Dr. Lyu’s Group has been mostly focusing on the method innovations and translational applications of functional metabolomics in the interdisciplinary sciences of life and health. The academic achievements of the candidate can be summarized as the follows: 1) definition and development of novel methods and strategies of functional metabolomics, such as precision-modification metabolomics and spatial temporal operative real metabolomics (STORM). 2) elucidation of the new regulatory-mechanism of siderophore biosynthesis on the virulence formation of pathogenic Escherichia coli; 3) clarification of novel mechanism of biofilm formation in pathogenic Escherichia coli at a functional-metabolism level, conserving novel strategy to tangle all the harmful impact of biofilms by targeting functional metabolites, which are extremely threaten-microorganisms mostly accounted for high-frequency drug resistance, air pollution and food contamination. 4) identification of novel metabolite biomarkers that can facilitate the diagnosis and metastasis monitoring of pancreatic cancer, as well as characterization of novel metabolic targets for disease therapy. Currently, Dr. Lyu’s Group further studies the novel methods of next-generation functional metabolomics (STORM+) aiming at promoting the interdisciplinary applications of life and health sciences by the discovery of poly-functional metabolites.