As an emerging yet interdisciplinary field, bioimaging is revolutionizing biological and medical research. Our research philosophy features: 1，Spectroscopic Probes and Sensing Analysis Boronic acid glucose probes with good water solubility and high selectivity were prepared. 2，Cellular Glucose Homeostasis At present, we attempted to explore the cellular glucose homeostasis and blood glucose changes in CUMS rats to help us understand the association between diabetes and depression.