发表论文：
2025
(61) Li, C.; Fu, Y.; Zhu, L.; Jiang, Q.; Gu, L.; Zhao, Y.-C.;* Yang, M.;* Kong, L.*, Biosynthesis of γ-Alkylidenebutenolide Derivatives Reveals an Atom-Deleting Lactone Ring Contraction by Dual-Enzyme Cascade. J Am Chem Soc. 2025, 10, 47(45):41210-41215. Link
(60) Peng, G.; Qin, Y.; Yan, Z.; He, M.; Zhao, Y.-C.;* Jiang, N.;* Wei, C.*, The high-quality telomere-to-telomere genome assembly of the earthworm (Amynthas aspergillum). Sci Data. 2025, 6, 12(1):931. Link
(59) Hu, B.; Zhou, J.; Li, J.; Chen, J.; Du, G.; Zhong, F.; Zhao, Y.-C.;* Zhao, X.*, Efficient Biosynthesis of Furanocoumarin Intermediate Marmesin by Engineered Escherichia coli. ACS Synth Biol. 2025, 14, 954-966. Link
(58) Dai, Y.;# He, M.;# Liu, H.;# Zeng, H.; Wang, K.; Wang, R.; Ma, X.; Zhu, Y.; Xie, G.; Zhao, Y.-C.;* Qin, M.*, The chromosome-scale assembly of the Salvia plebeia genome provides insight into the biosynthesis and regulation of rosmarinic acid. Plant Biotechnol J. 2025,14601. Link
2024
(57) Li, Y.;# Li, Z.;# Yan, P.;# Hua, C.;# Kong, J.;# Wu, W.; Cui, Y.; Duan, Y.; Li, S.; Li, G.; Ji, S.; Chen, Y.; Zhao, Y.-C.; Yang, P.; Hu, C.; Lu, M.;* Chen, M.;* Xiao, Y.*, Antiviral signaling of a type III CRISPR-associated deaminase. Science. 2024, adr0393. Link
(56) Zhao, Y.-C.;# He, Y.;# Han, L.;# Zhang, L.; Xia, Y.; Yin, F.; Wang, X.; Zhao, D.; Xu, S.; Qiao, F.;* Xiao, Y.;* Kong, L.*, Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis. Acta Pharm Sin B. 2024, 14, 869-880. Link
(55) Xu, D.;# Ye, Z.;# Huang, Y.;# Zhu, K.; Xu, H.; Yu, J.; Feng, Y.; Zhao, X.; Wang, L.; Xu, H.; Li, Q.; Qin, M.; Tang, Y.;* Zhang, X.;*
Zhao, Y.-C.*, Haplotype-resolved genome assembly of Corydalis yanhusuo, a traditional Chinese medicine with unusual telomere motif. Hortic Res. 2024, 11, uhad296. Link
(54) Ma, B.;# Wang, S.;# Li, H.; Wang, Q.; Hong, Y.; Bao, Y.; M, Liu, H.; Li, M.; Zhao, Y.-C.;* Guo, L.-P.*, Combining metabolomics and transcriptomics to reveal the potential medicinal value of rare species Glycyrrhiza squamulose. Heliyon. 2024, 10, e30868. Link
(53) Huang, X.-C.;# Tang, H.;# We, X.#; He, Y.; Hu, S.; Wu, J.-Y.; Xu, D.; Qiao, F.;* Xue, J.-Y.;* Zhao Y.-C.*, The gradual establishment of complex coumarin biosynthetic pathway in Apiaceae. Nat Commun. 2024, 15, 6864. Link
(52) Wang, K.;# Zeng, H.;# Dai, Y.; Wang, Z.; Tang, H.; Li J.; Lu, X.; Jiang, N.; Xie, G.; Zhu, Y.; Zhao, Y.-C.;* Qin, M.*, Three types of enzymes complete the furanocoumarins core skeleton biosynthesis in Angelica sinensis. Phytochemistry. 2024, 222, 114102. Link
(51) Zeng, H.;# Li, S.;# Wang, K.; Dai, Y.; Sun, L.; Gao, Y.; Yi, S.; Li, J.; Xu, S.; Xie, G.; Zhu, Y.; Zhao, Y.-C.;* Qin M.*, BvCGT1-mediated differential distribution of flavonoid C-glycosides contributes to plant's response to UV-B stress. Plant J. 2024, 120, 354-369. Link
(50) Wang, Z.;# He, J.;# Qi, Q.; Wang, K.; Tang, H.; Feng, Y.; Zhao, X.; Yi, S.; Zhao, Y.-C.;* Xu, D.*, Chromosome-level genome assembly of Cnidium monnieri, a highly demanded traditional Chinese medicine. Sci Data. 2024, 11, 667. Link
(49) Li, Q.;# Dai, Y.;# Huang, X.-C.;# Sun, L.; Wang, K.; Guo, X.; Xu, D.; Wan, D.; An, L.; Wang, Z.; Tang, H.; Qi, Q.; Zeng, H.; Qin, M.;* Xue, J.-Y.,* Zhao Y.-C.*, The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins. Acta Pharm Sin B. 2024, 14, 3760-3773. Link
2023
(48) Dai, Y.;# Ye, Z.;# Liu, H.; Zhu, R.; Sun, L.; Li, S.; Xie, G.; Zhu, Y.; Zhao, Y.-C.;* Qin, M.*, The chemical profiling of Salvia plebeia during different growth periods and the biosynthesis of its main flavonoids ingredients. Front Plant Sci. 2023, 14,1228356. Link
(47) Guo, E.; Yuan, M.; Xu, L.; Ren, Q.; Wang, Z.; Li, Z.; Wu, Z.; Liu, W.; Zhao, Y.-C.;* Feng, F.;* Xu, J.*, Identification of three key enzymes involved in the biosynthesis of tetracyclic oxindole alkaloids in Uncaria rhynchophylla. Bioorg Chem. 2023, 136, 106545. Link
(46) Han, L.; Zhang, L.; He, Y.; Liao, L.; Li, J.; Xu,S.; Zhao,Y.-C.;* Bian, X.;* Xia,Y.*, Three carbon-/oxygen-prenyltransferases responsible for furanocoumarin synthesis in Angelica dahurica. Ind Crop Prod. 2023, 200, 116814. Link
(45) Qiao, F.;# He, Y.;# Zhang, Y.;# Jiang, X.; Cong, H.; Wang, Z.; Sun, H.;* Xiao, Y.;* Zhao, Y.-C.;* Nick, P., Elucidation of the 1-phenethylisoquinoline pathway from an endemic conifer Cephalotaxus hainanensis. Proc Natl Acad Sci U S A. 2023, 120, e2209339120. Link
(44) Zhang, L.;# Zhang, S.;# Liao, L.;# Tang, H.; Wang, W.; Yin, F.; Han, L.; Zhu, K.; Liu, Y.; Xu, D.; Wang, X.; Qin, M.; Xiao, Y.;* Sheng, X.;* Zhao, Y.-C.*, Discovery, Structure, and Mechanism of the (R, S)-Norcoclaurine Synthase for the Chiral Synthesis of Benzylisoquinoline Alkaloids. ACS Catalysis. 2023,13,15164-15174. Link
(43) He, Y.;# Zhang, J.;# He, Y.;# Liu, H.; Wang, C.; Guan, G.; Zhao, Y.-C.; Tian, Y.;* Zhong, X.;* Lu, X.*, Two O-methyltransferases are responsible for multiple O-methylation steps in the biosynthesis of furanocoumarins from Angelica decursiva. Plant Physiol Biochem. 2023, 204, 108142. Link
2022
(42) Yu, W.;# Zhao, Y.-C.;#Ye, H.;# Wu, N.; Liao, Y.; Chen, N.; Li, Z.; Wan, N.; Hao, H.; Yan, H.; Xiao, Y.;* Lai M.*, Structure-Based Design of a Dual-Targeted Covalent Inhibitor Against Papain-like and Main Proteases of SARS-CoV-2. J Med Chem. 2022, 65, 16252-16267. Link
(41) Wang, Z.;# He, Y.;# Liao, L.; Zhang, Y.; Zhao, Y.-C.; Xiao, Y.; Jiang, X.;* Qiao, F., Forming coumarin C-glycosides via biocatalysis: Characterization of a C-glycosyltransferase from Angelica decursiva. Biochem Biophys Res Commun. 2022 ,614:85-91. Link
(40) Lu, G.; Qiao, J.; Wang, L.; Liu, H.; Wu, G.; Zhu, Y.; Zhao, Y.-C.; Xie, G.; Qin, M.*, An integrated study of Violae Herba (Viola philippica) and five adulterants by morphology, chemical compositions and chloroplast genomes: insights into its certified plant origin. Chin Med. 2022 ,17, 32. Link
2021
(39) Xu, D.; Lin, H.; Tang, Y.; Huang, L.; Xu, J.; Nian, S.;* Zhao, Y.-C.*, Integration of full-length transcriptomics and targeted metabolomics to identify benzylisoquinoline alkaloid biosynthetic genes in Corydalis yanhusuo. Hortic Res. 2021, 8, 16. Link
(38) Zhang, X.;# Zhu, Y.;# Ye, J.; Ye, Z.; Zhu, R.; Xie, G.; Zhao, Y.-C.;* Qin M.*, Iris domestica (iso) flavone 7- and 3'-O-Glycosyltransferases Can Be Induced by CuCl2. Front Plant Sci. 2021, 12, 632-557. Link
(37) Liao, L.;# Zhou, Y.;# Xu, Y.;# Zhang, Y.; Liu, X.; Liu, B.; Chen, X.; Guo, Y.; Zeng, Z.;* Zhao, Y.-C.*, Structural and Molecular Dynamics Analysis of Plant Serotonin N-Acetyltransferase Reveal an Acid/Base-Assisted Catalysis in Melatonin Biosynthesis. Angew Chem Int Ed Engl. 2021, 60, 12020-12026. Link
(36) Wang, L.;# Yu, X.;# Xu, W.; Zhang, J.; Lin, H.; Zhao, Y.-C.*, Complete chloroplast genome sequencing support Angelica decursiva is an independent species from Peucedanum praeruptorum. Physiol Mol Biol Plants. 2021, 27, 2503-2515. Link
(35) Xie, G.;# Jin, S.;# Li, H.; Ai, M.; Han, F.; Dai, Y.; Tao, W.; Zhu, Y.; Zhao, Y.-C.;* Qin M.*, Chemical constituents and antioxidative, anti-inflammatory and anti-proliferative activities of wild and cultivated Corydalis Saxicola. Ind Crop Prod. 2021, 169, 113647. Link
(34) Xu, D.-Q.;# Cheng, S.-Y.;# Zhang, J.-Q.; Lin, H.-F.; Chen, Y.-Y.; Yue, S.-J.; Tian, M.; Tang, Y.-P.;* Zhao, Y.-C.*, Morus alba L. Leaves - Integration of Their Transcriptome and Metabolomics Dataset: Investigating Potential Genes Involved in Flavonoid Biosynthesis at Different Harvest Times. Front Plant Sci. 2021, 12, 736332. Link
(33) Chen J.;# Wang L.;# Zhao, Y.-C.;* Qin M.*, The complete chloroplast genome of a Chinese medicinal plant, Peristrophe japonica (Thunb.) Bremek. (Lamiales: Acanthaceae) from Nanjing, China. Mitochondrial DNA B Resour. 2021, 6, 1888-1889. Link
(32) Yi S.;# Song X.;# Yu W.; Zhang R.; Wang W.; Zhao, Y.-C.; Han B.;* Gai Y.*, De novo assembly and Transcriptome Analysis of the Momordica charantia Seedlings Responding to methyl jasmonate using 454 pyrosequencing. Gene Expr Patterns. 2021, 40, 119-160. Link
(31) Zhu X.; Zhang Y.; Zhao, Y.-C.; Xiang D.; Zou J.; Andrisani O.; Zhang H.;* Kong L.*, LIX1-like protein drives hepatic stellate cell activation to promote liver fibrosis by regulation of chemokine mRNA stability. Signal Transduct Target Ther. 2021, 6, 319. Link
(30) Chen, J.;# Chen, J.;# Wang, L.; Zhao, Y.-C.; Qin, M.*, The complete chloroplast genome of Clerodendrum lindleyi Decne. ex Planch. (Tubiflorae: Verbenaceae) from nanjing, China. Mitochondrial DNA B Resour. 2021, 6, 3098-3099. Link
2020
(29) Wang, Z.; Jian, X.; Zhao, Y.-C.; Li, S.; Sui, Z.; Li, L.; Kong, L.;* Luo, J.*, Functional characterization of cinnamate 4-hydroxylase from Helianthus annuus Linn using a fusion protein method. Gene. 2020, 758, 144950. Link
(28) Zhang, J.;# Gao, D.;# Li, Q.; Zhao, Y.; Li, L.; Lin, H.; Bi, Q.;* Zhao, Y.-C.*, Biodegradation of polyethylene microplastic particles by the fungus Aspergillus flavus from the guts of wax moth Galleria mellonella. Sci Total Environ. 2020, 704, 135931. Link
(27) Zhao, Y.-C.;# Wang, N.;# Wu, H.; Zhou, Y.; Huang, C.; Luo, J.; Zeng, Z.;* Kong, L.*, Structure-based tailoring of the first coumarins-specific bergaptol O-methyltransferase to synthesize bergapten for depigmentation disorder treatment. J Adv Res. 2020, 21, 57-64. Link
(26) Chen, J.; Bao, Z.; Huang, Y.; Wang, Z.; Zhao, Y.-C.*, Selection of Suitable Reference Genes for qPCR Gene Expression Analysis of HepG2 and L02 in Four Different Liver Cell Injured Models. Biomed Res Int. 2020, 8926120. Link
(25) Gao, Y.;# Wang, Y.;# Qian, J.; Si, W.; Tan, Q.; Xu, J.; Zhao, Y.-C.*, Melatonin enhances the cadmium tolerance of mushrooms through antioxidant-related metabolites and enzymes. Food Chem. 2020, 330, 127263. Link
(24) Jian, X.; Zhao, Y.-C.; Wang, Z.; Li, S.; Li, L.; Luo, J.; Kong, L.*, Two CYP71AJ enzymes function as psoralen synthase and angelicin synthase in the biosynthesis of furanocoumarins in Peucedanum praeruptorum Dunn. Plant Mol Biol. 2020, 104, 327-337. Link
(23) Zhang, Z.; Li, C.; Zhang, J.; Chen, F.; Gong, Y.; Li, Y.; Su, Y.; Wei, Y.; Zhao, Y.-C.*, Selection of the Reference Gene for Expression Normalization in Papaver somniferum L. under Abiotic Stress and Hormone Treatment. Genes (Basel). 2020, 11, 124. Link
(22) Zhou, Y.; # Liao, L.; # Liu, X.; Liu, B.; Chen, X.; Guo, Y.; Huang, C.; Zhao, Y.-C.;* Zeng, Z.*, Crystal structure of Oryza sativa TDC reveals the substrate specificity for TDC-mediated melatonin biosynthesis. J Adv Res. 2020, 24, 501-511. Link
(21) Liao, L.; Zhou, Y.; Peng, T.; Guo, Y.; Zhao, Y.-C.;* Zeng, Z.*, Crystal structure of a S-adenosyl-L-methionine-dependent O-methyltransferase-like enzyme from Aspergillus flavus. Proteins. 2021, 89, 185-192. Link
2019
(20) Zhao, Y.-C.; Jian, X.-Y.; Wu, J.-L.; Huang, W.-C.; Huang, C.-L.; Luo, J.;* Kong, L.-Y.*, Elucidation of the biosynthesis pathway and heterologous construction of a sustainable route for producing umbelliferone. J. Biol. Eng. 2019, 13, 44. Link
(19) Zhao, Y.-C.;# Wang, N.-N.;# Sui, Z.-W.; Huang, C.-L.; Zeng, Z.-L.;* Kong, L.-Y.*, The Molecular and Structural Basis of O-methylation Reaction in Coumarin Biosynthesis in Peucedanum praeruptorum Dunn. Int. J. Mol. Sci. 2019, 20, 1533. Link
(18) Zhao, Y.-C.; Wang, Z.-L.; Li, D.-T.; Feng, W.-P.; Bian, X.-H.;* Xu, J.-Y.*, Two PBDEs exposure inducing feeding depression and disorder of digestive and antioxidative system of Daphnia magna. Ecotoxicol. Environ. Saf. 2019, 176, 279-287. Link
(17) Zhao, Y.-C.; Zhang, Z.-P.; Li, M.-Z.; Luo, J.; Chen, F.; Gong, Y.-F.; Li, Y.-R.; Wei, Y.-J.; Su, Y.-J.;* Kong, L.-Y.*, Transcriptomic profiles of 33 opium poppy samples in different tissues, growth phases, and cultivars. Sci. Data. 2019, 6, 66. Link
(16) Bao, Z.-Z.; Huang, Y.-L.; Chen, J.-Y.; Wang, Z.-L.; Qian, J.; Xu, J.-Y.;* Zhao, Y.-C.,* Validation of Reference Genes for Gene Expression Normalization in RAW264.7 Cells under Different Conditions. Biomed Res Int. 2019, 2019, 6131879. Link
(15) F. Sui, Z.-W.; Luo, J.; Yao, R.-L.; Huang, C.-L.; Zhao, Y.-C.;* Kong, L.-Y.*, Functional characterization and correlation analysis of phenylalanine ammonia-lyase (PAL) in coumarin biosynthesis from Peucedanum praeruptorum Dunn. Phytochemistry. 2019, 158, 35-45. Link
(14) Wang, Z.-L.;# Xu, J.-Y.;# Liu, Y.-H.;# Chen, J.-Y.; Lin, H.-F.; Huang, Y.-L.; Bian, X.-H.;* Zhao, Y.-C.*, Selection and validation of appropriate reference genes for real-time quantitative PCR analysis in Momordica charantia. Phytochemistry. 2019, 164, 1-11. Link
(13) H. Xie, B.-X.; Gai, Y.-N.; Zhu, Z.-Y.; Li, M.-Z.;* Zhao, Y.-C.*, Sequencing and phylogenetic analysis of the complete chloroplast genome of Cassia tora Linn. Mitochondrial DNA B Resour. 2019, 4, 4027-4028. Link
(12) Xie, B.; Jiang, C.; Zhu, Z.; Li, M.; Zhao, Y.-C.*, The complete chloroplast genome of Cirsium setosum and its phylogenetic analysis. Mitochondrial DNA B Resour. 2019, 4, 3756-3757. Link
(11) Zhang, H.;# Zhang, Y.;# Zhu, X.; Chen, C.; Zhang, C.; Xia, Y.; Zhao, Y.-C.; Andrisani, O.; Kong, L.*, DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1. Hepatology. 2019, 69, 1046-1063. Link
2018
(10) Wu, H.;# Zhao, Y.-C.;# Huang, Q.; Cai M; Pan, Q.; Fu, M.; An, X.; Xia, Z.; Liu, M.; Jin, Y.; He, L.; Shang, J.*, NK1R/5-HT1AR interaction is related to the regulation of melanogenesis. FASEB J. 2018, 32, 3193-3214. Link
(9) Qian, J.;# Gao, Y.;# Wáng, Y.; Wu, Y.; Wāng, Y.; Zhao, Y.-C.; Chen, H.; Bao, D.; Xu, J.;* Bian, X.*, Selection and Evaluation of Appropriate Reference Genes for RT-qPCR Normalization of Volvariella volvacea Gene Expression under Different Conditions. Biomed Res Int. 2018, 2018, 6125706. Link
(8) Zhang, H.;# Zhang, Y.;# Chen, C.; Zhu, X.; Zhang, C.; Xia, Y.; Zhao, Y.-C.; Andrisani, O. M.; Kong, L.*, A double-negative feedback loop between DEAD-box protein DDX21 and Snail regulates epithelial-mesenchymal transition and metastasis in breast cancer. Cancer Lett. 2018, 437, 67-78. Link
2017
(7) Liu, T.; Yao, R.; Zhao, Y.-C.; Xu, S.; Huang, C.; Luo, J.;* Kong, L.*, Cloning, Functional Characterization and Site-Directed Mutagenesis of 4-Coumarate: Coenzyme A Ligase (4CL) Involved in Coumarin Biosynthesis in Peucedanum praeruptorum Dunn. Front Plant Sci. 2017, 8, 4. Link
(6) Yao, R.; Zhao, Y.-C., Liu, T.; Huang, C.; Xu, S.; Sui, Z.; Luo, J.;* Kong, L.*, Identification and functional characterization of a p-coumaroyl CoA 2'-hydroxylase involved in the biosynthesis of coumarin skeleton from Peucedanum praeruptorum Dunn. Plant Mol Biol. 2017, 95, 199-213. Link
2016
(5) Zhao, Y.-C., Luo, J.; Xu, S.; Wang, W.; Liu, T.; Han, C.; Chen, Y.; Kong, L.*, Selection of Reference Genes for Gene Expression Normalization in Peucedanum praeruptorum Dunn under Abiotic Stresses, Hormone Treatments and Different Tissues. PLoS One. 2016, 11, e0152356. Link
(4) Zhao, Y.-C.;# Wang, N.;# Zeng, Z.; Xu, S.; Huang, C.; Wang, W.; Liu, T.; Luo, J.;* Kong, L.*, Cloning, Functional Characterization, and Catalytic Mechanism of a Bergaptol O-Methyltransferase from Peucedanum praeruptorum Dunn. Front Plant Sci. 2016, 7, 722. Link
(3) Ma, R.;# Xu, S.;# Zhao, Y.-C.; Xia, B.; Wang, R.*, Selection and Validation of Appropriate Reference Genes for Quantitative Real-Time PCR Analysis of Gene Expression in Lycoris aurea. Front Plant Sci. 2016, 7, 536. Link
2015
(1) Zhao, Y.-C.; Liu, T.; Luo, J.; Zhang, Q.; Xu, S.; Han, C.; Xu, J.; Chen, M.; Chen, Y.; Kong, L.*, Integration of a Decrescent Transcriptome and Metabolomics Dataset of Peucedanum praeruptorum to Investigate the CYP450 and MDR Genes Involved in Coumarins Biosynthesis and Transport. Front Plant Sci. 2015, 6, 996. Link
2013
(1) Zhao, Y.-C.; Bian, X.; You, Q.; Shao, F.; Xiang, X.; Deng, X.; Zhao, G.; Xu, J.*, Nystatin-enhanced glutathione production by Saccharomyces cerevisiae depends on γ-glutamylcysteine synthase activity and K+. Eng. Life Sci. 2013, 13, 156-162. Link
专利：
1. 一种前胡种苗的繁育方法。申请公布号：CN114027199A。
2. 用于合成复杂香豆素的CYP450环化酶基因PpDC与PpOC及其应用。申请公布号：CN117187268A。
3. 一种采用葫芦二烯醇合酶合成葫芦二烯醇的方法及其应用。申请公布号：CN116891871A。
4. 蛇床羟化酶基因CmC2′H及其应用。授权公告号：CN118028256B。
5. 用于催化异戊二烯化的异戊烯基转移酶基因CmPT及其应用。申请公布号：CN117904153A。
6. 一种减弱反馈抑制菌株生产谷胱甘肽的方法。授权公告号：CN102911960B。
7. 一种提高半胱氨酸利用率生物合成谷胱甘肽的方法。授权公告号：CN103849639B。
