2025年：
(45) Recent Advances in the Multifunctionalization Reactions of Indoles.
Xiaoxiang Zhang+, Maoyi Dai+, Pengyan Zhang+, Xiaohe Lu, and Taoyuan Liang*
Chin. J. Chem. 2025, 43, 2825–2868. DOI: 10.1002/cjoc.70176.
(44) Hypervalent Iodine-mediated One-pot Synthesis of C3,6-Dithioquinolin-2-ones.
Yukun Xie, Xiaodan Meng, Chenrui Liu, Xiaoxiang Zhang, Zhuan Zhang, and Taoyuan Liang*
Org. Chem. Front. 2025, 12, 4439–4444. DOI:10.1039/D5QO00337G.
(43) A one-pot multicomponent tandem reaction for the rapid synthesis of 2-amino-3-benzylindoles.
Pengyan Zhang, Chenrui Liu, Maoyi Dai, Guangyue Wang, Yurong Huang, Lina Zhang, Cheng Liu, Chengjie He, Xiaoxiang Zhang, Zhuan Zhang, and Taoyuan Liang*
Org. Biomol. Chem. 2025, 23, 3393–3399. DOI:10.1039/D5OB00187K.
(42) Transition-metal-free synthesis of C3,5-difunctionalized oxindole derivatives.
Yifeng Liu, Pengyan Zhang, Liangjie Feng, Zhuan Zhang, and Taoyuan Liang*
Org. Chem. Front. 2025, 12, 2704–2708. DOI: 10.1039/D4QO02428A.
(41) Recent Advances in the Multicomponent Reactions of Indoles.
Xiaoxiang Zhang+, Xiaohe Lu+, Pengyan Zhang+, Maoyi Dai, and Taoyuan Liang*
Eur. J. Org. Chem. 2025, 28, e202401446. DOI: 10.1002/ejoc.202401446.
(40) Palladium-Catalyzed Solvent-Controlled Divergent C2/C5 Site-Selective Alkynylation of Pyrrole Derivatives.
Zeng Huang, Chenjie Zhang, Pengfei Zhou, Cheng Wang, Taoyuan Liang, Shuangliang Zhao,* Zhuan Zhang*
J. Org. Chem. 2025, 90, 1115–1125. DOI: 10.1021/acs.joc.4c02680.
2024年：
(39) Catalyst-Controlled Regiodivergent C–H Alkynylation of 2-Pyridylthiophenes.
Yuting Gui, Yaokun Zhao, Xingchi Li, Taoyuan Liang, Shuangliang Zhao,* Zhuan Zhang*
Adv. Synth. Catal. 2024, 367, e202400856. DOI: 10.1002/adsc.202400856.
(38) Atmosphere Induces Tunable Oxygen Vacancies to Stabilize Single-Atom Copper in Ceria for Robust Electrocatalytic CO2 Reduction to CH4.
Fang Huang,+ Xiangyu Chen,+ Huanhuan Sun, Qingduo Zeng, Junjie Ma, Dong Wei, Jinliang Zhu, Zhengjun Chen, Taoyuan Liang, Xucai Yin, Xijun Liu, Jing Xu,* and Huibing He*
Angew. Chem. Int. Ed. 2024, e202415642. DOI: 10.1002/anie.202415642.
(37) Iron-catalyzed C−H arylphosphorylation of quinoxalines.
Maoyi Dai, Meilan Xu, Xiaoting Gu, Pengyan Zhang, Yukun Xie, Jin Zhuge, Xinting Liang, Runmin Liao, Zongwu Wei, Zhuan Zhang, and Taoyuan Liang*
Org. Lett. 2024, 26, 7672–7677. DOI: 10.1021/acs.orglett.4c02791.
(36) Rh-Catalyzed C–H Alkynylation of Indole Derivatives with Silver(I)-Controlled Regiodivergence.
Yaokun Zhao, Xingchi Li, Pengfei Zhou, Xing Han, Chenjie Zhang, Taoyuan Liang, Shuangliang Zhao,* Zhuan Zhang*
Org. Lett. 2024, 26, 7285–7290. DOI: 10.1021/acs.orglett.4c02151.
(35) Regiodivergent Metal-Catalyzed Oxidative Alkynylation of 2-Arylthiazoles with Terminal Alkynes under Air Conditions.
Pengfei Zhou, Cheng Wang, Guibin Wan,. Weining Zheng, Zongwu Wei, Taoyuan Liang, Jun Jiang,* Zhuan Zhang*
J. Org. Chem. 2024, 89, 10953–10964. DOI: 10.1021/acs.joc.4c01381.
(34) Iron-Catalyzed Friedel-Crafts-Type 3,5-Diacylation of Indoles.
Xiaoting Gu, Maoyi Dai, Xirui Qing, Yifeng Liu, Zhuan Zhang, Zongwu Wei,* Taoyuan Liang*
J. Org. Chem. 2024, 89, 10272–10282. DOI: 10.1021/acs.joc.4c01157.
(33) Regiodivergent C–H alkynylation of 2-arylthiazoles switched by RuII and PdII catalysis.
Pengfei Zhou,‡ Xinyao Liang,‡ Zekun Xu, Honggu Chen, Zongwu Wei, Taoyuan Liang, Jun Jiang* and Zhuan Zhang*
Chem. Commun., 2024, 60, 6679−6682. DOI: 10.1039/D4CC02254H.
(32) Organoselenium-catalyzed C2,3-diarylation of N−H indoles.
Yingying Zhang, Xiaoxiang Zhang, Junqiu Liao, Zongwu Wei, Zhuan Zhang, Taoyuan Liang*
J. Org. Chem. 2024, 89, 7216–7224. DOI: 10.1021/acs.joc.4c00622.
(31) Iodine–Mediated Oxidative Triple Functionalization of Indolines with Azoles and Diazonium Salts.
Yifeng Liu, Xiaoting Gu, Xiaoxiang Zhang, Meilan Xu, Zhuan Zhang and Taoyuan Liang*
Chem. Commun., 2024, 60, 4613–4616. DOI: 10.1039/D4CC00856A.
(30) Green Solvents in Organic Synthesis [BOOK] (Pages: 199-236).
Zhuan Zhang, Taoyuan Liang.
WILEY-VCH GmbH, Weinheim, Germany. 2024. Print ISBN: 9783527352005, Online ISBN: 9783527841943, DOI: 10.1002/9783527841943.
(29) Solvent-Controlled Switchable Multicomponent Tandem Oxidative Triple Functionalization of Indolines.
Xiaoxiang Zhang, Xiaoting Gu, Yingying Zhang, Junqiu Liao, Meilan Xu, Zhuan Zhang and Taoyuan Liang*
Org. Chem. Front., 2024, 11, 1933–1940. DOI: 10.1039/D4QO00030G.
Highlighted by Frontiers Journals, https://mp.weixin.qq.com/s/DHSfhqC-biIncGQCbS7EMQ.
(28) Iodine-Dependent Oxidative Regioselective Aminochalcogenation of Indolines.
Xiaoxiang Zhang, Chenrui Liu, Wanxing Wei, Zhuan Zhang and Taoyuan Liang*
Chem. Commun., 2024, 60, 1152–1155. DOI: 10.1039/D3CC05999E.
(27) Directing-group-free Strategy for the Iodine-mediated Regioselective Dichalcogenation of Indolines: Understanding the Full Catalytic Cycles.
Xiaoxiang Zhang, Chenrui Liu, Wenwei Pang, Xiaoting Gu, Wanxing Wei, Zhuan Zhang, Haiyan Chen and Taoyuan Liang*
Org. Chem. Front. 2024, 11, 871–884. DOI: 10.1039/D3QO01492D.
2023年：
(26) Organo-catalyzed C2,3−H Aminochalcogenation of Indoles with Secondary (Aliphatic) Amines.
Xiaoxiang Zhang,‡ Chenrui Liu,‡ Yingying Zhang, Fang Shen, Wanxing Wei, Zhuan Zhang and Taoyuan Liang*
Org. Chem. Front. 2023, 10, 5886–5894. DOI: 10.1039/D3QO01457F.
Highlighted by Frontiers Journals，https://mp.weixin.qq.com/s?_biz=MzI3NTk3Nzk3NQ.
(25) Iodine-mediated C2,3−H aminoheteroarylation of indoles.
Maoyi Dai, Yingying Zhang, Xiaoxiang Zhang, Ruiyi Wang, Wanxing Wei, Zhuan Zhang, Taoyuan Liang*
J. Org. Chem. 2023, 88, 15106–15117. DOI: 10.1021/acs.joc.3c01591.
(24) Catalyst-Controlled Divergent C3/C5 Site-Selective C−H Arylation of 2-Pyridylthiophenes.
Xuecong Huang, Pengfei Zhou, Xingdong Yang, Ruiyi Wang, Guan Huang, Taoyuan Liang, Zhuan Zhang*
Adv. Synth. Catal. 2023, 365, 3674–3679. DOI: 10.1002/adsc.202300724.
(23) Synthesis of 2,3-Diaminoindoles via a Copper-iodine Co-catalytic Strategy.
Wenhua Yu,‡ Yingying Zhang,‡ Xiaoxiang Zhang, Xiaoting Gu, Xirui Qing, Wanxing Wei, Zhuan Zhang, Guanghua Li,* Taoyuan Liang*
Chin. J. Chem. 2023, 41, 3567–3572. DOI: 10.1002/cjoc.202300470.
Highlighted by Chin J Chem, https://mp.weixin.qq.com/s/QKYHvkZWAj7DQ9IZks3-iA;
Highlighted by CBG, https://mp.weixin.qq.com/s/mvnzakwZ-QmKEvllqIO6tw.
(22) Ruthenium(II)-Catalyzed Remote C–H Sulfonylation of 2-Pyridones.
Fengqi Yang, Pengfei Zhou, Zeng Huang, Junqiu Liao, Guan Huang, Taoyuan Liang, and Zhuan Zhang*
Org. Lett. 2023, 25, 5779–5783. DOI: 10.1021/acs.orglett.3c02004.
(21) Catalyst-controlled regiodivergent C–H bond alkenylation of 2-pyridylthiophenes.
Qiang Zhang,‡ Pengfei Zhou,‡ Yaokun Zhao, Yeran Liu, Taoyuan Liang, Jun Jiang* and Zhuan Zhang*
Chem. Commun., 2023, 59, 8842–8845. DOI: 10.1039/D3CC02411C. 
(20) Cu-Co dual-atom catalysts supported on hierarchical USY zeolites for the efficient cross-dehydrogenative C(sp2)–N coupling reaction.
Tianxiang Chen,§ Wenhua Yu,§ Ching Kit Tommy Wun, Tai-Sing Wu, Mingzi Sun,Sarah Day, Zehao Li, Bo Yuan, Yong Wang, Mingjie Li, Zi Wang, Yung-Kang Peng,Wing-yiu Yu, Kwok-yin Wong, Bolong Huang,* Taoyuan Liang,* Tsz Woon Benedict Lo*
J. Am. Chem. Soc. 2023. 145, 8464–8473. DOI:10.1021/jacs.3c00114.
Highlighted by X-MOL, https://www.x-mol.com/news/851296;
Highlighted by CBG, https://mp.weixin.qq.com/s/gv6sHR4h8RT9-iscw-UFLg.
(19) Multicomponent Tandem Triple Functionalization of Indoles via a Directing-group-free Strategy.
Xiaoting Gu.§ Xiaoxiang Zhang,§ Wenhua Yu, Ke Sun, Wanxing Wei, Zhuan Zhang, and Taoyuan Liang*
Adv. Synth. Catal. 2023, 365, 990–996. DOI: 10.1002/adsc.202300208.
Highlighted by CBG, https://mp.weixin.qq.com/s/BMxNZCw6hcRiVUF30Q0dlw.
(18) Unlocking Regiodivergence in PdII- and RhIII-Mediated Site-Selective C–H Bond Alkynylation of Imidazopyridines.
Qiang Zhang, Xuecong Huang, Yuting Gui, Youyuan He, Siyang Liao, Guan Huang, Taoyuan Liang, and Zhuan Zhang*
Org. Lett. 2023, 25, 1447–1452. DOI: 10.1021/acs.orglett.3c00178.
(17) Design and Synthesis of (3-Phenylisoxazol-5-yl)methanimine Derivatives as Hepatitis B Virus Inhibitors.
Zhengcheng Liang, Yongqing Tan, Yunhou Huang, Taoyuan Liang,* Wanxing Wei,* Mian Wang,* Kaichuang Shi
Chem. Biodivers. 2023, 20, e202201247. DOI: 10.1002/cbdv.202201247.
(16) Synthesis and evaluation of 3-phenylisoxazoline derivatives as non-nucleoside hepatitis B virus inhibitors.
Zhengcheng Liang, Yunhou Huang, Huihua Li, Xiaoxiang Zhang, Kaichuang Shi, Ning Zang, Mian Wang,* Taoyuan Liang,* Wanxing Wei*
Tetrahedron 2023, 130, 133177. DOI: 10.1016/j.tet.2022.133177.
(15) Synthesis and bioactive evaluation of N-((1-methyl-1H-indol-3-yl)methyl)-N-(3,4,5-trimethoxyphenyl)acetamide derivatives as agents for inhibiting tubulin polymerization.
Aonan Ren, Wanxing Wei,* Zhengcheng Liang, Min Zhou, Taoyuan Liang, Ning Zang.
RSC Med. Chem., 2023, 14, 113–121. DOI: 10.1039/D2MD00340F.
(14) Discovery and biological evaluation of 2-((3-phenylisoxazol-5-yl) methoxy) benzamide derivatives as potent nucleocapsid inhibitors.
Ziyue Xie, Zhengcheng Liang, Yunhou Huang, Kaichuang Shi, Ning Zang, Mian Wang,* Taoyuan Liang*.Wanxing Wei*
J. Mol. Struct. 2023, 1272, 134103. DOI: 10.1016/j.molstruc.2022.134103.
2022年：
(13) Copper-mediated intermolecular C−H aminohalogenation of indoles at room temperature.
Yuanhui Lu, Xiaoxiang Zhang, Xiaoyu Xiao, Ninghua Huang, Yadong Dou, Chenrui Liu, Wanxing Wei, Zhuan Zhang, and Taoyuan Liang*
Asian J. Org. Chem. 2022, 11, e202200457. DOI: 10.1002/ajoc.202200457.
Highlighted by WileyChem, https://mp.weixin.qq.com/s/Iq7PkVe5_I_dRl3Iahvu2g.
(12) Intermolecular C−H aminocyanation of indoles via copper-iodine co-catalyzed tandem C−N/C−C bond formation.
Wenhua Yu, Xiaoxiang Zhang, Chenrui Liu, Yingying Zhang, Xiaoting Gu, Jiahao Liao, Zhuan Zhang, Wanxing Wei,* Guanghua Li,* and Taoyuan Liang*
J. Org. Chem. 2022, 87, 12424–12433. DOI: 10.1021/acs.joc.2c01703.
Highlighted by OPR&D, https://doi.org/10.1021/acs.oprd.3c00022.
(11) Iron-iodine co-catalysis towards tandem C−N/C−C bond formation: one-pot regioselective synthesis of 2-amino-3-alkylindoles.
Yingying Zhang, Yating Huang, Kewei Yu, Xiaoxiang Zhang, Wenhua Yu, Jiale Tang, Yiran Tian, Wanxing Wei, Zhuan Zhang,* and Taoyuan Liang*
Org. Chem. Front. 2022, 9, 6165–6171. DOI: 10.1039/D2QO01329K.
Highlighted by Frontiers Journals, https://mp.weixin.qq.com/s/KIK3R-eoV10xuicSRl1sNA.
(10) Copper dual-atom catalyst mediated C3−H amination of indoles at room temperature.
Yuanhui Lu,‡ Tianxiang Chen,‡ Xiaoyu Xiao, Ninghua Huang, Yadong Dou, Wanxing Wei, Zhuan Zhang, Benedict Tsz Woon Lo* and Taoyuan Liang*
Catal. Sci. Technol., 2022, 12, 5390–5396. DOI: 10.1039/D2CY01126C.
(9) Copper-iodine Co-catalyzed C−H Aminoalkenylation of Indoles via Temperature-Controlled Selectivity Switch: Facile Synthesis of 2-Azolyl-3-alkenylindoles.
Xiaoxiang Zhang, Wenhua Yu, Yiyu Nie, Yingying Zhang, Xiaoting Gu, Wanxing Wei, Zhuan Zhang,and Taoyuan Liang*
Org. Chem. Front. 2022, 9, 3794–3799. DOI: 10.1039/D2QO00627H.
Highlighted by Frontiers Journals, https://mp.weixin.qq.com/s/8i5m1WmL9o4SBNs50hEI4w.
(8) Design, synthesis, and biological evaluation of novel (E)-1-arylethan-1-one O-((3-arylisoxazol-5-yl) methyl) oxime derivatives as potent non-nucleoside HBV inhibitors.
Yunhou Huang, Na Liu, Qiuyue Ning, Min Zhou, Ning Zang*, Taoyuan Liang*, Wanxing Wei*
J. Mol. Struct. 2022, 1260, 132789. DOI: 10.1016/j.molstruc.2022.132789.
2021年：
(7) Synthesis of Functionalized Benzimidazoles via Oxidative Tandem Quartic C–H Aminations and Cleavage of C–N and C–C bonds.
Taoyuan Liang, He Zhao*, Lingzhen Gong, Huanfeng Jiang and Min Zhang*
Chem. Commun. 2021, 57, 12976–12979. DOI: 10.1039/D1CC05521F.
(6) Synthesis of 3-Halogenated 2,3′-Biindoles by a Copper-mediated 2,3-Difunctionalization of Indoles.
Xiaoxiang Zhang, Yingying Zhang, Xiaoting Gu, Zhuan Zhang, Wanxing Wei* and Taoyuan Liang*
Org. Biomol. Chem. 2021, 19, 10403–10407. DOI: 10.1039/D1OB02024B.
-2020年：
(5) Straightforward Access to Novel indolo[2,3-b]indoles via Aerobic Copper-catalyzed [3 + 2] Annulation of Diarylamines and Indoles.
Taoyuan Liang, Lingzhen Gong, He Zhao, Huanfeng Jiang, Min Zhang*
Chem. Commun. 2020, 56, 2807–2810. DOI: 10.1039/D0CC00178C.
(4) Direct Access to Functionalized Indoles via Single Electron Oxidation Induced Coupling of Diarylamines with 1,3-Dicarbonyl Compounds.
Taoyuan Liang, He Zhao, Lingzhen Gong, Huanfeng Jiang, Min Zhang*
Org. Lett. 2019, 21, 6736–6740. DOI: 10.1021/acs.orglett.9b02349.
(3) Synthesis of Multisubstituted Benzimidazolones via Copper-catalyzed Oxidative Tandem C–H Aminations and Alkyl Deconstructive Carbofunctionalization.
Taoyuan Liang, He Zhao, Lingzhen Gong, Huanfeng Jiang, Min Zhang*
iScience 2019, 15, 127–135. DOI: 10.1016/j.isci.2019.04.019.
(2) Silver-mediated Three-Component Cycloaddition Reaction for Direct Synthesis of 1-N-vinyl-substituted 1,2,3-Triazoles.
Jinpeng Chen, Taoyuan Liang, He Zhao, Chuyuan Lin, Lu Chen, Min Zhang*
Org. Biomol. Chem. 2019, 17, 4843–484. DOI: 10.1039/C9OB00686A.
(1) Aerobic Copper-Catalyzed Synthesis of Benzimidazoles from Diaryl- and Alkylamines via Tandem Triple C–H Aminations.
Taoyuan Liang, Zhenda Tan, He Zhao, Xiuwen Chen, Huanfeng Jiang, Min Zhang*
ACS Catal. 2018, 8, 2242-2246. DOI: 10.1021/acscatal.8b00082.
发明专利：
1. 张珉，梁桃源，一种一步合成5-二芳氨基苯并咪唑衍生物的方法，已授权，ZL201710256605.0;
2. 张珉，梁桃源，一种一步合成5-二芳氨基苯并咪唑酮衍生物的方法，已授权，ZL201711225340.4;
3. 张珉，梁桃源，一种一步合成2-氨基吲哚并[2,3-b]吲哚衍生物的方法，CN202010133018.4;
4. 梁桃源，张晓翔，韦万兴，2-烷基对苯二醌类化合物的合成方法，已授权，ZL202110415372.0;
5. 梁桃源，卢远辉，肖晓宇，黄宁华，豆雅东，一种2-氨基-3-卤代吲哚衍生物的合成方法，CN202210194273.9;
6. 梁桃源，余珂微，张莹莹，唐嘉乐，田一然，一种2-唑基-3-烷基吲哚衍生物的合成方法，CN202211183607.9；
7. 梁桃源，肖晓宇，张晓翔，黄宁华，豆雅东，一种2-氨基-5-硫基吲哚衍生物的合成方法，已授权， ZL202310193470.3；
8. 梁桃源，刘宸瑞，谢玉昆，一种多取代环胺类化合物的合成方法，CN202411953802.4;
9. 梁桃源，徐梅兰，代茂旖，梁欣婷，廖润民，诸葛金，一种喹喔啉直接 C−H 键胺化的方法, CN202411961074.1.