赵健元，男，上海交通大学医学院附属新华医院研究员，博士生导师。国家自然科学基金优秀青年科学基金（2017）和重点项目（2023）、科技部863青年科学家专项（2015）获得者，上海市优秀学科带头人（2021）。现任教育部和上海市环境与儿童健康重点实验室副主任、新华医院人力资源部主任、党委教师工作委员会办公室主任、学科人才党支部书记、上海科学院科技发展部副部长（挂职）。
2011年博士毕业于复旦大学，之后赴美国约翰霍普金斯大学医学院从事博士后工作，2013年作为人才引进回复旦大学，任生命科学学院、遗传工程国家重点实验室PI，复旦大学附属中山医院双聘PI，2021年入选复旦大学卓识杰出人才。2022年作为引进人才全职加入上海交通大学医学院附属新华医院。
研究方向为营养代谢失调致发育相关疾病的分子机制，在出生缺陷、心血管病等复杂疾病的发病机制研究中取得系列高水平研究成果。以通讯或第一作者（含共同）发表SCI论文80篇，篇均影响因子14（其中IF>10论文47篇），包括Circulation（2篇）、Eur Heart J（2篇）、Nat Commun（12篇）、Nat Neurosci、Nat Metab、Cell Rep（4篇）、Cell Rep Med（3篇）、Cell Res、Cardiovasc Res（2篇）、STTT（3篇）、Adv Sci（3篇）、EMBO Mol Med（2篇）、EMBO J、J Hepatol、Hepatology、J Clin Invest等，其中6篇论文入选ESI高被引论文，12篇论文获专文评述，被引超5200次。近五年获批十余项省部级项目，主持国家自然科学基金重点项目、优青、面上和863青年科学家专项等项目，获基金委创新群体、国家重大研究计划和重点研发计划资助（骨干）；作为主要完成人获教育部自然科学一等奖和国家妇幼健康科学技术一等奖。
研究方向
营养代谢调控发育
受教育经历
2008.09-2011.07：复旦大学，生命科学学院，遗传学，博士（导师：王红艳、金力）
2003.09-2006.07：安徽大学，生命科学学院，生化分子生物学，硕士（导师：李进华）
1999.09-2003.07：安徽大学，生命科学学院，生物技术，本科
工作经历
2022.03- 至今：上海交通大学医学院附属新华医院（引进人才），教育部和上海市环境与儿童健康重点实验室副主任、人力资源部主任、党委教师工作委员会办公室主任、学科人才党支部书记、心血管发育与再生医学研究所PI、环境与儿童健康教育部和上海市重点实验室 PI
2025.03-2026.02: 上海科学院科技发展部，副部长（挂职）
2024.07-2029 : 中国环境诱变剂学会致畸专业委员会第六届副主任委员
2013.09-2022.02：复旦大学生命科学学院(引进人才)，研究员、博导;复旦大学附属中山医院，双聘教授
2011.11-2013.08：美国 The Johns Hopkins University，博士后(导师:陶元祥)
2006.10-2007.01：美国 Fred Hutchinson Cancer Research Center，访问学者(导师:Linial Maxine)
2006.07-2008.09：安徽省体育局，助理研究员
代表论文
（*第一作者，#通讯作者）
1. Tu B, … Yang JJ#, Zhang Y#, Zhao JY#, Tao H#. SLC31A1 loss depletes mitochondrial copper and promotes cardiac fibrosis. European Heart Journal 2025; ehaf130. doi: 10.1093/eurheartj/ehaf130. (IF: 35.86) Eur Heart J同期Invited editorial专文评述
2. Sun H, … Zhao JY#, Tao H#. Cirrhosis Promotes Cardiac Fibrosis Development by Inhibiting Notch1 in Cardiac Fibroblasts. JACC-Basic to Translational Science 2025; 10(5):612-631. (IF: 9.53) JACC-BTS同期Editorial Comment专文评述
3. Qin Z, … Qin J#, Tan L#, Zhao JY#, Yang W#, Hou Y#, Ding C#. Proteogenomic characterization reveals that lipid droplet formation promotes esophageal squamous cell cancer progression. Science Translational Medicine 2025; 17(802):eadt0214. (IF: 19.34)
4. Wang J, … Wang F#, Gui YH#, Tao H#, Zhao JY#. NOTCH1 mitochondria localization during heart development promotes mitochondrial metabolism and the endothelial-to-mesenchymal transition in mice. Nature Communications 2024; 15(1):9945. (IF: 17.69) 作为Featured article入选From molecules and cells to organisms精选集
5. Cai K, … Gui YH#, Shi Y#, Zhao JY#. Maternal folic acid over-supplementation impairs cardiac function in mice offspring by inhibiting SOD1 expression. Cardiovascular Research 2024;120(16):2092-2103. doi: 10.1093/cvr/cvae203. (IF: 13.08) 封面论文、Editor’s Choice
6. Ding JF, … Yang JJ#, Zhao JY#, Tao H#. Epitranscriptomic regulation of cardiac fibrosis via YTHDF1-dependent PIEZO2 mRNA m6A modification Cardiovascular Research 2024; Nov 5:cvae239. (IF: 13.08) Cardiovas Res同期Invited editorial专文评述
7. Zhou ZY, … Tao H#, Zhao JY#. Branched-chain amino acids deficiency promotes diabetic cardiomyopathy by activating autophagy of cardiac fibroblasts. Theranostics 2024;14(19):7333-7348. (IF: 12.4)
8. Zhou ZY, … Pan ZQ#, Cao J#, Lin FQ#, Zhao JY#. Branched-Chain Amino Acids Deficiency Promotes Diabetic Neuropathic Pain Through Upregulating LAT1 and Inhibiting Kv1.2 Channel. Advanced Science 2024;e2402086. (IF: 17.52)
9. Shi JW, … Zhao JY#, Li MQ#. TNFSF14+ natural killer cells prevent spontaneous abortion by restricting leucine-mediated decidual stromal cell senescence. The EMBO Journal 2024;doi: 10.1038/s44318-024-00220-3. (IF: 9.4)
10. Liu ZY, … Yang JJ#, Zhao JY#, Tao H#. N6-Methyladenosine-mediated phase separation suppresses NOTCH1 expression and promotes mitochondrial fission in diabetic cardiac fibrosis. Cardiovascular Diabetology 2024;23(1):347. doi: 10.1186/s12933-024-02444-3. (IF: 8.5)
11. Chen J, … Zhao JY#, Zhu T#, Sun L#, Fan G#. Lactylated Apolipoprotein C-II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis. Advanced Science 2024;e2406333. (IF: 17.52)
12. Xiang H, … Xu C#, Zhou Y#, Gu J#, Zhao JY#, Hou Y#, Ding C#. Proteogenomic insights into the biology and treatment of pan-melanoma. Cell Discovery 2024;10(1):78. doi: 10.1038/s41421-024-00688-7. (IF: 38.08)
13. Yin YN, …. Zhao R#, Sun K#, Ding C#, Zhao JY#. Proteome profiling of early gestational plasma reveals novel biomarkers of congenital heart disease. EMBO Molecular Medicine. 2023; e17745. (IF: 14.26) EMBO Mol Med同期News & Views专文评述
14. Zhao R, … Zhou XY#, Cao J#, Sun K#, Zhao JY#. Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease. Cell Reports Medicine 2023; 4(3):100953. (IF: 16.99) Cell Rep Med同期Preview专文评述
15. Zhao R, … Tao H#, Zhao SM#, Zhao JY#. Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response. Cell Reports 2023; 42(4):112400. (IF: 9.99)
16. Tang L, … Zhao JY#, Jin L#. Dysregulated Gln-Glu-α-ketoglutarate axis impairs maternal decidualization and increases the risk of recurrent spontaneous miscarriage. Cell Reports Medicine 2023; doi:10.1016/j.xcrm.2023.101026. (IF: 16.99)
17. Hu S, … Zhao JY#, Xu W#, Zhao SM#. Amino acids downregulate SIRT4 to detoxify ammonia through the urea cycle. Nature Metabolism 2023;5(4):626-641. (IF: 19.74)
18. Yao Z, …Hou J#, Guo J#, Zhao JY#, Hou Y#, Ding C#. Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ. Nature Communications 2023 Jul 17; 14(1):5670. (IF: 17.69) 作为Featured article入选Nature系列Cancer at Nature Portfolio和Focus Cancer精选集
19. Wang Y, … Zhang X#, Zhao JY#, Hou Y#, Ding C#. Proteogenomics of diffuse gliomas reveal molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms. Nature Communications 2023;14(1):505. (IF: 17.69)
20. Zhang H, … Zhao JY#, Qu Y#, Ye D#, Ding C#. Proteogenomics of clear cell renal cell carcinoma response to tyrosine kinase inhibitor. Nature Communications 2023 Jul 17;14(1):4274. (IF: 17.69)
21. Li L, … Zhao JY#, Hou Y#, Ding C#. Comprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes. Nature Communications 2023;14(1):1751. (IF: 17.69)
22. Li L, … Zhou P#, Zhao JY#, Hou Y#, Ding C#. Integrative proteogenomic characterization of early esophageal cancer. Nature Communications 2023;14(1):1666. (IF: 17.69)
23. Qu Y, … Zhao JY#, Zhang H#, Ye D#, Ding C#. Plasma proteomic profiling discovers molecular features associated with upper tract urothelial carcinoma. Cell Reports Medicine 2023;doi: 10.1016/j.xcrm.2023.101166. (IF: 16.99)
24. Deng M, … Xu C#, Shi G#, Ji Y#, Zhao JY#, Zhou J#, Fan J#, Hou Y#, Ding C#. Proteogenomic Characterization of Cholangiocarcinoma. Hepatology 2023;77(2):411-429. (IF: 17.3)
25. Zhang X, … Gui YH#, Zhao JY#. Gestational Leucylation Suppresses Embryonic T-Box Transcription Factor 5 Signal and Causes Congenital Heart Disease. Advanced Science. 2022; 9(15):e2201034. (IF: 17.52) ESI高被引论文
26. Cai K, … Gui YH#, Zhao JY#. Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-CoA Hydratase 1 Deficiency. JACC-Basic to Translational Science 2022;7(4):348-362. (IF: 9.53) JACC-BTS同期Editorial Comment专文评述，ESI高被引论文
27. Zhou WJ, … Zhao JY#, Jin LP#, Li MQ#. Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2+ macrophage differentiation. Science Advances 2022;8(8):eabj2488. (IF: 14.96)
28. Li C, … Zhao JY#, Wang H#. Master MicroRNA-222 Regulates Cardiac MicroRNA Maturation and Triggers Tetralogy of Fallot. Signal Transduction and Targeted Therapy 2022;7:165. (IF: 38.1)
29. Hu SH, … Zhao JY#, Xu W#, Zhao SM#. Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake.Cell Reports 2022;38(11):110509. (IF: 9.99)
30. Li Y, … Liu T#, Shen K#, Zhao JY#, Hou Y#, Ding C#. Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals new therapeutic strategies. Nature Communications 2022; 29;13(1):5723. (IF: 17.69)
31. Qu Y, … Zhang H#, Zhao JY#, Ye D#, Ding C#. A Proteogenomic Analysis of Clear Cell Renal Cell Carcinoma in a Chinese Population. Nature Communications 2022;13(1):2052. (IF: 17.69)
32. Qu Y, … Zhao JY#, Zhang H#, Ye D#, Ding C#. Proteogenomic characterization of MiT family translocation renal cell carcinoma. Nature Communications 2022;13(1):7494. (IF: 17.69) Nat Rev Urol 2023 Research highlights专文评述
33. Shen Y, … Zhao JY#, Cheng L#. Tripartite motif 25 ameliorates doxorubicin-induced cardiotoxicity by degrading p85α. Cell Death & Disease 2022;13(7):643. (IF: 9.69)
34. Zhang Y, … Jin L#, Zhao JY#, Zhou X#. Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice. Cell Death & Disease 2022;13(3):279. (IF: 9.69)
35. Zhou Y, … Zhang Y#, Zhao JY#, Tao H#. METTL3 boosts glycolysis and cardiac fibroblast proliferation by increasing AR methylation. International Journal of Biological Macromolecules 2022;223(A):899-915. (IF: 8.03)
36. Sun H, … Zhao JY#, Zhang Y#, Tao H#. MTHFR epigenetic derepression protects against diabetes cardiac fibrosis. Free Radical Biology and Medicine 2022;193(1):330-341. (IF: 8.1)
37. Zhang X, … Zhao JY#. Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation. Cell Reports 2021;37(2):109821. (IF: 9.99) ESI高被引论文
38. Wang XH, … Jin LP#, Zhao JY#. Low embryonic villous succinate accumulation increases recurrent spontaneous abortion risk. Nature Communications 2021;12(1):3428. (IF: 17.69) ESI高被引论文
39. Xu S, … Zhao JY#. Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. Signal Transduction and Targeted Therapy 2021;6(1):54. (IF: 38.1) ESI高被引论文，入选2023年度中国科协优秀论文、中华医学科技论文TOP100
40. Zhang Y, … Zhao JY#, Zhou XY#. Two sides of NNMT in alcoholic and nonalcoholic fatty liver development. Journal of Hepatology2021;74(5):1250-1253. (IF: 30.08)
41. Xu W, … Zhao JY#, Zhang H#, Ye D#. Adenylate cyclase-activating polypeptide 1 gene methylation predicts prognosis and the immune microenvironment of bladder cancer. Clinical and Translational Medicine 2021;11:e597. (IF: 8.55)
42. Qu YY, … Ye DW#, Zhao SM#, Zhao JY#. Inactivation of the AMPK-GATA3-ECHS1 Pathway Induces Fatty Acid Synthesis That Promotes Clear Cell Renal Cell Carcinoma Growth. Cancer Research 2020; 80(2):319-333. (IF: 13.31)
43. Mei X, … Wang H#, Zhao JY#, Zhao S#, Xu W#. Inhibiting MARSs reduces hyperhomocysteinemia-associated neural tube and congenital heart defects. EMBO Molecular Medicine 2020; 12(3):e9469. (IF: 14.26)
44. Li Y, … Zhao SM#, Zhao JY#. APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression. Nature Communications 2019; 10(1):2502. (IF: 17.69)
45. Wang D, … Zhao SM#, Zhao JY#. Colonic lysine homocysteinylation induced by high-fat diet suppresses DNA damage repair. Cell Reports 2018; 25:398-412. (IF: 9.99) Trends Cancer 2019 Spotlight专文评述
46. Wang D, … Zhao SM#, Wang H#, Zhao JY#. Lower circulating folate induced by a Fidgetin intronic variant is associated with reduced congenital heart disease Susceptibility. Circulation 2017; 135(18):1733-1748. (IF: 39.92)
47. Xu S, … Zhao JY#, Zhao SM#. Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation. Signal Transduction and Targeted Therapy 2017; 2, e16035. (IF: 38.1)
48. Zhao JY*, Liang L*, Gu X*, …Tao YX#. DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons. Nature Communications 2017; 8:14712. (IF: 17.69)
49. Xu JT*, Zhao JY*, Zhao X*, … Tao YX#. Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia. Journal of Clinical Investigation 2014; 124(2):592-603. (IF: 19.46) JCI同期Editor’s Picks专文评述
50. Zhao JY*, Qiao B*, Duan WY*, … Huang GY#, Jin L#, Wang HY#. Genetic variants reducing MTR gene expression increase the risk of congenital heart disease in Han Chinese populations. European Heart Journal 2014; 35(11):733-42. (IF: 35.86) 封面论文
51. Zhao X*, Tang Z*, Zhang H*, Atianjoh FE*, Zhao JY*, … Tao YX#. A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. Nature Neuroscience 2013; 16(8):1024-31. (IF: 28.77) Nat Neurosci同期News and Views专文评述，ESI高被引论文
52. Zhao JY*, Yang XY*, Shi KH*, … Wang HY#. A functional variant in the cystathionine β-synthase gene promoter significantly reduces congenital heart disease susceptibility in a Han Chinese population. Cell Research 2013, 23:242-253. (IF: 46.3)
53. Zhao JY*, Yang XY*, Gong XH*, … Qiao B#, Wang HY#. Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the Han Chinese population. Circulation 2012; 125(3):482-90. (IF: 39.92) 入选Circulation“近两年最重要论文”（2012）和“先心病领域热度佳作”（2013）
