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李二庆 副教授    

基本信息

李二庆,男,1987年生,学历:博士,职称:副教授,硕士生导师,郑州大学青年拔尖人才,邮箱:lierqing@zzu.edu.cn,

教育背景

2010-2015年 南开大学 元素有机化学国家重点实验室 博士(导师:黄有 教授)

2006-2010年 河南师范大学  学士

工作履历

2020.06-至今        郑州大学        化学学院               副教授,硕士生导师,郑州大学青年拔尖人才 

2016.11-2020.06   郑州大学 化学与分子工程学院    讲师(校聘副教授),硕士生导师

2015-2016   德国哥廷根大学  博士后(adviser: Prof. Lutz F. Tietze

研究领域

(1)    过渡金属催化的不对称催化反应

(2)    新型磷手性中心手性膦配体的设计合成

(3)    有机磷化学

获得基金:

1)国家自然科学基金青年项目,21702189,在研,主持;

2 中国博士后科学基金第十一批特别资助项目,2018T110737,在研,主持;

3)中国博士后科学基金第61批面上一等资助项目,2017M610458,在研,主持;

(4)河南省博士后基金一等资助,  No.001701006   在研, 主持

(5)河南省科技攻关项目,No.202102310004 ,    在研, 主持       

代表性文章:

42. Qian Wang, Yinggao Meng,* Lulu Wu, Er-Qing Li* Recent advances in annulations enabled by nucleophilic Lewis base/metal dual catalysis. Chin. Chem. Lett. 2023, 34, 108544

41. Li Jing, Zhong-Jun Li* and Er-Qing Li* Palladium-catalyzed (3 + 2) annulations of 1,3-bis-electrophilic motifs: straightforward synthesis of functionalized pyrrolidines. Org. Chem. Front., 2023,10, 2746-2751.

40. Yinggao Meng,‡ Manman Song,‡ Yue Wang, Yuxin Wang and Er-Qing Li* Palladium-catalyzed asymmetric (4 + 3) cycloaddition of N-2,2,2-trifluoroethylisatin ketimines: access to optically active spirooxindoles. Org. Chem. Front., 2023,10, 2648-2652

39. Yue Wang, Er-Qing Li,* and Zheng Duan* Ligand-Dependent, Palladium-Catalyzed Stereodivergent Synthesis of Chiral Tetrahydroquinolines. Chem. Sci.2022,138131-8136

38. Yinggao Meng, Qian Wang, Xinyu Yao, Donghui Wei, Er-Qing Li*, and Zheng Duan* Rigid P-Chiral Phosphorus Ligands for Highly Selective Palladium-Catalyzed (4+2) and (4+4) Annulations. Org. Lett. 2022, 24, 50, 9205–9209.

37. Zhipeng Zhang, Li Jing, Er-Qing Li*, Zheng Duan* Cooperative Palladium-Catalyzed and P(NEt2)3-Mediated (4+1) Annulation of Isatins with 2-Hydroxymethylallylcarbonates.  Org. Chem. Front., 2022, 9, 3215-3221.

36. Yinggao Meng, Lihui Chen,* Er-Qing Li,* Recent Advances in Lewis Base-Catalysed Chemo-, Diastereo- and Enantiodivergent Reactions. The Chemical Record, 2022, 22, e202100276.

35. Manman Song,  Jing Zhao, Er-Qing Li,* Recent advances in tertiary amine Lewis base-promoted cycloadditions of allenoates. Chin. Chem. Lett. 2022, 33,2372-2382..

34.  Ke Li, Zhipeng Zhang, Jiahui Zhu,  Yuxin Wang,  Jing Zhao,  Er-Qing Li* and Zheng Duan*  Org. Chem. Front. 2022, 9, 19 - 24.

33. Siming Jia, Mengmeng Ma, Er-Qing Li,*  Zheng Duan,* and Françis Mathey  Design of 1‑Phosphanorbornene Derivatives as Chiral Organocatalysts for Enantioselective (4 + 2) Annulation Reactions of γ‑Benzyl Allenoates. Org. Lett. 202123, 3337-3342.

32. Wang Yue, Song Manman, Li Er-Qing*, and Duan Zheng* Auto-Tandem Palladium/Phosphine Cooperative Catalysis: Synthesis of Bicyclo[3.1.0]hexenes by Selective Activation of Morita–Baylis–Hillman Carbonates. Org. Chem. Front.2021,  8, 3366-3371.

31. Ke Li, Zhenjie Gan, Er-Qing Li,*and Zheng Duan*  Phosphine-Catalyzed (4 + 2) Cycloaddition of Conjugated Dienes with Enones and Its Asymmetric Variant. Org. Lett2021,  23, 3094-3099.  

30.  Gan Zhenjie*, Li Ke, Zhang Hui, Li Er-Qing* Copper/GanPhos-Catalyzed 1,3-Dipolar Cycloaddition of Azo­methine Ylides: An Efficient Access to Chiral Pyrrolidine Spirocycles.   Synthesis  2021, 53(07): 1331-1340.

29. Lulu Wu, Bing Yu,* Er-Qing Li,* Recent Advances in Organocatalyst‐Mediated Benzannulation Reactions. Adv. Synth. Catal.2020362, 4010-4126.

28. Lulu Wu, Kaihong Chen,* You Huang,* Er-Qing Li,* Phosphine‐Catalyzed δ‐Addition Reaction of γ‐Substituted Allenoates with Isatin Derivatives. Asian J. Org. Chem., 2020, 9, 1179-1182.

27. Er-Qing Li, You Huang,* Recent advances in phosphine catalysis involving γ-substituted allenoates. Chem. Commun., 2020, 56, 680-694

26.  Hao Cui, Ke Li, Yue Wang, Manman Song, Congcong Wang, Donghui Wei,* Er-Qing Li,* Zheng Duan* and Francois Mathey, Copper(I)/Ganphos Catalysis: Enantioselective Synthesis of Diversified Spirooxindoles Using Alkyl Substituted Imino Ester and Methyleneindolinones. Org. Biomol. Chem., 202018, 3740-3746.

25. Ruiping Han, Yue Ding, Xueke Jin and Er-Qing Li,* Silver/palladium relay catalyzed 1,3-dipole annulation/allylation reactions to access fully substitutedallyl imidazolidines.  Org. Biomol. Chem.  202018, 646-649

24.  Wang Yue, Jia Siming, Li Er-Qing* and Duan Zheng*,  Phosphine/Palladium Cooperative Catalysis: (4 + 3) Annulations of Morita–Baylis–Hillman Carbonates and Vinyl BenzoxazinanonesJ. Org. Chem. 2019, 8415323-15330.

23.  马蓉,  宋格格, 奚秋贞, 杨柳, 李二庆*, 段征有机磷催化γ-甲基联烯酸酯[3 + 2]环化反应 有机化学2019 2019, 39 (8), pp 2196-2202.

22. Phosphine-catalyzed regiodivergent annulations of γ-substituted allenoates with conjugated dienes. Zhenjie Gan, Yanchuan Gong, Yunpeng Chu, Er-Qing Li,* You Huang* and Zheng Duan* Chem. Commun., 201955, 10120 - 10123.

21. Ag/P-Stereogenic Phosphine-Catalyzed Enantioselective 1,3-Dipolar Cycloadditions: A Method to Optically Active Pyrrolidines Zhi Mengna, Gan Zhenjie, Ma Rong, Cui Hao, Li Er-Qing,* Duan Zheng,* and Mathey François Org. Lett. 2019, 21, 3210-3213.

20. P-Stereogenic Phosphines Directed Copper(I)-Catalyzed Enantioselective 1,3-Dipolar Cycloadditions Gan Zhenjie, Zhi Mengna, Han Ruiping, Li Er-Qing ,* Duan Zheng,* and Mathey François Org. Lett.201921,  2782–2785.  

19. Enanti‐and Diastereoselective Synthesis of β‐Aryl‐β‐pyrazolyl α‐Amino Acid Esters via Copper‐Catalyzed Reaction of Azomethine Ylides with Benzylidenepyrazolones Gong Yan-Chuan, Wang Yue, Li Er-Qing,* Cui Hao, Duan Zheng * Adv. Synth. Catal. 2019, 361, 1389-1393.

18. Brønsted Acid Tuned, Lewis Base Promoted [4 + 2] Annulation Reactions of Allenoates with Electron-Deficient Olefins. Xi Qiu-Zhen, Gan Zhen-Jie, Li Er-Qing,* Duan Zheng * Eur. J. Org. Chem. 2018, 2018, 4917-4925

17. Phosphine‐Catalyzed [3 + 2] Annulation of  γ‐Substituted Allenoates: Novel Access to Functionalized Cyclopentenes and Bicyclic[3, 3, 0]octene Derivatives. Li Erqing, Jin Hongxing and Huang You * ChemistrySelect 20183, 12007-12010.

工作之前发表论文:  

16. Bifunctional-Phosphine-Catalyzed Sequential Annulations of Allenoates and Ketimines: Construction of Functionalized Poly-heterocycle Rings. Li Erqing, Jin Hongxing, Jia Penghao, Dong Xuelin, and Huang You * Angew. Chem. Int. Ed. 2016, 55, 11591 –11594.  

15. Divergent Phosphine Catalyzed [2 + 4] or [3 + 2] Cycloaddition Reactions of γ- Substituted Allenoates with Oxo-dienes. Li Erqing, Chang Meijia, Liang Ling and Huang You * Eur. J. Org. Chem. 2015, 710-714.  

14. Phosphine-catalyzed Domino Reaction: A Novel Sequential [2+3] and [3+2] Annulation Reaction of γ-Substituent Allenoates to Construct Bicyclic[3, 3, 0]octene Derivatives.  Li, Erqing; Huang, You* Chem. Commun., 2014, 50, 948-950

13. Phosphine-Catalyzed Domino Reaction: A Novel Method Access to Functionalized Bicyclic Skeletons Li, Erqing; Huang, You* Chem. Eur. J., 2014, 20, 3520

12. Phosphine-Catalyzed Sequential [2 +3] and [3 + 2] Annulation Domino Reaction of γ- Benzyl Substituted Allenoates with α,β-Unsaturated Ketimines To Construct Aza-bicyclo[3, 3, 0]octane Derivatives. Li, Erqing; Jia, Penghao; Liang, Ling; Huang, You* ACS Catal. 2014, 4, 600-603.
11. Phosphine-Catalyzed [4+2] Annulation of gamma-Substituent Allenoates: Facile Access to Functionalized Spirocyclic Skeletons. Li, Erqing; Huang, You*; Liang, Ling; Xie Peizhong. Org. Lett. 2013, 15, 3138-3141

10. Tuning Catalysts to Tune the Products: Phosphine-Catalyzed Aza-Michael Addition Reaction of Hydrazones with Allenoates.  Li, Erqing; Xie, Peizhong; Yang, Lihua, Liang Ling, Huang You*. Chem. Asian J. 2013, 8, 603-610

合作发表论文:

9. Wei Hu, Er-Qing Li, Zheng Duan* and Francois Mathey, Concise synthesis of phospholene and its P-stereogenic derivatives. J. Org. Chem. 202085, 14772–14778.

8. Jin Hongxing, Li Erqing, Huang You*  Divergent synthesis of hydropyridine derivatives via nitrogen-containing Lewis base mediated regioselective [4+2] cyclizations Org. Chem. Front. 20174, 2216-2220. 

7. Jin Hongxing, Zhang Qinglong, Li Erqing, Jia, Penghao, Li Ning, Huang You* Phosphine-catalyzed intramolecular Rauhut-Currier reaction: enantioselective synthesis of hydro-2H-indole derivatives  Org. Biomol. Chem., 2017, 15, 7097-7101.

6.  Liang Ling, Li Erqing, Dong Xuelin, and Huang You*  DABCO-Mediated [4 + 4]-Domino Annulation: Access to Functionalized Eight-Membered Cyclic Ethers.Org. Lett. 2015, 17, 4914-4917.

5. Dong Xuelin, Liang Ling, Li Erqing, and Huang You * Highly Enantioselective Intermolecular Cross Rauhut–Currier Reaction Catalyzed by a Multifunctional Lewis Base Catalyst.  Angew. Chem. Int. Ed. 2015, 54, 1621-1624.

4. Liang, Ling; Li, Erqing; Xie, Peizhong; Huang You*, Phosphine Initiated Domino Reaction: A Convenient Method for the Preparation of Spiro-cyclopentanones.   Chem. Asian J. 2014, 9, 1270-1273.

3. Xie, Peizhong; Li, Erqing; Zheng, Jie; Li, Xin; Huang, You*; Chen, Ruyu, Tunable Phosphine-Mediated Domino Reaction: Selective Synthesis of 2,3-Dihydrofurans and Biaryls.  Adv. Synth. Catal. 2013, 355, 161 – 169.

2.  Yang, Lihua; Xie, Peizhong; Li, Erqing; Li, Xin; Huang, You*; Chen, Ruyu Phosphine-catalyzed Domino Reaction: an Efficient Method for the Synthesis of Highly Functionalized Spirooxazolines. Org. Biomol. Chem. 2012, 10, 7628-7634.

1. Xie, Peizhong; Wang, Liye; Yang, Lihua; Li, Erqing; Ma, Jianze; Huang, You*; Chen, Ruyu. Domino Reaction for the Chemo- and Stereoselective Synthesis of Trans-2,3-Dihydrobenzofurans from N-Thiophosphinyl Iimines and Sulfur Ylides.  J. Org. Chem. 2011, 76, 7699-7705 



授权专利

段征,李二庆,支梦那,甘贞洁 手性1-磷杂降冰片二烯衍生物及其合成方法,专利号:ZL201811293427.X