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成果及论文


2023

1.Huang R#, Jia B#, Su D, Li M, Xu Z, He C, Huang Y, Fan H, Chen H*, Cheng F*, Plant Exosomes Fused with Engineered Mesenchymal Stem Cell-Derived Nanovesicles for Synergistic Therapy of Autoimmune Skin Disorders. J Extracell Vesicles. 2023, accept (IF=25.8)

2.Xiao Y#, Xu Z#, Cheng Y#, Huang R, Xie Y, Tsai H, Zha H, Xi L, Wang K, Cheng X, Gao Y, Zhang C*, Cheng F*, Chen H*, Fe3+-binding transferrin nanovesicles encapsulating sorafenib induce ferroptosis in hepatocellular carcinoma. Biomater Res. 2023, accept (IF=11.27)


2022


3.He C; Zhang M; Liu L; Han Y; Xu Z; Xiong Y; Yan F; Su D; Chen H*; Zheng Y*; Cheng F*; Cellular membrane-based vesicles displaying a reconstructed B cell maturation antigen for multiple myeloma therapy by dual targeting APRIL and BAFF. Acta Biomater. 2022 Apr 15;143:406-417. (IF=10.633)

4.Zhang W, Lin J, Shi P, Su D, Cheng X, Yi W, Yan J, Chen H*, Cheng F*. Small Extracellular Vesicles Derived From MSCs Have Immunomodulatory Effects to Enhance Delivery of ASO-210 for Psoriasis Treatment. Front Cell Dev Biol. 2022 Mar 10;10:842813. (IF=6.081)

5.Zha H, Xu Z, Xu X, Lu X, Shi P, Xiao Y, Tsai H, Su D, Cheng F*, Cheng X* and Chen H*. Cellular Nanovesicles Carrying Gemcitabine to Inhibit the Proliferation of Triple Negative Breast Cancer Cell. Pharmaceutics. 2022 Jun 14;14(6):1263. (IF=6.525)

6.Tsai H#, Wu Y#, Liu X#, Xu Z, Liu L, Huang Y, Wang L, Zhang W, Zhang H, Su D, Khan F, Wang C, Eriksson JE, Jia B*, Cheng F*, Chen H*. Engineered small extracellular vesicles as a FGL1/PD-L1 dual-targeting delivery system for alleviating immune rejection. Adv Sci (Weinh). 2022 Jan;9(3):e2102634. (IF=17.521)

7.Tsai H#, Wu Y#,Huang R#,Su D, Wu Y, Liu X, Wang L, Xu Z, Pang Y, Sun C, He C, Shu F, Cheng F*, Huang L*, Chen H*. PHF6 functions as a tumor suppressor by recruiting methyltransferase SUV39H1 to nucleolar region and offers a novel therapeutic target for PHF6-muntant leukemia. Acta Pharm Sin B. 2022 Apr;12(4):1913-1927. (IF=14.903)


2021


8.Tsai H#, Zeng X#, Liu L#, Xin S, Wu Y, Xu Z, Zhang H, Liu G, Bi Z, Su D, Yang M, Tao Y, Wang C, Zhao J, Eriksson JE, Deng W*, Cheng F*, Chen H*. NF45/NF90-mediated rDNA transcription provides a novel target for immunosuppressant development. 2021 Mar 5;13(3):e12834. (IF=14.260)

9.Li L#, Miao Q#, Meng F, Li B, Xue T, Fang T, Zhang Z, Zhang J, Ye X, Kang Y, Zhang X, Chen Q, Liang X*, Chen H*, Zhang X*. Genetic engineering cellular vesicles expressing CD64 as checkpoint antibody carrier for cancer immunotherapy. Theranostics. 2021 Apr 7;11(12):6033-6043. (IF=11.600

10.Yang M#, Xu Z#, Yan H#, Tsai H, Su D, Yan F, Lu Q, Feng J, Zeng W, Xi L, Zha H, Ling Y, He C, Wu Y, Xu X, Zheng G, Liu G, Chen H*, Cheng F*. PD-L1 cellular nanovesicles carrying rapamycin inhibit alloimmune responses in transplantation. Biomater Sci. 2021 Feb 23;9(4):1246-1255.IF=7.590

11.Wang K#, Zhang Z#, Tsai H #, Liu Y, Wang M, Song L, Cao X, Xu Z, Chen H, Gong A, Wang D*, Cheng F*, Zhu* H. Branched chain amino acid aminotransferase 2 Regulates Ferroptotic Cell Death in Cancer Cells. Cell Death Differ. 2021 Apr;28(4):1222-1236. (IF=12.067)


2020


1.  Xu Z#, Tsai H#, Xiao M, Wu Y, Su D, Yang M, Zha H, Yan F, Liu X, Cheng F*, Chen H*. Engineering PD-L1/CTLA-4 Dual-Targeting Nanovesicles for Immunosuppressive Therapy in Transplantation. ACS Nano, 2020 Jul 28;14(7):7959 7969. IF=14.588

2.Su D#, Tsai H#Xu Z#Yan FWu Y, Xiao Y,Liu X, Wu Y, Parvanian S, Zhu W, Eriksson J, Wang D, Zhu H*, Chen H*Cheng F*. Exosomal PD-L1 functions as an immunosuppressant to promote wound healing. Journal of Extracellular Vesicles, 2020,(9):1709262. IF=14.976

3.   Xue Y#, Zhu X#, Meehan B, Venneti S, Martinez D, Morin G, Maïga RI, Chen H, Papadakis AI, Johnson RM, O'Sullivan MJ, Erdreich-Epstein A, Gotlieb WH, Park M, Judkins AR, Pelletier J, Foulkes WD, Rak J, Huang S*. SMARCB1 loss induces druggable cyclin D1 deficiency via upregulation of MIR17HG in atypical teratoid rhabdoid tumors. The Journal of pathology, 2020;e5493. IF=5.979

4. Kang Wang#Zhengyang Zhang#Tsai Hsiangi#Yanfang LiuMing WangLian SongXiongfeng CaoZhanxue XuHongbo ChenAihua GongDongqing Wang*Fang Cheng*, Haitao Zhu*. Branched chain amino acid aminotransferase 2 Regulates Ferroptotic Cell Death in Cancer Cells. Cell Death and Dedifferention.2020;10.1038/s41418-020-00644-4.   (IF=10.717)

5.Parvanian S, Yan F, Su D, Coelho-Rato LS, Venu AP, Yang P, Zou X, Jiu Y, Chen H, Eriksson JE, Cheng F. Exosomal vimentin from adipocyte progenitors accelerates wound healing. Cytoskeleton (Hoboken). 2020 Sep 26. doi: 10.1002/cm.21634. 


2019

(13)Zhang L#, Shi H#, Chen H#, Gong A, Liu Y, Song L, Xu X, You T, Fan X, Wang D*, Cheng F*, Zhu H*. Dedifferentiation process driven by radiotherapy-induced HMGB1/TLR2/YAP/HIF-1α signaling enhances pancreatic cancer stemness. Cell Death Dis. 2019 Sep 26;10(10):724. IF=9.685(12)Su D#, Tsai H#Xu Z#Yan FWu Y, Xiao Y,Liu X, Wu Y, Parvanian S, Zhu W, Eriksson J, Wang D, Zhu H*, Chen H*Cheng F*. Exosomal PD-L1 functions as an immunosuppressant to promote wound healing. J Extracell Vesicles. 2019 Dec 27;9(1):1709262.IF=25.841

6. Zhang L#, Shi H#, Chen H#, Gong A, Liu Y, Song L, Xu X, You T, Fan X, Wang D*, Cheng F*, Zhu H*. Dedifferentiation process driven by radiotherapy-induced HMGB1/TLR2/YAP/HIF-1α signaling enhances pancreatic cancer stemness. Cell Death Dis. 2019 Sep 26;10(10):724. IF=6.304

7.Xue Y#, Meehan B, Macdonald E, Venneti S, Wang XQD, Witkowski L, Jelinic P, Kong T, Martinez D, Morin G, Firlit M, Abedini A, Johnson RM, Cencic R, Patibandla J, Chen HPapadakis AI, Auguste A, de Rink I, Kerkhoven RM, Bertos N, Gotlieb WH, Clarke BA, Leary A, Witcher M, Guiot MC, Pelletier J, Dostie J, Park M, Judkins AR, Hass R, Levine DA, Rak J, Vanderhyden B, Foulkes WD*, Huang S*. CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary. Nat Commun. 2019 Feb 4;10(1):558. (IF=12.121)

8. Ling Y#, Zhu Y#, Fan H#, Zha H, Yang M, Wu L, Chen H, Li W, Wu Y*, Chen H*. Rapid Method for Detection of Staphylococcus aureus in Feces. J Biomed Nanotechnol. 2019 Jun 1;15(6):1290-1298.IF=5.068

9. Lirong Zhang, Hui Shi, Hongbo Chen, Aihua Gong, Yanfang Liu, Lian Song, Xuewen Xu, Tao You, Xin Fan, Dongqing Wang*, Fang Cheng* & Haitao Zhu* (2019) Dedifferentiation process driven by radiotherapy-induced HMGB1/TLR2/YAP/HIF-1α signaling enhances pancreatic cancer stemness.. Cell death & Disease, 10:724. (IF=5.638)

10.Chen, X. #; Cheng, F. #; Liu, Y.; Zhang, L.; Song, L.; Cai, X.; You, T.; Fan, X.; Wang, D.; Gong, A.; Zhu, H. Toll-like receptor 2 and Toll-like receptor 4 exhibit distinct regulation of cancer cell stemness mediated by cell death-induced high-mobility group box 1. EBioMedicine 2019, 40, 135-150. (IF=6.68).

11. Rajendran Senthilkumar, Yury Brusentsev, Preethy Paul, Parthiban Marimuthu, Fang Cheng, Patrik Eklund*, John Elias Eriksson*. (2019) Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas. Scientific Reports. 9: 20295. doi:10.1038/s41598-019-56410-1. IF=3.998

12.Xu W, Zhang B, Cheng F, Milonio P, Yue Z, Wang X*, Willfor S, Xu C*, Wallace G. (2019) On Low-Concentration Inks Formulated by Nanocellulose Assisted with Gelatin Methacrylate (GelMA) for 3D Printing toward Wound Healing Application. ACS Applied Materials & Interfaces. 11(9): 8838-8848.

13.Wenyang Xu, Xue Zhang, Peiru Yang, Otto Långvik, Xiaoju Wang*, Yongchao Zhang, Fang Cheng, Monika Österberg, Stefan Willför, Chunlin Xu*. (2019) Surface engineered biomimetic inks based on UV cross-linkable wood biopolymers for 3D printing. ACS Applied Materials & Interfaces, 11 (13): 12389–12400 

14. Zhang Y, Wang S, Xu W, Cheng F, et al. (2019) Valorization of lignin-carbohydrate complexes from hydrolysates of Norway spruce: Efficient separation, structural characterization, and antioxidant activity. ACS Sustainable Chem. Eng., 7 (1): 1447–1456. (JCR:1 区,IF 6.140)


2018

15. Tsai HI#, Jiang L#, Zeng X, Chen H, Li Z*, Cheng W, Zhang J, Pan J, Wan D, Gao L, Xie Z, Huang L*, Mei L, Liu G*. DACHPt-Loaded Nanoparticles Self-assembled from Biodegradable Dendritic Copolymer Polyglutamic Acid-b-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate for Multidrug Resistant Lung Cancer Therapy. Front Pharmacol. 2018 Feb 21;9:119. doi: 10.3389/fphar.2018.00119.IF=4.225

16.  Zhu X#, Ji X, Kong N, Chen Y, Mahmoudi M, Xu X, Ding L, Tao W*, Cai T, Li Y, Gan T, Barrett A, Bharwani Z, Chen H, Farokhzad OC*. Intracellular Mechanistic Understanding of 2D MoS2 Nanosheets for Anti-Exocytosis-Enhanced Synergistic Cancer Therapy. ACS Nano. 2018 Mar 27;12(3):2922-2938.IF=14.588

17.Chunlin Xu, Binbin Zhang Molino, Xiaoju Wang, Fang Cheng, Wenyang Xu, Paul Molino, Markus Bacher, Dandan Su, Thomas Rosenau, Stefan Willfor and Gordon Wallace. (2018) 3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application,Journal of Materials Chemistry B. 6:7066-7075.

18. Mohammad I, Nousiainen K, Bhosale S, Starskaia I, Moulder R, Rokka A, Cheng F, Mohanasundaram P, Eriksson J, Goodlett D, Lähdesmäki H, Chen Z*. (2018) Quantitative proteomic characterization and comparison of T helper 17 and induced regulatory T cells. PLOS Biology, 16(5): e2004194. (JCR:1 区,IF 9. 163)

19. Chen X, Zhang L, Jiang Y, Song L, Liu Y, Cheng F, Fan X, Cao X, Gong A, Wang D*, Zhu H*. (2018) Radiotherapy-induced cell death activates paracrine HMGB1-TLR2 signaling and accelerates pancreatic carcinoma metastasis. Journal of experimental & clinical cancer research, 37: 77-91. (JCR:2 区,IF 6.217)

 

2017

20.Sjöqvist M. #, Antfolk D. #, Cheng F. *, et al (2017) Selective regulation of Notch ligands during angiogenesis is mediated by Vimentin. PNAS, 2017, 114(23):E4574-E4581. (JCR:1 区,IF=9.661)

21 Jiu Y., Peranen J., Schaible N., Cheng F., et al., Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA. J Cell Sci, 2017,130: 892-902 (JCR:2 区,IF =4. 431)

22.  Zhang L#, Hao W#, Xu L, Gao Y, Wang X, Zhu D, Chen Z, Zhang X*, Chen H*, Mei L*. A pH-sensitive methenamine mandelate-loaded nanoparticle induces DNA damage and apoptosis of cancer cells. Acta Biomater. 2017 Oct 15;62:246-256. (IF=7.242)

23.    Duo Y#Li Y# Chen K, Liu B, Wang X*, Zeng X*Chen H*.  DOX-loaded pH-sensitive mesoporous silica nanoparticles coated with PDA and PEG induce pro-death autophagy in breast cancer. RSC Adv. 2017, 7, 39641-39650. IF=3.119


2016

24. Cheng X#, Zhong F, He K, Sun S, Chen H*, Zhou J*. EHHM, a novel phenolic natural product from Livistona chinensis, induces autophagy-related apoptosis in hepatocellular carcinoma cells. Oncol Lett. 2016 Nov;12(5):3739-3748. IF=2.311

25.   Chen H#, Han L#, Tsai H#, Wang Z, Wu Y, Duo Y, Cao W, Chen L, Tan Z, Xu N, Huang X, Zhuang J*, Huang L*. PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway. Oncotarget. 2016 Dec 13;7(50):83241-83257.IF=6.363

26.  Chen H#*, Duo Y#, Hu B, Wang Z, Zhang F, Tsai H, Zhang J, Zhou L, Wang L, Wang X*, Huang L*. PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway. Oncotarget. 2016 Nov 29;7(48):78747-78763. IF=6.363

27. Wang X. *, Cheng F. *, et al, Biocomposites of copper-containing mesoporous bioactive glass and nanofibrillated cellulose: Biocompatibility and angiogenic promotion in chronic wound healing application, Acta Biomaterialia, 2016, 46:286-298 (JCR:1 区 IF=6.319)

28. Cheng F., et al., Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF1-Slug signaling. PNAS, 2016, 113(30):4320-4327 (JCR:1 区,IF=9.661)


2015

29. Jiu Y., Lehtimäki J., Tojkander S., Cheng F., et al. Bidirectional interplay between Vimentin intermediate filaments and contractile actin stress fibers. Cell Reports , 2015, 11(10): 1511–1518 (JCR:1 区,IF=7.870)

30.  Björk J.K., Åkerfelt M., Joutsen J., Puustinen M.C., Cheng F., Sistonen L., Nees M. (2015) Heat shock factor 2 is a suppressor of prostate cancer invasion, Oncogene, 35(14): 1770-1784 (JCR:1 区,IF=7.519)

31.    Sun X#, Chen H#,*, Deng Z, Hu B, Luo H, Zeng X, Cai G*, Ma L*. The Warsaw Breakage Syndrome-related protein DDX11 is required for ribosomal RNA synthesis and embryonic development. Hum Mol Genet. 2015 Sep 1;24(17):4901-15.IF=7.692

32.   Chen H#, Zeng X#, Gao C#, Ming P, Zhang J, Guo C, Zhou L, Lu Y, Wang L, Huang L*, He X*, Mei L*. A new arylbenzofuran derivative functions as an anti-tumour agent by inducing DNA damage and inhibiting PARP activity. Sci Rep. 2015 Jun 4;5:10893.IF=5.578

33. Xiong W#, Peng L, Chen H*, Li Q*. Surface modification of MPEG-b-PCL-based nanoparticles via oxidative self-polymerization of dopamine for malignant melanoma therapy. Int J Nanomedicine.2015 Apr 16;10:2985-96.IF=5.115


2014

34. Zhu H#, Chen H#, Zeng X#, Wang Z, Zhang X, Wu Y, Gao Y, Zhang J, Liu K, Liu R, Cai L, Mei L*, Feng S*. Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance. Biomaterials. 2014, 35(7):2391-400. (IF=10.317)

35.  Wang Z#, Wu Y#, Wang H, Zhang Y, Mei L, Fang X, Zhang X, Zhang F, Chen H, Liu Y, Jiang Y, Sun S, Zheng Y, Li N, Huang L*. Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proc Natl Acad Sci USA. 2014, 111(1):E89-98. (IF=9.412)

36. Xiaobin Zeng#*, Hongbo Chen , Jun Tian *, Yang Wang, Liao Cui1,Xueyan Wang. The effective activation of apoptosis by AO-95 from the aerial part of Alpiniae officinarum in A549 cell line. Journal of health Science. Volume 2, Number 7, July 2014.(IF=0.805)

37.   Zhang X#, Zeng X#, Liang X, Yang Y, Li X, Chen H, Huang L, Mei L*, Feng SS*.  The chemotherapeutic potential of PEG-b-PLGA copolymer micelles that combine chloroquine as autophagy inhibitor and docetaxel as an anti-cancer drug. Biomaterials. 2014, 35(33):9144-54.(IF=10.317)


Before 2014

38.  Zheng Y#, Chen H, Zeng X, Liu Z, Xiao X, Zhu Y, Gu D*, Mei L*.  Surface modification of TPGS-b-(PCL-ran-PGA) nanoparticles with polyethyleneimine as a co-delivery system of TRAIL and endostatin for cervical cancer gene therapy. Nanoscale Res Lett. 2013,8(1):161. (IF=3.581)

39. Cheng F., et al (2011) KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition, Cell Host Microbe, 10(7): 577-590 (JCR:1 区,IF=14.946)

40.. Cheng F., et al, (2009) KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA, PloS Pathogens, 5(3): e1000324 (JCR:1 区,IF=6.608)

41. Cheng F., Pekkonen P., and Ojala P.M. (2012) Instigation of Notch signaling in the pathogenesis of Kaposi sarcoma herpesvirus and other human tumor viruses. Future Microbiology 7:1191-1205 (JCR:2 区,IF=3.374)

42. Varjosalo M*., Bjorklund M*., Cheng F., et al (2008) Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling, Cell, 133(3): 537-548 (JCR:1 区,IF=30.410)

43   Chen H#, Mei L, Zhou L, Shen X, Guo C, Zheng Y, Zhu H, Zhu Y, Huang L*. PTEN restoration and PIK3CB knockdown synergistically suppress glioblastoma growth in vitro and in xenografts. J Neurooncol. 2011, 104(1):155-167. IF=3.267

44  Chen H#, Zheng Y#, Tian G, Tian Y, Zeng X, Liu G, Liu K, Li L, Li Z, Mei L*, Huang L*. Oral delivery of DMAB-modified docetaxel-loaded PLGA-TPGS nanoparticles for cancer chemotherapy. Nanoscale Res Lett. 2011 6(1):4-14. IF=3.581

45   Xu X#, Chen H#, Cao X, Ben K*. Efficient infection of tree shrew (Tupaia belangeri) with hepatitis C virus grown in cell culture or from patient plasma. J Gen Virol. 2007, 88(Pt 9):2504-2512. IF=3.376

46  Chen H#, Shen X, Guo C, Zhu H, Zhou L, Zhu Y, Wang H, Zheng Y, Huang L*. Phosphatase and tensin homolog reconstruction and vascular endothelial growth factor knockdown synergistically inhibit the growth of glioblastoma. Cancer Biother Radio. 2010, 25(6):713-721. IF=2.314

47  Chen HB#, Zhou LZ, Mei L, Shi XJ, Wang XS, Li QL*, Huang L*. Gambogenic acid-induced time- and dose-dependent growth inhibition and apoptosis involving Akt pathway inactivation in U251 glioblastoma cells. J Nat Med. 2012, 66(1):62-69.IF=2.0


授权专利


(1) 陈红波; 查华联; 徐占雪; 程芳; 贺超; 吴彦萍 ; PD-L1/CTLA-4在制备免疫抑制剂中的应用, 2023-8-1, 中国, ZL 2019 1 1397890.3

(2) 陈红波; 韩雨航; 杨欣蕊; 程芳; PD-1细胞膜纳米囊泡联合干细胞膜片在恶性黑色素瘤术后治疗中的应用,2023-07-31,中国, ZL202210453760.2

(3) 陈红波; 蔡湘仪; 程芳; 邓文斌; 刘龙山; 王长希 ; C27H27N7O2S在制备抑制器官异体移植排斥药剂中的应用, 2023-7-28, 中国, ZL 2019 1 1115394.4

(4) 陈红波; 石培霖; 程芳; 刘龙山; 王长希; 毕梓荣 ; CX-5461在治疗肾移植免疫排斥中的应用, 2023-3-21, 中国, ZL 2022 1 0514892.1

(5) 陈红波; 杨敏; 程芳; 徐占雪; 颜海兰; 贺超 ; 一种包裹免疫抑制剂并过表达PD-L1的细胞膜纳米囊泡及其制备方法和应用, 2022-9-13, 中国, ZL 2022 1 0601231.3

(6) 陈红波; 朵燕红; 曾小伟; 杨敏; 梅林 ; 一种携带Polymerase I抑制剂的核仁靶向纳米载体及其制备方法和应用, 2022-4-5, 中国, ZL201810332801.6

(7) 陈红波; 蔡湘仪; 杨敏; 吴彦萍; 邓文斌 ; Polymerase I 抑制剂的新用途, 2021-3-12, 中国, ZL2018 1 0588234.0

(8) 陈红波; 黄来强; 吴彦萍; 蔡湘仪; 王丽君 ; 调节rDNA基因染色质组蛋白甲基化水平的物质及其应用, 2020-12-18, 中国, ZL201811038473.5

(9)曾小伟; 梅林; 黄来强; 陶伟; 郑义; 陈红波 ; CA-(PLA-ran-PCL)-b-PEG嵌段共聚物及其制备方法与应用,2015-07-22,中国,ZL 201210578931.0

(10)梅林; 曾小伟; 黄来强; 郑义; 陈红波 ; 一种CA-PLGA-TPGS星型共聚物及其制备方法与应用,2014-04-12,中国,ZL201210292220.7

(11)黄来强; 陈红波; 李俊畅; 梅林; 周兰贞; 郑义 ; 一种核仁定位信号肽及其编码基因和应用,2013-10-30,中国,ZL201210027105.7

(12)周志文; 冯宇霞; 张洪山; 陈红波 ; 神经生长因子基因定位改造动物及其制备方法和应用, 2013-06-05,中国 ,授权公布号: ZL200710086017.3

(13) 程芳,刘晓燕,陈红波,苏丹丹, 蔡湘仪,徐占雪,颜福霞,杨欣蕊,贺超,伍颖艺,肖有梅,颜海兰,查华联,杨敏.PD-L1 外泌体的新用途, 2020.09.11 中国, CN 111643523,ZL 2018 I 1038473.5(13)Zhou Zhiwen; Chen Hongbo; Zhang Hongshan ; Transgenic Rodents Having Ngf Beta Gene Mutants And Its Preparation Methods, The Preparation Methods Of The Corresponding Mutant Proteins And The Resulting Mutant Proteins. PCT:  欧洲EP2135951 B1. 美国US 8487157 B2