(50) Li Xianfeng#; Ma Simin#; Li Yijun; Gao Yuting; Zhang Gong*; Zhao Peng; Li Yangfeng*; Fan Xiaohong*; Li Yizhou*, DNA-Compatible Synthesis of Pyrrolidine-Fused Scaffolds via a One-Pot Three-Component Cycloaddition Strategy, Organic Letters, 2025, 27, 9024-9029.
https://doi.org/10.1021/acs.orglett.5c02757
(49) Gao Yuting#; Liu Jinlu#; Huang Sijie; Du Nana; Zhang Gong*; Li Yizhou*, Recent advances in DNA-encoded libraries, Chemical Communication, 2025, 61, 10952-10968
https://doi.org/10.1039/D5CC02904J
(48) Fang Xianfu; Li, Yizhou, Selenoxides unlock C–H bonds of biomacromolecules, Nature Chemistry, 2025, 17, 1304-1306.
https://doi.org/10.1038/s41557-025-01921-w
(47) Fang Xianfu#; Ju Yunzhu#; Nie Qigui; Fan Xiaohong; Wang Huihong; Li Yangfeng; Zhang Gong; Li Yizhou, Synthesis of 5-Arylidene Thiohydantoin Derivatives via DNA-Compatible Knoevenagel Condensation, Acta Chimica Sinica, 2025, 83(10): 1119-1123.
https://sioc-journal.cn/Jwk_hxxb/CN/10.6023/A25050155
https://doi.org/10.1002/anie.202507064
(45) Wang Huihong#; Huang Jiale#; Fang Xianfu; Liao Huilin; Zhang Gong*; Fang Wei*; Li Yizhou*, DNA-compatible synthesis of amidine pharmacophores via late-stage amine modification, Organic Chemistry Frontiers, 2025, 10.1039/d5qo00818b
https://doi.org/10.1039/D5QO00818B
(44) Liao Huilin#; Fang Xianfu; Wang Huihong; Chen Chang; Zhang Gong; Li Yangfeng*; Li Yizhou*, DNA-Compatible N‑Formylation of Amines by Using TMSCF2Br, The Journal of Organic Chemistry, 2025, 90 (16), 5453-5459.
https://doi.org/10.1021/acs.joc.5c00055
(43) Fang Xianfu#; Ning Xianguo#; Li Yangfeng; Zhang Gong*; Fan Xiaohong*; Li Yizhou*, DNA-compatible one-pot synthesis of multi-substituted dihydrofuran via pyridinium ylide-mediated cyclization, Organic & Biomolecular Chemistry, 2025, 23, 9890-9895.
https://doi.org/10.1039/D4OB02089H
(42) Wang Huihong#; Huang Jiale#; Fang Xianfu; Liu Mengyao; Fan Xiaohong*; Li Yizhou*, Advances in Next-Generation Sequencing (NGS) Applications in Drug Discovery and Development, Expert Opinion on Drug Discovery, 2025, 20 (4), 537–550.
https://doi.org/10.1080/17460441.2025.2481262
(41) Nie Qigui#; Fang Xianfu#; Huang Jiale; Xu Tingting; Li Yangfeng; Zhang Gong*; Li Yizhou*, The Evolution of Nucleic Acid Nanotechnology: From DNA Assembly to DNA‐Encoded Library, Small Methods, 2025, 9 (6), 2401631.
https://doi.org/10.1002/smtd.202401631
(40) Nie Qigui#; Xu Tingting#; Fang Xianfu; Dan Yanrong; Zhang Gong; Li Yangfeng*; Li Jianbo;* Li Yizhou*, The Furan–Thiol Amine Reaction Facilitates DNA-Compatible Thiopyrrole-Grafted Macrocyclization and Late-Stage Amine Transformation, Organic Letters, 2025, 27, 498−503.
https://doi.org/10.1021/acs.orglett.4c04505
(39) Zhao Guixian#; Zhu Mengping; Li Yangfeng; Zhang Gong*; Li Yizhou*, Using DNA-encoded libraries of fragments for hit discovery of challenging therapeutic targets, Expert Opinion on Drug Discovery, 2024, 19(6): 725-740
https://doi.org/10.1080/17460441.2024.2354287
(38) Fang Xianfu#; Ju Yunzhu#; Wang Jiayou; Zhang Gong; Li Yangfeng*; Li Yizhou*, Synthesis of Thiohydantoin Scaffolds on DNA for Focused DNA-Encoded Library Construction, Organic Letters, 2024, 26(41), 8916–8921.
https://pubs.acs.org/doi/10.1021/acs.orglett.4c03369
(37) Zhang Tianyang#;Fang Xianfu#; Wang Xin; Wang Huicong; Zhang Gong; Fang Wei*; Li Yangfeng*; Li Yizhou*, DNA-Compatible Nitriles Hydrolysis for Late-Stage Functionalization of DNA-Encoded Libraries, Asian Journal of Organic Chemistry, 2024, 13(11), e202400280.
https://aces.onlinelibrary.wiley.com/doi/10.1002/ajoc.202400280
(36) Wang Huihong#; Chen Teng#; Fan Xiaohong; Li Yangfeng*; Zhang Gong*; Li Yizhou*, Isothiocyanate intermediates facilitate divergent synthesis of N-heterocycles for DNA-encoded libraries, Chemical Communications, 2024, 20, 537
https://doi.org/10.1039/D4CC02547D
(35) He Pengyang#; Zhao Guixian#; Zhu Mengping; Li Yangfeng*; Zhang Gong*; Li Yizhou*, DNA-Compatible Functional Group Transformations via K2RuO4-mediated Oxidation, Organic Chemistry Frontiers, 2024, 11(10), 2851–2856
https://doi.org/10.1039/D4QO00203B
(34) Fan Xiaohong#; Li Xianfeng; Li Yangfeng*; Li Yizhou*, Application of DNA-Conjugated Aryl Diazonium Intermediates in DNA-Encoded Libraries, European Journal of Organic Chemistry, 2024
https://doi.org/10.1002/ejoc.202301172
(33) Zhang Juan#; Liu Jinlu#; Zhang Gong; He Xun; Xiong Feng; Fan Xiaohong*; Li Yangfeng*; Li Yizhou*, Synthesis of Diacylhydrazine Derivatives Based on Tetrazole-Focused DNA-Encoded Library, Organic Letters, 2024, 26(5),1094-1099
https://pubs.acs.org/doi/10.1021/acs.orglett.3c04374
(32) Zhang Juan#; Liu Jinlu; Li Xianfeng; Ju Yunzhu; Li Yangfeng; Zhang Gong*; Li Yizhou*, Unexpected Cyclization Product Discovery from the Photoinduced Bioconjugation Chemistry between Tetrazole and Amine, Journal of the American Chemical Society, 2024, 146(3), 2122-2131
https://pubs.acs.org/doi/10.1021/jacs.3c11574
(31) Fang Xianfu#; Zhang Tianyang#; Fang Wei; Zhang Gong*; Li Yangfeng*; Li Yizhou*, Synthesis of Functionalized Triazoles on DNA via Azide-Acetonitrile "Click" Reaction, Organic Letters, 2023, 25(46), 8326-8331
https://doi.org/10.1021/acs.orglett.3c03404
(30) Wang Huicong#; Zhao Guixian; Zhang Tianyang; Li Yangfeng*; Zhang Gong*; Li Yizhou*, Comparative Study of DNA Barcode Integrity Evaluation Approaches in the Early-Stage Development of DNA-Compatible Chemical Transformation, ACS Pharmacology & Translation Science, 2023, 6, 1724-1733
(29) Wei Haimei#; Zhang Tianyang#; Li Yangfeng; Zhang Gong*; Li Yizhou*, Covalent Capture and Selection of DNA-Encoded Chemical Libraries via Photo-Activated Lysine-Selective Crosslinkers, Chemistry - An Asian Journal, 2023, 18, e202300652
https://doi.org/10.1002/asia.202300652
(28) Li Xianfeng#; Liu Changyang#; Gao Yuting; Zhang Gong*; Li Yangfeng*; Li Yizhou*, DNA-Compatible Combinatorial Synthesis of Functionalized 2-Thiobenzazole Scaffolds, Chemical Communications, 2023, 59(62), 9489-9492
https://doi.org/10.1039/D3CC02593D
(27) Wang Huihong#; Fan Xiaohong#; Chen Teng; Li Yangfeng; Zhang Gong*; Fang Wei*; Li Yizhou*, DNA-Compatible Synthesis of Enaminones via Amination of Alenic Ketones, Organic Chemistry Frontiers, 2023, 10(16), 4105
https://doi.org/10.1039/d3qo00901g
(26) Liu Changyang#; Li Xianfeng#; Zhang Juan; Li Yangfeng; Zhang Gong*; Li Yizhou*, DNA-Compatible Benzotriazinone Formation through Aryl Diazonium Intermediates, The Journal of Organic Chemistry, 2023, 88(11), 6565-6572
https://doi.org/10.1021/acs.joc.2c02686
(25) Wang Yiting#; Fang Xianfu#; Liao Huilin; Zhang Gong*; Li Yangfeng*; Li Yizhou*; DNA-Compatible Synthesis of Thiazolidione Derivatives via Three-Component Annulation and Knoevenagel Condensation, Organic Letters, 2023, 25(24), 4473–4477
https://pubs.acs.org/doi/10.1021/acs.orglett.3c01482
(24) Fang Xianfu#; Liao Huilin#; Fan Xiaohong; Wang Yiting; Wang Huihong; Zhang Gong; Fang Wei*; Li Yangfeng*; Li Yizhou *, Incorporation of Viridicatin Alkaloids-like Scaffolds into DNA-Encoded Chemical Libraries, Organic & Biomolecular Chemistry, 2023, 21(10), 2162–2166
https://doi.org/10.1039/D2OB02278H
(23) Zhao Guixian#; Wang Huihong#; Luo Jie#; He Xun; Xiong Feng; Li Yangfeng; Zhang Gong*; Li Yizhou*; Multicomponent DNA-Compatible Synthesis of an Annelated Benzodiazepine Scaffold for Focused Chemical Libraries, Organic Letters, 2023, 25(4), 665–670
https://pubs.acs.org/doi/10.1021/acs.orglett.2c04293
(22) Nie Qigui#; Sun Jie#; Fang Xianfu; He Xun; Xiong Feng; Zhang Gong*; Li Yangfeng*; Li Yizhou*, Antimony Salt-promoted Cyclization Facilitating on-DNA Syntheses of Dihydroquinazolinone Derivatives and its Applications, Chinese Chemical Letters, 2023, 34(8), 108132
https://doi.org/10.1016/j.cclet.2023.108132
(21) Li Xianfeng#; Zhang Juan#; Liu Changyang; Sun Jie; Li Yangfeng; Zhang Gong*; Li Yizhou*; Aryl Diazonium Intermediates Enable Mild DNA-compatible C-C Bond formation for medicinally relevant combinatorial library synthesis, Chemical Science, 2022, 13(44), 13100-13109
https://pubs.rsc.org/en/content/articlelanding/2022/sc/d2sc04482j
(20) Gao Yuting; Sun Yang; Zhao Guixian, Zhang Gong*; Li Yangfeng*; Li Yizhou*, On-DNA Synthesis of Functionalized 4H‑Pyran Scaffolds for Focused DNA-Encoded Chemical Libraries, Organic Letters, 2022, 24(36), 6664-6669
https://doi.org/10.1021/acs.orglett.2c02714
(19) Gao Yuting#; Sun Yang#; Fang Xianfu; Zhao Guixian; Li Xufeng, Zhang Gong; Li Yangfeng*; Li Yizhou*, Development of on-DNA Vinyl Sulfone Synthesis for DNA-Encoded Chemical Library, Organic Chemistry Frontiers, 2022, 9(17), 4542-4548
https://doi.org/10.1039/D2QO00881E
(18) Zhao Guixian#; Fan Xiaohong#; Li Yangfeng; Zhang Gong*; Li Yizhou*, Switchable DNA-Encoded Chemical Library: Interconversion between Double- and Single-Stranded DNA Formats, ChemBioChem, 2022, 23(14), e202200025
https://doi.org/10.1002/cbic.202200025
(17) Sun Jie#; Nie Qigui#; Fang Xianfu; He Zhiwei; Zhang Gong; Li Yangfeng*; Li Yizhou*, Vinyl Azide as a Synthon for DNA-Compatible Divergent Transformations into N-Heterocycles, Organic & Biomolecular Chemistry, 2022, 20(25), 5045-5049
https://doi.org/10.1039/D2OB00862A
(16) Gui Yuhan; Wong Shania Clara; Zhao Guixian; Xie Chao; Hou Rui; Li Yizhou*; Li Gang*; Li xiaoyu*, Converting Double-Stranded DNA-Encoded Libraries (DELs) to Single-Stranded Libraries for more Versatile Selections, ACS Omega, 2022, 7(13), 11491-11500
https://doi.org/10.1021/acsomega.2c01152
(15) Fang Xianfu#; Wang Yiting#; He Pengyang; Liao Huilin; Zhang Gong; Li Yangfeng*; Li Yizhou*, Visible Light-Promoted Divergent Benzoheterocyclization from Aldehydes for DNA-Encoded Chemical Libraries, Organic Letters, 2022, 24(17), 3291-3296
https://pubs.acs.org/doi/abs/10.1021/acs.orglett.2c01187
(14) Nie Qigui#; Zhong Shuting; Li Yangfeng; Zhang Gong*; Li Yizhou*, Second-Generation DNA-Encoded Multiple Display on a Constant Macrocyclic Scaffold Enabled by an Orthogonal Protecting Group Strategy, Chinese Chemical Letters, 2022, 33(5), 2559-2563
https://doi.org/10.1016/j.cclet.2021.09.041
(13) Yang Shilian#; Zhao Guixian#; Gao Yuting; Sun Yang; Fan Xiaohong; Zhang Gong; Li Yangfeng*; Li Yizhou*, In-Solution Direct Oxidative Coupling for the Integration of Sulfur /Selenium into DNA-Encoded Chemical Libraries, Chemical Science, 2022, 13(9), 2604-2613
https://pubsrsc.53yu.com/en/content/articlehtml/2022/sc/d1sc06268a
(12) Nie Qigui#; Fang Xianfu; Liu Changyang; Zhang Gong; Fan Xiaohong; Li Yangfeng*; Li Yizhou*, DNA-Compatible Ortho-Phthalaldehyde (OPA)-Mediated 2-Substituted Isoindole Core Formation and Applications, The Journal of Organic Chemistry, 2022, 87(5), 2551-2558
https://pubs.acs.org/doi/10.1021/acs.joc.1c02496
(11) Zhao Guixian#; Zhong Shuting#; Zhang Gong; Li Yangfeng; Li Yizhou*, Reversible Covalent Headpiece Enables Interconversion Between Double‐and Single‐Stranded DNA‐Encoded Chemical Libraries, Angewandte Chemie International Edition, 2022, 61(7), e202115157
https://onlinelibrary.wiley.com/doi/10.1002/anie.202115157
(10) Huang Yiran; Li Yizhou*; Li Xiaoyu*, Strategies for Developing DNA-Encoded Libraries beyond Binding Assays, Nature Chemistry, 2022, 14(2), 129-140
https://www.nature.com/articles/s41557-021-00877-x
(9) Zhong Shuting#; Fang Xianfu#; Wang Yiting; Zhang Gong; Li Yangfeng*; Li Yizhou*, DNA-Compatible Diversification of Indole π-Activated Alcohols via a Direct Dehydrative Coupling Strategy, Organic Letters, 2022, 24(4), 1022-1026
https://doi.org/10.1021/acs.orglett.1c04169
(8) Gao Yuting#; Zhao Guixian; He Pengyang; Zhang Gong; Li Yangfeng*; Li Yizhou*, DNA-Compatible Synthesis of α, β-Epoxyketones for DNA-Encoded Chemical Libraries, Bioconjugate Chemistry, 2022, 33(1), 105-110
https://doi.org/10.1021/acs.bioconjchem.1c00567
(7) Zhang Gong#; Zhang Juan; Gao Yuting; Li Yangfeng*; Li Yizhou*, Strategies for Targeting Undruggable Targets, Expert Opinion on Drug Discovery, 2022, 17(1), 55-69
https://doi.org/10.1080/17460441.2021.1969359
(6) Zhang Juan#; Li Xianfeng; Wei Haimei; Li Yangfeng; Zhang Gong*; Li Yizhou*, Sequential DNA-Encoded Building Block Fusion for the Construction of Polysubstituted Pyrazoline Core Libraries, Organic Letters, 2021, 23(21), 8429-8433
https://doi.org/10.1021/acs.orglett.1c03145
(5) Tan Jiang; Li Yizhou*; Zhou Jiang*, Progress of Study on G-quadruplex by Mass Spectrometry, Journal of Chinese Mass Spectrometry Society, 2021, 42(5), 914-925
https://doi.org/10.7538/zpxb.2021.0111
(4) Huang Yiran; Meng Ling; Nie Qigui; Zhou Yu; Chen Langdong; Yang Shilian; Fung Yi Man Eva; Li Xiaomeng; Huang Cen; Cao Yan*; Li Yizhou*; Li Xiaoyu*, Selection of DNA-Encoded Chemical Libraries Against Endogenous Membrane Proteins on Live Cells, Nature Chemistry, 2021, 13(1), 77-88
https://doi.org/10.1038/s41557-020-00605-x
(3) Xi Min; Li Yizhou*; Zhou Jiang*, Exploration of the Formation and Structure Characteristics of a MiR-92a Promoter G-quadruplex by ESI-MS and CD, Talanta, 2020, 211, 120708
https://doi.org/10.1016/j.talanta.2019.120708
(2) Zhao Guixian; Huang Yiran; Zhou Yu; Li Yizhou*; Li Xiaoyu*, Future Challenges with DNA-Encoded Chemical Libraries in the Drug Discovery Domain, Expert Opinion on Drug Discovery, 2019, 14(8), 735-753
https://doi.org/10.1080/17460441.2019.1614559
(1) Li Yizhou*; De Luca Roberto; Cazzamalli Samuele; Pretto Francesca; Bajic Davor; Scheuemann Jörg*; Neri Dario*, Versatile Protein Recognition by the Encoded Display of Multiple Chemical Elements on a Constant Macrocyclic Scaffold, Nature Chemistry, 2018, 10(4), 441-448
https://doi.org/10.1038/s41557-018-0017-8
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Pre-CQU-Publications
(12) Zimmermann Gunther; Li Yizhou; Rieder Ulrike; Mattarella Martin; Neri Dario*; Scheuemann Jörg*, Hit-Validation Methodologies for Ligands Isolated from DNA-Encoded Chemical Libraries, ChemBioChem, 2017, 18(9), 853-857
https://doi.org/10.1002/cbic.201600637
(11) Li Yizhou; Zimmermann Gunther; Scheuemann Jörg; Neri Dario*, Quantitative PCR is a Valuable Tool to Monitor the Performance of DNA-Encoded Chemical Library Selections, ChemBioChem, 2017, 18(9), 848-852
https://doi.org/10.1002/cbic.201600626
(10) Li Yizhou#; Gabriele Elena#; Samain Florent; Favalli Nicholas; Sladojevich Filippo; Scheuemann Jörg; Neri Dario*, Optimized Reaction Conditions for Amide Bond Formation in DNA-Encoded Combinatorial Libraries, ACS Combinatorial Science, 2016, 18(8), 438-443
https://doi.org/10.1021/acscombsci.6b00058
(9) Chen Xinping#; Zhao Chunyue#; Li Xiaolong#; Wang Tao#; Li Yizhou; Cao Cheng; Ding Yuehe; Dong Mengqiu; Finci Lorenzo; Wang Jia-huai*; Li Xiaoyu*; Liu Lei*, Terazosin Activates Pgk1 and Hsp90 to promote stress resistance, Nature Chemical Biology, 2015, 11(1), 19-25
https://doi.org/10.1038/nchembio.1657
(8) Zhao Peng; Chen Zitian; Li Yizhou; Sun Dawei; Gao Yuan; Huang Yanyi*; Li Xiaoyu*, Selection of DNA-Encoded Small Molecule Libraries Against Unmodified and non-Immobilized Protein Targets, Angewandte Chemie International Edition, 2014, 53 (38), 10056-10059
https://doi.org/10.1002/ange.201404830
(7) Li Yizhou; Zhao Peng; Zhang Mingda; Zhao Xianyuan; Li Xiaoyu*, Multistep DNA-Templated Synthesis Using a Universal Template, Journal of the American Chemical Society, 2013, 135(47), 17727-17730
https://doi.org/10.1021/ja409936r
(6) Li Yizhou; Zhang Mingda; Zhang Chi; Li Xiaoyu*, Detection of Bond Formations by DNA-Programmed Chemical Reactions and PCR Amplification, Chemical Communications, 2012, 48(76), 9513-9515
https://doi.org/10.1039/C2CC35230C
(5) Zhang Chi; Li Yizhou; Zhang Mingda; Li Xiaoyu*, DNA-Directed Formation of Peptide Bond: a Model Study toward DNA-Programmed Peptide Ligation, Tetrahedron, 2012, 68(26), 5152-5156
https://doi.org/10.1016/j.tet.2012.04.032
(4) Li Yizhou#; Li Bijie#; Lu Xingyu; Lin Song; Shi Zhangjie*, Cross Dehydrogenative arylation (CDA) of a Benzylic C-H Bond with Arenes by Iron Catalysis, Angewandte Chemie International Edition, 2009, 48(21), 3817-3820
https://doi.org/10.1002/anie.200900341
(3) Li Bijie; Li Yizhou; Lu Xingyu; Liu Jia; Guan Bingtao; Shi Zhangjie*, Cross-Coupling of Aryl/Alkenyl Pivalates with Organozinc Reagents through Nickel-Catalyzed C-O Bond Activation under Mild Reaction Conditions, Angewandte Chemie International Edition, 2008, 47(52), 10124-10127
https://doi.org/10.1002/ange.200803814
(2) Yang Shangdong; Sun Changliang; Fang Zhao; Li Bijie; Li Yizhou; Shi Zhangjie*, Palladium-Catalyzed Direct Arylation of (Hetero)Arenes with Aryl Boronic Acids, Angewandte Chemie International Edition, 2008, 47(8), 1473-1476
https://doi.org/10.1002/ange.200704619
(1) Cai Guixing; Fu Ye; Li Yizhou; Wan Xiaobing; Shi Zhangjie*, Indirect Ortho Functionalization of Substituted Toluenes through Ortho Olefination of N, N-Dimethylbenzylamines Tuned by the Acidity of Reaction Conditions, Journal of the American Chemical Society, 2007, 129(24), 7666-7673
https://doi.org/10.1021/ja070588a
