhu*, Lang Rao*, Feihe Huang, & Guocan Yu*. Science Bulletin, 2022, 67, 1898-1909.

18.   A decoy microrobot that removes SARS-CoV‑2 and its variants in wastewater   

Jialin Lai^#, Qian-Fang Meng^#, Mingyao Tian^#, Xinyu Zhuang, Pan Pan, Liang Du, Lin Deng, Jinyao Tang, Ningyi Jin, & Lang Rao*. Cell Reports Physical Science, 2022, 3, 101061.

17.   Neutrophil membrane-coated immunomagnetic nanoparticles for efficient isolation and analysis of circulating tumor cells  

Xianjia Wu^#, Zhousheng Lin^#, Chenchen Zhao, Lujie Liu, Kelin Zhang, Jialin Lai, Qian-Fang Meng, Gaungyu Yao, Qinqin Huang*, Xing-Zhong Zhao*, & Lang Rao*. Biosensors & Bioelectronics, 2022, 213, 114425.

16.   Engineered extracellular vesicles and their mimics in cardiovascular diseases  

Jialin Lai, Chaobo Huang, Yuxuan Guo, & Lang Rao*. Journal of Controlled Release, 2022, 347, 27-43.

2021

15.   Genetically Programmable Fusion Cellular Vesicles for Cancer Immunotherapy 

Qian-Fang Meng^#, Yuyue Zhao^#, Chunbo Dong^#, Lujie Liu, Yuanwei Pan, Jialin Lai, Zhida Liu, Guang-Tao Yu*, Xiaoyuan Chen*, & Lang Rao*. Angewandte Chemie International Edition, 2021, 60, 26320-26326.

14.   Capturing Cytokines with Advanced Materials: A Potential Strategy to Tackle COVID-19 Cytokine Storm 

Qian-Fang Meng^#, Rui Tian^#, Haiyi Long, Xianjia Wu, Jialin Lai, Olga Zharkova, Jiong-Wei Wang*, Xiaoyuan Chen*, & Lang Rao*. Advanced Materials, 2021, 33, 2100012. (Highlighted by MaterialsViews).

13.   Engineered Cell Membrane-Derived Nanoparticles in Immune Modulation 

Yixiao Yang, Kai Wang, Yuanwei Pan, Lang Rao*, & Gaoxing Luo*. Advanced Science, 2021, 8, 2102330.

12.   A platelet-mimicking theranostic platform for cancer interstitial brachytherapy 

Meng Lyu, Mingzhu Chen, Lujie Liu, Daoming Zhu, Xianjia Wu, Yang Li*, Lang Rao*, & Zhirong Bao*. Theranostics, 2021, 11, 7589-7599.

11.   Supramolecular cancer nanotheranostics

Jiong Zhou^#, Lang Rao^#, Guocan Yu*, Timothy R. Cook*, Xiaoyuan Chen*, & Feihe Huang*. Chemical Society Reviews, 2021, 50, 2839-2891. 

Before Joining to SZBL

10.   Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines 

Lang Rao^#, Shuai Xia^#, Wei Xu^#, Rui Tian, Guocan Yu, Chenjian Gu, Pan Pan, Qian-Fang Meng, Xia Cai, Di Qu, Lu Lu*, Youhua Xie*, Shibo Jiang*, & Xiaoyuan Chen*. Proceedings of the National Academy of Sciences, 2020, 117, 27141-27147. (Featured as Cover; Highlighted by The Scientist; ChemistryViews; Inverse; Infosurhoy; Scitech Daily). 

9.   Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis 

Lang Rao^#, Lei Wu^#, Zhida Liu^#, Rui Tian, Guocan Yu, Zijian Zhou, Kuikun Yang, Hong-Gang Xiong, Anli Zhang, Guang-Tao Yu, Wenjing Sun, Han Xu, Jingya Guo, Andrew Li, Hongmin Chen*, Zhi-Jun Sun*, Yang-Xin Fu*, & Xiaoyuan Chen*. Nature Communications, 2020, 11, 4909. (Highly Cited Paper).

8.   Activating Macrophage-Mediated Cancer Immunotherapy by Genetically Edited Nanoparticles 

Lang Rao, Shu-Kun Zhao, Churan Wen, Rui Tian, Lisen Lin, Bo Cai, Yue Sun, Fei Kang, Zhen Yang, Liangcan He, Jing Mu, Qian-Fang Meng, Guangyu Yao*, Ni Xie*, & Xiaoyuan Chen*. Advanced Materials, 2020, 32, 2004853. (Highlighted by MaterialsViews).

7.   Engineering Macrophages for Cancer Immunotherapy and Drug Delivery 

Yuqiong Xia^#, Lang Rao^#, Huimin Yao, Zhongliang Wang*, Pengbo Ning*, & Xiaoyuan Chen*. Advanced Materials, 2020, 32, 2002054. (Highly Cited Paper).

6.   A Biomimetic Nanodecoy Traps Zika Virus to Prevent Viral Infection and Fetal Microcephaly Development

Lang Rao^#, Wenbiao Wang^#, Qian-Fang Meng, Mingfu Tian, Bo Cai, Yingchong Wang, Aixin Li, Ming-Hui Zan, Feng Xiao, Lin-Lin Bu, Geng Li, Andrew Li, Yingle Liu, Shi-Shang Guo, Xing-Zhong Zhao, Tza-Huei Wang, Wei Liu*, & Jianguo Wu*. Nano Letters, 2019, 19, 2215-2222. (Featured as Inside Cover).

5.   Cancer Cell Membrane-Coated Nanoparticles for Personalized Therapy in Patient-Derived Xenograft Models 

Lang Rao, Guang-Tao Yu, Qian-Fang Meng, Lin-Lin Bu, Rui Tian, Li-Sen Lin, Hongzhang Deng, Weijing Yang, Ming-Hui Zan, Jianxun Ding, Andrew Li, Haihua Xiao*, Zhi-Jun Sun*, Wei Liu*, & Xiaoyuan Chen*. Advanced Functional Materials, 2019, 29, 1905671.

4.   Platelet-Facilitated Photothermal Therapy of Head and Neck Squamous Cell Carcinoma 

Lang Rao^#, Lin-Lin Bu^#, Liang Ma, Wenbiao Wang, Huiqin Liu, Da Wan, Andrew Li, Shi-Shang Guo, Wen-Feng Zhang, Xing-Zhong Zhao, Zhi-Jun Sun*, & Wei Liu*. Angewandte Chemie International Edition, 2018, 57, 986-991.

3.   Platelet–Leukocyte Hybrid Membrane-Coated Immunomagnetic Beads for Highly Efficient and Highly Specific Isolation of Circulating Tumor Cells 

Lang Rao^#, Qian-Fang Meng^#, Qinqin Huang, Zixiang Wang, Guang-Tao Yu, Andrew Li, Weijie Ma, Nangang Zhang, Shi-Shang Guo, Xing-Zhong Zhao, Kan Liu*, Yufeng Yuan*, & Wei Liu*. Advanced Functional Materials, 2018, 28, 1803531. (Featured as Back Cover).

2.   Microfluidic Electroporation-Facilitated Synthesis of Erythrocyte Membrane-Coated Magnetic Nanoparticles for Enhanced Imaging-Guided Cancer Therapy 

Lang Rao, Bo Cai, Lin-Lin Bu, Qing-Quan Liao, Shi-Shang Guo, Xing-Zhong Zhao, Wen-Fei Dong*, & Wei Liu*. ACS Nano, 2017, 11, 3496-3505. (Highly Cited Paper).

1.   Cancer Cell Membrane-Coated Upconversion Nanoprobes for Highly Specific Tumor Imaging 

Lang Rao, Lin-Lin Bu, Bo Cai, Jun-Hua Xu, Andrew Li, Wen-Feng Zhang, Zhi-Jun Sun, Shi-Shang Guo, Wei Liu*, Tza-Huei Wang, & Xing-Zhong Zhao. Advanced Materials, 2016, 28, 3460-3466. (Highly Cited Paper).