部分代表性论文

1. Gao JM#, Xia SY#, Hide G, Li BH, Liu YY, Wei ZY, Zhuang XJ, Yan Q, Wang Y, Yang W, Chen JH*, Rao JH*. Multiomics of parkinsonism cynomolgus monkeys highlights significance of metabolites in interaction between host and microbiota. npj Biofilms Microbiomes. 2024;10(1):1–14.

2. Kong FS, Feng J, Yao JP, Lu Y, Guo T, Sun M, Ren CY, Jin YY, Ma Y*, Chen JH*. Dysregulated RNA editing of EIF2AK2 in polycystic ovary syndrome: clinical relevance and functional implications. BMC Medicine. 2024;22(1):229. 

3. Jin YY#, Liang YP#, Huang WH, Guo L, Cheng LL, Ran TT, Yao JP, Zhu L, Chen JH*. Ocular A-to-I RNA editing signatures associated with SARS-CoV-2 infection. BMC Genomics. 2024;25(1):431.

4. Ren CY#, Liu YS#, He YS, Zhang LP, Rao JH, Rao Y, Chen JH*. Engineered CBEs based on Macaca fascicularis A3A with improved properties for precise genome editing. Cell Reports. 2024;43(3).   

5. Ye J, Huang Z, Li Q, Li Z, Lan Y, Wang Z, Ni C, Wu X, Jiang T, Li Y, Yang Q, Lim J, Ren CY, Jiang M, Li S, Jin P, Chen JH*, Zhao C*. Transition of allele-specific DNA hydroxymethylation at regulatory loci is associated with phenotypic variation in monozygotic twins discordant for psychiatric disorders. BMC Medicine. 2023;21(1):491.     
6. Yan-Shan Liu#*, Jia-Qi Pan#, Xu-Bin Pan, Fan-sheng Kong, Jing-Qian Zhang, Zhi-Yuan Wei, Zhou-Heng Xu, Jun-Hua Rao, Ji-Hong Wang, Jian-Huan Chen*. Comparative Analysis of Molecular Landscape in Mouse Models and Patients Reveals Conserved Inflammation Pathways in Age-related Macular Degeneration, Investigative Ophthalmology & Visual Science, accepted. 2023
7. Zhi-Yuan Wei#, Zhi-Xin Wang#, Jia-Huan Li, Yan-Shuo Wen, Di Gao, Shou-Yue Xia, Yu-Ning Li, Xu-Bing Pan, Yan-Shan Liu, Yun-Yun Jin*, Jian-Huan Chen*. Host A-to-I RNA editing signatures in intracellular bacterial and single-strand RNA viral infections. Frontiers in Immunology. 2023;14.
8. Kong F, Ren C, Jia R, Zhou Y, Chen J*, Ma Y*. Systematic Pan-Cancer Analysis Identifies SLC31A1 as a Biomarker in Multiple Tumor Types. BMC Medical Genomics. 2023;14.

9. Ying Chen, Fu-Xia Ru, Jun-Jie Feng, JJi Tao, Zhi-Yuan Wei, Chengjia Qian, Qiong Lin*, Jian-Huan Chen*. Gastric juice microbiota in pediatric chronic gastritis clinically tested positive and negative for Helicobacter pylori. Frontiers in Microbiology. 2023 accepted.

10. He A, Wang P, Zhu A, Liu Y, Chen J*, Liu L*. Predicting IDH Mutation Status in Low-Grade Gliomas Based on Optimal Radiomic Features Combined with Multi-Sequence Magnetic Resonance Imaging. Diagnostics. Diagnostics; 2022;12(12):2995.
11. Wei ZY#, Rao JH#, Tang MT, Zhao GA, Li QC, Wu LM, Liu SQ, Li BH, Xiao BQ, Liu XY, Chen JH*. Characterization of changes and driver microbes in gut microbiota during healthy aging using a captive monkey model. Genomics Proteomics and Bioinformatics, 2022.
12. Gao JM#, Rao JH*#, Wei ZY#, Xia SY, Huang L, Tang MT, Hide G, Zheng TT, Li JH, Zhao GA, Sun YX, Chen JH*. Transplantation of Gut Microbiota from High-Fat-Diet-Tolerant Cynomolgus Monkeys Alleviates Hyperlipidemia and Hepatic Steatosis in Rats. Frontiers in Microbiology. 2022 (accepted)
13. Xia Y*#, Wei ZY#, He R, Li JH, Wang ZX, Huo JD, Chen JH*. Hybrid de novo Genome Assembly of Erwinia sp. E602 and Bioinformatic Analysis Characterized a New Plasmid-Borne lac Operon Under Positive Selection. Frontiers in Microbiology. 2021;12:3471.
14. Zhang J, Tao J, Gao RN, Wei ZY, He YS, Ren CY, Li QC, Liu YS, Wang KW, Yang G, Qian C*, Chen JH*. Cytotoxic T-Cell Trafficking Chemokine Profiles Correlate With Defined Mucosal Microbial Communities in Colorectal Cancer. Frontiers in Immunology. 2021;12:3274.
15. Tao J, Ren CY, Wei ZY, Zhang F, Xu J, Chen JH*. Transcriptome-Wide Identification of G-to-A RNA Editing in Chronic Social Defeat Stress Mouse Models. Front. Genet.; 2021;12.
16. Liu Z, Wei Z-Y, Chen J, Chen K, Mao X, Liu Q, Sun Y, Zhang Z, Zhang Y, Dan Z, Tang J, Qin L, Chen JH*, Liu X*. Acute Sleep-Wake Cycle Shift Results in Community Alteration of Human Gut Microbiome. mSphere. 2020.5(1).
17. Xue CB#, Xu ZH#, Zhu J, Wu Y, Zhuang XH, Chen QL, Wu CR, Hu JT, Zhou HS, Xie WH, Yi X, Yu SS, Peng ZY, Yang HM, Hong XH*, Chen JH*. Exome Sequencing Identifies TENM4 as a Novel Candidate Gene for Schizophrenia in the SCZD2 Locus at 11q14-21. Frontiers in Genetics. 2018;9.
18. Wang KW#, Xiao BQ#, Li BH, Liu YY, Wei ZY, Rao JH*, Chen JH*. Effects of fat-to-sugar ratio in excess dietary energy on lipid abnormalities: a 7-month prospective feeding study in adult cynomolgus monkeys. Lipids Health Dis. 2019;18(1):1.
19. Chen JH, Huang C, Zhang B, Yin S, Liang J, Xu C, et al. Mutations of RagA GTPase in mTORC1 Pathway Are Associated with Autosomal Dominant Cataracts. PLOS Genetics. 2016;12: e1006090.
20. Chen JH, Wang D, Huang C, Zheng Y, Chen H, Pang CP, Zhang M. Interactive effects of ATOH7 and RFTN1 in association with primary open angle glaucoma. Investigative Ophthalmology & Visual Science, 2012;53:779-85
21. Chen J#, Tsang SY#, Zhao C, Pun FW, Yu Z, Mei L, Lo WS, Ng SK, Liu H; Stöber G, Xue H. GABRB2 in schizophrenia and bipolar disorder: disease association, gene expression and clinical correlations. Biochemical Society Transactions. 2009, 37, 1415-8
22. Zhao C#, Xu Z#, Chen J#, Yu Z, Tong KL, Lo WS, Pun FW, Ng SK, Tsang SY, Xue H. Two isoforms of GABAA receptor [beta]2 subunit with different electrophysiological properties: differential expression and genotypical correlations in schizophrenia. Mol Psychiatry, 2006, 11, 1092-105

科研成果：

团队成员主持的科研立项

发明专利:

1.肿瘤标记物及其在制备结直肠癌诊断试剂盒中的应用，陈建欢，何雨珊，钱程佳，任春艳，陶寄，魏志远，2023，中国，专利号ZL 2022 1 1303789.9（第一发明人）

2.一种具有护肝作用的巨球菌制剂及其应用，陈建欢，饶军华，魏志远，郑亭亭，唐明甜，李比海，高江梅，2023，中国，专利号ZL 2021 1 1060859.8（第一发明人）

3.肿瘤标记物及其在制备结直肠癌诊断试剂盒中的应用，陈建欢，张嘉丽，钱程佳，何雨珊，魏志远，2024，中国，专利号号:ZL 2021 1 0975001.8（第一发明人）

4. FOXC1基因突变体及其应用，陈建欢，张铭志，管李萍，王丽娟，吴斌，陈浩宇，黄楚开，彭智培，王俊，汪建，杨焕明，2017，中国，专利号CN103571847B（第一发明人）

获奖荣誉：

团队独立承担临床本医学本科专业的医学遗传学与分子医学实验课程，以及研究生的医学分子遗传学和生物信息学课程；指导的本科生获奖累计20人次，研究生获奖及立项累计14人次。