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成果及论文

[1] Li X, Chen S, Zhang WD*, Hu HG*. Stapled Helical Peptides Bearing Different Anchoring Residues, Chemical Reviews, 2020, 120, 10079-10144. https://pubs.acs.org/doi/10.1021/acs.chemrev.0c00532

[2] Li X, Liao C, Xu Y, Lu QH, Chen S, Su L, Zou Y, Shao F, Lu W*, Zhang WD*, Hu HG*. Configuration-specific antibody for bacterial heptosylation: An antiadhesion therapeutic strategy, J. Am. Chem. Soc., 2022, DOI: 10.1021/jacs.2c09990. https://pubs.acs.org/doi/10.1021/jacs.2c09990

[3] Zheng Q, Wang T, Mao J, Chu G, Liang L, Jing Y, Zuo C, Yu Y, Hu HG*, Pan M*. A bifunctional molecule-assisted synthesis of mimics for use in probing the ubiquitination system, Nature Protocols, 2022, DOI: 10.1038/s41596-022-00761-z. https://www.nature.com/articles/s41596-022-00761-z

[4] Liao H, Li X, Zhao L, Wang Y, Wang X, Wu Y, Zhou X, Fu W, Liu L, Hu HG*, Chen YG*. A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer, Cell Discovery, 2020, 6,  35. https://www.nature.com/articles/s41421-020-0171-1

[5] Chen A, Lu H, Cao R, Zhu Y, Li Y, Ge R, Zhang S, Li Y, Xiao L, Su L, Zhao J*, Hu HG*, Wang Z*. A novel MMP-responsive nanoplatform with transformable magnetic resonance property for quantitative tumor bioimaging and synergetic chemo-photothermal therapy, Nano Today 2022, 45, 101524. https://www.sciencedirect.com/science/article/pii/S1748013222001517

[6] Li X, Gohain N, Chen S, Li Y, Zhao X, Li B, Tolbert WD, He W, Pazgier M*, Hu H*, Lu W*, Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression. Acta Pharm. Sin. B, 2021, 11, 2655-2669. https://www.sciencedirect.com/science/article/pii/S2211383521002227

[7] Zhang JR, Sun J, Li B, Yang CJ, Shen JL, Wang N, Gu R, Wang DG*, Chen D, Hu HG*, Fan CH, Zhang HJ, Liu K*. Robust Biological Fibers Based on Widely Available Proteins: Facile Fabrication and Suturing Application, Small, 2020, 1907598.  https://onlinelibrary.wiley.com/doi/10.1002/smll.201907598

[8] Qu Q, Pan M, Gao S, Zheng QY, Yu YY, Su JC*, Li X*, Hu HG*. A Highly Efficient Synthesis of Polyubiquitin Chains, Advanced Science, 2018, 5, 1800234.  http://europepmc.org/article/PMC/6051384

[9] Pan M, Li S, Li X, Shao F*, Liu L*, Hu HG*. Synthesis of and Specific Antibody Generation for Glycopeptides with Arginine N-GlcNAcylation. Angew. Chem. Int. Ed. 2014, 53, 14517-14521.  https://onlinelibrary.wiley.com/doi/pdf/10.1002/ange.201407824

[10] Wu Y, Li YH, Li X, Zou Y, Liao HL, Liu L, Chen YG*, Bierer D*, Hu HG*. A novel peptide stapling strategy enables the retention of ring-closing amino acid side chains for the Wnt/b-catenin signalling pathway, Chem. Sci., 2017, 8, 7368-7373.  https://pubs.rsc.org/en/content/articlehtml/2017/sc/c7sc02420g
[11] Li X, Krafczyk R, Macošek J, Li YL, Zou Y, Simon B, Pan X, Wu QY, Yan F, Li S, Hennig J, Jung K, Lassak J*, Hu HG*. Resolving the α-glycosidic linkage of arginine rhamnosylated translation elongation factor P triggers generation of the first Arg specific antibody, Chem. Sci., 2016, 7, 6995-7001.  https://pubs.rsc.org/en/content/articlelanding/2016/SC/C6SC02889