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钱锋 教授,博士生导师,药学院院长    

  钱锋博士现为清华大学药学院教授,院长。 钱锋博士本科、硕士毕业于清华大学材料科学与工程系,2003年于美国Case Western Reserve University获得生物医学工程博士学位后,就职于美国Bristol-Myers Squibb Company (百时美-施贵宝公司),从事药剂学科研和新药开发工作。2012年回国加入清华大学药学院,主要从事针对癌症和眼科疾病的新型药物治疗,以及各类药物的递送技术研究。钱锋博士已发表~60余篇学术论文,是Molecular Pharmaceutics副主编,Journal of Pharmaceutical Science, AAPS PharmSciTech 等期刊的 Editorial Advisory Board 成员,中国药学会纳米药物专业委员会委员。钱锋博士在工业界和学术界的科研工作涉及数十个新药的转化研究,其中包括已在中美上市的产品。


研究方向

(1)针对癌症、眼科疾病的药物递送:本实验室致力于设计和评估针对胰腺癌、老年黄斑病变等疾病的新型药物和药物递送体系。主要研究兴趣是针对或利用疾病的生物学特征和临床需求进行合理的药物和递送体系设计,以期获得具有更好的治疗效果,并可临床和工业转化的新型治疗药物。

 

(2) 物理药剂学在化学药物和多肽药物制剂领域,本实验室长期研究新型制剂的设计策略,用于提高不符合“rule of five”新药分子的生物利用度。在蛋白药物制剂领域,本课题组的研究兴趣为研究设计用于皮下和局部注射用的高浓度蛋白制剂。以上研究的根本目的是为未来新药产品开发提供理论依据和技术手段。



代表性论文


1. Kong W, Liu Z, Sun M, Liu H, Kong C, Ma J, Wang R, Qian F.*; Synergistic Autophagy Blockade and VDR Signaling Activation Enhance Stellate Cell Reprogramming in Pancreatic Ductal Adenocarcinoma, Cancer Letters. 2022 Jul 28;539:215718. doi: 10.1016/j.canlet.2022.215718. Epub 2022 May 5.

2. Huang C, Chen C, Franzen L, Anderski J, Qian F.*; Spray-Dried Monoclonal Antibody Suspension for High-Concentration and Low-Viscosity Subcutaneous Injection, Mol. Pharmaceutics. April 13, 2022, https://doi.org/10.1021/acs.molpharmaceut.2c00039

3. Huiqin Liu, Qian F*,  Exploiting macropinocytosis for drug delivery into KRAS mutant cancer. Theranostics. 2022; 12(3): 1321-1332. doi: 10.7150/thno.67889

4. Fang Yuan, Mengnan Sun, Zhengsheng Liu, Huiqin Liu, Weijian Kong, Rui Wang, Qian F*,  Macropinocytic dextran facilitates KRAS-targeted delivery while reducing drug-induced tumor immunity depletion in pancreatic cancer. Theranostics. 2022; 12(3): 1061-1073. doi: 10.7150/thno.65299

5. Liu C; Wang C; Wang S; Liu L; Sun C; Qian F*, An Elusive Drug–Drug Cocrystal Prepared Using a Heteroseeding Strategy, Cryst. Growth Des. 2021, 21, 10, 5659–5668, https://doi.org/10.1021/acs.cgd.1c00512

6. Liu H; Yu S; Qian F*, Opportunities and delusions regarding drug delivery targeting pancreatic cancer-associated fibroblasts, Advanced Drug Delivery Reviews, 2021 May;172:37-51. https://doi.org/10.1016/j.addr.2021.02.012

7. Mi W; Chen H; Zhu A, Zhang T, Qian F*, Melting point prediction of organic molecules by deciphering the chemical structure into a natural language, Chemical Communications, 2021, 57, 2633 – 2636

8. Zhou T,; Qian F.*;  Adenosine Triphosphate-Induced Rapid Liquid–Liquid Phase Separation of a Model IgG1 mAb, Mol. Pharmaceutics. 2021 18 (1), 267-274, DOI: 10.1021/acs.molpharmaceut.0c00905 

9. Zhou T; Xu L; Zhang N;, Qian F*,First-order nucleation and subsequent growth promote liquid-liquid phase separation of a model IgG1 mAb, Int. J. Pharm., 588 (2020) 119681

10. Wang S,; Liu C,; Chen H.; Zhu A.; Qian F*, Impact of Surfactants on Polymer Maintained Nifedipine Supersaturation in Aqueous Solution, Pharmaceutical Research, volume 37, Article number: 113 (2020)

11. Yuan F; Sun M; Liu H; Qian, F.*, Albumin-conjugated drug is irresistible by single gene mutation of endocytic system: verification by genome-wide CRISPR-Cas9 loss-of function screens, Journal of Controlled Release,Vol 323, 10 July 2020, Pages 311-320

12. Hu C.; Liu Z.; Liu C.; Zhang Y.; Fan H.; Qian F.*; Improvement of Antialveolar Echinococcosis Efficacy of Albendazole by a Novel Nanocrystalline Formulation with Enhanced Oral Bioavailability, ACS Infect. Dis. 2020, 6, 5, 802–810

13. Hu C.; Liu Z.; Liu C.; Li J.; Xu L.; Chen C.; Fan H.; Qian F.*; I Enhanced Oral Bioavailability and Anti-Echinococcosis Efficacy of Albendazole Achieved by Optimizing the “Spring” and “Parachute”, Mol. Pharmaceutics. 2019, 16, 12, 4978–4986

14. Liu Z.; Zhang L.; Tian Z.; Kong C.; Liu C.; Liu H.; Yuan F.; Kong W.; Qian F.*; Paclitaxel and Itraconazole Co-encapsulated Micelle Prolongs the Survival of Spontaneous LSL-KrasG12D/+; LSL-Trp53R172H/+; Pdx-1-Cre Genetically Engineered Mouse Model of Pancreatic Cancer, Advanced Therapeutics. 2019, 1900032, DOI: 10.1002/adtp.201900032

15. Chen Y.; Chen H.; Wang S.; Liu C.; Qian F*.; A Single Hydrogen to Fluorine Substitution Reverses the Trend of Surface Composition Enrichment of Sorafenib Amorphous Solid Dispersion upon Moisture Exposure, Pharmaceutical Research, (2019) 36: 105. https://doi.org/10.1007/s11095-019-2632-5

16.  Kong C; Li Y; Liu Z; Ye J; Wang Z; Zhang L; Kong W.; Liu H.; Liu C.; Pang H.; Hu Z.; Gao J.; and Qian, F*, Targeting the Oncogene KRAS Mutant Pancreatic Cancer by Synergistic Blocking of Lysosomal Acidification and Rapid Drug Release, ACS Nano, 2019 Apr 23;13(4):4049-4063.  doi: 10.1021/acsnano.8b08246.

17. Chen H.; Zhang X.; Cheng Y.; Qian,F*, Preparation of smectic itraconazole nanoparticles with tunable periodic order using microfluidics based anti-solvent precipitation, CrystEngComm, 2019, 21, 2362

18. Liu H; Sun M; Liu Z; Kong C; Kong W; Ye J; Gong J; Huang D; Qian, F.*, KRAS-enhanced macropinocytosis and reduced FcRn-mediated recycling sensitize pancreatic cancer to albumin-conjugated drugs, Journal of Controlled Release, Vol 296, 28 February 2019, Pages 40-53 

19. Liu C; Xu C; Yu J; Pui Y; Chen H; Wang S; Zhu A; Li J; Qian F.*, Impact of a Single Hydrogen Substitution by Fluorine on the Molecular Interaction and Miscibility between Sorafenib and Polymers, Mol. Pharmaceutics201916 (1), pp 318–326

20. Chen, Y.; Pui, Y.; Chen, H.; Wang, S; Serno, P.; Tonnis, W.; Chen, L.; Qian F.*, Polymer mediated drug supersaturation controlled by drug-polymer interactions persisting in aqueous environment, 19 Nov 2018, Mol. Pharmaceutics, 2019, 16 (1), pp 205–213 

21. Zhang L, Liu Z, Kong C, Liu C, Yang K, Chen H, Huang J, Qian F*., Improving Drug Delivery of Micellar Paclitaxel against NonSmall Cell Lung Cancer by Coloading Itraconazole as a Micelle Stabilizer and a Tumor Vascular Manipulator, Small, 16 November 2018 https://doi.org/10.1002/smll.201802112

22. Liu L.; Kong C.; Huo M.; Liu C.; Peng L.; Zhao T.; Wei Y.; Qian F*, Yuan J.*; Schiff base interaction tuned mesoporous organosilica nanoplatforms with pH-responsive degradability for efficient anti-cancer drug delivery in vivo, Chemical Communications, 2018, 54, 9190-9193

23. Wang S,; Liu C,; Chen Y.; Zhu A.; Qian F*, Aggregation of Hydroxypropyl Methylcellulose Acetate Succinate under Its Dissolving pH and the Impact on Drug Supersaturation, Mol. Pharmaceutics, 2018, 15, 4643−4653

24. Pui Y.; Chen Y.; Chen H.; Wang S.; Liu C.; Tonnis W.; Chen L.; Serno P.; Bracht S.; Qian F., Maintaining Supersaturation of Nimodipine by PVP with or without the Presence of Sodium Lauryl Sulfate and Sodium Taurocholate, Mol. Pharmaceutics, 2018, 15 (7), pp 2754–2763

25. Chen Z., Yang K., Huang C., Zhu A., Yu L., Qian F.*, Surface Enrichment and Depletion of the Active Ingredient in Spray Dried Amorphous Solid Dispersions, Pharmaceutical Research (2018) Jan 29;35(2):38.

26. Wang S.; Liu C.; Chen Y.; Zhang Z.; Zhub A.; Qian F.*; A high-sensitivity HPLC-ELSD method for HPMC-AS quantification and its application in elucidating the release mechanism of HPMC-AS based amorphous solid dispersions, Euro. J. Pharm. Sci. Vol. 122, 15 September 2018, Pages 303-310

27. Chen H, Pui Y, Liu C, Chen Z, Su C, Hageman M, Hussain M, Haskell R, Stefanski K, Foster K, Gudmundsson O, Qian, F*, Moisture-Induced Amorphous Phase Separation of Amorphous Solid Dispersions: Molecular Mechanism, Microstructure, and Its Impact on Dissolution Performance, J Pharm Sci., January 2018, Volume 107, Issue 1, Pages 317–326

28. Liu C.; Liu Z.; Chen Y.; Chen Z.; Chen H.; Pui Y.; Qian F.*, Oral bioavailability enhancement of β-lapachone, a poorly soluble fast crystallizer, by cocrystal, amorphous solid dispersion, and crystalline solid dispersion, Euro. J. Pharm. Biopharm, Vol. 124, March 2018, Pages 73-81, https://doi.org/10.1016/j.ejpb.2017.12.016

29. Zhang X., Chen H., Qian F.*;  Cheng Y., Preparation of itraconazole nanoparticles by anti-solvent precipitation method using a cascaded microfluidic device and an ultrasonic spray drier, Chemical Engineering Journal, 334 (2018) 2264-2272

30. Zhang L, Liu Z, Yang K, Kong C, Liu C, Chen H, Huang J, Qian F*. Tumor Progression of Non-Small Cell Lung Cancer Controlled by Albumin and Micellar Nanoparticles of Itraconazole, a Multitarget Angiogenesis Inhibitor, Mol Pharmaceutics. 201714 (12), pp 4705–4713

31. Zhang L, Sun H, Chen Z, Liu Z, Huang N, Qian F.*; Intermolecular Interactions between Coencapsulated Drugs Inhibit Drug Crystallization and Enhance Colloidal Stability of Polymeric Micelles. Mol Pharmaceutics. 2017, 14, 3568−3576 

32. Wang S, Zhang X, Wu G, Tian Z, Qian F.*; Optimization of high-concentration endostatin formulation: Harmonization of excipients' contributions on colloidal and conformational stabilities.,  Int J Pharm. 2017 Sep 15;530(1-2):173-186. doi: 10.1016/j.ijpharm.2017.07.057. Epub 2017 Jul 26.

33. Wu G, Wang Co-First S, Tian Z, Zhang N, Sheng H, Dai W, Qian F.*, Elucidating the Weak Protein-Protein Interaction Mechanisms behind the Liquid-Liquid Phase Separation of a mAb Solution by Different Types of Additives. Eur J Pharm Biopharm. Vol. 120, November 2017, Pages 1-8.

34. Wang, S.; Wu, G.; Zhang, X.; Tian, Z.; Zhang, N.; Hu, T.; Dai.; W.; Qian F*, Stabilizing two IgG1 monoclonal antibodies by surfactants: Balance between aggregation prevention and structure perturbation, Euro. J. Pharm. Biopharm., Volume 114, May 2017, Pages 263–277

35. Chen, Z.; Liu, CY.; Zhang, L.; Qian, F.*; Dissolution Characteristics of Fast-Crystallizing β-Lapachone within Different Semicrystalline Microstructures of Polyethylene Glycol or Poly(ethylene oxide)Poly(propylene oxide)Poly(ethylene oxide) Triblock Copolymer, Cryst. Growth Des., 2016, 16, 5367-5376

36.  Chen YJ.; Wang S; Wang S.; Liu C.; Su, C.; Hageman, M.; Hussain, M.; Haskell. R.; Stefanski K.;  Qian, F*.; Sodium Lauryl Sulfate Competitively Interacts with HPMC-AS and Consequently Reduces Oral Bioavailability of Posaconazole/HPMC-AS Amorphous Solid Dispersion, Mol. Pharmaceutics, 2016, 13, 2787-2795

37. Chen YJ.; Wang S; Wang S.; Liu C.; Su, C.; Hageman, M.; Hussain, M.; Haskell. R.; Stefanski K.;  Qian, F*.; Initial Drug Dissolution from Amorphous Solid Dispersions Controlled by Polymer Dissolution and Drug-Polymer Interaction, Pharmaceutical Research, 2016, 33(10), 2445-2458.

38.  Liu C, Chen Z, ChenYJ.; Lu J’; Li Y.; Wang S.; Wu G.; Qian F* Improving Oral Bioavailability of Sorafenib by Optimizing the “Spring” and “Parachute” Based on Molecular Interaction Mechanisms, Mol. Pharmaceutic,2016, 13 (2), pp 599–608

39. Wang S, Zhang N, Hu T, Dai W, Feng X, Zhang X, and Qian F*.; Viscosity-Lowering Effect of Amino Acids and Salts on Highly Concentrated Solutions of Two IgG1 Monoclonal Antibodies, Mol. Pharmaceutics, 2015, 12 (12), pp 4478–4487

40. Zhang L, Zhen Chen, Kuan Yang, Chun Liu, Jinming Gao, and Qian, F*.; β-Lapachone and Paclitaxel Combination Micelles with Improved Drug Encapsulation and Therapeutic Synergy as Novel Nanotherapeutics for NQO1-Targeted Cancer Therapy, Mol.Pharmaceutics, 2015, 12 (11), pp 3999–4010

41. Liu C, Kong C, Wu G, Zhu J, Javid B, Qian F*, Uniform and amorphous rifampicin microspheres obtained by freezing induced LLPS during lyophilization, Int. J. Pharm., Volume 495, Issue 1, 10 November 2015, Pages 500–507

42. Wang S, Liu H, Zhang X, Qian F*, Intranasal and oral vaccination with protein-based antigens: advantages, challenges and formulation strategies, Protein & Cell, July 2015, Volume 6, Issue 7, pp 480-503

43. Chen, Z.; Liu,ZS.; Qian, F.*; Crystallization of Bifonazole and Acetaminophen within the Matrix of Semicrystalline, PEO-PPO-PEO Triblock Copolymers, Mol. Pharmaceutics, 2015 Feb 21;12(2):590-9.

44. Chen YJ.; Liu CY.; Chen.Z.; Su, C.; Hageman, M.; Hussain, M.; Haskell. R.; Stefanski K.; Qian, F*.; Drug-polymer-water Interaction and its Implication to the Dissolution Performance of Amorphous Solid Dispersions, Mol. Pharmaceutics, 2015 Feb 12;12(2):576-89.