In the last five years*
2023
1. Chen, X., Zhao, Y., Huang, Y., Zhu, K.,Zeng, F., Zhao, J., Zhang, H., Zhu, X., Kettenmann, H.*, & Xiang,X*. (2023). “TREM2 promotes glioma progression andangiogenesis mediated by microglia/brain macrophages”.Glia,71(11), 2679–2695
2. Francesca Logiacco, Laura Cathleen Grzegorzek, Elizabeth C. Cordell, Oliver Popp, Philipp Mertins, David H. Gutmann, Helmut Kettenmann & Marcus Semtner,”Neurofibromatosis type 1-dependent alterations in mouse microglia function are not cell-intrinsic”,Acta Neuropathologica Communications, volume 11, Article number: 36 (2023)
3.Dilansu Guneykaya, Bilge Ugursu, Francesca Logiacco, Oliver Popp, Maria Almut Feiks, Niklas Meyer, Stefan Wendt, Marcus Semtner, Fatma Cherif, Christian Gauthier, Charlotte Madore, Zhuoran Yin, Özcan Çınar, Taner Arslan, Zoltan Gerevich, Philipp Mertins, Oleg Butovsky, Helmut Kettenmann, Susanne A Wolf* (2023), ”Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder”, Brain, Behavior, and Immunity 111, 61-75
4. Anika Neuschulz, Olga Bakina, Victor Badillo‐Lisakowski, Pedro Olivares‐Chauvet, Thomas Conrad, Michael Gotthardt, Helmut Kettenmann, Jan Philipp Junker*, “A single‐cell RNA labeling strategy for measuring stress response upon tissue dissociation”, Molecular Systems Biology 19 (2), e11147
5. Philipp Jordan, Amanda Costa, Edgar Specker, Oliver Popp, Andrea Volkamer, Regina Piske, Tessa Obrusnik, Sabrina Kleissle, Kevin Stuke, Andre Rex, Martin Neuenschwander, Jens Peter von Kries, Marc Nazare, Phillip Mertins, Helmut Kettenmann, Susanne A Wolf*, “Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation”, Plos one 18 (2), e0278325
6. Thomas Wallach, Martin Raden, Lukas Hinkelmann, Mariam Brehm, Dominik Rabsch, Hannah Weidling, Christina Krüger, Helmut Kettenmann, Rolf Backofen, Seija Lehnardt, “Distinct SARS-CoV-2 RNA fragments activate Toll-like receptors 7 and 8 and induce cytokine release from human macrophages and microglia”, Frontiers in immunology 13, 1066456
7. Johannes Gnörich , Anika Reifschneider , Karin Wind , Artem Zatcepin , Sebastian T Kunte , Philipp Beumers , Laura M Bartos , Thomas Wiedemann , Maximilian Grosch ,Xianyuan Xiang, Maryam K Fard , Francois Ruch , Georg Werner , Mara Koehler , Luna Slemann , Selina Hummel , Nils Briel , Tanja Blume , Yuan Shi , Gloria Biechele , Leonie Beyer , Florian Eckenweber , Maximilian Scheifele , Peter Bartenstein , Nathalie L Albert , Jochen Herms , Sabina Tahirovic , Christian Haass , Anja Capell , Sibylle Ziegler , Matthias Brendel, “Depletion and activation of microglia impact metabolic connectivity of the mouse brain”, J Neuroinflammation.2023 Feb 24;20(1):47
2022
1. Rosa C Paolicelli, Amanda Sierra, Beth Stevens, Marie-Eve Tremblay, Adriano Aguzzi, Bahareh Ajami, Ido Amit, Etienne Audinat, Ingo Bechmann, Mariko Bennett, Frederick Bennett, Alain Bessis, Knut Biber, Staci Bilbo, Mathew Blurton-Jones, Erik Boddeke, Dora Brites, Bert Brône, Guy C Brown, Oleg Butovsky, Monica J Carson, Bernardo Castellano, Marco Colonna, Sally A Cowley, Colm Cunningham, Dimitrios Davalos, Philip L De Jager, Bart De Strooper, Adam Denes, Bart JL Eggen, Ukpong Eyo, Elena Galea, Sonia Garel, Florent Ginhoux, Christopher K Glass, Ozgun Gokce, Diego Gomez-Nicola, Berta González, Siamon Gordon, Manuel B Graeber, Andrew D Greenhalgh, Pierre Gressens, Melanie Greter, David H Gutmann, Christian Haass, Michael T Heneka, Frank L Heppner, Soyon Hong, David A Hume, Steffen Jung, Helmut Kettenmann, Jonathan Kipnis, Ryuta Koyama, Greg Lemke, Marina Lynch, Ania Majewska, Marzia Malcangio, Tarja Malm, Renzo Mancuso, Takahiro Masuda, Michela Matteoli, Barry W McColl, Veronique E Miron, Anna Victoria Molofsky, Michelle Monje, Eva Mracsko, Agnes Nadjar, Jonas J Neher, Urte Neniskyte, Harald Neumann, Mami Noda, Bo Peng, Francesca Peri, V Hugh Perry, Phillip G Popovich, Clare Pridans, Josef Priller, Marco Prinz, Davide Ragozzino, Richard M Ransohoff, Michael W Salter, Anne Schaefer, Dorothy P Schafer, Michal Schwartz, Mikael Simons, Cody J Smith, Wolfgang J Streit, Tuan Leng Tay, Li-Huei Tsai, Alexei Verkhratsky, Rommy von Bernhardi, Hiroaki Wake, Valérie Wittamer, Susanne A Wolf, Long-Jun Wu, Tony Wyss-Coray, “Microglia states and nomenclature: A field at its crossroads” ,Neuron 110 (21), 3458-3483
2. Olga Bakina, Helmut Kettenmann, Christiane Nolte, “Microglia form satellites with different neuronal subtypes in the adult murine central nervous system”, J Neurosci Res. 2022;00:1–18.
3. Laura M Bartos, Sebastian T Kunte, Philipp Beumers, Xianyuan Xiang, Karin Wind, Sibylle Ziegler, Peter Bartenstein, Hongyoon Choi, Dong Soo Lee, Christian Haass, Louisa von Baumgarten, Sabina Tahirovic, Nathalie L Albert, Simon Lindner, Matthias Brendel, “Single-Cell Radiotracer Allocation via Immunomagnetic Sorting to Disentangle PET Signals at Cellular Resolution”, J Nucl Med. 2022 Oct;63(10):1459-1462
4. Yimin Huang, Edyta Motta, Cynthia Nanvuma, Leonard D. Kuhrt, Yang Yuan, Pengfei Xia, Malgorzata Lubas, Shuai Zhu, Marina Schnauss, Niyeti Qazi, Feng Hu, Huaqiu Zhang, Ting Lei, Michael Synowitz, Charlotte Fluh* and Helmut Kettenmann*, “Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model”, Cell Reports,39, 110670
5.Tanja Blume#, Maximilian Deussing#, Gloria Biechele, Finn Peters, Benedikt Zott, Claudio Schmidt, Nicolai Franzmeier, Karin Wind, Florian Eckenweber,Christian Sacher, Yuan Shi, Katharina Ochs, Gernot Kleinberger, Xianyuan Xiang, Carola Focke, Simon Lindner, Franz-Josef Gildehaus, Leonie Beyer,Barbara von Ungern-Sternberg, Peter Bartenstein, Karlheinz Baumann,Helmuth Adelsberger, Axel Rominger, Paul Cumming, Michael Willem,Mario M. Dorostkar, Jochen Herms†,and Matthias Brendel*†, ”Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition”, Frontiers in Aging Neuroscience,Volume 14 | Article 854031
6. Laura M Bartos, Sebastian T Kunte, Philipp Beumers, Xianyuan Xiang, Karin Wind, Sibylle Ziegler, Peter Bartenstein, Hongyoon Choi, Dong Soo Lee, Christian Haass, Louisa von Baumgarten, Sabina Tahirovic, Nathalie L Albert, Simon Lindner*, Matthias Brendel*,”Single cell radiotracer allocation via immunomagentic sorting (scRadiotracing) to disentangle PET signals at cellular resolution”, Journal of Nuclear Medicine,doi:10.2967/jnumed.122.264171
2021
1.Markus G. Klammer, Omar Dzaye, Thomas Wallach, Christina Krüger, Dorothea Gaessler, Alice Buonfiglioli, Katja Derkow, Helmut Kettenmann, Melanie M. Brinkmann and Seija Lehnardt *.”UNC93B1 Is Widely Expressed in the Murine CNS and Is Required for Neuroinflammation and Neuronal Injury Induced by MicroRNA let-7b” , Frontiers in Immunology Volume 12 | Article 715774
2. Francesca Logiacco, Pengfei Xia, Svilen Veselinov Georgiev, Celeste Franconi, Yi-Jen Chang, Bilge Ugursu, Anje Sporbert, Ralf Keuhn, Helmut Kettenmann and Marcus Semtner*, “Microglia sense neuronal activity via GABA in the early postnatal hippocampus,” Cell Reports,37, 110128
3. Xianyuan Xiang#, Karin Wind, Thomas Wiedemann, Tanja Blume,……, Gesine Respondek, Katharina Buerger, Robert Perneczky, Johannes Levin, Günter U. HöglingerJochen Herms, Christian Haass*, Matthias Brendel*,” Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases”, Sci. Transl. Med. 13, eabe5640 (2021)
4. Gloria Biechele, Tanja Blume, Maximilian Deussing, Benedikt Zott, Yuan Shi, Xianyuan Xiang, Nicolai Franzmeier, Gernot Kleinberger, Finn Peters, Katharina Ochs, Carola Focke, Christian Sacher, Karin Wind, Claudio Schmidt, Simon Lindner, Franz-Josef Gildehaus, Florian Eckenweber, Leonie Beyer, Barbara von, Ungern-Sternberg, Peter Bartenstein, Karlheinz Baumann, Mario M. Dorostkar, Axel Rominger, Paul Cumming, Michael Willem, Helmuth Adelsberger, Jochen Herms, Matthias Brendel*,” Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation”, Theranostics 2021, Vol. 11, Issue 18
5. Pengfei Xia, Francesca Logiacco, Yimin Huang, Helmut Kettenmann, Marcus Semtner, “Histamine triggers microglial responses indirectly via astrocytes and purinergic signaling”, Glia, 2021;69:2291–2304
6. Safaiyan, S., S. Besson-Girard, T. Kaya, L. Cantuti-Castelvetri, L. Liu, H. Ji, M. Schifferer, G. Gouna, F. Usifo, N. Kannaiyan, D. Fitzner, Xiang, X., M. J. Rossner, M. Brendel, O. Gokce and M. Simons. "White matter aging drives microglial diversity." Neuron 109(7): 1100-1117 e1110.
7. Camille Philippot, Stephanie Griemsmann, Ronald Jabs, Gerald Seifert, Helmut Kettenmann, Christian Steinhauser*,”Astrocytes and oligodendrocytes in the thalamus jointly maintain synaptic activity by supplying metabolites”, Cell Reports 34, 108642
8. Yimin Huang, Baole Zhang, Hannah Haneke, Verena Haage, Malgorzata Lubas, Yang Yuan, Pengfei Xia, Edyta Motta, Cynthia Nanvuma, Omar Dzaye, Feng Hu, Helmut Kettenmann*, “Glial cell line-derived neurotrophic factor increases matrix metallopeptidase 9 and 14 expression in microglia and promotes microglia-mediated glioma progression”, J Neurosci Res. 2021;99:1048–1063
9. Carole Escartin , Elena Galea, András Lakatos # , James P O'Callaghan # , Gabor C Petzold # , Alberto Serrano-Pozo #, Christian Steinhäuser #, Andrea Volterra # ,Giorgio Carmignoto #, Amit Agarwal, ……Ksenia V Kastanenka, Helmut Kettenmann, Baljit S Khakh, ……Robert Zorec, Michael V Sofroniew*, Alexei Verkhratsky*,” Reactive astrocyte nomenclature, definitions, and future directions”, Nature Neuroscience 2021 | 312–325
10. Huang W, Zeng F, Gu Y, Jiang M, Zhang X, Yan X, Kadowaki T, Mizutani S, Kashiwazaki H, Ni J, Wu Z. “Porphyromonas Gingivalis Infection Induces Synaptic Failure via Increased IL-1β Production in Leptomeningeal Cells”. Journal of Alzheimer’s Disease. 2021;83(2):665-681. doi: 10.3233/JAD-210031. PMID: 34334391
2020
1. Schlepckow, K., K. M. Monroe, G. Kleinberger, L. Cantuti-Castelvetri, S. Parhizkar, D. Xia, M. Willem, G. Werner, N. Pettkus, B. Brunner, A. Sulzen, B. Nuscher, H. Hampel, Xiang, X., R. Feederle, S. Tahirovic, J. I. Park, R. Prorok, C. Mahon, C. C. Liang, J. Shi, D. J. Kim, H. Sabelstrom, F. Huang, G. Di Paolo, M. Simons, J. W. Lewcock and C. Haass. "Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region." EMBO Mol Med 12(4): e11227.
2. Takalo, M., R. Wittrahm, B. Wefers, S. Parhizkar, K. Jokivarsi, T. Kuulasmaa, P. Makinen, H. Martiskainen, W. Wurst, Xiang, X., M. Marttinen, P. Poutiainen, A. Haapasalo, M. Hiltunen and C. Haass. "The Alzheimer's disease-associated protective Plcgamma2-P522R variant promotes immune functions." Mol Neurodegener 15(1): 52.
3. Paul Triller, Julia Bachorz, Michael Synowitz, Helmut Kettenmann and Darko Markovic*, “O-Vanillin Attenuates the TLR2 Mediated Tumor-Promoting Phenotype of Microglia” , Int. J. Mol. Sci. 2020, 21, 2959.
4. Masataka Ifuku, Lukas Hinkelmann, Leonard D. Kuhrt, Ibrahim E. Efe, Victor Kumbol, Alice Buonfglioli, Christina Krüger, Philipp Jordan, Marcus Fulde, Mami Noda, Helmut Kettenmann and Seija Lehnardt*. “Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury”, Acta Neuropathol Commun (2020) 8:159.
5. Nirmeen Elmadany, Felipe de Almeida Sassi, Stefan Wendt, Francesca Logiacco, Josien Visser, Verena Haage, Daniel Perez Hernandez, Philipp Mertins, Dolores Hambardzumyan, Susanne Wolf, Helmut Kettenmann, and Marcus Semtner, “The VGF-derived Peptide TLQP21 Impairs Purinergic Control of Chemotaxis and Phagocytosis in Mouse Microglia”, The Journal of Neuroscience 40(13):2606 –2617.
6. Yimin Huang, Quan Zhang, Malgorzata Lubas, Yang Yuan, Fatih Yalcin, Ibrahim E. Efe, Pengfei Xia, Edyta Motta, Alice Buonfiglioli, Seija Lehnardt, Omar Dzaye, Charlotte Flueh, Michael Synowitz, Feng Hu* and Helmut Kettenmann*, “Synergistic Toll-like Receptor 3/9 Signaling Affects Properties and Impairs Glioma-Promoting Activity of Microglia”, Neurobiology of Disease 40(33):6428–6443.
7. Nirmeen Elmadanya, Francesca Logiaccoa, Alice Buonfigliolia, Verena C. Haagea, Elizabeth C. Wright-Jinb, Alexander Schattenberga, Roxane M. Papawassilioua, Helmut Kettenmanna*, Marcus Semtnera*, David H. Gutmanna*, “Neurofibromatosis 1 - Mutant microglia exhibit sexually-dimorphic cyclic AMP-dependent purinergic defects”, Neurobiology of Disease 2020.105030.
8. Bruce R. Ransom, Helmut Kettenmann, ”Studying Human Glial Cells: Where Are We Today?” Glia 23800.
9. Feng Hu, Yimin Huang, Marcus Semtner, Kai Zhao, Zhoubin Tan, Omar Dzaye, Helmut Kettenmann, Kai Shu*, Ting Lei*. “Down-regulation of Aquaporin-1 mediates a microglial phenotype switch affecting glioma growth”, Experimental Cell Research 2020.112323.
10. Sinead Rooney, Anupam Sah, Michael S. Unger, Maria Kharitonova, Simone B. Sartori, Christoph Schwarzer, Ludwig Aigner, Helmut Kettenmann, Susanne A. Wolf and Nicolas Singewald*, “Neuroinflammatory alterations in trait anxiety: modulatory effects of minocycline”, Translational Psychiatry (2020)10:256.
11. Malgorzata Sielska, Piotr Przanowski, Maria Pasierbińska, Kamil Wojnicki, Katarzyna Poleszak, Bartosz Wojtas, Dominika Grzeganek, Aleksandra Ellert-Miklaszewska, Min-Chi Ku, Helmut Kettenmann and Bozena Kaminska*，” Tumour-derived CSF2/granulocyte macrophage colony stimulating factor controls myeloid cell accumulation and progression of gliomas”, British Journal of Cancer 123:438–448.
12. Zeng F, Liu Y, Huang W, Qing H, Kadowaki T, Kashiwazaki H, Ni J, Wu Z. “Receptor for Advanced Glycation End Products Upregulation in Cerebral Endothelial Cells Mediates Cerebrovascular-related Amyloid β Accumulation after Porphyromonas gingivalis Infection”. Journal of Neurochemistry. 2020;10.1111/jnc.15096. doi:10.1111/jnc.15096.
2019
1. Amanda Sierra,* Rosa C. Paolicelli,* and Helmut Kettenmann*, “Cien An˜ os de Microglı´a: Milestones in a Century of Microglial Research”, Trends in Neurosciences November, Vol. 42, No. 1
2. Ioannis Kaffes, Frank Szulzewsky, Zhihong Chen, Cameron J. Herting, Ben, Gabanic, José E. Velázquez Vega, Jennifer Shelton, Jeffrey M. Switchenko, James L. Ross, Leon F. McSwain, Jason T. Huse, Bengt Westermark, Sven Nelander, Karin Forsberg-Nilsson, Lene Uhrbom, Naga Prathyusha Maturi, Patrick. J. Cimino, Eric C. Holland, Helmut Kettenmann, Cameron W. Brennan, Daniel J. Brat & Dolores Hambardzumyan,” Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors”, OncoImmunology 2019.1655360
3. Verena Haage, Nirmeen Elmadany, Lars Roll, Andreas Faissner, David H. Gutmanna, Marcus Semtnera, Helmut Kettenmann*, “Tenascin C regulates multiple microglial functions involving TLR4 signaling and HDAC1”, Brain, Behavior, and Immunity 81 (2019) 470–483
4. Verena Haage, Marcus Semtner, Ramon Oliveira Vidal, Daniel Perez Hernandez, Winnie W. Pong, Zhihong Chen, Dolores Hambardzumyan, Vincent Magrini, Amy Ly, Jason Walker, Elaine Mardis, Philipp Mertins, Sascha Sauer, Helmut Kettenmann and David H. Gutmann*, “Comprehensive gene expression metaanalysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma”, Acta Neuropathologica Communications (2019) 7:20
5. David H. Gutmann and Helmut Kettenmann*, “Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology”, Neuron.2019.08.028
6. Alice Buonfiglioli, Ibrahim E. Efe, Dilansu Guneykaya, Andranik Ivanov, Yimin Huang, Elisabeth Orlowski, Christina Kruger, Rudolf A. Deisz, Darko Markovic, Charlotte Fluh, Andrew G. Newman, Ulf C. Schneider, Dieter Beule, Susanne A. Wolf, Omar Dzaye, David H. Gutmann, Marcus Semtner, Helmut Kettenmann* and Seija Lehnardt, “let-7 MicroRNAs Regulate Microglial Function and Suppress Glioma Growth through Toll-Like Receptor 7”, Cell Reports 29, 3460–3471