Publications

Peer-reviewed Manuscripts

1. Zhang, K.; Zhu, X.; Jia, F.; Auyeung, E.; Mirkin, C. A. Temperature-Activated Nucleic Acid Nanostructures. J. Am. Chem. Soc. 2013, 135 (38), 14102–14105.

2. Lu, X.; Watts, E.; Jia, F.; Tan, X.; Zhang, K. Polycondensation of Polymer Brushes via DNA Hybridization. J. Am. Chem. Soc. 2014, 136 (29), 10214–10217.

3. Jia, F.; Lu, X.; Tan, X.; Zhang, K. Facile Synthesis of Nucleic Acid–polymer Amphiphiles and Their Self-Assembly. Chem. Commun. 2015, 51 (37), 7843–7846

4. Tan, X.; Li, B. B.; Lu, X.; Jia, F.; Santori, C.; Menon, P.; Li, H.; Zhang, B.; Zhao, J. J.; Zhang, K. Light-Triggered, Self-Immolative Nucleic Acid-Drug Nanostructures. J. Am. Chem. Soc. 2015, 137 (19), 6112–6115.

5. Lu, X.; Tran, T.-H.; Jia, F.; Tan, X.; Davis, S.; Krishnan, S.; Amiji, M. M.; Zhang, K. Providing Oligonucleotides with Steric Selectivity by Brush-Polymer-Assisted Compaction. J. Am. Chem. Soc. 2015, 137 (39), 12466–12469.

6. Lu, X.; Jia, F.; Tan, X.; Wang, D.; Cao, X.; Zheng, J.; Zhang, K. Effective Antisense Gene Regulation via Noncationic, Polyethylene Glycol Brushes. J. Am. Chem. Soc. 2016, 138 (29), 9097–9100.

7. Tan, X.; Lu, X.; Jia, F.; Liu, X.; Sun, Y.; Logan, J. K.; Zhang, K. Blurring the Role of Oligonucleotides: Spherical Nucleic Acids as a Drug Delivery Vehicle. J. Am. Chem. Soc. 2016, 138 (34), 10834–10837.

8. Jia, F.; Lu, X.; Tan, X.; Wang, D.; Cao, X.; Zhang, K. Effect of PEG Architecture on the Hybridization Thermodynamics and Protein Accessibility of PEGylated Oligonucleotides. Angew. Chem. 2017, 129 (5), 1259–1263.

9. Cao, X.; Lu, X.; Wang, D.; Jia, F.; Tan, X.; Corley, M.; Chen, X.; Zhang, K. Modulating the Cellular Immune Response of Oligonucleotides by Brush Polymer-Assisted Compaction. Small. 2017, 13 (43), doi: 10.1002/smll.201701432.

10. Jia, F.; Lu, X.; Wang, D.; Cao, X.; Tan, X.; Lu, H.; Zhang, K. Depth-Profiling the Nuclease Stability and the Gene Silencing Efficacy of Brush-Architectured Poly(ethylene glycol)–DNA Conjugates. J. Am. Chem. Soc. 2017, 139 (31), 10605–10608.

11. Wang, D.; Lu, X.; Jia, F.; Tan, X.; Sun, X.; Cao, X.; Wai, F.; Zhang, C.; Zhang, K. Precision Tuning of DNA- and Poly(ethylene Glycol)-Based Nanoparticles via Coassembly for Effective Antisense Gene Regulation. Chem. Mater. 2017, 29 (23), 9882–9886.

12. Li, H.; Zhang, B.; Lu, X.; Tan, X.; Jia, F.; Xiao, Y.; Cheng, Z.; Li, Y.; Silva, D. O.; Schrekker, H. S.; et al. Molecular Spherical Nucleic Acids. Proc. Natl. Acad. Sci. 2018, 115 (17), 4340–4344.

13. Jia, F.; Wang, D.; Lu, X.; Tan, X.; Wang, Y.; Lu, H.; Zhang, K., Improving the Enzymatic Stability and the Pharmacokinetics of Oligonucleotides via DNA-Backboned Bottlebrush Polymers. Nano Lett. 2018, 18, 11, 7378-7382

14. Wang, D.; Lin, J.; Jia, F.; Tan, X.; Wang, Y.; Sun, X.; Cao, X.; Che, F.; Lu, H.; Gao, X.; Shimkonis, J.; Nyoni, Z.; Lu, X.; Zhang, K. Bottlebrush-architectured Poly(ethylene Glycol) as an Efficient Vector for RNA Interference in Vivo. Sci. Adv. 2019; 5, eaav9322

15. Jia, F.; Li, H.; Chen, R.; Zhang, K. Self-assembly of DNA-containing copolymers. Bioconjugate Chem. 2019, 30, 1880-1888

16. Tan, X.; Lu, H.; Sun, Y.; Chen, X.; Wang, D.; Jia, F.; Zhang, K. Expanding the materials space of DNA via organic-phase ring-opening metathesis (co)polymerization. Chem. 2019, 5, 1584–159

17. Tan, X.; Jia, F.; Wang, P.; Zhang, K. Nucleic Acid-Based Drug Delivery Strategies. J. Control. Release., 2020, doi:10.1016/j.jconrel.2020.03.040. (co-first author)

18. Wang, X.; Yang, Y.; Shi, Y.; Jia, F. Editorial: Smart Hydrogels in Tissue Engineering and Regenerative Medicine. Front. Chem. 2020, 8. doi:10.3389/fchem.2020.00245.

19. Lu, X.; Fu, H.; Shih, K.; Jia, F.; Sun, Y.; Wang, D.; Wang, Yu.; Ekatan, S.; Nieh, M.; Lin, Y.; Zhang, K. DNA-mediated Step-growth Polymerization of Bottlebrush Macromonomers. J. Am. Chem. Soc. 2020, 142, 2 3, 10297-10301.

20. Wang, Y.; Wang, D.; Jia, F.; Miller, A.; Tan, X.; Chen, P.; Zhang, L.; Lu, H.; Fang, Y.; Kang, X.; Cai, J.; Ren, M.; Zhang, K. Self-Assembled DNA−PEG Bottlebrushes Enhance Antisense Activity and Pharmacokinetics of Oligonucleotides. ACS Appl. Mater. Interfaces 2020, 12, 45830−45837.

21. Fang, Y.; Lu, X.; Wang, D.; Cai, J.; Wang, Y.; Chen, P.; Ren, M.; Lu, H.; Union, J.; Zhang, L.; Sun, Y.; Jia, F.; Kang, X.; Tan, X.; Zhang, K. Spherical Nucleic Acids for Topical Treatment of Hyperpigmentation. J. Am. Chem. Soc. 2021, 143, 23, 1296-1300.

22. Jia, F.; Kubiak, J. M.; Onoda, M.; Wang, Y.; Macfarlane, R. J. Design and Synthesis of Quick Setting Nonswelling Hydrogels via Brush Polymers. Adv. Sci. 2021, 8, 2100968.

23. Jia, F.; Song, J.; Kubiak, J. M.; Onoda, M.; Santos, P. J.; Sano, K.; Holten-Andersen, N.; Zhang, K.; Macfarlane, R. J. Brush Polymers as Nanoscale Building Blocks for Hydrogel Synthesis. Chem. Mater. 2021, 33, 5748–5756.

24. Jia, F.; Wang, D.; Lu, X.; Tan, X.; Wang, Y.; Sun, Y.; Zhang, K. Bottlebrush Polymer-Conjugated Melittin Exhibits Enhanced Anti-Tumor Activity and Better Safety Profile. ACS Appl. Mater. Interfaces 2021, doi:10.1021/acsami.1c14285.

25. Lu, H.; Cai, J.; Fang, Y.; Ren, M.; Tan, X.; Jia, F.; Wang, D.; Zhang, K. Exploring the Structural Diversity of DNA Bottlebrush Polymers Using an Oligonucleotide Macromonomer Approach. Macromolecules 2022, 55, 2235–2242.

26. Onoda, M.; Jia, F.; Takeoka, Y.; Macfarlane, R.J. Controlling the dynamics of elastomer networks with multivalent brush architectures. Soft Mater. 2022, accepted.

27. Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides

28. Jia, F.; Yee, D. W.; Kubiak, J. M.; Wang, Y.; Lee, S. M.; Onoda, M.; Macfarlane, R. J. Linking Colloidal Crystals Through Multifunctional Polymers. 2021, In preparation.

Book Chapters

1. Li, H.; Zhang, B.; Lu, X.; Tan, X.; Jia, F.; Xiao, Y.; Cheng, Z.; Li, Y.; Silva, D. O.; Schrekker, H. S.; et al. Molecular Spherical Nucleic Acids. Spherical Nucleic Acids, 2020, 1669-1686.