Focus on the discovery of innovative drugs and their druggability to carry out interdisciplinary basic application research, the specific directions include:

1. Computer-aided small molecule drug design and synthesis: New technologies such as drug design principles, bioinformatics and computer-aided technology are applied to the design and synthesis of active molecules with new mechanisms and structures, the study of structure-activity relationship and the prediction of drug formability, and the preclinical transformation research of the selected molecules.

2. Pharmacochemical biology: Systematically establish and optimize small molecule compound libraries and screening technologies to interfere with and explore intracellular biological processes, reveal unknown life activities and life molecule interactions, promote research based on active small molecule signal transduction and gene transcription, and realize drug target identification and lead compound discovery.

3. Pharmacology: Focus on the study of new mechanisms and targets of the action of drugs and bioactive substances, including the application of chemical small molecules to study the pathological mechanism of diseases and new molecular mechanisms and targets of drug action, as well as new animal models, precise interventions, strategies and means to overcome drug resistance, and new targets based on systems biology, epigenetics and bioinformatics. In-depth research on new drugs and new strategies of drug combinations.

4. Structural biology: biophysical strategies, such as molecular cloning, protein expression and purification, combined with fragment-based drug design, carry out research on the discovery of bioactive small molecules and the co-crystallization of small molecules and proteins.