一、基金:
1. 2025年国家自然科学基金面上项目1项(49万);
2. 2023年国家自然科学基金青年基金1项(30万);
3. 2025年人力资源和社会保障部国家外国专家重点支撑项目1项(20万);
4. 2024年香江学者计划1项(72万);
5. 2024年黑龙江省自然科学基金联合基金培育项目(10万);
6. 2024年哈尔滨医科大学引进人才项目(100万);
7. 2024年哈尔滨医科大学附属肿瘤医院海燕计划优秀青年项目(50万);
二、论文:
Da-Yong Hou#; Haoran Wang#*; Yue-Ze Wang; Dong-Bing Cheng*; Ben Zhong Tang*; Wanhai Xu*. Intracellular aggregation of exogenous molecules for biomedical applications. Chemical Society Reviews, 2025, 54(13):6412-6447.(第一作者)
Da-Yong Hou#; Dong-Bing Cheng#; Ni-Yuan Zhang#; Zhi-Jia Wang; Xing-Jie Hu; Xin Li; Mei-Yu Lv; Xiang-Peng Li; Ling-Rui Jian; Jin-Peng Ma; Taolei Sun*; Zeng-Ying Qiao*; Wanhai Xu*; Hao Wang*. In vivo assembly enhanced binding effect augments tumor specific ferroptosis therapy. Nature Communications, 2024, 15(1):454.(第一作者)
Da-Yong Hou#; Ni-Yuan Zhang#; Peng Zhang; Xiang-Peng Li; Jiong-Cheng Wu; Mei-Yu Lv; Zhi-Jia Wang; Xing-Jie Hu; Jian-Xiao Liang; Hong-Lei Wang; Yue-Ze Wang; Hui-Hui You; Hong-Wei An*; Hao Wang* and Wanhai Xu*. In Vivo Self-Assembled Bispecific Fluorescence Probe for Early Detection of Tumor Metastasis. Science Bulletin, 2025, 70(3):407-418.(第一作者)
Da-Yong Hou#; Ni-Yuan Zhang#; Lu Wang#; Mei-Yu Lv; Xiang-Peng Li; Peng Zhang; Yue-Ze Wang; Lei Shen; Xiu-Hai Wu; Bo Fu; Peng-Yu Guo; Zi-Qi Wang; Dong-Bing Cheng*; Hao Wang*; Wanhai Xu*. Inducing mitochondriopathy-like damages by transformable nucleopeptide nanoparticles for targeted therapy of bladder cancer. National Science Review, 2024, 11(4):nwae028.(第一作者)
Da-Yong Hou#; Qing You#,*; Peng Zhang#; Xiang-Peng Li; Jiong-Cheng Wu; Yue-Ze Wang; Hui-Hui You; Mei-Yu Lv; Gege Wu; Xiao Liu; Pengyu Guo; Dong-Bing Cheng*; Xiaoyuan Chen* and Wanhai Xu*. Cascade-Activatable Nanoprodrug System Augments Sonochemotherapy of Bladder Cancer. ACS Nano, 2024, 18(52):35507-35519.(第一作者)
Mei-Yu Lv#; Da-Yong Hou#,*; Shao-Wei Liu#; Dong-Bing Cheng* and Haoran Wang*. Strategy and Design of In Situ Activated Protein Hydrolysis Targeted Chimeras. ACS Nano, 2025, 19(1):101-119.(共同第一作者, 共同通讯作者)
Da-Yong Hou#; Ni-Yuan Zhang#; Man-Di Wang#; Shao-Xin Xu; Zhi-Jia Wang; Xing-Jie Hu; Gan-Tian Lv; Jia-Qi Wang; Xiu-Hai Wu; Lu Wang; Dong-Bing Cheng*; Hao Wang*; Wanhai Xu*. In Situ Constructed Nano-Drug Depots through Intracellular Hydrolytic Condensation for Chemotherapy of Bladder Cancer. Angewandte Chemie, 2022, 61(18):e202116893.(第一作者)
Da-Yong Hou#; Wu-Yi Xiao#; Jia-Qi Wang#; Muhammad Yaseen; Zhi-Jia Wang; Yue Fei; Man-Di Wang; Lu Wang; Hui Wang; Xinghua Shi; Meng-meng Cai; Hai-Tao Feng*; Wanhai Xu*; Li-Li Li*. OGA activated glycopeptide-based nano-activator to activate PKM2 tetramerization for switching catabolic pathways and sensitizing chemotherapy resistance. Biomaterials, 2022, 284:121523.(第一作者)
Da-Yong Hou#; Man-Di Wang#; Ni-Yuan Zhang#; Shaoxin Xu#; Zhi-Jia Wang; Xing-Jie Hu; Gan-Tian Lv; Jia-Qi Wang; Mei-Yu Lv; Li Yi; Lu Wang; Dong-Bing Cheng*; Taolei Sun*; Hao Wang*; Wanhai Xu*. A Lysosome-Targeting Self-Condensation Prodrug-Nanoplatform System for Addressing Drug Resistance of Cancer. Nano Letters, 2022, 22(10):3983-3992.(第一作者)
Da-Yong Hou#; Man-Di Wang#; Xing-Jie Hu#; Zhi-Jia Wang#; Ni-Yuan Zhang; Gan-Tian Lv; Jia-Qi Wang; Xiu-Hai Wu; Lu Wang; Hao Wang*; Wanhai Xu*. An activated excretion-retarded tumor imaging strategy towards metabolic organs. Bioactive Materials, 2022, 14:110-119.(第一作者)
Kui Xiao#; Da-Yong Hou#; Ni-Yuan Zhang#; Wan Wang; Ming-Yi Leung; Wing-Kei Kwok; Ziyong Chen; Cong Jin; Wanhai Xu*; Hao Wang*; Vivian Wing-Wah Yam*; and Liang Zhao*. Synergistic Enhancement of Ferroptosis via Mitochondrial Accumulation and Photodynamic-Controlled Release of an Organogold(I) Cluster Prodrug. Journal of the American Chemical Society, 2025, 147(5):4482-4492.(共同第一作者)
Yi Hao#; Da-Yong Hou#; Lei Zhou#; Yan-Lei Fan; Xiu-Hai Wu; Yi-Xuan Liu; Yin-Sheng Xu; Ben-Li Song; Li Yi; Zeng-Ying Qiao*; Hao Wang*; Shou-Ping Xu*. Tumor-Specific Protein Induced in Situ Self-Assembly of Peptide Drugs for Synergistic Mitochondria Disruption. Advanced Materials, 2025, 37(3):e2413069.(共同第一作者)
Hong-Wei An#; Da-Yong Hou#; Ni-Yuan Zhang; Xing-Jie Hu; Li Yi; Jian-Xiao Liang; Yi-Xuan Liu; Ying-Jin Zhang; Yu-Si Liao; Wanhai Xu*; Hao Wang*. A self-assembled fluorescent contrast agent targeting XIAP for image-guided surgery of bladder cancer. Nano Today, 2024, 56:102313.(共同第一作者)
Ni-Yuan Zhang#; Da-Yong Hou#; Xing-Jie Hu; Jian-Xiao Liang; Man-Di Wang; Zhang-Zhi Song; Li Yi; Zhi-Jia Wang; Hong-Wei An*; Wanhai Xu*; Hao Wang*. Nano Proteolysis Targeting Chimeras (PROTACs) with Anti-Hook Effect for Tumor Therapy. Angewandte Chemie, 2023, 62(37):e202308049.(共同第一作者)
Hong-Wei An#; Da-Yong Hou#; Jia Yang; Zi-Qi Wang; Man-Di Wang; Rui Zheng; Ni-Yuan Zhang; Xing-Jie Hu; Zhi-Jia Wang; Lu Wang; Di Liu; Jun-Feng Hao; Wanhai Xu*; Yuliang Zhao*; Hao Wang*. A bispecific glycopeptide spatiotemporally regulates tumor microenvironment for inhibiting bladder cancer recurrence. Science Advances, 2023, 9(9):eabq8225.(共同第一作者)
Xing-Jie Hu#; Ni-Yuan Zhang#; Da-Yong Hou#; Zhi-Jia Wang; Man-Di Wang; Li Yi; Zhang-Zhi Song; Jian-Xiao Liang; Xiang-Peng Li; Hong-Wei An; Wanhai Xu*; Hao Wang*. An In Vivo Self-Assembled Bispecific Nanoblocker for Enhancing Tumor Immunotherapy. Advanced Materials, 2023, 35(45):2303831.(共同第一作者)
Lu Wang#; Bo Fu#; Da-Yong Hou#; Yu-Lin Lv#; Guang Yang#; Cong Li; Jia-Chen Shen; Bin Kong; Li-Bo Zheng; Yu Qiu; Hong-Lei Wang; Chen Liu; Jian-Ji Zhang; Shi-Yu Bai; Li-Li Li*; Hao Wang*; Wan-Hai Xu*. PKM2 allosteric converter: A self-assembly peptide for suppressing renal cell carcinoma and sensitizing chemotherapy. Biomaterials, 2023, 296:122060.(共同第一作者)
Yan-Lei Fan#; Ni-Yuan Zhang#; Da-Yong Hou#; Yi Hao; Rui Zheng; Jia Yang; Zhi Fan*; Hong-Wei An*; Hao Wang*. Programmable Peptides Activated Macropinocytosis for Direct Cytosolic Delivery. Advanced Healthcare Materials, 2023, 12(27):2301162.(共同第一作者)
Kui Xiao#; Niyuan Zhang#; Feifei Li#; Dayong Hou#; Xiaoyi Zhai; Wanhai Xu*; Gelin Wang*; Hao Wang*; Liang Zhao*. Pro-oxidant response and accelerated ferroptosis caused by synergetic Au(I) release in hypercarbon-centered gold(I) cluster prodrugs. Nature Communications, 2022, 13(1):4669.(共同第一作者)
Jiaqi Wang#; Peipei Yang#; Dayong Hou#; Yaqiong Yan; Kai Yue; Weishen Zhong; Ting Xiao; Xiuhai Wu; Ziqi Wang; Peng Wu; Lei Wang*; Hao Wang*; Wanhai Xu*. Bacteria-inspired transformable nanoparticle targets and covers residual tumor against bladder cancer recurrence. Nano Today, 2022, 45:101551.(共同第一作者)
Man-Di Wang#; Da-Yong Hou#; Gan-Tian Lv#; Ru-Xiang Li; Xing-Jie Hu; Zhi-Jia Wang; Ni-Yuan Zhang; Li Yi; Wan-Hai Xu*; Hao Wang*. Targeted in situ self-assembly augments peptide drug conjugate cell-entry efficiency. Biomaterials, 2021, 278:121139.(共同第一作者)
Hong-Wei An#; Dayong Hou#; Rui Zheng; Man-Di Wang; Xiang-Zhong Zeng; Wu-Yi Xiao; Tong-Da Yan; Jia-Qi Wang; Chang-Hao Zhao; Li-Ming Cheng; Jin-Ming Zhang; Lu Wang; Zi-Qi Wang*; Hao Wang*; Wanhai Xu*. A Near-Infrared Peptide Probe with Tumor-Specific Excretion-Retarded Effect for Image-Guided Surgery of Renal Cell Carcinoma. ACS Nano, 2020, 14(1):927-936.(共同第一作者)