Current Work:
53. Jinxi Huang, Donghui Xing, Xiaohong Li*, Liangbin Huang*, Formal Reductive Amination of Carboxylic Acids via Iron-Catalyzed Photoredox Decarboxylative a-Aminomethylation, Org. Lett. 2025. DOI: 10.1012/acs.orglett.5c04273.
52. Jiayi Shen, Ganchun Wu, Zhi Wang, Zeyuan Fu, Liangbin Huang*, Rhodium-Catalyzed Chemo-Divergent Reaction between Oxetan-3-one/Azetidin-3-ones and Arylboronic Acids. J. Org. Chem., 2025., accepted.
51. Jiahui Yu, Xiaohong Li, Rui-Min Zhong, Yin-Long Lai*, Huishi Guo*, Liangbin Huang*, Direct Conversion of Carboxylic Groups to Furans, Org. Lett. 2025., 27, DOI:10.1021/acs.orglett.5c03757.
50. Xiaoyan Jia, Shuo Zhang, Yue Zeng, Zhewei Li, Ganchun Wu, Ming Lei*, Liangbin Huang*, Regiodivergent Access to alfa- and beta-Amino Acids via Solvent-Controlled Rh-Catalyzed Carboamidation of beta,garm-Unsaturated Carboxylic Acids, J. Am. Chem. Soc., 2025, DOI: 10.1021/jacs.5c08142
49. Zining Liu, Liangbin Huang*, Nickel-Catalyzed Ipso-Cross-Coupling of Homopropargyl Bromides with Aryl/Vinyl Electrophiles, Org. Lett. 2025, 27, 8534-8539.
48. Shuaikai Ding, Jinlin Liu, Chengkai Pu, Liangbin Huang*, Rh(III)-Catalyzed Ipos and Remote Hydroamidation of Alkenyl Carboxylic Acids to Access Valuable b-Amino Acids, Org. Lett. 2025, 27, 8504-8509.
47. Donghui Xing, Jinxi Huang, Jiaxiang Chen, Liangbin Huang*, Transition -Metal-Free Alkynylthiolation of Tertiary a-Carbonyl Bromides, Eur. J. Org. Chem. 2025, DOI:10.1002/ejoc.202500618.
46. Zeyuan Fu, Qingtong Huang*, Liangbin Huang*, Pd-Catalyzed Convergent Coupling of Alkenyl Bromide, Isocyanides and Thiocarboxylate to Synthesize Thiophene Derivatives, Org. Lett., 2025. 27, 7590-7596.
45. Xiaohong Li, Jinxi Huang, Huanfeng Jiang*, Liangbin Huang*, A Reductive Ugi Reaction with Carboxylic Acids Replacing Aldehyde, Org. Lett. 2025. 27, 5899-5904.
44. Jianpeng Cai, Jiahui Yu, Xiaohui Cao*, Liangbin Huang*, Binlin Yin*, Photoredox-Induced Dearomatization of 2-Alkenyl Aromatic Carboxylic Acids with Terminal Alkynes, ACS Catal., 2025, 15, 9672-9681
43. Donghui Xing, Jinlin Liu, Liangbin Huang*, Alkynyl Sulfide: An Unexplored yet Versatile Alkynyl Speices for Chemoselective Cross-Electrophile Coupling, Org. Lett. 2025, 27, 5829-5834.
42. Zining Liu, Yandong Wang, Jiahui Liu, Huanfeng Jiang, Minyan Wang*, Liangbin Huang*, Nickel-Catalyzed Cross-Electrophile Coupling to Access Polysubstituted Cyclobutenes, Angew. Chem. Int. Ed. 2025, DOI: 10.1002/anie.202507087. (Hot Paper)
41. Yi Xiong, Fengchao Sun, Liangbin Huang* Bi-doped NiCo2O4 catalyst for electrocatalysis glucose oxidation accompanied hydrogen generation, Chem. Asian J. 2025, DOI: 10.1002/ASIA.202401811.
40. Guohui Zeng, Zeyuan Fu, Biaolin Yin, Liangbin Huang* Visible-Light Induced Single-Atom-Insertion of Indenes via Aerobic Ring Scission-Condensation-Rearomatization, Chem.-Eur. J. 2025, DOI: 10.1002/chem.202403828.
39. Zeyuan Fu, Bingjie Rong, Liangbin Huang* Pd-catalyzed Coupling of Aryl Chloride, Isocyanides and Thiocarboxylate to Synthesize Thioamides, Org. Lett. 2025, 27, 2782-2787.
38. Yifeng Kuang, Jiayi Shen, Kunjie Xu, Liangbin Huang* Ruthenium-Catalyzed meta-Alkylation of (Hetero)aromatic Acids with Pyridinium Salts Utilizing Ubiquitous Amines as Substrates, ACS Catal. 2025, 15, 3162-3172.
37. Shunqin Chang, Yueping Linm Pei Gu, Changhui Lu, Minyan Wang,* Liangbin Huang* Liang-Controlled Nickel-Catalyzed C-O Bond Cleavage of Silylenol Ether for the Divergent Synthesis of Aryl Alkenes and Silicon-Containing Product, Org. Chem. Front., 2025, 12, 402-413.
36. 冯梦霞, 李小洪, 胡建强, 黄良斌*, 稀土金属催化糠醛合成环戊-2-烯酮衍生物的本科实验设计, 大学化学, 2025, 40, 341-347.
35. Bin Huang, Donghui Xing, Huanfeng Jiang, Liangbin Huang*, Lewis Acid-Catalyzed Formal [4+2] Reaction of Alkynyl Sulfides and 2-Pyrones to Access Polysubstituted Aryl Sulfides., J. Org. Chem. 2024, 89, 7280-7285.
34. Bowen Wang, Jianxiao Li, Wanqing Wu, Liangbin Huang*, Huanfeng Jiang*, Palladium-Catalyzed Vinylation of Indoles with Vinyl Ethers via Deoxygenative Coupling. Sci. China Chem. 2024, 67, 3785-3790
33. Yan Su, Bo Li, Zaoming Wang, Alexandre Legrand, Takuma Aoyama, Shuai Fu, Yishi Wu, Ken-Ichi Otake, Mischa Bonn, Hai I. Wang, Qing Liao, Kenji Urayama, Susumu Kitagawa, Liangbin Huang*, Shuhei Furukawa*, and Cheng Gu*, Quasi-Homogeneous Photocatalysis in Ultrastiff Microporous Polymer Aerogels, J. Am. Chem. Soc. 2024, 146, 15479-15487.
32. Xianglin Luo, Peichao Hou, Jiayi Shen, Yifeng Kuang, Fengchao Sun, Huanfeng Jiang, Lukas J. Gooßen*, Liangbin Huang*, Ligand-Enabled Ruthenium-Catalyzed meta-C−H Alkylation of (hetero)Aromatic Carboxylic Acids, Nature Communications. 2024. 15, DOI: 10.1038/s41467-024-49362-2.
31. Donghui Xing, Jinlin Liu, Dingxin Cai, Bin Huang, Huanfeng Jiang, Liangbin Huang*, Cobalt-Catalyzed Cross-Electrophile Coupling of Alkynyl Sulfides with Unactivated Chlorosilanes, Nature Communications. 2024. DOI: 10.1038/s41467-024-48873-2.
30. Shunqin Chang, Chenxia Guo, Rui-Min Zhong,* Yin-Long, Lai,* Huishi Guo,* Liangbin Huang*, Synthesis of Tetrasubstituted Alkenes by Rhodium-Catalyzed Regioselective Cyano Transfer, Org. Lett. 2024. 26, 3733-3738.
29. Mengxia Feng, Bin Huang, Huanfeng Jiang, Liangbin Huang*, Synthesis of γ-Thiapyrones by Diels–Alder/Retro-Diels–Alder Reaction of α-Pyrones with 5-H-1,2,3-Thiadiazoles, J. Org. Chem. 2024, 89, 5846-5850.
Highligh by https://www.organic-chemistry.org/abstracts/lit9/549.shtm
28. Xiaoyan Jia, Gui-Lin Hao, Mengxia Feng, Huanfeng Jiang, Shou-Guo Wang*, Liangbin Huang*, Rh(III)-Catalyzed Diastereo- and Enantioselective Regiodivergent (Het-ero)Arylamidation of (Homo)Allylic Sulfides, J. Am. Chem. Soc. 2024. 146, 9768-9778.
27. Xiaohong Li, Shenfan Wang, Xiangxiang Fu, Donghui Xing, Zeyuan Fu, Yuanfeng Deng, Huanfeng Jiang, Liangbin Huang*, Nickel-Catalyzed Arylcyanation of Alkenes via Cyano Group Translocation: Access to 1,n-Dinitriles or 4-amino Nitriles. Sci. China. Chem., 2024. 67, 375-2981.
26. Xiaoyan Jia, Donghui Xing, Jiayi Shen, Bo Li, Yue Zeng, Huanfeng Jiang, Liangbin Huang*, 1,2,3-Thiadiazole as a Modifiable and Scalable Directing Group for ortho C-H Functionalization, Org. Lett. 2024, 26, 1544-1549.
24. Chenxia Guo, Donghui Xing, Huanfeng Jiang, and Liangbin Huang*, Redox-neutral ipso/ortho alkenylcyanation of (hetero)arylboronic acid enabled by 1,4-rhodium migration and fragmentation. Sci. China Chem., 2023, 66, 2283-2291.
23. Bin Chen, Yifeng Kuang, Lu Liu, Linkun Cai, Zaoming Wang, Panchao Yin*, Liangbin Huang* and Cheng Gu*. Controlled Synthesis of Pronton-Conductive Porous Organic Polymer Gels via Electrostatically Stabilized Colloidal Formation. CCS Chem. 2023, 10.31635/ccschem.023.202303308.
22. Yueping Lin, Changhui Lu, Yue Zeng, Huangfeng Jiang and Liangbin Huang*. Transistion-metal-free synthesis of functional 2-arylphenols by an intermolecular SNAr reaction between dibenzofurans and various nucleophiles. Org. Chem. Front., 2023, 10, 3781-3785.
21. Jiahui Yu, Liangbin Huang*. The Ring-Opening Reaction of Benzofuran Involving the Cleavage of C-O Bond. ChemCatChem. 2023,15, e202300986
20. Pimiao Huang, Zining Liu, Liangbing Huang,* Chun Cui*. Synthesis of N’-[(2,4-dimethoxyphenyl)methyl]-N-(2-pyridin-2-ylethyl) Oxamide and Evaluation of Its Taste-Enhancing Effect. Food Bioscience. 2023, 56, 103120.
19. Donghui Xing, Mengxia Feng, Yuzhen Zheng, Bin Huang, Huanfeng Jiang, and Liangbin Huang*. Alkyne/thio umpolung tactic replacement: synthesis of alkynyl sulfides via capturing the in situ formed alkynylthiolate anion. Org. Chem. Front., 2023,10, 3603-3611.
18. Bo Li, Donghui Xing, Xiaohong Li, Shunqin Chang, Huanfeng Jiang, and Liangbin Huang*. Chemo-divergent Cyano Group Migration: Involving Elimination and Substitution of the Key α-Thianthrenium Cyano Species. Org. Lett. 2023, 25, 6633–6637.
17. Xianglin Luo, Zhewei Li, Yuzhen Zheng, Yueping Lin, Huanfeng Jiang, Lukas J. Goossen*, Ming Lei* and Liangbin Huang*. Ligand-Enabled ortho-Arylation of (hetero)Aromatic Acids with 2,6-Disubstituted Aryl Halides. ACS Catal. 2023, 13, 18, 12104–12113.
16. Shunqing Chang, Donghui Xing, Yuzhen Zheng, and Liangbin Huang*, Copper-Catalyzed Synthesis of Quinoline-4-thiols from Diaryliodonium Salts, Alkynyl Sulfides, and Nitriles. Org. Lett. 2023, 25, 28, 5350-5355.
14. Yan Su, Bo Li, Hong Xu, Chuangye Lu, Shengdong Wang, Bin Chen, Zaoming Wang, Weitao Wang, Ken-ichi Otake, Susumu Kitagawa*, Liangbin Huang*, and Cheng Gu*. Multi-Component Synthesis of a Buta-1,3-diene-Linked Covalent Organic Framework. J. Am. Chem. Soc. 2022, 144, 18218-18222.
13. Jiechun Liu, Xiaoyan Jia, Liangbin Huang*. Sulfilimines as Transformable and Retainable Directing Groups in Rhodium-Catalyzed ortho-C–H Bond Functionalization. Org. Lett. 2022, 24, 6772-6776.
Highlight by https://www.organic-chemistry.org/abstracts/lit8/629.shtm
12. Mengxia Feng, Huanfeng Jiang, Liangbin Huang*. Silver-Mediated Annulation between 5-H-1,2,3-Thiadiazoles and 1,3-Dicarbonyl Compounds to Construct Polysubstituted Furans. Org. Chem. Front., 2022,9, 5864-5871.
11. Changhui Lu, Xiaohong Li, Shunqin Chang, Yuqi Zhang, Donghui Xing, Shuo Wang, Yueping Lin, Huanfeng Jiang, Liangbin Huang*. Thioamide synthesis via copper-catalyzed C–H activation of 1,2,3-thiadiazoles enabled by slow release and capture of thioketenes. Org. Chem. Front. 2022, 9, 2382.
10. Jiechun Liu, Haojiang Lin, Huanfeng Jiang, Liangbin Huang*. Polysubstituted Indole Synthesis via Palladium/Norbornene Cooperative Catalysis of Oxime Esters. Org. Lett. 2022, 24, 484−489.
9. Jiaming Zhou, Jin Huang, Changhui Lu*, Huanfeng Jiang, Liangbin Huang*. B(C6F5)3-Catalyzed Hydroarylation of Terminal Alkynes with Phenols. Adv. Synth. Catal.2021, 363, 3962–3967.
8. Zhiguan Lin, Liangbin Huang* and Gaoqing Yuan*. Electrosynthesis of sulfonamides from DMSO and amines under mild conditions. Chem. Commun., 2021,57, 3579-3582.
7. Cheng Zeng, Bohan Wang, Huanhuan Zhang, Mingxiao Sun, Liangbin Huang, Yanwei Gu, Zijie Qiu, Klaus Müllen,* Cheng Gu,* and Yuguang Ma* Electrochemical Synthesis, Deposition, and Doping of Polycyclic Aromatic Hydrocarbon Films. J. Am. Chem. Soc. 2021, 143, 2682−2687.
6. Kai Kang, Liangbin Huang, and Daniel J. Weix*. Sulfonate Versus Sulfonate: Nickel and Palladium Multimetallic Cross-Electrophile Coupling of Aryl Triflflates with Aryl Tosylates. J. Am. Chem. Soc. 2020, 142, 10634-10640.
5. Yan Su, Yuejuan Wan, Hong Xu, Ken-ichi Otake, Xiaohui Tang, Liangbin Huang, Susumu Kitagawa, and Cheng Gu*. Crystalline and Stable Benzofuran-Linked Covalent Organic Frameworks from Irreversible Cascade Reactions. J. Am. Chem. Soc. 2020, 142, 13316−13321.
4. Liangbin Huang,†,§ Laura K. G. Ackerman,‡,∥ Kai Kang,† Astrid M. Parsons,‡ and Daniel J. Weix*,† LiCl-Accelerated Multimetallic Cross-Coupling of Aryl Chlorides with Aryl Triflflates. J. Am. Chem. Soc. 2019, 141, 10978−10983.
3. Jinghe Cen, Yaodan Wu, Jianxiao Li, Liangbin Huang, Wanqing Wu, Zhongzhi Zhu, Shaorong Yang,* and Huanfeng Jiang*. Switchable Reactivity between Vinyl Azides and Terminal Alkyne by Nano Copper Catalysis. Org. Lett. 2019, 21, 2090−2094.
2. Dandan He, Liangbin Huang, Jianxiao Li, Wanqing Wu,* and Huanfeng Jiang*. Palladium-Catalyzed Nitrile-Assisted C(sp3)−Cl Bond Formation for Synthesis of Dichlorides. Org. Lett. 2019, 21, 8308−8311.
1. En Liang,a Junqi Wang,a Yinrong Wu,a Liangbin Huang,b,* Xingang Yao,a and Xiaodong Tanga,* Direct Alkenylation of 2-Methylquinolines with Aldehydes through Synergistic Catalysis of 1,3-Dimethylbarbituric Acid and HOAc. Adv. Synth. Catal. 2019, 361, 3619– 3623.
Supervisor Work:
1. L. Huang, H. Jiang,* C. Qi, X. Liu. Copper-Catalyzed Intermolecular Oxidative [3+2] Cycloaddition between Alkenes and Anhydrides: A New Synthetic Approach to γ-Lactones. J. Am. Chem. Soc. 2010, 132, 17652–17654.
2. L. Huang, Q. Wang, X. Liu, H. Jiang,* Switch of Selectivity in the Synthesis of a-Methylene-g-Lactones: Palladium-Catalyzed Intermolecular Carboesterification of Alkenes with Alkynes. Angew. Chem., Int. Ed. 2012, 51, 5696–5701.
3. L. Huang, Q. Wang, J. Qi, X. Wu, K. Huang, H. Jiang,* Rh(III)-catalyzed ortho-oxidative alkylation of unactivated arenes with allylic alcohols. Chem. Sci. 2013, 4, 2665–2669.
4. L. Huang, Q. Wang, J. Qi, X. Wu, W. Wu, H. Jiang,* Aerobic Oxidative Coupling between Carbon Nucleophiles and Allylic Alcohols: A Strategy to Construct β-(Hetero)Aryl Ketones and Aldehydes through Hydrogen Migration. Chem. Eur. J. 2013, 19, 15462–15466.
5. L. Huang, J. Qi, X. Wu, K. Huang, H. Jiang,* Highly Selective β-Hydride Elimination in Pd-Catalyzed Decarboxylative Heck-Type Reaction. Org. Lett. 2013, 15, 2330–2333.
6. Q. Wang,† L. Huang,† X. Wu, H. Jiang,* Nucleopalladation Triggering the Oxidative Heck Reaction: A General Strategy to Diverse β-Indole Ketones. Org. Lett. 2013, 15, 5940–5943. (†contributed equally to this work)
7. L. Huang, Q. Wang, W. Wu, H. Jiang,* Nucleopalladation-Initiated Oxyalkenylation of Alkenes: A Strategy To Construct Functionalized Oxygenated Heterocycles. J. Org. Chem., 2014, 79, 7734–7739.
8. L. Huang, Q. Wang, W. Wu, H. Jiang,* Palladium/Copper Bimetallic System-Mediated Cross-Coupling of Alkynes and Alkenes: Two Strategies to Suppress β-H Elimination on Alkyl-Palladium Center. Adv. Synth. Catal, 2014, 356, 1949–1954.
9. L. Huang, Q. Wang, W. Wan, H. Jiang,* Hydroxyl Group-Assisted Palladium-Catalyzed Lactonization of Homoallylic Alcohols. ChemCatChem. 6, 561–566.
10. Y. Yu,† L. Huang,† W. Wan, H. Jiang,* Palladium-Catalyzed Oxidative Annulation of Acrylic Acid and Amide with Alkynes: A Practical Route to Synthesize α-Pyrones and Pyridones. Org. Lett., 2014, 16, 2146–2149. (†contribution equally to this work).
11. L. Huang, M. Arndt, K. Goossen, H. Heydt, L. J. Goossen,* Late Transition Metal-Catalyzed Hydroamination and Hydroamidation. Chem. Rev. 2015, 115, 2596–2697.
12. L. Huang, D. Hackenberger, L. J. Goossen,* Iridium-Catalyzed ortho-Arylation of Benzoic acids with Arenediazonium Salts. Angew. Chem., Int. Ed., 2015, 54, 12607–12611.
13. L. Huang, A. Biafora, G. Zhang, V. Bragoni, L. J. Goossen,* Regioselective C–H Hydroarylation of Internal Alkynes with Arenecarboxylates: Carboxylates as Deciduous Directing Groups. Angew. Chem., Int. Ed., 2016, 55, 6933 –6937.
14. L. Huang, D. J. Weix,* Ruthenium-Catalyzed C–H Arylation of Diverse Aryl Carboxylic Acids with Aryl and Heteroaryl Halides. Org. Lett. 2016, 18, 5432–5435.
15. L. Huang, A. M. Olivares D. J. Weix,* Reductive Decarboxylative Alkynylation of N-Hydroxyphthalimide Esters with Bromoalkynes. Angew. Chem., Int. Ed., 2017, 56, 11901-11905.
