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成果及论文

近5年发表论文

2024

1.        Shi P, Lei L, Chu M, Pang Z, Xu Z, Sun Y, Fang L(房雷)*. Optimizing phototherapy efficiency via dynamic adjusting the contributions of photodynamic and photothermal therapy of diketopyrrolopyrrole-based compounds. Dyes and Pigments, 2024, 224:112049.

 

2023

1.        Fang L(房雷), Huang R, Gong W, Ji Y, Sun Y, Gou S*, Zhao J*. A Self-Assembly-Induced Exciton Delocalization Strategy for Converting a Perylene Diimide Derivative from a Type-II to Type-I Photosensitizer. Small, 2023, 8:e2307414.

2.        Zhao J, Huang R, Gao Y, Xu J, Sun Y, Bao J, Fang L(房雷)*, Gou S*. Realizing Near-Infrared (NIR)-Triggered Type-I PDT and PTT by Maximizing the Electronic Exchange Energy of Perylene Diimide-Based Photosensitizers. ACS Materials Lett, 2023, 5(6): 1752–1759.

 

2022

1.        Fang L(房雷)*, Shen S, Liu Q, Liu Z, Zhao J. Combination of NSAIDs with donepezil as multi-target directed ligands for the treatment of Alzheimer's disease. Bioorg Med Chem Lett, 2022, 75:128976.

2.        Li C, Gao Y, Huang R, Fang L(房雷)*, Sun Y, Yang Y, Gou S*, Zhao J*. An Effective Supramolecular Approach to Boost the Photodynamic Therapy Efficacy of a Near-Infrared Activating Perylene Diimide-Based Photosensitizer. ACS Materials Lett, 2022, 4(4): 657-664.


2021

1. Liu Z, Zhang B, Liu Q, Fang L*, Gou S*. Blood-Brain Barrier Permeable and NO-Releasing Multifunctional Nanoparticles for Alzheimer's Disease Treatment: Targeting NO/cGMP/CREB Signaling Pathways. J Med Chem, 2021, 64(18):13853-13872.


2020

1. Zhao J, Zhang X, Fang L*, Gao C, Xu C*, Gou S*. Iridium(III) Complex-Derived Polymeric Micelles with Low Dark Toxicity and Strong NIR Excitation for Phototherapy and Chemotherapy. Small, 2020, doi: 10.1002/smll.202000363.

2. Liu Z, Wang M, Wang H, Fang L*, Gou S*. Platinum-Based Modification of Styrylbenzylsulfones as Multifunctional Antitumor Agents: Targeting the RAS/RAF Pathway, Enhancing Antitumor Activity, and Overcoming Multidrug Resistance. J Med Chem, 2020, 63(1):186-204.

3. Liu Z , Wang M, Wang H, Fang L, Gou S. Targeting RAS-RAF pathway significantly improves antitumor activity of Rigosertib-derived platinum(IV) complexes and overcomes cisplatin resistance. Eur J Med Chem, 2020,  194(1):112269.  

 

2019

1. Fang L, Qin X, Zhao J, Gou S*. Construction of Dual Stimuli-Responsive Platinum(IV) Hybrids with NQO1 Targeting Ability and Overcoming Cisplatin Resistance. Inorg Chem, 2019, 58(3):2191-2200.

2. Sun C, Fang L, Zhang X, Gao P, Gou S*. Novel 7-formyl-naphthyridyl-ureas derivatives as potential selective FGFR4 inhibitors: Design, synthesis, and biological activity studies. Bioorg Med Chem, 2019, 27(10):1932-1941.

3. Sun C, Fang L, Gou S*. Discovery of a novel FGFR4 selective inhibitor via SAR studies of FGF401. Chinese Journal of Organic Chemistry, 2019, accept.

 

发明专利:

  申请国家发明专利10,已获授权6

 

荣誉与称号:

 

2009年江苏省优秀博士论文(导师:张奕华教授)

 

2010年全国优秀博士论文提名奖(导师:张奕华教授)

 

2011-2012获德国洪堡基金资助

 

2016年获第十届世界华人药物化学研讨会“优秀青年学者”称号

 

2018年获江苏省教育教学与研究成果奖(研究类)二等奖(排名第2

 

     2019年获评为江苏省高校“青蓝工程”优秀青年骨干教师。