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成果及论文


34. Xu Chang, Chao Zhang, Cheng Lv, Yang Sun, Mingzhi Zhang, Yumeng Zhao, Linlin Yang, Da Han*, Weihong Tan*. Construction of a Multitple-aptamer-based DNA Logic Device on Live Cell Membranes via Associative Toehold Activation for Accurate Cancer Cell Identification. Journal of the American Chemistry Society, 2019, Accept



33. Linlin Yang, Lingyan Meng, Jiaying Song, Yue Xiao, Ruowen Wang, Huaizhi Kang* and Da Han *. Dynamic Colloidal Nanoparticle Assembly Triggered by Aptamer-receptor Interactions on Live Cell Membranes. Chemical Science, 2019, doi: 10.1039/c9sc02693b. (Full text)

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32. Ding Ding, Da Han, Juan Li and Weihong Tan. Improving Early Detection of Cancers by Profiling Extracellular Vesicles, Expert Review of Proteomics, 2019, doi:10.1080/14789450.2019.1624531. (Full text)

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31. Yumeng Zhao and Da Han*. Nucleic Acid Based Intelligent Systems and Their Biomedical Applications. SCIENTIA SINICA Chimica (中国科学:化学), 2019, doi: 10.1360/SSC-2019-0018. (Full text)

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30. Yifan Lyu, Cuichen Wu, Charles Heinke, Da Han* (Co-corresponding author), Ren Cai, I-Ting Teng, Yuan Liu, Hui Liu, Xiao-Bing Zhang, Qiaoling Liu, Weihong Tan*. Constructing Smart Protocells with Built-in DNA Computational Core to Eliminate Exogenous Challenge. Journal of the American Chemical Society, 2018, 140 (22), 6912–6920. (Full text)

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29. Wanghua Wu, Tao Zhang, Da Han, Hongliang Fan, Guizhi Zhu, Xiong Ding, Cuichen Wu, Mingxu You, Liping Qiu, Juan Li, Liqin Zhang, Xiang Lian, Rong Hu, Ying Mu, Jianguang Zhou, Weihong Tan. Aligner-Mediated Cleavage of Nucleic Acids and Its Application to Isothermal Exponential Amplification. Chemical science, 2018, 9, 3050-3055. (Full text)

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28. Ruili Zhang, Shi Gao, Zhongliang Wang, Da Han, Lin Liu, Qingjie Ma, Weihong Tan, Jie Tian, Xiaoyuan Chen. Multifunctional Molecular Beacon Micelles for Intracellular mRNA Imaging and Synergistic Therapy in Multidrug Resistant Cancer Cells. Advanced functional materials, 2017, 27, 170127.

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27. Mingxu You, Yifan Lv, Da Han (Co-first author), Liping Qiu, Qiaoling Liu, Tao Chen, Cuicheng Wu, Lu Peng, Liqin Zhang, Gang Bao and Weihong Tan. DNA Probe Signals Rapid Molecular Encounter Dynamics on Live Cell Membranes. Nature Nanotechnology, 2017, 5, 453-459.

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26. Da Han and Weihong Tan. Molecular Engineering to Enhance Aptamer Functionality. In: Aptamers Selected by Cell SELEX for Theranostics, Springer, 2015. Book Chapters.


25. Da Han, Cuichen Wu, Mingxu You, Tao Zhang, Shuo Wan, Tao Chen, Liping Qiu, Zheng Zheng, Hao Liang, and Weihong Tan. A Cascade Reaction Network Mimicking the Basic Functional Steps of Acquired Immune Response. Nature Chemistry, 2015, 7(10),835-841.

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24. Guizhi Zhu, Sena Cansiz, Mingxu You, Liping Qiu, Da Han, Liqin Zhang, Lei Mei, and Ting Fu and Weihong Tan. Nuclease-resistant Synthetic Drug-DNA Adducts: Programmable Drug-DNA Conjugation for Targeted Anticancer Drug Delivery. NPG Aisa Materials, 2015, 7, e169.

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23. Da Han, Huaizhi Kang, Tao Zhang, Cuichen Wu, Cuisong Zhou, Mingxu You, Zhuo Chen, Xiaobing Zhang, Weihong Tan. Nucleic Acid Based Logical Systems (Concept paper), Chemistry-A European Journal, 2014,20, 5866-5873.

 

 


22. Liping Qiu, Tao Chen, Ismail Öçsoy, Emir Yasun, Cuichen Wu, Guizhi Zhu, Mingxu You, Da Han, Jianhui Jiang, Ruqin Yu, Weihong Tan. A Cell-Targeted, Size-Photocontrollable, Nuclear-Uptake Nanodrug Delivery System for Drug-Resistant Cancer Therapy. Nano letter, 2014, 15, 457-463.

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21. Cuichen Wu, Da Han (Co-first author), Tao Chen, Lu Peng, Guizhi Zhu, Mingxu You, Liping Qiu, Kwame Sefah, Xiao-Bing Zhang, Weihong Tan. Building a Multifunctional Aptamer-Based DNA Nanoassembly for Targeted Cancer Therapy. Journal of the American Chemical Society, 2013, 135, 18644-18650.

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20. Da Han, Guizhi Zhu, Cuichen Wu, Zhi Zhu, Tao Chen, Xiaobing Zhang and Weihong Tan. Engineering a Cell-Surface Aptamer Circuit for Targeted and Amplified Photodynamic Cancer Therapy. ACS Nano, 2013,7,2312-2319.

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19. Fujian Huang, Mingxu You, Da Han, Xiangling Xiong, Haojun Liang, and Weihong Tan. DNA Branch Migration Reactions Through Photocontrollable Toehold Formation. Journal of the American Chemical Society, 2013,135, 21, 7967-7973.

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18. Liping Qiu#, Cuichen Wu, Mingxu You, Da Han, Tao Chen, Guizhi Zhu, Jianhui Jiang, Ruqin YuQiu and Weihong Tan.A Targeted, Self-Delivered, and Photocontrolled Molecular Beacon for mRNA Detection in Living Cells. Journal of the American Chemical Society, 2013, 135, 12952-12955.

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17. Cuichen Wu, Tao Chen, Da Han, Mingxu You, Lu Peng, Sena Cansiz, Guizhi Zhu, Chunmei Li, Xiangling Xiong, Elizabeth Jimenez, Chaoyong James Yang, Weihong Tan. Engineering of Switchable Aptamer Micelle Flares for Molecular Imaging in Living Cells. ACS Nano,2013,7,5724-5731.

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16. Lu Peng, Cuichen Wu, Mingxu You, Da Han, Yan Chen, Ting Fu, Mao Ye, Weihong Tan. Engineering and Applications of DNA-Grafted Polymer Materials. Chemical Science, 2013, 5, 1928-1938.

 


15. Tao Chen, Cuichen Wu, Elizabeth Jimenez, Zhi Zhu, Joshua Dajac, Mingxu You, Da Han, Xiaobing Zhang and Weihong Tan. DNA Micelle Flares for Intracellular mRNA Imaging and Gene Therapy. Angewandte Chemie,International Edition, 2013, 52, 2012-2016.

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14. Da Han, Zhi Zhu, Cuichen Wu, Lu Peng, Leiji Zhou, Basri Gulbakan, Guizhi Zhu, Kathryn Williams, Weihong Tan. A Logical Molecular Circuit for Programmable and Autonomous Regulation of Protein Activity Using DNA Aptamer–Protein Interactions. Journal of the American Chemical Society, 2012, 134, 20797-20804.
(C&EN-NEWS, http://cen.acs.org/articles/90/web/2012/12/DNA-Circuits-Control-Clotting-Protein.html ).

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13. Mohammed I. Shukoor, Meghan O’Donoghue, Da Han, Tahir Bayrac, Ismail Ocsoy, Zhi Zhu and Weihong Tan. Aptamer-Nanoparticle Assembly for Logic-Based Detection. ACS Applied Materials & Interfaces, 2012, 4, 3007-3011.

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12. Lu Peng, Mingxu You, Quan Yuan, Cuichen Wu, Da Han, Yan Chen, Zhihua Zhong, Jiangeng Xue and Weihong Tan. Macroscopic Volume Change of Dynamic Hydrogels Induced by Reversible DNA Hybridization. Journal of the American Chemical Society, 2012, 134, 12302-12307.

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11. Cuichen Wu, Lu Peng, Mingxu You, Da Han, Tao Chen, Kathryn Williams, Chaoyong Yang and Weihong Tan. Engineering Molecular Beacons for Intracellular Imaging. International journal of molecular imaging, 2012,501579.

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10. Wei Zhang, Bo Zhang, Yulong Zhang, Da Han, Yongliang Zhou. Trapping Yeast Cells on PDMS Micropillar Array. Advanced Material Research, 2012, 476-478.

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9. Lu Peng, Zhi Zhu, Yan Chen, Da Han, and Weihong Tan. An exonuclease III and graphene oxide-aided assay for DNA detection. Biosensors and Bioelectronics, 2012, 35, 475-478.

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8. Da Han, Chaoyong Yang and Weihong Tan. Functional materials for signal amplification of molecular beacons. In: Molecular Beacons, Springer, Heidelberg, 2011. Book Chapters.

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7. Da Han, Jin Huang, Zhi Zhu, Quan Yuan, Mingxu You, Yan Chen and Weihong Tan. Molecular Engineering of Photoresponsive Three-Dimensional DNA Nnanostructures. Chemical Communications, 2011, 47, 4670-4672.

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6. Pu Ying, Zhi Zhu, Da Han (Co-first author), Huixia Liu, Jun Liu, Jie Xia, Kejing Zhang and Weihong Tan. Insulin-Binding Aptamer-Conjugated Graphene Oxide for Insulin Detection. Analyst, 2011,136, 4138-4140.

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5. Kelong Wang, Mingxu You, Yan Chen, Da Han, Zhi Zhu, Jin Huang, Kathryn Williams, Chaoyong James Yang and Weihong Tan. Self-Assembly of a Bifunctional DNA Carrier for Drug Delivery. Angewandte Chemie, International Edition, 2011, 50, 6098-6101.

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4. Mingxu You, Yan Chen, Lu Peng, Da Han, Bincheng Yin, Bangce Ye and Weihong Tan. Engineering DNA Aptamers for Novel Analytical and Biomedical Applications. Chemical Science, 2011, 2, 1003-1010.  

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3. Yunfei Zhang, Yan Chen, Da Han, Ismail Ösçoy and Weihong Tan. Aptamers Selected by Cell-SELEX for Application in Cancer Studies. Bioanalyst, 2010, 2, 907-918.

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2. Mingxu You, Zhi Zhu, Haipeng Liu, Basri Gulbakan, Da Han, Ruowen Wang, Kathryn Williams and Weihong Tan. Pyrene-Assisted Efficient Photolysis of Disulfide Bonds in DNA-Based Molecular Engineering. ACS Applied Materials & Interfaces, 2010, 2, 3601-3605

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1. Yuan Li, Da Han, Shumin Han, Xilin Zhu, Lin Hu, Zhong Zhang, Yuwen Liu. Effect of Rare Earth Elements on Electrochemical Properties of La-Mg-Ni-Based Hydrogen Storage Alloys. International Journal of Hydrogen Energy, 2009, 34, 1399-1404.

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