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成果及论文

还涛博士目前已在综合或专业领域内权威期刊(Nature Methods, Nature Protocols, Analytical Chemistry)等发表论文近 40 篇,引用1200余次。详见Google Scholar:https://scholar.google.ca/citations?user=n30snbsAAAAJ&hl=en

2020

          1. T. Oh; S. Kim, C. Caussy, T. Fu; J. Guo; S. Bassirian, S. Singh, E. Madamba, R. Bettencourt, L, Richards, M. Raffatellu, P. Dorrestein, R. Yu, A. Atkins, T Huan, D. Brenner, C. Sirlin, R. Knight, R. Loomba, ‘A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis’, Cell Metabolismaccepted, 2020
          2. A. Palermo, T. Huan, D. Rinehart, MM. Rinschen, S. Li, V. B. O’Donnell, E. Fahy, J. Xue, S. Subramaniam, HP. Benton, G. Siuzdak, ‘Cloud‐based archived metabolomics data: A resource for in‐source fragmentation/annotation, meta‐analysis and systems biology’, Analytical Science Advancesaccepted, 2020
          3. D. Chen, W. Han, T. Huan; L. Li, L. Li, ‘Effects of Freeze-Thaw Cycles of Blood Samples on High-Coverage Quantitative Metabolomics’, Analytical Chemistry, accepted, 2020
          4. J. Guo, T. Huan, ‘Comparison of Full-Scan, Data-Dependent, and Data-Independent Acquisition Modes in Liquid Chromatography-Mass Spectrometry Based Untargeted Metabolomics’, Analytical Chemistryaccepted, 2020
          5. H. Yu, S. Xing, L. Nierves, P. Lange, T. Huan, ‘Fold-Change Compression: An Unexplored But Correctable Quantitative Bias Caused by Nonlinear Electrospray Ionization Responses in Untargeted Metabolomics‘, Analytical Chemistry92(10), 7011-7019, 2020
          6. Cirstea, AC. Yu, E. Golz, K. Sundvick, D. Kliger, N. Radisavljevic, LH. Foulger, M. Mackenzie, T. Huan, BB. Finlay, S. Appel-Cresswell, ‘Microbiota Composition and Metabolism are Associated with Gut Function in Parkinson’s Disease’, Movement Disorders, accepted, 2020
          7. Y. Dong, AA. Arif, J. Guo, Z. Ha, S. Lee-Sayer, G. Poon, M. Dosanjh, C. Roskelley, T. Huan, P. Johnson, ‘CD44 Loss Disrupts Lung Lipid Surfactant Homeostasis and Exacerbates Oxidized Lipid-Induced Lung Inflammation’, Frontiers in Immunology, 11, 29, 2020

            2019

          8. X. Tang, Y. Kudo, J. Baker, S. LaBonte, P. Jordan, S. McKinne, J. Guo, T. Huan, B. Morre, A. Edlund, ‘Cariogenic Steptococcus Produces Tetramic Acid Strain-Specific Antibiotics That Impair Commensal Colonization’, ACS Infectious Diseases6(4), 563-571, 2019
          9. L. Li, X. Zheng, Q. Zhou, N. Villanueva, W. Nian, X. Liu, T. Huan, ‘Metabolomics-Based Discovery of Molecular Signatures for Triple Negative Breast Cancer in Asian Female Population’, Scientific Reports10(1), 1-12, 2019 (Reported in Nature Research Cancer Community)
          10. J. Yang, Y. Han, C.H. Mah, E. Wanjaya, B. Peng, T. Xu, M. Liu, T. Huan, M. Fang, ‘Streamlined MRM method transfer between instruments assisted with HRMS matching and Retention-time prediction’Analytica Chimca Acta1100, 88-96, 2019
          11. Y. Hu, B. Cai, T. Huan, ‘Enhancing metabolome coverage in data-dependent LC-MS/MS analysis through an integrated feature extraction strategy’, Analytical Chemistry91(22), 14433-14441, 2019
          12. J.J. Zhang, X. Tang, T. Huan, A.C. Ross, B.S. Morre, ‘Pass-Back Chain Extension Expands Multi-Modular Assembly Line Biosynthesis’, Nature Chemical Biology16, 42-49, 2019
          13. RC. Gimple, RL. Kidwell, L. J.Y. Kim, T. Sun, A. D. Gromovsky, Q. Wu, M. Wolf, D. Lv, S. Bhargava, L. Jiang, B. C. Prager, X. Wang, Q. Ye, Z. Zhu, G. Zhang, Z. Dong, L. Zhao, D. Lee, J. Bi, A. E. Sloan, P. S. Mischel, J. M. Brown, H. Cang, T. Huan, S. C. Mack, Q. Xie, J. N. Rich, ‘Glioma Stem Cell Specific Super Enhancer Promotes Polyunsaturated Fatty Acid Synthesis to Support EGFR Signaling’, Cancer Discovery9(9), 1248-1267, 2019
          14. S. Jia, T. Xu. T. Huan, M. Chong, M. Liu, W. Fang, M. Fang, ‘Chemical Isotope Labeling Exposome (CIL-EXPOSOME): One High-Throughput Platform for Human Urinary Global Exposome Characterization’, Environmental Science & Technology53(9), 5445-5453, 2019

            Pre-UBC Publications

            2018

          15. T. Huan, T. Tran, J. Zheng, S. Sapkota, S.W. MacDonald, R. Camicioli, R. Dixon, L. Li, ‘Metabolomics Analyses of Saliva Detect Novel Biomarers of Alzheimer’s Disease’, Journal of Alzheimer’s Disease, 65, 1401-1416, 2018
          16. T. Huan, A. Palermo, J. Ivanisevic, D. Rinehart, D. Edler, T. Phommavongsay, HP. Benton, C. Guijas, X. Domingo-Almenara, B. Warth, G. Siuzdak, ‘Autonomous Multi-Modal Metabolomics Data Integration for Comprehensive Pathway Analysis’, Analytical Chemistry, 90(14), 8396-8403, 2018
          17. S. Sapkota, T. Huan, T. Tran, J. Zheng, R. Camicioli, L. Li, R. Dixon, ‘Alzheimer’s Biomarkers from Multiple Modalities Selectively Discriminate Clinical Status: Relative Importance of Salivary Metabolomics Panels, Genetic, Lifestyle, Cognitive, Functional Health, and Demographic Risk Markers’. Frontiers in Aging Neuroscience, 10, 296, 2018
          18. C. Guijas, JO. Montenegro-Burke, X. Dominogo-Almenara, A. Palermo, B. Warth, G. Hermann, G. Koellensperger, T. Huan, W. Uritboonthai, A. Aisporna, D. Wolan, M. Spiker, HP. Benton, G. Siuzdak, ‘METLIN: a Technology Platform for Identifying Knows and Unknowns’, Analytical Chemistry, 5(90), 3156-3164, 2018
          19. B. Warth, A. Granados, T. Huan, M. Fang, E. Forsberg, P. Benton, L. Goetz, CH. Johnson, G. Gary, ‘Dietary Xenoestrogens Strongly Alters the Cellular Metabolic Response of Palbociclib/Letrozole Combination Therapy’, Cell Chemical Biology, 25(3), 291-3002018
          20. CC. Lee, YJ. Hsieh, SW. Chen, SH. Fu, CW. Hsu, CC. Wu, W. Han, Y. Li, T. Huan, YS. Chang, JS. Yu, L. Li, CH. Chang, YT. Chen, ‘Bretschneider Solution-Induced Alterations in the Urine Metabolome in Cardiac Surgery Patients’, Scientific Reports, 8, 17774, 2018

            2017

          21. T. Huan, E. Forsberg, D. Rinehart, CH. Johnson, J. Ivanisevic, HP. Benton, M. Fang, A. Aisporna, B. Hilmers, FL. Poole, MP. Thorgersen, MWW. Adams, G. Krantz, MW. Field, PD. Robbins, LJ. Niedernhofer, T. Ideker, EL. Majumder, JD. Wall, NJW. Rattray, R. Goodacre, LL. Larison, G. Siuzdak, ‘Systems Biology Guided by XCMS Online Metabolomics’, Nature Methods14(5), 461-462, 2017
          22. E. Forsberg, T. Huan, D. Rinehart, H. Benton, B. Hilmers, G. Siuzdak, ‘Metabolic Pathway Mapping and Multi-omic Analysis using XCMS Online’, Nature Protocols13(4), 633-651, 2017
          23. B. Warth, S. Spangler, M. Fang, C. Johnson, E. Forsberg, R. Martin, A. Granados, X. Domingo-Almenara, T. Huan, D. Rinehart, J. Montenegro-Burke, B. Hilmers, A. Aisporna, L. Hoang, W. Heim, P. Benton, S. Richardson, S. Spangler, A. Williams, G. Siuzdak, ‘Exposome-Scale Investigations Guided by Global Metabolomics, Pathway Analysis, and Cognitive Computing’, Analytical Chemistry89(21), 11505-11513, 2017

            2016

          24. JR Montenegor-Burke, AE. Aisporna, HP. Benton, D. Rinehart, M. Fang, T. Huan, B. Warth, EM. Forsberg, BT. Abe, J. Ivanisevic, L. Teyton, L. Lairson, G. Siuzdak, ‘Data Streaming for Metabolomics: Accelerating Data Processing and Analysis from Days to Minutes’, Analytical Chemistry89(2), 1254, 2016
          25. JR Montenegor-Burke, T. Phommavongsay, AE. Aisporna, T. Huan, D.Rinehart, E. Forsberg, FL. Poole, MP. Thorgersen, MWW. Adams, G. Krantz, MW. Fields, TR. Northen, PD. Robbins, LJ. Niedemhofer, L. Lairson, HP. Benton, G. Siuzdak, ‘Smartphone Analytics: Mobilizing the Lab into the Cloud for Omic-Scale Analyses’, Analytical Chemistry, 88 (19), 2016
          26. T. Huan, JW. Xia, WN. Leung, L. Li, CW. Chan, ‘Cerebrospinal Fluid Metabolomics After Natural Product Treatment in an Experimental Model of Cerebral Ischemia’, OMICS: A Journal of Integrative Biology, 20(11), 670-680, 2016
          27. T. Huan, DA. Troyer, L. Li, ‘Metabolite Analysis and Histology on the Exact Same Tissue: Comprehensive Metabolomics Profiling and Metabolic Classification of Prostate Cancer’, Scientific Reports, 6, 2016
          28. X. Luo, S. Zhao, T. Huan, D. Sun, RMN. Friis, MC. Schultz, L. Li, ‘High-Performance Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry for Profiling the Metabolomic Reprogramming Elicited by Ammonium Limitation in Yeast’, Journal of Proteome Research, 15(5) 1602-1612, 2016
          29. S. Geng, C. Zhou, W. Chen, S. Yu, W. Huang, T. Huan, J. Xu, X. Yan, ‘Fatty Acid and Sterol Composition Reveal Food Selectivity of Juvenile Ark Shell Tegillarca Granosa Linnaeus after Feeding with Mixed Microalgae’, Aquaculture, 455 109-117, 2016
          30. X. Su, N. Wang, D. Chen, Y. Li, Y. Lu, T. Huan, W. Xu, L. Li, L. Li, ‘Dansylation Isotope Labeling Liquid Chromatography Mass Spectrometry for Parallel Profiling of Human Urinary and Fecal Submetabolomes’, Analytical Chimica Acta, 903 100-109, 2016

            2015

          31. T. Huan, Y. Wu, C. Tang, G. Lin, L. Li, ‘DnsID in MyCompoundID for Rapid Identification of Dnsylated Amine- and Phenol-containing Metabolites in Metabolomics’. Analytical Chemistry, 87(19) 9838-9845, 2015
          32. T. Huan, C. Tang, R. Li, Y. Shi, G. Lin, L. Li, ‘MyCompoundID MS/MS search: Metabolite Identification Using a Library of Predicted Fragment-Ion-Spectra of 383,830 Possible Human Metabolites’. Analytical Chemistry, 87(20) 10619-10626, 2015
          33. T. Huan, L. Li, ‘Quantitative Metabolome Analysis Based on Chromatographic Peak Reconstruction in Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry’, Analytical Chemistry, 87(14) 7011-7016, 2015
          34. R. Zhou, T. Huan, L. Li, ‘Development of Versatile Isotopic Labelling Reagents for Profiling the Amine Submetabolome by Liquid Chromatography Mass Spectrometry’, Analytical Chimica Acta, 881 107-116, 2015
          35. T. Huan, L. Li, ‘Counting Missing Values in Metabolome Dataset for Measuring the Analytical Performance of a Metabolomics Platform’Analytical Chemistry, 87(2) 1306-1313. 2015

            2014

          36. W. Xu, D. Chen, X. Su, N. Wang, R. Zhou,T. Huan, Q. Xie, L. Li, L. Li, ‘Development of High-Performance Chemical Isotope Labeling LC-MS for Profiling the Human Fecal Metabolome’, Analytical Chemistry, 87(2) 829-836. (ACS Editor Choice Paper), 2014
          37. R. Zhou, CL. Tseng, T. Huan, L. Li, ‘IsoMS: Automated Processing of LC-MS Data Generated by a Chemical Isotope Labeling Metabolomics Platform’, Analytical Chemistry, 86(10) 4675-4679, 2014
          38. RMN. Friis, JP. Glaves, T. Huan, L. Li, BD. Sykes, MC. Schultz, ‘Rewiring AMPK and mitochondrial retrograde signaling for metabolic control of aging and histone acetylation in respiratory-defective cells’, Cell Reports, 7(2) 565-574, 2014

            2013

          39. L. Li, R. Li, J. Zhou, A. Zuniga, AE. Stanislaus, Y. Wu, T. Huan, J. Zheng, Y. Shi, DS. Wishart, G. Lin, ‘MyCompoundID: Using an Evidence-based Metabolome Library for Metabolite Identification’, Analytical Chemistry, 85(6) 3401-3408, 2013