第一作者/通讯作者 论文
2023
118. Yang M, Li C, Ye G, Shen C, Shi H, Zhong L, Tian Y, Zhao M, Wu P, Hussain A, Zhang T, Yang H, Yang J, Weng Y, Liu X, Wang Z, Gan L, Zhang Q, Liu Y, Yang G*, Huang Y*, Zhao Y*. Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibited potential anti pan-coronavirus activity. Signal Transduction and Targeted Therapy. (IF=39.3). Accepted.
117.Moazzam M, Zhang M, Hussain A, Yu X*, Huang J*, Huang Y*. The Landscape of Nanoparticle-based siRNA Delivery and Therapeutic Development. Molecular Therapy. (IF=12.4). Accepted.
116. Julien Milon Essola, Mengjie Zhang, Haiyin Yang, Fangzhou Li, Bozhang Xia, Jacques François Mavoungou, Abid Hussain, Yuanyu Huang*. Exosome regulation of immune response mechanism: Pros and cons in immunotherapy. Bioactive Materials, 2024; 32:124-146. (IF=18.9) https://doi.org/10.1016/j.bioactmat.2023.09.018
115. Shuai Guo, Mengjie Zhang, Yuanyu Huang*. Three 'E'challenges for siRNA drug development. Trends in Molecular Medicine, 2023. (IF=13.6) https://doi.org/10.1016/j.molmed.2023.10.005
114. Yafang Xiao, Yuanyu Huang*, Maobin Xie, Minghui Yang, Ying Tao, Lu Liu, Jiasheng Wu, Guoxi Xie, Jinbao Liu, Tao Xu, Weisheng Guo*, Xing-Jie Liang*. Immunoregulatory nanomedicine for respiratory infections. Nature Reviews Bioengineering, 2023. https://doi.org/10.1038/s44222-023-00131-8
113. Yuxin Tian, Mengjun Li, Yang Yang, Chunhui Li, Yun Peng, Haiyin Yang, Mengyuan Zhao, Pengfei Wu, Shaobo Ruan, Yuanyu Huang*, Chenguang Shen*, Minghui Yang*. An MPXV mRNA-LNP vaccine candidate elicits protective immune responses against monkeypox virus. Chinese Chemical Letters, 2023. (IF=9.1) https://doi.org/10.1016/j.cclet.2023.109270
112. Lulu Zheng, Bo Hu, Deyao Zhao, Wenjing Liua, Qing Liu, Yuanyu Huang*, Shaobo Ruan*. Recent progresses of exosome–liposome fusions in drug delivery. Chinese Chemical Letters, 2024; 35:108647(IF=9.1) https://doi.org/10.1016/j.cclet.2023.108647
111. Bo Hu#, Sudong Kong#, Yuhua Weng, Deyao Zhao, Abid Hussain, Qingze Jiao, Shijing Zhan, Ling Qiu, Jianguo Lin, Minhao Xie*, Bo Li*, Yuanyu Huang*. Lipid-conjugated siRNA hitchhikes endogenous albumin for tumor immunotherapy. Chinese Chemical Letters.2023:108210 . (IF=8.455) https://doi.org/10.1016/j.cclet.2023.108210
110. Mei Lu, Haonan Xing, Wanxuan Shao, Pengfei Wu, Yuchuan Fan, Huining He, Stefan Barth, Aiping Zheng, Xingjjie Liang, Yuanyu Huang*. Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles. Acta Pharmaceutica Sinica B, 2023. (IF=14.903) https://doi.org/10.1016/j.apsb.2023.03.020
109. Wenshu Cong, Yajie Wang, Chunhui Yuan, Mei Xu, Han Wang, You Hu, Xuyan Dai4, Yuhua Weng, Peter Timashev, Xing-Jie Liang, Yuanyu Huang*. Dietary cobalt oxide nanoparticles alleviate aging through activation of mitochondrial UPR in Caenorhabditis elegans. Theranostics, 2023; 13:3276-3289. (IF=12.4) https://doi.org/10.7150/thno.81817
108. Xiaomin Zhang, Ge Yang*, Wenjing Liu , Qing Liu , Zhuoran Wang, Kelong Fan, Feng Qu, Yuanyu Huang*. Screening and Identification of ssDNA Aptamers for Low-Density Lipoprotein (LDL) Receptor-Related Protein 6. Molecules. 2023, 28(9):3838.(IF=4.927) doi: 10.3390/molecules28093838.
107.Bo Hu, Yuanyu Huang*. siRNA targeting ANGPTL3 stands in the spotlight for lipid-lowering therapy. Molecular Therapy-Nucleic Acids. 2023; 32:369-370. (IF=10.183) https://doi.org/10.1016/j.omtn.2023.03.020
106. Xiaomin Zhang, Ge Yang, Yi Zhao, Xuyan Dai, Wenjing Liu, Feng Qu, Yuanyu Huang*. Selection and Identification of an ssDNA Aptamer for Fibroblast Activation Protein. Molecules. 2023, 28 (4): 1682. (IF=4.927) https://doi.org/10.3390/molecules28041682
105. Mei Lu*, Wanxuan Shao, Haonan Xing, Yuanyu Huang*. Extracellular vesicle-based nucleic acid delivery. Interdisciplinary Medicine, 2023; 1:e20220007. https://doi.org/10.1002/INMD.20220007
104.Mei Lu, Haonan Xing, Aiping Zheng, Yuanyu Huang*, Xing-Jie Liang*. Overcoming Pharmaceutical Bottlenecks for Nucleic Acid Drug Development. Accounts of Chemical Research. 2023: eaaw6264-3689. (IF=24.466) https://doi.org/10.1021/acs.accounts.2c00464
103.Wenshu Cong, Li Meng, Yuanjie Pan, Han Wang, Jiahui Zhu, Yuanyu Huang*, Qingli Huang*. Mitochondrial-mimicking nanozyme-catalyzed cascade reactions for aging attenuation.NanoToday.202348:101757 (IF=18.962) https://doi.org/10.1016/j.nantod.2023.101757
102. Mengjie Zhang, Abid Hussain*, Haiyin Yang, Jinchao Zhang, Xing-Jie Liang, Yuanyu Huang*. mRNA-based modalities for infectious disease management. Nano Research. 2022: 1-20.(IF=10.269) https://doi.org/10.1007/s12274-022-4627-5
101. Rui Liu#, Cong Luo#, Zhiqing Pang#, Jinming Zhang#, Shaobo Ruan#, Meiying Wu#, Lei Wang#, Tao Sun#, Nan Li#, Liang Han#, Jinjin Shi#, Yuanyu Huang#, Weisheng Guo#, Shaojun Peng#, Wenhu Zhou#, Huile Gao*. Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment. Chinese Chemical Letters.2023; 34(2):107518. (IF= 9.1,)
https://doi.org/10.1016/j.cclet.2022.05.032
100. Mei Lu, Wanxuan Shao, Haonan Xing, Yuanyu Huang*. Extracellular vesicle‐based nucleicaciddelivery.InterdisciplinaryMedicine. 2023: e20220007. https://doi.org/10.1002/INMD.20220007
2022
99. Mengjie Zhang, Yuanyu Huang*. siRNA modification and delivery for drug development.TrendsinMolecularMedicine. 2022. (IF=15.272) https://doi.org/10.1016/j.molmed.2022.08.003
98. Tian Zhang#, Shuai Guo#, Fangzhou Li, Xinmiao Lan, Yaru Jia, Jinchao Zhang, Yuanyu Huang*, Xing-Jie Liang*, Image-guided/improved diseases management: from immune-strategies and beyond. Advanced Drug Delivery Reviews. 2022: 114446.（IF=17.873） https://doi.org/10.1016/j.addr.2022.114446
97. Mei Lu, Haonan Xing, Wanxuan Shao, Tian Zhang, Mengjie Zhang, Yongchao Wang, Fangzhou Li, Yuhua Weng, Aiping Zheng, Yuanyu Huang*, Xing-Jie Liang*. Photo-activatable Silencing Extracellular Vesicle (PASEV) Sensitizes Cancer Immunotherapy. Advanced Materials. 2022:e2204765.（IF=32.086） https://doi.org/10.1002/adma.202204765
96. Chanchan Yu, Kun Li, Lin Xu , Bo Li, Chunhui Li, Shuai Guo, Ziyue Li, Yuquan Zhang,AbidHussain,Hong Tan, Mengyu Zhang, Yongxiang Zhao*, Yuanyu Huang*, Xing-Jie Liang*. siRNA-Functionalized Lanthanide Nanoparticle Enables Efficient Endosomal Escape and Cancer Treatment. Nano Research. 2022. (IF=10.269)https://doi.org/10.1007/s12274-022-4573-2
95. Mengjie Zhang, Wanxuan Shao, Tongren Yang, Houli Liu, Shuai Guo, Deyao Zhao, Yuhua Weng, Xing-Jie Liang, Yuanyu Huang*. Conscription of Immune Cells by Light-Activatable Silencing NK-Derived Exosome (LASNEO) for Synergetic Tumor Eradication. Advanced Science. 2022: 2201135.（IF=17.521） https://doi.org/10.1002/advs.202201135
94. Wenjing Liu, Yuanyu Huang*. Cell membrane-engineered nanoparticles for cancer therapy.Journalof Materials Chemistry B. 2022. (IF=7.571)https://doi.org/10.1039/D2TB00709F
93. Abid Hussain, Haiyin Yang, Mengjie Zhang, Qing Liu*, Ghallab Alotaibi, Muhammad Irfan, Huining He, Jin Chang, Xing-Jie Liang, Yuhua Weng, Yuanyu Huang*. mRNA vaccines for COVID-19 and diverse diseases. Journal of Controlled Release. 2022，345:314-333.(IF=11.467) https://doi.org/10.1016/j.jconrel.2022.03.032
92. Yuquan Zhang#，Ziyue Li#， JulienMilon Essola，Kun Ge，Xuyan Dai，Huining He，Haihua Xiao，Yuhua Weng*，Yuanyu Huang*. Biosafety materials: ushering in a new era of infectious disease diagnosis and treatment with the CRISPR/Cas system. Biosafety and Health. 2022， 4(2):70-78. https://doi.org/10.1016/j.bsheal.2022.03.010
91. Wenjing Liu#, Yuanyu Huang#, Zhengping Li, Lele Li, Yuliang Zhao, Mengyuan Li*， Multivalent Engineering of Exosomes with Activatable Aptamer Probes for Specific Regulation and Monitoring of Cell Targeting. Analytical Chemistry. 2022, 94, 9, 3840–3848.(IF=8.008)https://doi.org/10.1021/acs.analchem.1c04741
90. Bo Hu, Bo Li, Kun Li, Yuanyuan Liu, Chunhui Li, Lulu Zheng, Mengjie Zhang, Tongren Yang, Shuai Guo, Xiyu Dong, Tian Zhang, Qing Liu, Abid Hussain, Yuhua Weng, Ling Peng, Yongxiang Zhao, Xing-Jie Liang, Yuanyu Huang*，Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia. Science Advances. 2022,8(7):eabm1418.(IF= 14.957)http://doi.org/10.1126/sciadv.abm1418
89. Yuanyu Huang*, Shuquan Zheng, Zhaoxu Guo, Xavier de Mollerat du Jeu, Xing-Jie Liang, Zhiwei Yang, Hong-Yan Zhang, Shan Gao, Zicai Liang*. Ionizable liposomal siRNA therapeutics enables potent and persistent treatment of Hepatitis B. Signal Transduction and Targeted Therapy. 2022, 7(1):38. (IF=38.104) http://doi.org/10.1038/s41392-021-00859-y
88. Mengjie Zhang, Yuanyu Huang*. Correction to: siRNA modification and delivery for drug development: (Trends in Molecular Medicine, 28:10 p:892-893, 2022). Trends Mol Med. 2022; S1471-4914(22)00234-9. (IF=15.272) https://doi.org/10.1016/j.molmed.2022.09.003
87.Chunhui Li, Yuhua Weng, Anjie Dong, Xing-Jie Liang & Yuanyu Huang*. Preparation and Evaluation of Rationally Designed Polymers for Efficient Endosomal Escape of siRNA. Gene Delivery. 2022. https://doi.org/10.1007/978-981-33-6198-0_4-1
86.Chunhui Li#, Tongren Yang#, Yuhua Weng#, Mengjie Zhang, Deyao Zhao, Shuai Guo, Bo Hu, Wanxuan Shao, Xiaoxia Wang, Abid Hussain, Xing-Jie Liang, Yuanyu Huang*. Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapy. Bioactive Materials.2022, 9:590-601.（IF=16.874） https://doi.org/10.1016/j.bioactmat.2021.05.051
2021
85. Qing Liu, Bo Wu, Mengyuan Li*, Yuanyu Huang*, Lele Li*. Heterostructures Made of Upconversion Nanoparticles and Metal–Organic Frameworks for Biomedical Applications.AdvancedScience.2021,2103911. (IF=16.806)http://doi.org/10.1002/advs.202103911
84. Shuai Guo, Kun Li, Bo Hu, Chunhui Li, Mengjie Zhang, Abid Hussain, Xiaoxia Wang, Qiang Cheng, Feng Yang, Kun Ge, Jinchao Zhang, Jin Chang, XingJie. Liang, Yuhua Weng, Yuanyu Huang*. Membrane-destabilizing ionizable lipid empoweredimaging-guided siRNA delivery and cancer treatment. Exploration. 2021, 1: 35-49. https://doi.org/10.1002/EXP.20210008
83. Kun Li, Yuquan Zhang, Abid Hussain*, Yuhua Weng*, Yuanyu Huang*. Progress of Photodynamic and RNAi Combination Therapy in Cancer Treatment. ACS Biomaterials Science andEngineering.2021,7(9):4420–4429. (IF=4.749) https://doi.org/10.1021/acsbiomaterials.1c00765
82. 杨海银, 张萌洁, 翁郁华, 曹毅, 黄渊余*. COVID-19核酸疫苗及其纳米递送系统. 中国科学: 生命科学, 2021, 51.
81.Ge Yang, Ziyue Li, Irfan Mohammed, Liping Zhao, Wei Wei, Haihua Xiao, Weisheng Guo, Yongxiang Zhao, Feng Qu, Yuanyu Huang*. Identification of SARS-CoV-2-against aptamer with high neutralization activity by blocking the RBD domain of spike protein 1. Signal transduction and targeted therapy. 2021, 6(1): 1-4. (IF=18.187) https://doi.org/10.1038/s41392-021-00649-6
80. 李子玥, 杨同仁, 杨歌, 黄渊余*. 病原微生物的核酸检测分析研究进展. 应用化学. 2021, 38(5):592-604.
79. Yuhua Weng, Yuanyu Huang*. Advances of mRNA vaccines for COVID-19: a new prophylactic revolution begins. Asian Journal of Pharmaceutical Sciences. 2021, 16(3): 263-264. （IF=6.598）https://doi.org/10.1016/j.ajps.2021.02.005
78. Chunhui Li#, Junhui Zhou, Yidi Wu, Yanliang Dong, Lili Du, Tongren Yang, Yongheng Wang, Shuai Guo, Mengjie Zhang, Abid Hussain, Haihua Xiao, Yuhua Weng, Yong Huang, Xiaoxia Wang, Zicai Liang, Huiqing Cao, Yongxiang Zhao, Xing-Jie Liang, Anjie Dong, and Yuanyu Huang*. Core Role of Hydrophobic Core of Polymeric Nanomicelle in Endosomal Escape of siRNA. Nano Letters. 2021, 21(8): 3680–3689. （IF=11.189）https://dx.doi.org/10.1021/acs.nanolett.0c04468
77. Tongren Yang#, Dong Huang#, Chunhui Li, Deyao Zhao, Junshi Li, Mengjie Zhang, Yufeng Chen, Qining Wang, Zicai Liang, Xing-Jie Liang, Zhihong Li*, Yuanyu Huang*. Rolling microneedle electrode array (RoMEA) empowered nucleic acid delivery and cancer immunotherapy. Nano Today. 2021, 36：101017. （IF=20.722）https://doi.org/10.1016/j.nantod.2020.101017
76. Shuai Guo, Bei Liu, Mengjie Zhang, Chunhui Li, Xiaoxia Wang, Yuhua Weng, Lele Li, Yuanyu Huang*. A novel polyethyleneimine-decorated FeOOH nanoparticle for efficient siRNA delivery. Chinese Chemical Letters. 2021, 32(1): 102-106. （IF=6.779）https://doi.org/10.1016/j.cclet.2020.11.024
2020
75. Tongren Yang#, Chunhui Li#, Xiaoxia Wang#, Deyao Zhao, Mengjie Zhang, Huiqing Cao, Zicai Liang, Haihua Xiao, Xing-Jie Liang, Yuhua Weng*, Yuanyu Huang*. Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle. Bioactive Materials. 2020, 5 (4): 1053-1061. （IF=14.593）https://doi.org/10.1016/j.bioactmat.2020.07.003
74. Shuyi Wang, Jing Ma, Shuai Guo, Yuanyu Huang*, Yi Cao*. Transcriptomic analysis revealed that multi-walled carbon nanotubes diameter-dependently induced pyroptosis in THP-1 macrophages. NanoImpact. 2020, 20: 100270. （IF=5.478）https://doi.org/10.1016/j.impact.2020.100270
73. Tongren Yang, Chanchan Yu, Changrong Wang, Chunhui Li, Mengjie Zhang, Xiaofan Luo, Yuhua Weng, Anjie Dong, Xiaoqiong Li, Yulin Deng, Yuanyu Huang*. The microgravity enhanced polymer-mediated siRNA gene silence by improving cellular uptake. Biophysics Reports. 2020. 6(6): 266-277. https://doi.org/10.1007/s41048-020-00121-y
72. Kun Li, Mei Lu, Xinhua Xia, Yuanyu Huang*. Recent advances in photothermal and RNA interfering synergistic therapy. Chinese Chemical Letters. 2020, 32(3): 1010-1016.（IF=6.779） https://doi.org/10.1016/j.cclet.2020.09.010
71. Dongxiao Yin, Mengjie Zhang, Jiaxin Chen, Yuanyu Huang*, Dehai Liang*. Shear-responsive peptide/siRNA complexes as lung-targeting gene vectors. Chinese ChemicalLetters. 2020, 32(5): 1731-1736. （IF=6.779） https://doi.org/10.1016/j.cclet.2020.12.005
70. Houli Liu, Lili Huang, Mingchuan Mao, Jingjing Ding, Guanghao Wu, Wenlin, Fan Tongren Yang, Mengjie Zhang, Yuanyu Huang*, Hai‐Yan Xie*. Viral Protein‐Pseudotyped and siRNA‐Electroporated Extracellular Vesicles for Cancer Immunotherapy. Adv. Funct. Mater. 2020: 2006515. https://doi.org/10.1002/adfm.202006515
69. Yuquan Zhang, Shuai Guo, Yuhua Weng, Yongfei Yang, Yuanyu Huang*. Progresses of aggregation-induced emission materials in drug delivery and disease treatment. CIESC Journal. 2020, 71(9): 4102-4111. https://doi.org/10.11949/0438-1157.20200569
68.张玉权,黄渊余*.聚集诱导发光荧光探针在生物成像中的研究进展.生命科学仪器.2020,18(04): 3-11. https://doi.org/10.11967/2020180801
67. Mengjie Zhang, Yuhua Weng, Ziyang Cao, Shuai Guo, Bo Hu, Mei Lu, Weisheng Guo, Tongren Yang, Chunhui Li, Xianzhu Yang, and Yuanyu Huang*. ROS-Activatable siRNA-Engineered Polyplex for NIR-Triggered Synergistic Cancer Treatment. Acs Applied Materials & Interfaces. 2020, 12(29): 32289-32300. （IF=8.758）https://doi.org/10.1021/acsami.0c06614
66. Bo Hu, Liping Zhong, Yuhua Weng, Ling Peng, Yuanyu Huang*, Yongxiang Zhao*, Xing-Jie Liang*. Therapeutic siRNA: state of the art. Sig Transduct Target Ther. 2020, 5(1): 1-25.（IF=13.493） https://doi.org/10.1038/s41392-020-0207-x
65. 赵子璇＃,李春辉＃,周莉莉,赵德尧,翁郁华,夏新华,黄渊余*.CRISPR/Cas系统递送技术及其应用研究进.生物化学与生物物理进展. 2020,47(04): 286-299. https://doi.org/10.16476/j.pibb.2019.0281
64. Mei Lu, Yuanyu Huang*. Bioinspired exosome-like therapeutics and delivery nanoplatforms.Biomaterials.2020,242:119925.（IF=10.317）https://doi.org/10.1016/j.biomaterials.2020.119925
63. Deyao Zhao, Ge Yang, Qing Liu, Wenjing Liu, Yuhua Weng, Yi Zhao, Feng Qu, Lele Li, Yuanyu Huang*. A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNAdelivery.Nanoscale.2020,12(20):10939-10943.（IF=6.895） https://doi.org/10.1039/D0NR00301H
62. Yuhua Weng, Chunhui Li, Tongren Yang, Bo Hu, Mengjie Zhang, Shuai Guo, Haihua Xiao, Xing-Jie Liang, Yuanyu Huang*. The challenge and prospect of mRNA therapeutics landscape.BiotechnologyAdvances.2020,40:107534.（IF=10.744） https://doi.org/10.1016/j.biotechadv.2020.107534
61. Yuhua Weng, Qianqian Huang, Chunhui Li, Yongfeng Yang, Xiaoxia Wang, Jie Yu, Yuanyu Huang*, Xing-Jie Liang*. Improved Nucleic Acid Therapy with Advanced Nanoscale Biotechnology.Molecular Therapy - Nucleic Acids.2020.19: 581-601. https://doi.org/10.1016/j.omtn.2019.12.004
2019
60. Bo Hu#, Yuhua Weng#, Xin Hua Xia, Xing‐jie Liang, Yuanyu Huang*. Clinical advances of siRNA therapeutics. J Gene Med. 2019, 21 (7): e3097. https://doi.org/10.1002/jgm.3097
59. 李春辉,胡泊,翁郁华,黄渊余*.基因治疗的现状与临床研究进展.生命科学仪器,2019,17(Z1): 3-12. https://doi.org/10.11967/2019170801
58. Yuhua Weng, Haihua Xiao, Jinchao Zhang, Xing-Jie Liang, Yuanyu Huang*. RNAi therapeutic and its innovative biotechnological evolution. Biotechnology Advances. 2019, 37 (5): 801-825. （IF=10.744）https://doi.org/10.1016/j.biotechadv.2019.04.012
57.黄渊余*.首例RNA干扰药物问世及该领域技术演化历程.生物化学与生物物理进展. 2019,46 (3): 313-322. https://doi.org/10.16476/j.pibb.2018.0249
56. Dong Huang#, Deyao Zhao#, Jinhui Li, Yuting Wu, Lili Du, Xin-Hua Xia, Xiaoqiong Li, Yulin Deng, Zhihong Li and Yuanyu Huang*. Continuous Vector-free Gene Transfer with a Novel Microfluidic Chip and Nanoneedle Array. Current Drug Delivery. 2019, 16: 164-170. （IF=1.582）https://doi.org/10.2174/1567201815666181017095044
2018
55. Tingbin Zhang#, Yuanyu Huang#, Xiaowei Ma#, Ningqiang Gong, Xiaoli Liu, Lu Liu, Xiaoxia Ye, Bo Hu, Chunhui Li, Jian-Hua Tian, Andrea Magrini, Jinchao Zhang, Weisheng Guo*, Jin-Feng Xing*, Massimo Bottini, Xing-Jie Liang*. Fluorinated Oligoethylenimine Nanoassemblies for Efficient siRNA-Mediated Gene Silencing in Serum-Containing Media by Effective Endosomal Escape. Nano Letters. 2018, 18 (10): 6301-6311. （IF=11.238）https://doi.org/10.1021/acs.nanolett.8b02553
54. Shuquan Zheng#, Xiaoxia Wang#, Yu-Hua Weng#, Xingyu Jin, Jia-Li Ji, Liangxia Guo, Bo Hu, Nan Liu, Qiang Cheng, Jianqi Zhang, Huicheng Bai, Tongren Yang, Xin-Hua Xia, Hong-Yan Zhang, Shan Gao, Yuanyu Huang*. siRNA Knockdown of RRM2 Effectively Suppressed Pancreatic Tumor Growth Alone or Synergistically with Doxorubicin. Molecular Therapy - Nucleic Acids. 2018, 12: 805-816. https://doi.org/10.1016/j.omtn.2018.08.003
53. Dong Huang#, Deyao Zhao#, Xiaoxia Wang, Chunhui Li, Tongren Yang, Lili Du1, Zewen Wei, Qiang Cheng, Huiqing Cao, Zicai Liang, Yuanyu Huang*, Zhihong Li*. Efficient delivery of nucleic acid molecules into skin by combined use of microneedle roller and flexible interdigitated electroporation array. Theranostics. 2018, 8 (9): 2361-2376. （IF=8.579）http://www.thno.org/v08p2361.htm
2017
52.Yuanyu Huang*. Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics.MolecularTherapy-NucleicAcids.2017,6:116-132. https://doi.org/10.1016/j.omtn.2016.12.003
2016
51. Junhui Zhou#, Yidi Wu#, Changrong Wang, Qiang Cheng, Shangcong Han, Xiaoxia Wang, Jianhua Zhang, Liandong Deng, Deyao Zhao, Lili Du, Huiqing Cao, Zicai Liang, Yuanyu Huang*, Anjie Dong*. pH-Sensitive Nanomicelles for High-Efficiency siRNA Delivery in Vitro and in Vivo: An Insight into the Design of Polycations with Robust Cytosolic Release. Nano Lett. 2016, 16(11):6916-6923. https://doi.org/10.1021/acs.nanolett.6b02915
50.Yuanyu Huang*, Qiang Cheng, Jia-Li Ji, Shuquan Zheng, Lili Du, Lingwei Meng, Yidi Wu, Deyao Zhao, Xiaoxia Wang, Li Lai, Huiqing Cao, Kai Xiao, Shan Gao, Zicai Liang*. Pharmacokinetic behaviors of intravenously administered siRNA in glandular tissues. Theranostics. 2016, 6(10): 1528-1541. （IF=8.579）https://www.thno.org/v06p1528.htm
49.Yuanyu Huang*, Qiang Cheng, Xingyu Jin, Jia-Li Ji, Shutao Guo, Shuquan Zheng, Xiaoxia Wang, Huiqing Cao, Shan Gao, Xing-Jie Liang, Quan Du*, Zicai Liang*. Systemic and Tumor-targeted Delivery of siRNA by Cyclic NGR and isoDGR Motif-containing Peptide. Biomater Sci. 2016, 4(3):494-510. https://doi.org/10.1039/C5BM00429B
2015
48. Yuanyu Huang*, Xiaoxia Wang , Weiyan Huang, Qiang Cheng, Shuquan Zheng, Shutao Guo, Huiqing Cao, Xing-Jie Liang, Quan Du*, Zicai Liang*. Systemic Administration of siRNA via cRGD-containing Peptide. Sci Rep. 2015, 5:12458. https://doi.org/10.1038/srep12458
47. Yuanyu Huang*, Zicai Liang*. Asialoglycoprotein Receptor and Its Application in Liver-targeted Drug Delivery. Prog Biochem Biophys. 2015, 42(6): 501-10. https://doi.org/10.16476/j.pibb.2015.0028
46. Zewen Wei#, Yuanyu Huang#, Deyao Zhao, Zhiyuan Hu*, Zhihong Li*, Zicai Liang*. A pliable electroporation patch (ep-Patch) for efficient delivery of nucleic acid molecules into animal tissues with irregular surface shapes. Sci Rep. 2015 , 5:7618. https://doi.org/10.1038/srep07618
2013
45.Qiang Cheng#, Yuanyu Huang# *, Hua Zheng, Tuo Wei, Shuquan Zheng, Shuaidong Huo, Xiaoxia Wang, Quan Du, Xiaoning Zhang, Hong-Yan Zhang, Xing-Jie Liang, Chun Wang, Rupei Tang*, Zicai Liang*. The effect of guanidinylation of PEGylated poly(2-aminoethyl methacrylate) on the systemic delivery of siRNA. Biomaterials. 2013, 34(12):3120-31. （IF=10.317）https://doi.org/10.1016/j.biomaterials.2013.01.043
2012
44. Yuanyu Huang#, Daoshu Lin#, Qian Jiang, Wendi Zhang, Shutao Guo, Ping Xiao, Shuquan Zheng, Xiaoxia Wang, Hongbo Chen, Hong-Yan Zhang, Liandong Deng, Jinfeng Xing, Quan Du*, Anjie Dong*, Zicai Liang*. Binary and ternary complexes based on polycaprolactone-graft-poly (N, N-dimethylaminoethyl methacrylate) for targeted siRNA delivery. Biomaterials. 2012, 33(18):4653-64. （IF=10.317）https://doi.org/10.1016/j.biomaterials.2012.02.052
2011
43. Daoshu Lin#, Yuanyu Huang#, Qian Jiang, Wendi Zhang, Xinye Yue, Shutao Guo, Ping Xiao, Quan Du, Jinfeng Xing, Liandong Deng, Zicai Liang*, Anjie Dong*. Structural contributions of blocked or grafted poly(2-dimethylaminoethyl methacrylate) on PEGylated polycaprolactone nanoparticles in siRNA delivery. Biomaterials. 2011, 32(33):8730-42. （IF=10.317） https://doi.org/10.1016/j.biomaterials.2011.07.089
42. Shutao Guo#, Yuanyu Huang#, Wendi Zhang, Weiwei Wang, Tuo We, Daoshu Lin, Jinfeng Xing, Liandong Deng, Quan Du, Zicai Liang*, Xing-Jie Liang*, Anjie Dong*. Ternary complexes of amphiphilic polycaprolactone-graft-poly (N,N-dimethylaminoethyl methacrylate), DNA and polyglutamic acid-graft-poly(ethylene glycol) for gene delivery. Biomaterials. 2011, 32(18):4283-92. （IF=10.317） https://doi.org/10.1016/j.biomaterials.2011.02.034
41. Huang Huang#, Zewen Wei#, Yuanyu Huang, Deyao Zhao, Lianghong Zheng, Tianjing Cai, Mengxi Wu, Wei Wang, Xianfeng Ding, Zhuan Zhou, Quan Du*, Zhihong Li*, Zicai Liang*. An efficient and high-throughput electroporation microchip applicable for siRNA delivery. Lab Chip. 2011, 11(1):163-72. （IF=6.774） https://doi.org/10.1039/C0LC00195C
2010
40. Guo S#, Huang Y#, Jiang Q, Sun Y, Deng L, Liang Z, Du Q, Xing J, Zhao Y, Wang PC, Dong A, Liang XJ*. Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyelectrolyte. ACS Nano. 2010 Sep 28. 4(9):5505-11. (ESI 1%) (IF= 17.1, 中科院1区)
共同作者 论文
2023
39. Qing Liu, Yuanyu Huang, Lele Li, Zhengping Li, Mengyuan Li*. Endogenous Enzyme-Operated Spherical Nucleic Acids for Cell-Selective Protein Capture and Localization Regulation. Angewandte Chemie International Edition. 2023; 62:e202214958. (IF=16.6). https://doi.org/10.1002/anie.202214958
38. Runlian Lin, Kun Ge*, Dehui Fan, Jing Li, Guoqiang Zhou, Kaihan Zhang, Yuanyu Huang, Lili Ma*, Jinchao Zhang. Multi-walled carbon nanotubes reversing the bone formation of bone marrow stromal cells by activating M2 macrophage polarization. Regenerative Biomaterials. 2023; 10:rbad042. (IF=6.7). https://doi.org/10.1093/rb/rbad042
37. Zhi Li, Wenpei Li, Shaoping Jiang, Chuan Hu, Yuanyu Huang, Maxim Shevtsov, Huile Gao*, Shaobo Ruan*. Legumain-triggered aggregable gold nanoparticles for enhanced intratumoral retention. Chinese Chemical Letters, 2023. (IF=9.1) https://doi.org/10.1016/j.cclet.2023.109150
36. Shuai Guo, Chunhui Li, Changrong Wang, Xiaowen Cao, Xinyue Liu, Xing-Jie Liang, Yuanyu Huang, Yuhua Weng*. pH-Responsive polymer boosts cytosolic siRNA release for retinal neovascularization therapy. Acta Pharmaceutica Sinica B, 2023. (IF=14.5) https://doi.org/10.1016/j.apsb.2023.09.001
35.Qing Liu, Yuanyu Huang, Lele Li, Zhengping Li, Mengyuan Li*. Endogenous Enzyme‐Operated Spherical Nucleic Acids for Cell‐Selective Protein Capture and Localization Regulation. Angewandte Chemie International Edition. 2023:e202214958. (IF=16.823) https://doi.org/10.1002/anie.202214958
2022
34. Qing Liu, Yuanyu Huang, Zhengping Li, Lele Li*, Yuliang Zhao, Mengyuan Li*. An Enzymatically Gated Catalytic Hairpin Assembly Delivered by Lipid Nanoparticles for the Tumor‐Specific Activation of Signal Amplification in miRNA Imaging. Angewandte Chemie InternationalEdition.2022,61(51):e202214230.(IF=16.823) https://doi.org/10.1002/anie.202214230
33. Chuangui Sheng, Jian Zhao, Zhenghan Di, Yuanyu Huang, Yuliang Zhao, Lele Li. Spatially resolved in vivo imaging of inflammation-associated mRNA via enzymatic fluorescence amplification in a molecular beacon. Nature Biomedical Engineering. 2022, 6(9): 1074-1084. (IF=29.234) https://doi.org/10.1038/s41551-022-00932-z
32. Shaobo Ruan*, Yuanyu Huang, Mei He, Huile Gao. Advanced Biomaterials for Cell-Specific Modulation and Restore of Cancer Immunotherapy. Advanced Science. 2022: e2200027. (IF=17.521)https://doi.org/10.1002/advs.202200027
31. Weiran Cao, Rui Li, Xing Pei, Meihong Chai, Lu Sun, Yuanyu Huang, Jiancheng Wang, Stefan Barth, Fei Yu*, Huining He*. Antibody-siRNA conjugates (ARC): Emerging siRNA drug formulation. Medicine in Drug Discovery, 2022; 15: 100128.https://doi.org/10.1016/j.medidd.2022.100128
2021
30. Yufeng Zhang, Yanliang Dong, Junhui Zhou, Wenjun Huang, Yidi Wu, Shuyue Zhao, Yongli Shi*, Suping Bai, Chunhui Li, Yuanyu Huang, Anjie Dong*. Possibility for Double Optimization of siRNA Intracellular Delivery Efficiency and Antibacterial Activity: Structure Screening of pH-sensitive Triblock Amphiphilic Polycation Micelles. Colloids Surf B Biointerfaces.2021,112178.(IF=5.268) https://doi.org/10.1016/j.colsurfb.2021.112178
29. Xue Xia, Bingyang Shi*, Lei Wang, Yang Liu, Yan Zou, Yun Zhou, Yu Chen, Meng Zheng, Yingfang Zhu, Jingjing Duan, Siyi Guo, Ho Won Jang, Yuchen Miao, Kelong Fan, Feng Bai, Wei Tao, Yong Zhao, Qingyu Yan, Gang Cheng, Huiyu Liu, Yan Jiao, Shanhu Liu, Yuanyu Huang, Daishun Ling, Wenyi Kang, Xue Xue, Daxiang Cui, Yongwei Huang, Zongqiang Cui, Xun Sun, Zhiyong Qian, Zhen Gu, Gang Han, Zhimou Yang, David Tai Leong, Aiguo Wu, Gang Liu, Xiaogang Qu, Youqing Shen, Qiangbin Wang, Gregory V. Lowry, Ertao Wang, Xing-Jie Liang, Jorge Gardea-Torresdey, Guoping Chen, Wolfgang J. Parak, Paul S. Weiss, Lixin Zhang, Martina M. Stenzel, Chunhai Fan, Ashley I. Bush, Gaiping Zhang, Christopher P. L. Grof, Xuelu Wang, David W. Galbraith, Ben Zhong Tang, Christina E. Offler*, John W. Patrick*, Chun-Peng Song*. From mouse to mouse-ear cress: Nanomaterials as vehicles in plant biotechnology.Exploration.2021,1-12. https://doi.org/10.1002/EXP.20210002
28. Dengshuai Wei#, Yingjie Yu#, Yun Huang, Yuming Jiang, Yao Zhao, Zongxiu Nie, Fuyi Wang, Wen Ma, Zhiqiang Yu, Yuanyu Huang, Xiao-Dong Zhang, Zhao-Qian Liu, Xingcai Zhang, and Haihua Xiao*. A Near-Infrared-II Polymer with Tandem Fluorophores Demonstrates Superior Biodegradability for Simultaneous Drug Tracking and Treatment Efficacy Feedback.ACSNano.2021,15(3):5428-5438.（IF=15.881） https://dx.doi.org/10.1021/acsnano.1c00076
27. Changrong Wang#, Xiaoxia Wang#, Lili Du, Yanliang Dong, Bo Hu, Junhui Zhou, Yongli Shi, Suping Bai, Yuanyu Huang, Huiqing Cao, Zicai Liang*, Anjie Dong. Harnessing pH-Sensitive Polycation Vehicles for the Efficient siRNA Delivery. ACS Applied Materials & Interfaces. 2021,13(2):2218-2229.（IF=8.758） https://dx.doi.org/10.1021/acsami.0c17866
26. Xiaoli Wu#, Han Yang#, Xingmeng Chen, Junxiao Gao, Yue Duan, Daohe Wei, Jinchao Zhang, Kun Ge, Xing-Jie Liang, Yuanyu Huang, Sizhou Feng, Rongli Zhang, Xi Chen*, Jin Chang*. Nano-herb medicine and PDT induced synergistic immunotherapy for colon cancer treatment.Biomaterials.2021,269:120654. （IF=12.479）https://doi.org/10.1016/j.biomaterials.2021.120654
25. Ge Yang#, Chao Zhu# , Liping Zhao, Linsen Lia, Yuanyu Huang, Yukui Zhang, Feng Qu*. Pressure controllable aptamers picking strategy by targets competition. Chinese Chemical Letters. 2021, 13(2): 2218- 2229. （IF=6.779） https://doi.org/10.1016/j.cclet.2020.10.018
2020
24. Chanchan Yu#, Lanju Xu, Yuanyuan Zhang, Peter S. Timashev, Yuanyu Huang, and Xing-Jie Liang*. Polymer-Based Nanomaterials for Noninvasive Cancer Photothermal Therapy.ACSAppliedPolymerMaterials.2020,2(10):4289-4305. https://dx.doi.org/10.1021/acsapm.0c00704
23. Ting Yang#, Jiamao Chen#, Lingqiang Gao, Yuanyu Huang, Guochao Liao*, Yi Cao*. Induction of lipid droplets in THP-1 macrophages by multi-walled carbon nanotubes in a diameter-dependent manner: A transcriptomic study. Toxicology Letters. 2020. 332: 65-73.（IF=3.569） https://doi.org/10.1016/j.toxlet.2020.07.007
22. Ling Ding, Zhenbin Lyu, Beatrice Louis, Aura Tintaru, Erik Laurini, Domenico Marson, Mengjie Zhang, Wanxuan Shao, Yifan Jiang, Ahlem Bouhlel, Laure Balasse, Philippe Garrigue, Eric Mas, Suzanne Giorgio, Juan Iovanna, Yuanyu Huang, Sabrina Pricl, Benjamin Guillet, and Ling Peng. Surface Charge of Supramolecular Nanosystems for In Vivo Biodistribution: A MicroSPECT/CT Imaging Study. Small. 2020, 16 (37). （IF=13.281）https://doi.org/10.1002/smll.202003290
21. Guanghao Wu#, Wei Wei#, Jinfeng Zhang, Weidong Nie, Lan Yuan, Yuanyu Huang, Liping Zuo, Lili Huang, Xiaobo Xi, Hai-Yan Xie*. self-driven bioinspired nanovehicle by leukocyte membrane-hitchhiking for early detection and treatment of atherosclerosis.Biomaterials. 2020, 250. （IF=12.479）https://doi.org/10.1016/j.biomaterials.2020.119963
20. Yang Ge, Han Shi-Miao, Zhao Li-Ping, Zhu Chao, Huang Yuan Yu, Qu Feng*. Screening of Aptamer for Human IgG Fc Fragment by Capillary Electrophoresis-Systematic Evolution of Ligands by Exponential Enrichment. Chinese Journal of Analytical Chemistry. 2020. 48(5): 601-607. （IF=0.936） https://doi.org/10.1016/S1872-2040(20)60016-0
19. Yang Ge, Zhao Yi, Han Shi-Miao, Zhu Chao, Huang Yuan Yu, Qu Feng*. Screening Aptamer of Apo-transferrin via Capillary Electrophoresis-Systematic Evolution of Ligands by Exponential Enrichment and Environmental Factors Analysis. Chinese Journal of Analytical Chemistry. 2020. 48(5): 632-641. （IF=0.936） https://doi.org/10.1016/S1872-2040(20)60019-6
2018
18. Philippe Garrigue, Jingjie Tang, Ling Ding, Ahlem Bouhlel, Aura Tintaru, Erik Laurini, Yuanyu Huang, Zhenbin Lyu, Mengjie Zhang, Samantha Fernandez, Laure Balasse, Wenjun Lan, Eric Mas, Domenico Marson, Yuhua Weng, Xiaoxuan Liu, Suzanne Giorgio, Juan Iovanna, Sabrina Pricl, Benjamin Guillet, Ling Peng*. Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors. Proceedings of the National Academy of Sciences Nov.2018,115(45):11454-11459. https://doi.org/10.1073/pnas.1812938115
17. Yiwen Dong, Tianzhu Yu, Ling Ding, Erik Laurini, Yuanyu Huang, Mengjie Zhang, Yuhua Weng, Shuting Lin, Peng Chen, Domenico Marson, Yifan Jiang, Suzanne Giorgio, Sabrina Pricl, Xiaoxuan Liu*, Palma Rocchi, Ling Peng*. A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy. J Am Chem Soc. 2018, 140(47): 16264-16274. https://doi.org/10.1021/jacs.8b10021
2017
16. Lili Du#, Junhui Zhou#, Lingwei Meng#, Xiaoxia Wang, Changrong Wang, Yuanyu Huang, Shuquan Zheng, Liandong Deng, Huiqing Cao, Zicai Liang, Anjie Dong*, Qiang Cheng*. The pH-Triggered Triblock Nanocarrier Enabled Highly Efficient siRNA Delivery for Cancer Therapy. Theranostics. 2017, 7 (14): 3432-3445. （IF=8.579）https://www.thno.org/v07p3432.htm
15. Changrong Wang#, Lili Du#, Junhui Zhou, Lingwei Meng, Qiang Cheng, Chun Wang, Xiaoxia Wang, Deyao Zhao, Yuanyu Huang, Shuquan Zheng, Huiqing Cao, Jianhua Zhang, Liandong Deng, Zicai Liang*, Anjie Dong*. Elaboration on the Distribution of Hydrophobic Segments in the Chains of Amphiphilic Cationic Polymers for Small Interfering RNA Delivery.ACSApplMaterInterfaces.2017,9(38):32463-32474. https://doi.org/10.1021/acsami.7b07337
2016
14. Juan Liu#, Tuo Wei#, Jing Zhao, Yuanyu Huang, Hua Deng, Anil Kumar, Chenxuan Wang, Zicai Liang, Xiaowei Ma*, Xing-Jie Liang*. Multifunctional aptamer-based nanoparticles for targeted drug delivery to circumvent cancer resistance. Biomaterials. 2016, 91:44-56. （IF=10.317）https://doi.org/10.1016/j.biomaterials.2016.03.013
13. Qiang Cheng*, Lili Du, Lingwei Meng, Shangcong Han, Tuo Wei, Xiaoxia Wang, Yidi Wu, Xinyun Song, Junhui Zhou, Shuquan Zheng, Yuanyu Huang, Xing-jie Liang, Huiqing Cao, Anjie Dong, Zicai Liang. The promising nanocarrier for doxorubicin and siRNA co-delivery by PDMAEMA based amphiphilic nanomicelles. ACS Appl Mater Interfaces. 2016, 8(7):4347-56. https://doi.org/10.1021/acsami.5b1178
2015
12. Shangcong Han#, Qiang Cheng#, Yidi Wu, Junhui Zhou, Xingwen Long, Tuo Wei, Yuanyu Huang, Shuquan Zheng, Jianhua Zhang, Liandong Deng, Xiaoxia Wang, Xing-Jie Liang, Huiqing Cao, Zicai Liang*, Anjie Dong*. Effects of hydrophobic core components in amphiphilic PDMAEMA nanoparticles on siRNA delivery. Biomaterials. 2015, 48:45-5（IF=10.317）https://doi.org/10.1016/j.biomaterials.2015.01.026
2014
11. Xiaoxuan Liu, Jiehua Zhou, Tianzhu Yu, Chao Chen, Qiang Cheng, Kheya Sengupta, Yuanyu Huang, Haitang Li, Cheng Liu, Yang Wang, Paola Posocco, Menghua Wang, Qi Cui, Suzanne Giorgio, Maurizio Fermeglia, Fanqi Qu, Sabrina Pricl, Yanhong Shi, Zicai Liang, Palma Rocchi, John J. Rossi, and Ling Peng*.Adaptive amphiphilic dendrimer based nanoassemblies as robust and versatile siRNA delivery systems. Angew Chem Int Ed . 2014 , 53(44):11822-7. https://doi.org/10.1002/anie.201406764
10. Yan Li#, Qiang Cheng#, Qian Jiang, Yuanyu Huang, Hongmei Liu, Yuliang Zhao, Weipeng Cao, Guanghui Ma, Fengying Dai*, Xingjie Liang*, Zicai Liang*, Xin Zhang*. Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine-polycarboxybetaine lipid for systemic delivery of siRNA. J Control Release. 2014 , 176:104-14. https://doi.org/10.1016/j.jconrel.2013.12.007
2013
9. Yun Sun#, Weipeng Cao#, Shengliang Li, Shubin Jin, Kelei Hu, Liming Hu, Yuanyu Huang, Xueyun Gao, Yan Wu*, Xing-Jie Liang*. Ultrabright and multicolorful fluorescence of amphiphilic polyethyleneimine polymer dots for efficiently combined imaging and therapy. Sci Rep. 2013 , 3:3036. https://doi.org/10.1038/srep03036
8. Tuo Wei#, Juan Liu#, Huili Ma, Qiang Cheng, Yuanyu Huang, Jing Zhao, Shuaidong Huo, Xiangdong Xue, Zicai Liang, Xing-Jie Liang*. Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo. Nano Lett. 2013 ,13(6):2528-34. https://doi.org/10.1021/nl400586t
7. Daoshu Lin#, Qian Jiang#, Qiang Cheng, Yuanyu Huang, Pingsheng Huang, Shangcong Han, Shutao Guo, Zicai Liang*, Anjie Dong*. Polycation-detachable nanoparticles self-assembled from mPEG-PCL-g-SS-PDMAEMA for in vitro and in vivo siRNA delivery. Acta Biomater. 2013, 9(8):7746-57. https://doi.org/10.1016/j.actbio.2013.04.031
6. Daoshu Lin#, Qiang Cheng#, Qian Jiang, Yuanyu Huang, Zheng Yang, Shangcong Han, Yuning Zhao, hutao Guo, Zicai Liang*, Anjie Dong*. Intracellular cleavable poly(2-dimethylaminoethyl methacrylate) functionalized mesoporous silica nanoparticles for efficient siRNA delivery in vitro and in vivo. Nanoscale. 2013, 5(10):4291-301. （IF=6.895） https://doi.org/10.1039/C3NR00294B
2011
5. Jiehua Zhou#, C Preston Neff#, Xiaoxuan Liu, Jane Zhang, Haitang Li, David D Smith, Piotr Swiderski, Tawfik Aboellail, Yuanyu Huang, Quan Du, Zicai Liang, Ling Peng, Ramesh Akkina. John J Rossi*. Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice. Mol Ther. 2011 19(12):2228-38. https://doi.org/10.1038/mt.2011.207
4.Yuanyu Huang, Junmei Hong, Shuquan Zheng, Yi Ding, Shutao Guo, Hongyan Zhang, Xiuqin Zhang, Quan Du*, Zicai Liang*. Elimination pathways of systemically delivered siRNA. Mol Ther. 2011, 19(2):381-5. https://doi.org/10.1038/mt.2010.266
3. Shutao Guo, Yuanyu Huang, Tuo Wei, Wendi Zhang, Weiwei Wang, Daoshu Lin , Xu Zhang, Anil Kumar, Quan Du, Jinfeng Xing, Liandong Deng, Zicai Liang, Paul C. Wang, Anjie Dong*, Xing-Jie Liang*. Amphiphilic and biodegradable methoxy polyethylene glycol-block-(polycaprolactone-graft-poly(2-(dimethylamino)ethyl methacrylate)) as an effective gene carrier. Biomaterials. 2011, 32(3):879-89. （IF=10.317） https://doi.org/10.1016/j.biomaterials.2010.09.052
2010
2. Xiong J#, Yu D#, Wei N, Fu H, Cai T, Huang Y, Wu C, Zheng X, Du Q, Lin D*, Liang Z*. An estrogen receptor alpha suppressor, microRNA-22, is downregulated in estrogen receptor alpha-positive human breast cancer cell lines and clinical samples. FEBS J. 2010 Mar 15. 277(7):1684-94.
1. Junmei Hong, Yuanyu Huang, Jun Li, Fan Yi, Jie Zheng, Huang Huang, Na Wei, Yongqiang Shan, Mingrui An, Hongyan Zhang, Jianguo Ji, Peizhuo Zhang, Zhen Xi, Quan Du*, Zicai Liang*. Comprehensive analysis of sequence-specific stability of siRNA. FASEB J. 2010, 24(12):4844-55. https://doi.org/10.1096/fj.09.142398
专利：
14. 梁兴杰; 黄渊余. siRNA输送载体及其制备方法和应用. 申请号: 202111240545.6.
13. 黄渊余. 特异性抑制PAK4基因表达的siRNA及其应用. 申请号: 202111242145.9.
12. 黄渊余. 可电离脂质纳米颗粒组合物、制备方法及应用. 申请号：202110713233.6.
11. 黄渊余. 一种特异识别人PLK1位点的sgRNA、质粒、纳米复合物和应用. 申请号：202110699974.3.
10. 黄渊余. 一种抗肿瘤的工程化外泌体、制备方法和应用. 申请号：2021106043119.9.
09. 黄渊余. 化合物、脂质体及其用途. 申请号：PCT/CN2021/094937.
08. 屈锋;黄渊余. 一组2019-nCoV S1蛋白的ssDNA适配体、筛选方法及应用. 申请号：202110286076.5.
07. 黄渊余.抑制 BACE1 基因表达的 siRNA 修饰物及其应用. 申请号：202110192420.4.
06. 黄渊余. 一种抑制caspase 1 基因表达的siRNA 分子及其应用. 申请号:202010990803.1.
05. 黄渊余. 一种抑制NLRP3基因表达的siRNA分子及其应用. 申请号: 202010990805.0.
04. 赵永祥;黄渊余. 银纳米靶向治疗肿瘤系统的制备与应用. 申请号:202010351882.1.
03. 张鸿雁;高山;黄渊余.一种小干扰核酸和药物组合物及其用途（Small Interfering RNA, Pharmaceutical Composition, and Application Thereof）. 申请号：201510551827. 6. PCT/CN2016/097560；国际公布号：WO2017036398A1. 中国授权公告号: CN108431224B.
02. 张鸿雁;高山;黄渊余. 一种siRNA、含有该siRNA的药物组合物和缀合物及它们的应用（siRNA, Pharmaceutical Composition and Conjugate Which Contain siRNA, and Uses Thereof）. 申请号：201510364229.8. PCT/CN2016/087034；国际公布号：WO2016206626A1. 日本授权号: JP6715325B2.
01. 李志宏;梁子才;杜权;魏泽文;黄渊余. 一种用于向活体组织中的细胞内部输运核酸的柔性电极芯片. 申请号：201110150176.1；公告号：CN102367414B.
书籍章节：
09. Chunhui Li, Yuhua Weng, Anjie Dong, Xing-Jie Liang & Yuanyu Huang*. Preparation and Evaluation of Rationally Designed Polymers for Efficient Endosomal Escape of siRNA. Gene Delivery. 2022.
08. Bo Hu, Abid Hussain, Qing Liu, Yuhua Weng, Yuanyu Huang*. Advances in mRNA Delivery and Clinical Applications. Messenger RNA Therapeutics, 277-305, 2022.
07. Abid Hussain, Yuhua Weng, Yuanyu Huang*. Chapter 9 - Graphene and graphene-based nanomaterials current applications and future perspectives. In: Shahzad, Rizvi, Yousaf, and Hussain. (eds) Drug Delivery using Nanomaterials. 2021, 209-228.
06. Zaizai Dong#, Tongren Yang#, Han Wu, Justin Brooks, Ruiguo Yang*, Yuanyu Huang*, Lingqian Chang*. Chapter 5 - Advanced microfluidic devices for cell electroporation and manipulation. In: Liu X, Sun Y. (eds) Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms. 2021, 105-123. https://doi.org/10.1016/B978-0-12-823990-2.00005-2
05. Ge Yang, Yuanyu Huang*. Aptamers for Targeted Therapy. In: Dong Y. (eds) Aptamers for Medical Applications. Springer, Singapore. 2021, Chapter 6，129-178. https://doi.org/10.1007/978-981-33-4838-7_6
04. Mei Lu#, Mengjie Zhang#, Bo Hu, Yuanyu Huang*. siRNA Design and GalNAc-Empowered Hepatic Targeted Delivery. In:Henrik J. Ditzel et al. (eds.) Design and Delivery of SiRNA Therapeutics, Methods in Molecular Biology. Springer, Singapore. 2021 ,Chapter 6. https://doi.org/10.1007/978-1-0716-1298-9_6
03. Dong Huang, Yuanyu Huang, Zhihong Li*. Transdermal Delivery of Nucleic Acid Mediated by Punching and Electroporation. In: Li S., Chang L., Teissie J. (eds) Electroporation Protocols. Methods in Molecular Biology. Humana, New York, 2020, Chapter 11, 101-112. https://doi.org/10.1007/978-1-4939-9740-4_11
02. Yuhua Weng, Yuanyu Huang*. The Advances of Biomacromolecule-based Nanomedicine in Brain Disease. In: Xue X. (eds) Nanomedicine in Brain Diseases. Springer, Singapore. 2019, chapter7, 181-208. https://doi.org/10.1007/978-981-13-8731-9_7
01. 黄渊余*, 谭信.基因与遗传.马宏.生命科学原理与技术.北京：科学出版社.2019,第五章,97-140.
