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成果及论文

2021

71 Zhang, J.; Qi, L.; Chen, G.; Yin,W.-B*. Discovery and genetic identification of amphiphilic coprogen siderophores from Trichoderm hypoxylon. Appl Microbiol Biotechnol 2021, 105 (7), 2831-2839.

70 Xu, X.; Feng, J.; Zhang, P.; Fan, J.; Yin,W.-B*. A CRISPR/Cas9 Cleavage System for Capturing Fungal Secondary Metabolite Gene Clusters. J Microbiol Biotech 2021, 31 (1), 8-15.

69 Liu, H.; Fan, J.; Zhang, P.; Hu, Y.; Liu, X.; Li, S.-M.; Yin,W.-B*. New insights into the disulfide bond formation enzymes in epidithiodiketopiperazine alkaloids. Chem Sci 2021, 12 (11), 4132-4138.

68 Liang, M.; Lyu, H. N.; Ma, Z. Y.; Li, E. W.; Cai, L.; Yin,W.-B*. Genomics-driven discovery of a new cyclodepsipeptide from the guanophilic fungus Amphichorda guana. Org Biomol Chem 2021, 19 (9), 1960-1964.

67 Liang, M.; Li, W.; Qi, L.; Chen, G.; Cai, L.; Yin,W.-B*. Establishment of a Genetic Transformation System in Guanophilic Fungus Amphichorda guana. J Fungi (Basel) 2021, 7 (2).

66  Liu, Z.; Li, W.; Zhang, P.; Fan, J.; Zhang, F.; Wang, C.; Li, S.; Sun, Y*.; Chen, S*.;Yin,W.-B*. Tricarbocyclic core formation of tyrosine-decahydrofluorenes implies a three-enzyme cascade with XenF-mediated sigmatropic rearrangement as a prerequisite. Acta Pharmaceutica Sinica B 2021.

65 Guo, Q.; Chen, J.; Ren, Y.; Yin, Z.; Zhang, J.; Yang, B.; Wang, X.; Yin, W.; Zhang, W*.; Ding, G*.; Chen, L*. Hydrazine-Containing Heterocycle Cytochalasan Derivatives From Hydrazinolysis of Extracts of a Desert Soil-Derived Fungus Chaetomium madrasense 375. Front Chem 2021, 9, 620589.

2020

64 Lyu, H. N.; Liu, H. W.; Keller, N. P.; Yin,W.-B*. Harnessing diverse transcriptional regulators for natural product discovery in fungi. Nat Prod Rep 2020, 37 (1), 6-16.

63 Xiang, P.; Ludwig-Radtke, L.; Yin,W.-B.; Li, S. M*. Isocoumarin formation by heterologous gene expression and modification by host enzymes. Org Biomol Chem 2020, 18 (26), 4946-4948.

62 Nies, J.; Ran, H.; Wohlgemuth, V.; Yin,W.-B; Li, S. M*. Biosynthesis of the Prenylated Salicylaldehyde Flavoglaucin Requires Temporary Reduction to Salicyl Alcohol for Decoration before Reoxidation to the Final Product. Org Lett 2020, 22 (6), 2256-2260.

61 Liu, H.; Pu, Y. H.; Ren, J. W.; Li, E. W.; Guo, L. X.; Yin,W.-B*. Genetic dereplication driven discovery of a tricinoloniol acid biosynthetic pathway in Trichoderma hypoxylon. Org Biomol Chem 2020, 18 (28), 5344-5348.

60 Fan, J.; Liao, G.; Ludwig-Radtke, L.; Yin,W.-B.; Li, S. M*. Formation of Terrestric Acid in Penicillium crustosum Requires Redox-Assisted Decarboxylation and Stereoisomerization. Org Lett 2020, 22 (1), 88-92.

2019

59 Zhou, S.; Zhang, P.; Zhou, H.; Liu, X.; Li, S. M.; Guo, L.; Li, K.; Yin,W.-B*. A new regulator RsdA mediating fungal secondary metabolism has a detrimental impact on asexual development in Pestalotiopsis fici. Environ Microbiol 2019, 21 (1), 416-426.

58 Zhang, P.; Zhou, S.; Wang, G.; An, Z.; Liu, X.; Li, K.; Yin,W.-B*. Two transcription factors cooperatively regulate DHN melanin biosynthesis and development in Pestalotiopsis fici. Mol Microbiol 2019, 112 (2), 649-666.

57 Wang, J.; Zhang, Y.; Liu, H.; Shang, Y.; Zhou, L.; Wei, P.; Yin,W.-B.; Deng, Z.; Qu, X*.; Zhou, Q*. A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids. Nat Commun 2019, 10 (1), 3378.

56 Chen, L.; Wu, H.; Liu, H.; Li, E.; Ren, J.; Wang, W.; Wang, S.; Yin,W.-B*. Genetic dereplication of Trichoderma hypoxylon reveals two novel polycyclic lactones. Bioorg chem 2019, 91, 103185.

55 Ma, K.; Zhang, P.; Tao, Q.; Keller, N. P.; Yang, Y.; Yin,W.-B*.; Liu, H*. Characterization and Biosynthesis of a Rare Fungal Hopane-Type Triterpenoid Glycoside Involved in the Antistress Property of Aspergillus fumigatus. Org Lett 2019, 21 (9), 3252-3256.

54 Fan, J.; Liao, G.; Kindinger, F.; Ludwig-Radtke, L.; Yin,W.-B.; Li, S. M*. Peniphenone and Penilactone Formation in Penicillium crustosum via 1,4-Michael Additions of ortho-Quinone Methide from Hydroxyclavatol to γ-Butyrolactones from Crustosic Acid. J Am Chem Soc 2019, 141 (10), 4225-4229.

53 Li, W.; Yu, J.; Li, Z.; Yin,W.-B*. Rational design for fungal laccase production in the model host Aspergillus nidulans. Sci China Life Sci 2019, 62 (1), 84-94, DOI: 10.1007/s11427-017-9304-8.

52 Li, W.; Yin,W.-B*. Genetic mining of the "dark matter" in fungal natural products. Sci China Life Sci 2019, 62 (9), 1250-1252.

51 Li, R.; Li, Z.; Ma, K.; Wang, G.; Li, W.; Liu, H. W.; Yin,W.-B.; Zhang, P.; Liu, X. Z*. Strategy for efficient cloning of biosynthetic gene clusters from fungi. Sci China Life Sci 2019, 62 (8), 1087-1095.

2018

50 Zeng, G.; Zhang, P.; Zhang, Q.; Zhao, H.; Li, Z.; Zhang, X.; Wang, C.; Yin,W.-B; Fang, W*. Duplication of a Pks gene cluster and subsequent functional diversification facilitate environmental adaptation in Metarhizium species. PLoS Genet 2018, 14 (6), e1007472.

49 Lin, H.; Lyu, H.; Zhou, S.; Yu, J.; Keller, N. P.; Chen, L.; Yin,W.-B*. Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans. Org Biomol Chem 2018, 16 (48), 4973-4976.

48 Yang, Y.; Zhang, Y.; Zhang, S.; Chen, Q.; Ma, K.; Bao, L.; Tao, Y.; Yin,W.-B; Wang, G.; Liu, H*. Identification and Characterization of a Membrane-Bound Sesterterpene Cyclase from Streptomyces somaliensis. J Nat Prod 2018, 81 (4), 1089-1092.

47 Liu, H.; Wang, G.; Li, W.; Liu, X.; Li, E.; Yin,W.-B*. A highly efficient genetic system for the identification of a harzianum B biosynthetic gene cluster in Trichoderma hypoxylon. Microbiology (Reading) 2018, 164 (5), 769-778.

46 Liu, L.; Bao, L.; Wang, L.; Ma, K.; Han, J.; Yang, Y.; Liu, R.; Ren, J.; Yin,W.-B.; Wang, W.; Liu, H*. Asperorydines A-M: Prenylated Tryptophan-Derived Alkaloids with Neurotrophic Effects from Aspergillus oryzae. J Org Chem 2018, 83 (2), 812-822.

45 Chen, L.; Wu, G. W.; Liu, D.; Zhuang, W. Y.; Yin,W.-B*. Trichodermatides E and F from fungus Trichoderma applanatum. J Asian Nat Prod Res 2018, 21 (7), 659-665.

44 Wang, Y.; Wang, L.; Wu, F.; Liu, F.; Wang, Q.; Zhang, X.; Selvaraj, J. N.; Zhao, Y.; Xing, F.; Yin,W.-B; Liu, Y*. A Consensus Ochratoxin A Biosynthetic Pathway: Insights from the Genome Sequence of Aspergillus ochraceus and a Comparative Genomic Analysis. Appl Environ Microbiol 2018, 84 (19).

43 Wang, S.-s.; Cui, H.; Ye, J.; Wu, Y.; Wang, S.-x.; Yin,W.-B*. Identification and Determination of Rubrofusarin, Rubrofusarin Isomer, and Their Quinone Forms in Grains Using High-Resolution Mass Spectrometry. ACS Omega 2018, 3 (11), 15924-15932.

42 Ma, Z.; Li, W.; Zhang, P.; Lyu, H.; Hu, Y.; Yin,W.-B*. Rational design for heterologous production of aurovertin-type compounds in Aspergillus nidulans. Appl Microbiol Biotechnol 2018, 102 (1), 297-304.

41 Liu, Z. G.; Bao, L.; Liu, H. W.; Ren, J. W.; Wang, W. Z.; Wang, L.; Li, W.; Yin,W.-B*. Chemical diversity from the Tibetan Plateau fungi Penicillium kongii and P. brasilianum. Mycology 2018, 9 (1), 10-19.

40 Li, W.; Ma, Z.; Chen, L.; Yin,W.-B*. Synthesis and production of the antitumor polyketide aurovertins and structurally related compounds. Appl Microbiol Biotechnol 2018, 102 (15), 6373-6381.

39 Li, W.; Fan, A.; Wang, L.; Zhang, P.; Liu, Z.; An, Z.; Yin,W.-B*. Asperphenamate biosynthesis reveals a novel two-module NRPS system to synthesize amino acid esters in fungi. Chem Sci 2018, 9 (9).

2017

38 Zheng, Y.; Wang, X.; Zhang, X.; Li, W.; Liu, G.; Wang, S.; Yan, X.; Zou, H.; Yin,W.-B*. COP9 signalosome subunit PfCsnE regulates secondary metabolism and conidial formation in Pestalotiopsis fici. Sci China Life Sci 2017, 60 (6), 656-664.

37 Zhao, W.; Fan, A.; Tarcz, S.; Zhou, K.; Yin,W.-B.; Liu, X. Q.; Li, S. M*. Mutation on Gly115 and Tyr205 of the cyclic dipeptide C2-prenyltransferase FtmPT1 increases its catalytic activity toward hydroxynaphthalenes. Appl Microbiol Biotechnol 2017, 101 (5), 1989-1998.

36 Zhang, P.; Wang, X.; Fan, A.; Zheng, Y.; Liu, X.; Wang, S.; Zou, H.; Oakley, B. R.; Keller, N. P.; Yin,W.-B*. A cryptic pigment biosynthetic pathway uncovered by heterologous expression is essential for conidial development in Pestalotiopsis fici. Mol Microbiol 2017, 105 (3), 469-483.

35 Yang, Y. L.; Zhang, S.; Ma, K.; Xu, Y.; Tao, Q.; Chen, Y.; Chen, J.; Guo, S.; Ren, J.; Wang, W.; Tao, Y.; Yin,W.-B ; Liu, H*. Discovery and Characterization of a New Family of Diterpene Cyclases in Bacteria and Fungi. Angew Chem Int Ed Engl 2017, 56 (17), 4749-4752.

34 Feng, J.; Zhang, P.; Cui, Y.; Li, K.; Qiao, X.; Zhang, Y.-T.; Li, S.-M.; Cox, R. J.; Wu, B.; Ye, M.; Yin,W.-B*. Regio- and StereospecificO-Glycosylation of Phenolic Compounds Catalyzed by a Fungal Glycosyltransferase from Mucor hiemalis. Adv Synth Catal 2017, 359 (6), 995-1006.

33 Fan, A.; Mi, W.; Liu, Z.; Zeng, G.; Zhang, P.; Hu, Y.; Fang, W.; Yin,W.-B*. Deletion of a Histone Acetyltransferase Leads to the Pleiotropic Activation of Natural Products in Metarhizium robertsii. Org Lett 2017, 19 (7), 1686-1689.

32 Zheng, Y.; Ma, K.; Lyu, H.; Huang, Y.; Liu, H.; Liu, L.; Che, Y.; Liu, X.; Zou, H.; Yin,W.-B*. Genetic Manipulation of the COP9 Signalosome Subunit PfCsnE Leads to the Discovery of Pestaloficins in Pestalotiopsis fici. Org Lett 2017, 19 (17), 4700-4703.

31 Han, J.; Liu, C.; Li, L.; Zhou, H.; Liu, L.; Bao, L.; Chen, Q.; Song, F.; Zhang, L.; Li, E.; Liu, L.; Pei, Y.; Jin, C.; Xue, Y.; Yin,W.-B.; Ma, Y.; Liu, H*. Decalin-Containing Tetramic Acids and 4-Hydroxy-2-pyridones with Antimicrobial and Cytotoxic Activity from the Fungus Coniochaeta cephalothecoides Collected in Tibetan Plateau (Medog). J Org Chem 2017, 82 (21), 11474-11486,.

30 Liu, L.; Wang, L.; Bao, L.; Ren, J.; Bahadur Basnet, B.; Liu, R.; He, L.; Han, J.; Yin,W.-B; Liu, H*. Versicoamides F-H, Prenylated Indole Alkaloids from Aspergillus tennesseensis. Org Lett 2017, 19 (4), 942-945.

2016

29 Wang, G.; Liu, Z.; Lin, R.; Li, E.; Mao, Z.; Ling, J.; Yang, Y.; Yin,W.-B*; Xie, B*. Biosynthesis of Antibiotic Leucinostatins in Bio-control Fungus Purpureocillium lilacinum and Their Inhibition on Phytophthora Revealed by Genome Mining. PLoS Pathog 2016, 12 (7), e1005685.

28 Wu, G.; Zhou, H.; Zhang, P.; Wang, X.; Li, W.; Zhang, W.; Liu, X.; Liu, H. W.; Keller, N. P.; An, Z.; Yin,W.-B*. Polyketide Production of Pestaloficiols and Macrodiolide Ficiolides Revealed by Manipulations of Epigenetic Regulators in an Endophytic Fungus. Org Lett 2016, 18 (8), 1832-5.

27 Tao, Q.; Ma, K.; Yang, Y.; Wang, K.; Chen, B.; Huang, Y.; Han, J.; Bao, L.; Liu, X. B.; Yang, Z.; Yin,W.-B; Liu, H*. Bioactive Sesquiterpenes from the Edible Mushroom Flammulina velutipes and Their Biosynthetic Pathway Confirmed by Genome Analysis and Chemical Evidence. J Org Chem 2016, 81 (20), 9867-9877.

26 Wang, K.; Bao, L.; Ma, K.; Qi, W.; Song, F.; Yao, Y.-J.; Yin,W.-B; Zhang, L.; Huang, Y.; Han, J.; Liu, H*. Bioactive Spirobisnaphthalenes and Lactones from a Cup Fungus Plectania sp. Collected in the Tibet Plateau Region. Eur J Org Chem 2016, 2016.

25 Ma, Z.; Li, W.; Yin,W.-B*. [Progress in heterologous expression of fungal natural products-A review]. Wei sheng wu xue bao = Acta microbiologica Sinica 2016, 56 (3), 429-40.

24 Sun, J.; Pei, Y.; Li, E.; Li, W.; Hyde, K. D.; Yin,W.-B*; Liu, X*. A new species of Trichoderma hypoxylon harbours abundant secondary metabolites. Sci Rep 2016, 6, 37369.

23 Han, X.; Qiu, M.; Wang, B.; Yin,W.-B; Nie, X.; Qin, Q.; Ren, S.; Yang, K.; Zhang, F.; Zhuang, Z.; Wang, S*. Functional Analysis of the Nitrogen Metabolite Repression Regulator Gene nmrA in Aspergillus flavus. Front Microbiol 2016, 7, 1794.

2015

22 Wang, X.; Zhang, X.; Liu, L.; Xiang, M.; Wang, W.; Sun, X.; Che, Y.; Guo, L.; Liu, G.; Guo, L.; Wang, C.; Yin,W.-B; Stadler, M.; Zhang, X*.; Liu, X*. Genomic and transcriptomic analysis of the endophytic fungus Pestalotiopsis fici reveals its lifestyle and high potential for synthesis of natural products. BMC Genomics 2015, 16, 28.

21 Wang, L.; Feng, Y.; Tian, J.; Xiang, M.; Sun, J.; Ding, J.; Yin,W.-B; Stadler, M.; Che, Y*; Liu, X*. Farming of a defensive fungal mutualist by an attelabid weevil. ISME J 2015, 9 (8), 1793-801.

20 Wang, K.; Bao, L.; Xiong, W.; Ma, K.; Han, J.; Wang, W.; Yin,W.-B; Liu, H*. Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and alpha-Glucosidase. J Nat Prod 2015, 78 (8), 1977-89.

19 Mao, X. M.; Zhan, Z. J.; Grayson, M. N.; Tang, M. C.; Xu, W.; Li, Y. Q.; Yin,W.-B; Lin, H. C.; Chooi, Y. H.; Houk, K. N.; Tang, Y*. Efficient Biosynthesis of Fungal Polyketides Containing the Dioxabicyclo-octane Ring System. J Am Chem Soc 2015, 137 (37), 11904-7.

18 Mao, X. M.; Xu, W.; Li, D.; Yin,W.-B; Chooi, Y. H.; Li, Y. Q.; Tang, Y*.; Hu, Y*. Epigenetic genome mining of an endophytic fungus leads to the pleiotropic biosynthesis of natural products. Angew Chem Int Ed Engl 2015, 54 (26), 7592-6.

17 Han, J. J.; Bao, L.; Tao, Q. Q.; Yao, Y. J.; Liu, X. Z.; Yin,W.-B; Liu, H. W*. Gloeophyllins A-J, Cytotoxic Ergosteroids with Various Skeletons from a Chinese Tibet Fungus Gloeophyllum abietinum. Org Lett 2015, 17 (10), 2538-41.

16 Wang, X.; Zhang, X.; Liu, L.; Xiang, M.; Wang, W.; Sun, X.; Che, Y.; Guo, L.; Liu, G.; Guo, L.; Wang, C.; Yin,W.-B.; Stadler, M.; Zhang, X*; Liu, X*. Genomic and transcriptomic analysis of the endophytic fungus Pestalotiopsis fici reveals its lifestyle and high potential for synthesis of natural products. BMC Genomics 2015, 16 (1), 28.

15 Qi, Q. Y.; Ren, J. W.; Sun, L. W.; He, L. W.; Bao, L.; Yue, W.; Sun, Q. M.; Yao, Y. J.; Yin,W.-B; Liu, H. W*. Stucturally Diverse Sesquiterpenes Produced by a Chinese Tibet Fungus Stereum hirsutum and Their Cytotoxic and Immunosuppressant Activities. Org Lett 2015, 17 (12), 3098-101.

14 Wang, C.; Lu, L.; Yin,W.-B.; Zhang, K. Q*. From taxonomy and industry to genetics: Fungal Biology in China. Fungal genetics and biology : FG & B 2015, 81, 110-2.

2014年之前

13 Wiemann, P.; Lechner, B. E.; Baccile, J. A.; Velk, T. A.; Yin,W.-B; Bok, J. W.; Pakala, S.; Losada, L.; Nierman, W. C.; Schroeder, F. C.; Haas, H.; Keller, N. P*. Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus. Front Microbiol 2014, 5, 530.

12 Hu, Y.; Dietrich, D.; Xu, W.; Patel, A.; Thuss, J. A.; Wang, J.; Yin,W.-B.; Qiao, K.; Houk, K. N.; Vederas, J. C*.; Tang, Y*. A carbonate-forming Baeyer-Villiger monooxygenase. Nat Chem Biol 2014, 10 (7), 552-4.

11 Yin,W.-B.; Reinke, A. W.; Szilagyi, M.; Emri, T.; Chiang, Y. M.; Keating, A. E.; Pocsi, I.; Wang, C. C. C.; Keller, N. P*. bZIP transcription factors affecting secondary metabolism, sexual development and stress responses in Aspergillus nidulans. Microbiology (Reading) 2013, 159 (Pt 1), 77-88.

10 Yin,W.-B.; Chooi, Y. H.; Smith, A. R.; Cacho, R. A.; Hu, Y.; White, T. C.; Tang, Y*. Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans. ACS Synth Biol 2013, 2 (11), 629-34.

9 Yin,W.-B.; Baccile, J. A.; Bok, J. W.; Chen, Y.; Keller, N. P*; Schroeder, F. C*. A nonribosomal peptide synthetase-derived iron(III) complex from the pathogenic fungus Aspergillus fumigatus. J Am Chem Soc 2013, 135 (6), 2064-7.

8 Amaike, S.; Affeldt, K. J.; Yin,W.-B.; Franke, S.; Choithani, A.; Keller, N. P*. The bZIP protein MeaB mediates virulence attributes in Aspergillus flavus. PLoS One 2013, 8 (9), e74030.

7 Yin,W.-B.; Reinke, A. W.; Szilágyi, M.; Emri, T.; Chiang, Y. M.; Keating, A. E.; Pócsi, I.; Wang, C. C. C.; Keller, N. P*. bZIP transcription factors affecting secondary metabolism, sexual development and stress responses in Aspergillus nidulans. Microbiology (Reading) 2013, 159 (Pt 1), 77-88.

6 Yin,W.-B.; Amaike, S.; Wohlbach, D. J.; Gasch, A. P.; Chiang, Y. M.; Wang, C. C.; Bok, J. W.; Rohlfs, M.; Keller, N. P*. An Aspergillus nidulans bZIP response pathway hardwired for defensive secondary metabolism operates through aflR. Mol Microbiol 2012, 83 (5), 1024-34.

5 Yin,W.-B.; Keller, N. P*. Transcriptional regulatory elements in fungal secondary metabolism. J Microbiol 2011, 49 (3), 329-39.

4 Yin,W.-B.; Cheng, J.; Li, S. M*. Stereospecific synthesis of aszonalenins by using two recombinant prenyltransferases. Org Biomol Chem 2009, 7 (10), 2202-7.

3 Liu, X.; Wang, L.; Steffan, N.; Yin,W.-B.; Li, S. M*. Ergot alkaloid biosynthesis in Aspergillus fumigatus: FgaAT catalyses the acetylation of fumigaclavine B. Chembiochem 2009, 10 (14), 2325-8.

2 Ruan, H. L.; Yin,W.-B.; Wu, J. Z.; Li, S. M*. Reinvestigation of a cyclic dipeptide N-prenyltransferase reveals rearrangement of N-1 prenylated indole derivatives. Chembiochem 2008, 9 (7), 1044-7.

1 Yin,W.-B.; Ruan, H. L.; Westrich, L.; Grundmann, A.; Li, S. M*. CdpNPT, an N-prenyltransferase from Aspergillus fumigatus: overproduction, purification and biochemical characterisation. Chembiochem 2007, 8 (10), 1154-61.