一、 部分发表论文

[60] Nie, Mu-Zi; Zhang, Shuang-Shuang; Gu, Shuang-Xi*; Long, Jiao*; Zhu, Yuan-Yuan*. Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors (2019-2023). European Journal of Medicinal Chemistry 2024, 280, 116973.

[59]Peng, Jin-Qi; Xiao, Ya-Qi; Long, Jiao; Zhang, Shuang-Shuang*;  Zhu, Yuan-Yuan*; Gu, Shuang-Xi*. Design, synthesis, and biological evaluation of dithiocarbamate derivatives as SARS-CoV-2 Mpro inhibitors. Bioorganic & Medicinal Chemistry Letters 2024, 130011.

[58] Ni, Chuan-Zhi; Li, Ruo-Ming; Zhang, Fang-Qi; Li, Qu-Ao-Wei; Zhu, Yuan-Yuan*; Zeng, Jie*; Gu, Shuang-Xi*. A chiral fluorescent probe for molecular recognition of basic amino acids in solutions and cells. Chinese Chemical Letters 2024, 35, 109862.

[57] Li, Huan; Xia, Zhimin; Li, Lewan; Zeng, Jie; Lv, Jian; Wang, Haifeng*; Gu, Shuangxi*; Chen, Fener*. Regioselective Cleavage and Reconfiguration of C-S Bonds with Diazo Compounds. Organic Letters 2024, 26, 8405-8409.

[56] Jia, Feng-Cheng; Yuan, Zi-Yi; Luo, Na; Gu, Shuang-Xi; Hu, Xiao-Qiang. Modular Assembly of Six-Membered Carbocyclic Spirooxindoles via Peterson Olefination/Michael Addition/C(sp3) Arylation Cascade. Chinese Journal of Chemistry 2024, 42, 2614-2620.

[55] Xiao, Ya-Qi; Long, Jiao; Zhang, Shuang-Shuang*; Zhu, Yuan Yuan*; Gu, Shuang-Xi*. Non-peptidic inhibitors targeting SARS-CoV-2 main protease: A review. Bioorganic Chemistry 2024, 147, 107380.

[54] Peng, Jin-Qi; Xiao, Ya-Qi; Long, Jiao; Zhang, Shuang-Shuang*; Zhu, Yuan-Yuan*; Gu, Shuang-Xi*. Design, synthesis, and biological evaluation of dithiocarbamate derivatives as SARS-CoV-2 M pro inhibitors. Bioorganic & Medicinal Chemistry Letters 2024, 114, 130011.

[53] Zhou, Shuqi; Li, Chunyan; Zeng, Jie; Lv, Jian; Liao, Jie; Wang, Haifeng*; Yan, Qiongjiao*; Gu, Shuangxi*. Al(OTf)3-Catalyzed Regioselective N2-Arylation of Tetrazoles with Diazo Compounds. Journal of Organic Chemistry 2024, 89, 7859-7864.

[52] Zhang, Shuang-Shuang*; Yu, Jia-Hui; Jiang, Si Si; Wang, Lun; Chen, Jiong; Long, Jiao; Gu, Shuang-Xi*; Li, Hui*. T7 peptide-mediated co-delivery platform overcoming multidrug-resistant breast cancer: In vitro and in vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics 2024, 200, 114327.

[51] Luo, Mengxiang; Li, Lewan; Chen, Shixin; Yan, Qiongjiao; Lv, Jian; Zeng, Jie; Wang, Haifeng*; Gu, Shuangxi*; Chen, Fener*. Synthesis of 2,4-Disubstituted Oxazoles and Thiazoles via Brønsted Acid-Catalyzed Cyclization of α-diazoketones with Amides. Journal of Organic Chemistry 2024, 89, 5038-5048.

[50] Hu, Wen-Xiang; Yu, Kai-Heng; Jia, Feng-Cheng; Gu, Shuang-Xi. Convergent Assembly of 1,4-Benzothiazide Spiroindolinones via 4+2 Spiroannulation Under Open-Air Conditions. Journal of Organic Chemistry 2024, 89, 16531-16541.

[49] Li, Feifan; Yu, Kang; Chuanzhi, Ni; Zhu, Yuanyuan; Zeng, Jie; Gu, Shuangxi. Chiral Fluorescent Probes for Determination of Both Concentration and Enantiomeric Composition of Amino Acids. Chinese Journal of Organic Chemistry 2024, 44, 1862-1869.

[48] Feng, Kangbo; Chen, Jiong; Gu, Shuangxi; Wang, Haifeng; Chen, Fen'er. New Progress of Fully Continuous Flow Reaction             Technologies in Pharmaceutical Synthesis (20192022). Chinese Journal of Organic Chemistry 2024, 44, 378-397.

[47] Ming, Wei; Lu, Wen-Long; Pannecouque, Christophe; Chen, Jiong; Wang, Hai-Feng; Xiao, Ya-Qi; Hu, Sha; Gu, Shuang-Xi*; Zhu, Yuan-Yuan*; Chen, Fen-Er*. Hybrids of delavirdine and piperdin-4-yl-aminopyrimidines (DPAPYs) as potent HIV-1 NNRTIs: Design, synthesis and biological activities. European Journal of Medicinal Chemistry, 2023, 248, 115114.

[46] Hu, Sha; Chen, Jiong; Cao, Jin-Xu; Zhang, Shuang-Shuang; Gu, Shuang-Xi*; Chen, Fen-Er*. Quinolines and isoquinolines as HIV-1 inhibitors: Chemical structures, action targets, and biological activities. Bioorganic Chemistry, 2023, 136, 106549.

[45] Sun, Meng-Xin; Ni, Chuan-Zhi; Zhang, Fang-Qi; Zhu, Yuan-Yuan*; Zeng, Jie*; Gu, Shuang-Xi*. Chiral amino acid recognition in water: A BINOL-based fluorescent probe. Chinese Chemical Letters, 2023, published online, DOI: 10.1016/j.cclet.2023.108345. 

[44] Li, Chenzong; Xiang, Xun; Zhang, Xianghe; He, Zhao-Lin*; Gu, Shuang-Xi*; Dong, Xiu-Qin*. Iridium-Catalyzed Intramolecular Asymmetric Allylation of Vinyl Benzoxazinones for the Synthesis of Chiral 4H-3,1-Benzoxazines via Kinetic Resolution. Organic Letters, 2023, 25, 1172-1177. 

[43] Chen, Jiong; Zhu, Yuan-Yuan*; Gu, Shuang-Xi*. Preparation of (S)-5,5ʹ,6,6ʹ,7,7ʹ,8,8ʹ- Octahydro-1,1'-bi-2-naphthol [(S)-H8BINOL]. Organic Syntheses, 2023, 100, 404-417.

[42] Hong, Yu; Zhu, Yuan-Yuan*; Gu, Shuang-Xi*. Preparation of (S)-3,3ʹ-Bis(1- pyrrolidinylmethyl)-5,5ʹ,6,6ʹ,7,7ʹ,8,8ʹ-octahydro-1,1'-bi-2-naphthol. Organic Syntheses, 2023, 100, 394–403.

[41] Ming, Wei; Hu, Sha; Liu, Ye; Li, Qu-Ao-Wei; Zhu, Yuan-Yuan*; Gu, Shuang-Xi*. Recent Advances in the Chemical Synthesis of β-Nicotinamide Mononucleotide. Current Organic Chemistry, 2022, 26, 2151-2159.

[40] Jiang, Hanrui; Xiong, Huan; Gu, Shuang-Xi*; Wang, Mingliang*. E3 ligase ligand optimization of Clinical PROTACs. Frontiers in Chemistry, 2023, 11, 1098331.

[39] Chen, Jiong; Ming, Wei; Fan, De-Hua; Gu, Shuang-Xi*. Synthesis and Characterization of Related Substances of Torasemide. Pharmaceutical Fronts, 2022, 04, e157-e161.

[38] 刘烨; 明巍; 朱园园; 古双喜*. 临床应用中的新型冠状病毒肺炎治疗药物研究进展. 中国新药杂志, 2022, 31, 2022-2028.

[37] Gong, Zhihua; Hu, Sha; Jin, Xueping; Yu, Lei ; Zhu, Yuanyuan; Gu, Shuangxi*. Synthetic Methods and Application of Phosphoester Prodrugs[J]. Progress in Chemistry, 2022, 34(9), 1972-1981

[36] 刘玉, 明巍, 李陈宗, 朱园园, 古双喜*. 拟肽类冠状病毒主蛋白酶抑制剂的研究进展. 药学学报，2022，57, 1977-1990.

[35] Hong, Yu; Zhu, Yuan-Yuan; He, Qiuqin; Gu, Shuang-Xi. Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents. Bioorganic & Medicinal Chemistry, 2022, 55, 116597.

[34] 葛锐, 朱园园, 王海峰*, 古双喜*. 手性化合物绝对构型确定的方法与应用. 有机化学, 2022, DOI: 10.6023/cjoc202108047.

[33] 李陈宗, 朱园园, 古双喜. 手性药物及其中间体光学纯度的测定方法与应用. 分析试验室, 2022, DOI: 10.13595/j.cnki.issn1000-0720.2021.080905.

[32] 陈炯; 黄璐; 古双喜. 米拉贝隆合成路线图解. 中国药物化学杂志, 2021, 31, 403-407.

[31] Wang, Yue; Gu, Shuang-Xi*; He, Qiuqin*; Fan, Renhua. Advances in the development of HIV integrase strand transfer inhibitors.European Journal of Medicinal Chemistry, 2021, 225: 113787.

[30] 刘玎, 朱园园, 古双喜*, 陈芬儿*. 流动化学在卤化反应中的应用. 有机化学, 2021, 41, 1002-1011. 

[29] Gu, Shuang-Xi*; Zhu, Yuan-Yuan; Wang, Chao; Wang, Hai-Feng; Liu, Gen-Yan; Cao, Shuang; Huang, Lu. Recent discoveries in HIV-1 reverse transcriptase inhibitors. Current Opinion in Pharmacology, 2020, 54: 166-172.

[28] Xiao, Ting#; Tang, Jia-Fan#; Meng, Ge; Pannecouque, Christophe; Zhu, Yuan-Yuan; Liu, Gen-Yan; Xu, Zhi-Qiang; Wu, Feng-Shou; Gu, Shuang-Xi*; Chen, Fen-Er*. Indazolyl-substituted piperidin-4-yl-aminopyrimidines as HIV-1 NNRTIs: Design, synthesis and biological activities. European Journal of Medicinal Chemistry, 2020, 186: 111864.

[27] Wang, Chao; Liu, Xiao-Wen; Xiao, Ting; Xu, Zhi-Qiang; Cao, Shuang; Wang, Hai-Feng; Yan, Qiong-Jiao; Gu, Shuang-Xi*; Zhu, Yuan-Yuan*. Anticancer activity evaluation of indazolyl-substituted piperidin-4-yl-aminopyrimidines. Medicinal Chemistry Research, 2020, 29(5): 910-9  

[26] Wang, Haifeng*; Sun, Xiangli; Hu, Manman; Zhang, Xiaoyi; Xie, Lele; Gu, Shuangxi*. Bromination of α-Diazo Phenylacetate Derivatives Using Cobalt(II) Bromide.Advanced Synthesis & Catalysis,2020, 362(16): 3347-3351.                           

[25] Gu, Shuang-Xi; Wang, Hai-Feng; Zhu, Yuan-Yuan; Chen, Fen-Er. Natural Occurrence, Biological Functions, and Analysis of D-Amino Acids. Pharmaceutical Fronts,2020, 2(2): e79-e87. （Cover feature）                

[24] 黄璐，古双喜*.用于COVID-19潜在治疗的小分子药物及专利研究. 中国医药工业杂志,2020, 51(04): 467-475.                                                   

[23] 卢文龙, 陈炯, 古双喜, 徐志强.托匹司他的合成研究进展. 合成化学, 2020: 28(4): 360- 370.                        

[22] Zhu, Yuan-Yuan; Wu, Xue-Dan; Gu, Shuang-Xi*; Pu, Lin*. Free Amino Acid Recognition: A Bisbinaphthyl-Based Fluorescent Probe with High Enantioselectivity. Journal of the American Chemical Society, 2019, 141(1): 175-181. （ESI Highly cited paper）；https://www.x-mol.com/news/15900

[21] Zhu, Yuan-Yuan; Wu, Xue-Dan; Abed, Mehdi; Gu, Shuang-Xi*; Pu, Lin*. Biphasic Enantioselective Fluorescent Recognition of Amino Acids by a Fluorophilic Probe. Chemistry – A European Journal, 2019, 25(33): 7866-7873. Hot paper and cover feature article of Chem. Eur. J., Highlighted by ChemistryViews                      ；https://www.chemistryviews.org/details/news/11157496/Enantioselective_Recognition_of_Amino_Acids.html；https://www.x-mol.com/news/18278                        

[20] Gu, Shuang-Xi*; Xiao, Ting; Zhu, Yuan-Yuan; Liu, Gen-Yan; Chen, Fen-Er*. Recent progress in HIV-1 inhibitors targeting the entrance channel of HIV-1 non-nucleoside reverse transcriptase inhibitor binding pocket. European Journal of Medicinal Chemistry, 2019, 174: 277-291.

[19] Gu, Shuang-Xi*; Lu, Huan-Huan; Liu, Gen-Yan; Ju, Xiu-Lian; Zhu, Yuan-Yuan*. Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors. European Journal of Medicinal Chemistry, 2018, 158: 371-392.

[18] Liu, Genyan*; Wan, Youlan; Wang, Wenjie; Fang, Sai; Gu, Shuangxi*; Ju, Xiulian. Docking-based 3D-QSAR and pharmacophore studies on diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Molecular Diversity,2019, 23: 107-121.

[17] Liu, Genyan*; Wang, Wenjie; Wan, Youlan; Ju, Xiulian; Gu, Shuangxi*. Application of 3D-QSAR, Pharmacophore, and Molecular Docking in the Molecular Design of Diarylpyrimidine Derivatives as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors. International Journal of Molecular Sciences, 2018, 19(5): 1436.

[16] Lu, Huan-Huan; Xue, Ping; Zhu, Yuan-Yuan*; Ju, Xiu-Lian; Zheng, Xiao-Jiao; Zhang, Xun; Xiao, Ting; Pannecouque, Christophe*; Li, Ting-Ting; Gu, Shuang-Xi*. Structural modifications of diarylpyrimidines (DAPYs) as HIV-1 NNRTIs: Synthesis, anti-HIV activities and SAR. Bioorganic & Medicinal Chemistry, 2017, 25(8): 2491-2497.

[15] Xue, Ping; Lu, Huan-Huan; Zhu, Yuan-Yuan*; Ju, Xiu-Lian; Pannecouque, Christophe; Zheng, Xiao-Jiao; Liu, Gen-Yan; Zhang, Xiu-Lan; Gu, Shuang-Xi*. Design and synthesis of hybrids of diarylpyrimidines and diketo acids as HIV-1 inhibitors.Bioorganic & Medicinal Chemistry Letters, 2017, 27(8): 1640-1643.

[14] 张旬, 古双喜*, 肖婷, 朱园园, 巨修练. 富马酸喹硫平的合成研究进展. 中国医药工业杂志, 2017, 48(10): 1409-1423.

[13] Gu, Shuang-Xi*; Xue, Ping; Ju, Xiu-Lian; Zhu, Yuan-Yuan*. Advances in rationally designed dual inhibitors of HIV-1 reverse transcriptase and integrase. Bioorganic & Medicinal Chemistry, 2016, 24(21): 5007-5016.

[12] Gu, Shuang-Xi*; Qiao, Heng; Zhu, Yuan-Yuan; Shu, Qi-Chao; Liu, Hui; Ju, Xiu-Lian*; De Clercq, Erik; Balzarini, Jan; Pannecouque, Christophe. A novel family of diarylpyrimidines (DAPYs) featuring a diatomic linker: Design, synthesis and anti-HIV activities. Bioorganic & Medicinal Chemistry, 2015, 23(20): 6587-6593.

[11] Gu, Shuang-Xi*; Zhu, Yuan-Yuan; Chen, Fen-Er*; De Clercq, Erik; Balzarini, Jan; Pannecouque, Christophe. Structural modification of diarylpyrimidine derivatives as HIV-1 reverse transcriptase inhibitors. Medicinal Chemistry Research, 2015, 24(1): 220-225.

[10] Gu, Shuang-Xi; Huang, Wen-Cai; Wu, Xue-Dan; Ying, Jun; Pu, Lin*. Simple and Efficient One-Step Synthesis of a Highly Enantioselective Catalyst 3,3′-Di(pyrrolidinylmethyl)- H8BINOL. Synthetic Communications, 2015, 45(13): 1541-1545.

[9] 古双喜*, 薛萍, 朱园园, 巨修练. 依曲韦林的合成路线图解. 中国医药工业杂志, 2015, 46(7): 774-777.

[8] Gu, Shuang-Xi; Du, Jia-Wen; Ju, Xiu-Lian*; Chen, Qing-Ping. A Scalable One-Pot Process for the Synthesis of Florfenicol Phosphodiester. Organic Process Research & Development, 2014, 18(4): 552-554.

[7] 朱园园*, 古双喜*, 段婷, 巨修练. 1-溴-6-氰基-2-萘酚的合成. 精细化工, 2014, 31(1): 110-112+116.

[6] 古双喜*, 段婷, 乔恒, 巨修练. 氯沙坦的合成工艺研究进展. 精细化工, 2014, 31(3): 273-282.

[5] 古双喜*, 李婷婷, 朱园园. 盐酸文拉法辛合成路线图解. 中国医药工业杂志, 2014, (02): 187-189+10.

[4] Gu, Shuang-Xi; Li, Zhi-Ming; Ma, Xiao-Dong.; Yang, Shi-Qiong; He, Qiu-Qin*; Chen, Fen-Er*; De Clercq, Erik; Balzarini, Jan; Pannecouque, Christophe. Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors. European Journal of Medicinal Chemistry, 2012, 53: 229-234.

[3] Gu, Shuang-Xi; Yang, Shi-Qiong; He, Qiu-Qin; Ma, Xiao-Dong; Chen, Fen-Er*; Dai, Hui-Fang*; Clercq, Erik De; Balzarini, Jan; Pannecouque, Christophe. Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs. Bioorganic & Medicinal Chemistry, 2011, 19(23): 7093-7099.

[2] Gu, Shuang-Xi.; He, Qiu-Qin; Yang, Shi-Qiong; Ma, Xiao-Dong; Chen, Fen-Er*; De Clercq, Eric; Balzarini, Jan; Pannecouque, Christophe. Synthesis and structure-activity relationship of novel diarylpyrimidines with hydroxymethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs. Bioorganic & Medicinal Chemistry, 2011, 19(17): 5117-5124.

[1] Gu, Shuang-Xi; Zhang, Xuan; He, Qiu-Qin; Yang, Liu-Meng; Ma, Xiao-Dong; Zheng, Yong-Tang; Yang, Shi-Qiong; Chen, Fen-Er*. Synthesis and biological evaluation of naphthyl phenyl ethers (NPEs) as novel nonnucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry, 2011, 19(14): 4220-4226.

二、 参编专著

《Privileged Scaffolds in Drug Discovery》Chapter 23, 2023, Elsevier Academic Press.

三、 授权专利

获批授权中国发明专利14件。

ZL202210261337.2，吲哚哌啶嘧啶类衍生物在制备新型冠状病毒抑制剂中的应用；

ZL202210247140.3，吲哚哌啶嘧啶类衍生物及其制备方法和用途；

ZL202210802669.7，一种雌二醇磷酸酯及其盐的制备方法和应用；

ZL202210802691.1，一种泼尼松磷酸酯及其盐的制备方法和应用；

ZL202210802483.1，一种雌酮磷酸酯及其盐的制备方法和应用；

ZL202210671057.9，一种含有全氟烷基的手性荧光探针及其制备方法和应用；

ZL202210665107.2，一种具有苯并噻唑基团的手性荧光探针及其制备和应用；

ZL201910698458.1，一种吲唑哌啶嘧啶类衍生物及其制备方法和用途；

ZL201910811980.6，一种吲唑哌啶嘧啶类化合物的应用；

四、成果登记证书

《氟苯尼考磷酸二酯合成及小试工艺研究》已于2014年12月获湖北省科技成果登记证书（排名第三）。