Ge Lab @ SZBL

Ge Lab @ SZBL
Glycan Chemical Biology Lab

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Yun Ge PI , Ph.D. supervisor Glycan Chemical Biology Lab

Yun Ge is a junior PI at the Institute of Chemical Biology, Shenzhen Bay Laboratory, and an assistant professor at Peking University Shenzhen Graduate School. She is a recipient of the National Natural Science Foundation of China Excellent Young Scientists Fund (Overseas) and several other national grants. Dr. Ge received her B.S. from Xiamen University in 2013 and her Ph.D. from Peking University in 2018, followed by postdoctoral training in the Department of Chemistry and Chemical Biology at Harvard University. She joined SZBL in 2022 to establish her independent laboratory. The Ge Lab focuses on the chemical biology of glycan interaction and editing. Current efforts center on (i) profiling glycosylation and developing precision glycan-editing tools, (ii) uncovering the unique roles of glycosylation across diverse biological systems, and (iii) empowering functional biomolecules with glycan modifications for therapeutic applications. As first or corresponding author, Dr. Ge has published in Nature Cell Biology, Nature Chemical Biology, Nature Communications, Journal of the American Chemical Society, and Angewandte Chemie etc.. She holds several international and domestic patents and was invited by Cell on its 50th anniversary to comment on future directions in glycobiology. Major achievements in the Ge lab include: developing the first protein-selective “eraser” of glycosylation for precise functional dissection; establishing regulatory principles of glycosylation in biomolecular condensates and creating tools to modulate processes such as stress-granule dynamics; building a nanobody glycoengineering platform to enable glycan-based cancer immunotherapy strategies; and establishing systematic surfaceome profiling and intervention technologies for cell-membrane proteins.

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Glycan code is fundamental to molecular interactions and information flow in living systems.. Focusing on glycan interactions and modifications, our lab aims to build a profile–edit–engineer paradigm across the glycan–protein and glycan–RNA axes to achieve programmable control across scales and convert mechanistic and functional understanding into controllable and deployable solutions for the regulation of cellular activities and disease.

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