63. Wu, X.; Shi, Y.; Zhang, C.; Xu, K.; Xia, T.; Huang, G.*; Qu, J.; Chen, Y.* Nat. Synth. 2025, Accepted in Pricinple.
62. Fan, L.; Xi, Y.; Gu, H.; Huang, W.; Zhu, W.-H.; Qu, J.; Chen, Y.* Nat. Commun. 2025, Accepted in Pricinple.
61. Xia, T.+; Wang, Z.+; Zhang, X.; Hu, J.; Zhang, S.; Zhang, Y.; Gu, H.; Wu, X.; Zhu, W.-H.; Qu, J.; Chen, Y.* Enantioselective Redox-Neutral Radical Addition of α-Imino Esters with Sulfonyl Hydrazides. J. Am. Chem. Soc. 2025, https://doi.org/10.1021/jacs.5c16138.
60. Wu, X.+; Xia, T.+; Bai, J.+; Shi, Y.+; Fang, C.; Hu, J.; Wu, W.; Zhang, C.; Wang, Q.; Huang, G.*; Qu, J.; Chen, Y.* Enantioconvergent Radical Addition of Racemic Alkyl Halides to Access Vicinal Stereocentres.
Nat. Chem. 2025, 10.1038/s41557-025-01967-w.
59. Zhao, W.; Shen, Y.; Wu, X.; Xia, T.; Hu, J.; Qu, J.; Chen, Y.* Cobalt-Catalyzed Asymmetric Reductive Coupling of Isocyanates with Tertiary Alkyl Halides for Sterically Bulky Chiral Amide Synthesis. J. Am. Chem. Soc. 2025, 147, 27155.
58. Liu, N.+; Xia, H.+; Shi, Y.+; Xu, K.; Yu, Z.; Wu, X.; Huang, G.*; Qu, J.; Chen, Y.* 8‑Quinox Cobalt Catalyst Enables the Reductive Alkylative Addition of Sulfinylamines with Unactivated Alkyl Halides. J. Am. Chem. Soc. 2025, 147, 26786.
57. Xi, Y.; Xu, Y.; Fan, L.; Wang, C.; Xia, T.; Huang, G.*; Qu, J.; Chen, Y.* Palladium-catalyzed intermolecular asymmetric dearomatizative arylation of indoles and benzofurans. Sci. Adv. 2025, 11, eadw4471.
56. Xia, T.; Shu, X.-Z.*; Zhou, J. S.*; Chen, Y.* Catalytic Asymmetric Reductive Addition of Organic Electrophiles to Carbonyls and Beyond. CCS Chem. 2025, doi: 10.31635/ccschem.025.202506433. (invited review)
55. Bai, J.; Wang, Q.; Zhao, W.; Shen, Y.; Xin, Y.; Wu, X.; Qu, J.; Chen, Y.* Iron-Catalyzed Asymmetric Cross-Electrophile Alkylation of Imines. ACS Catal. 2025, 15, 15112.
54. Wang, Q.; Bai, J.; Wu, X.*; Qu, J.; Chen, Y.* Iron-Catalyzed Radical Addition Reaction of Dehydroglycine with Aliphatic Carboxylic Acids. Org. Lett. 2025, 27, 10212.
53. Wu, L.+; Xia, H.+; Bai, J.; Xi, Y.; Wu, X.; Gao, L.; Qu, J.; Chen, Y.* Diversified ring expansion of saturated cyclic amines enabled by azlactone insertion. Nat. Chem. 2024, 16, 1951.
Highlighted in Nat. Chem. DOI: 10.1038/s41557-024-01674-y.
Highlighted in Science. https://www.science.org/content/blog-post/rings-less-traveled.
52. Wu, X.; Xia, H.; Gao, C.; Luan, B.; Wu, L.; Zhang, C.; Yang, D.; Hou, L.; Liu, N.; Xia, T.; Li, H.; Qu, J.; Chen, Y.* Modular α-tertiary amino ester synthesis through cobalt-catalysed asymmetric aza-Barbier reaction. Nat. Chem. 2024, 16, 398.
51. Xia, H.; Jiang, X.; Lin, D.; Zhang, S.; Yu, Z.; Wu, X.; Qu, J.; Chen, Y.* Catalytic Asymmetric Barbier Reaction of Ketones with Unactivated Alkyl Electrophiles. J. Am. Chem. Soc. 2024, 146, 28468.
50. Zhang, C.; Wu, X.; Qu, J.; Chen, Y.* A General Enantioselective α-Alkyl Amino Acid Derivatives Synthesis Enabled by Cobalt-Catalyzed Reductive Addition. J. Am. Chem. Soc. 2024, 146, 25918.
49. Huang, W.+; Xi, Y.+; Pan, D.+; Fan, L.; Fang, K.; Huang, G.*; Zhu, W.-H.; Qu, J.; Chen, Y.* Palladium-Catalyzed Enantioselective Multicomponent Cross-Coupling of Trisubstituted Olefins. J. Am. Chem. Soc. 2024, 146, 16892.
48. Zhang, Y.; Cao, Q.; Xi, Y.; Wu, X.; Qu, J.; Chen, Y.* Nickel-Catalyzed Carbonylative Negishi Cross-Coupling of Unactivated Secondary Alkyl Electrophiles with 1 atm CO gas. J. Am. Chem. Soc. 2024, 146, 7971.
47. Xia, T.; Wu, W.; Wu, X.*; Qu, J.; Chen, Y.* Cobalt-Catalyzed Enantioselective Reductive α-Chloro-Carbonyl Addition of Ketimine to Construct the β-Tertiary Amino Acid Analogues. Angew. Chem. Int. Ed. 2024, 63, e202318991.
46. Xia, T.; Wu, Y.; Hu, J.; Wu, X.*; Qu, J.; Chen, Y.* Cobalt-Catalyzed Asymmetric Aza-Nozaki-Hiyama-Kishi (NHK) Reaction of α-Imino Esters with Alkenyl Halides. Angew. Chem. Int. Ed. 2024, 63, e202316012.
45. Hu, J.; Xia, T.; Wu, X.; Feng, H.; Qu, J.; Chen, Y.* Cobalt-catalyzed enantioselective reductive addition of ketimine with cyclopropyl chloride to construct chiral amino esters bearing cyclopropyl fragments. Org. Chem. Front. 2024, 11, 6311.
44. Zhang, C.; Zhang. Z.; Chen, Y.* Visible-Light-Mediated C−H Difluoroalkylation of (Hetero)arenes: A New Application of Vibration-Induced-Emission Molecule 9,14-Diphenyl- dihydrodibenzo[a,c]phenazine.
ChemCatChem. 2025, 17, e202401699.
43. Xia, T.; Yu, Z.; Wu, X.; Qu, J.; Chen, Y.* Catalytic Reductive Addition of Imine for Chiral Amine Synthesis: Recent Advances and Future Perspectives. ChemCatChem. 2024, 17, e202401407.
42. Wang, C.+; Xi, Y.+; Xia, T.; Qu, J.; Chen, Y.* Pd(0)-Catalyzed Diastereo- and Enantioselective Intermolecular Heck-Miyaura Borylation of Internal Enamides for the β-Aminoboronate Ester Synthesis. ACS Catal. 2024, 14, 418.
41. Huang, W.; Wang, C.; Zhang, Y.; Qu, J.; Chen, Y.* Nickel-Catalyzed Acylation of Vinylpyridine with Alkylzincs under 1 atm CO. Org. Biomol. Chem. 2024, 22, 2380.
40. Wang, C.+; Liu, N.+;Wu, X.*; Qu, J.; Chen, Y.* Nickel-Catalyzed Regiodivergent Acylzincation of Styrenes with Organozincs and CO. Chin. J. Chem. 2024, 42, 599.
39. Wu, X.; Wang, C.; Liu, N.; Qu, J.; Chen, Y.* Nickel-Catalyzed Acylzincation of Allenes with Organozincs and CO. Nat. Commun. 2023, 14, 6960.
38. Zhang, C. +; Xi, Y.+; Qu, J.; Chen, Y.* Pd-Catalyzed Diastereoselective 1,1-Diarylation of 1,1-Disubstituted Alkenes Enabling the Modular Synthesis of 1,1,2,2-Tetraarylethanes. Sci China Chem. 2023, 66, 3539.
37. Wu, L.; Wu, X.*; Qu, J.; Chen, Y.* Exploration of Quinim Ligand in Ni-catalyzed Enantioselective Reductive Carbamoyl-Alkylation of Alkene. Chin. J. Org. Chem. 2023, 43, 4239.
36. Chen, Y.* Ni-ANIPE-enabled Dynamic Kinetic Asymmetric Addition of Ketones with Organoboronates. Sci. China Chem. 2023, 66, 2437.
35. Wu, X.+; Li, H.+; He, F.; Qu, J.; Chen, Y.* Nickel/Quinim Enabled Asymmetric Carbamoyl-Acylation of Unactivated Alkenes. Chin. J. Chem. 2023, 41, 1673.
34. Wu, L.; Qu, J.; Chen, Y.* Merging Alkene Isomerization Enables Difunctionalization of Cyclic Enamines toward Ring-Fused Aminal Synthesis. Org. Lett. 2023, 25, 992.
33. Weng, Y.+; Zhang, Y.+; Turlik, A.+; Wu, X.+; Li, H.; Fei, F.; Yao, Y.; Wang, C.; Guo, Z.; Qu, J.; Houk, K. N.*; Chen, Y.*Nickel-Catalysed Regio- and Stereoselective Acylzincation of Unsaturated Hydrocarbons with Organozincs and CO. Nat. Synth. 2023, 2, 261.
32. Liu N.; Wu, X.*; Qu, J.; Chen, Y.* Nickel-Catalyzed Aminocarbonylation of Aryl Iodides with 1 atm CO. Chem-Asian J. 2023, 18, e202201061.
31. Zhang C.; Wu, X.; Xia, T.; Qu, J.; Chen, Y.* Ni-catalyzed Carbamoylation of Unactivated Alkenes for Stereoselective Construction of Six-Membered Lactams. Nat. Commun. 2022, 13, 5964.
30. He, F.; Hou, L.; Wu, X.; Ding, H.; Qu, J.; Chen, Y.* Enantioselective Synthesis of α-Alkenylated γ-Lactam Enabled by Ni-Catalyzed 1,4-Arycarbamoylation of 1,3-Dienes. CCS Chem. 2023, 5, 341.
29. Wang, C.; Wu, X.; Li, H.; Qu, J.; Chen, Y.* Carbonylative Cross-Coupling Reaction of Allylic Alcohols and Organoalanes with 1 atm CO Enabled by Nickel Catalysis. Angew. Chem. Int. Ed. 2022, 61, e202210484.
28. Xia, T.; Xi, Y.; Ding, H.; Zhang, Y.; Fang, K.; Wu, X.; Qu, J,; Chen, Y.* Palladium(II)-Catalyzed Enantioselective Intermolecular Oxidative Diarylation of Internal Enamides. Chem. Commun., 2022, 58, 9282.
27. Wu, X.+; Turlik, A.+; Luan, B.; He, F.; Qu, J.; Houk, K. N.*; Chen, Y.* Nickel-Catalyzed Enantioselective Reductive Alkyl-Carbamoylation of Internal Alkenes. Angew. Chem. Int. Ed. 2022, 61, e202207536.
26. Xi, Y.; Chen, Y.* Recent Advances in Transition Metal-Catalyzed Asymmetric Functionalization of Enamides. Synthesis. 2022, 54, 4464. (invited short review)
25. Luan B.; Tang Z.; Wu, X.*; Chen, Y.* 8-Quinolinyl Oxaoline: Ligand Exploration in Enantioselective Ni-Catalyzed Reductive Carbamoyl-Alkylation of Alkene to Access the Chiral Oxindoles. Synlett. 2022, 33, 1847.
24. Xi, Y.; Huang, W.; Wang, C.; Ding, H.; Xia, T.; Wu, L.; Fang, K.; Qu, J.; Chen, Y.* Catalytic Asymmetric Diarylation of Internal Acyclic Styrenes and Enamides. J. Am. Chem. Soc. 2022, 144, 8389.
23. Hou, L.; Huang, W.; Wu, X.; Qu, J.; Chen, Y.* Nickel-Catalyzed Carbonylation of Cyclopropanol with Benzyl Bromide for Multisubstituted Cyclopentenone Synthesis. Org. Lett. 2022, 24, 2699.
22. Wu, X.; Luan, B.; Zhao, W.; He, F.; Wu, X.-Y.; Qu, J.; Chen, Y.* Catalytic Desymmetric Dicarbofunctionalization of Unactivated Alkenes. Angew. Chem. Int. Ed. 2022, 61, e202111598.
21. Liu, N.+; Wu, X.+; Wang, C.; Qu, J.; Chen, Y.* Nickel-Catalyzed Alkoxycarbonylation of Aryl Iodides with 1 atm CO. Chem. Commun., 2022, 58, 4643.
20. Fang, K.; Huang, W.; Shan, C.; Qu, J.; Chen, Y.* Synthesis of 3,3-Dialkyl-Substituted Isoindolinones Enabled by Nickel-Catalyzed Reductive Dicarbofunctionalization of Enamides. Org. Lett. 2021, 23, 5523.
19. Huang, W.; Shrestha, M.; Wang, C.; Fang, K.; Teng, Y.; Qu, J.; Chen, Y.* Asymmetric Synthesis of 3-Benzyl and Allyl Isoindolinones by Pd-Catalyzed Dicarbofunctionalization of 1,1-Disubstituted Enamides. Org. Chem. Front. 2021, 8, 4106.
18. Shrestha, M.; Wu, X.; Huang, W.; Qu, J.; Chen, Y.* Recent Advances in Transition Metal-Catalyzed Reactions of Carbamoyl Chlorides. Org. Chem. Front. 2021, 8, 4024.
17. Wu, X.; Chen, Y.* Carbamoyl Fluoride-Promoted Ni-Catalyzed Asymmetric Carbamoyl-Arylation of Unactivated Alkenes. Chin. J. Org. Chem. 2021, 41, 867.
16. Weng, Y.; Qu, J.; Chen, Y.* Palladium-Catalyzed Allylic Carbonylative Negishi Cross-Coupling Reactions with Sterically Bulky Aromatic Isocyanides. Chin. J. Org. Chem. 2021, 41, 1949. (当选为当期封面文章）
15. Wu, L.;Wang, T.; Gao, C.; Huang, W.; Qu, J.; Chen, Y.* Skeletal Reconstruction of 3-Alkylidenepyrrolidines to Azepines Enabled by Pd-Catalyzed C–N Bond Cleavage. ACS Catal. 2021, 11, 1774.
14. Wu, X. #; Shrestha, M. #; Chen, Y.* Asymmetric Synthesis of α-Alkylated γ-Lactam via Nickel/8-Quinim-Catalyzed Reductive Alkyl-Carbamoylation of Unactived Alkene. Synlett. 2021, 32, 955. (invited Synpacts)
13. Xi, Y.; Wang, C.; Zhang, Q.; Qu, J.; Chen, Y.* Palladium-Catalyzed Regio-, Diastereo-, and Enantioselective1,2-Arylfluorination of Internal Enamides. Angew. Chem. Int. Ed. 2021, 60, 2699.
12. Wang, C.; Xi, Y.; Huang, W.; Qu, J.; Chen, Y.* Nickel-Catalyzed Regioselective Hydroarylation of Internal Enamides. Org. Lett. 2020, 22, 9319.
11. Wang, C.; Zhao, W.; Wu, X.; Qu, J.*; Chen, Y.* Palladium-Catalyzed Regioselective Domino Spirocyclization of Carbamoyl Chlorides with Alkynes and Benzynes. Adv. Synth. Catal. 2020, 362, 4996.
10. Wu, X.; Qu, J.*; Chen, Y.* Quinim: A New Ligand Scaffold Enables Nickel-Catalyzed Enantioselective Synthesis of α-Alkylated γ-Lactam. J. Am. Chem. Soc. 2020, 142,15654.
9.Wang, C.; Wu, L.; Xu, W.; He, F.; Qu, J.*; Chen, Y.* Palladium-Catalyzed Secondary Benzylic Imidoylative Reactions. Org. Lett. 2020, 22, 6954.
8. Zhang, C.; Wu, X.; Wang, C.; Zhang, C.; Qu, J.*; Chen, Y.* Pd/Cu-Catalyzed Domino Cyclization/Deborylation of Alkene-Tethered Carbamoyl Chloride and 1,1-Diborylmethane. Org. Lett. 2020, 22, 6376.
7. Wang, Y.; Huang, W.; Wang, C.; Qu, J.*; Chen, Y.* Nickel-Catalyzed Formal Aminocarbonylation of Secondary Benzyl Chlorides with Isocyanides. Org. Lett. 2020, 22, 4245.
6. Wu, X.; Tang, Z.; Zhang, C.; Wang, C.; Wu, L.; Qu, J.*; Chen, Y.* Pd-Catalyzed Regiodivergent Synthesis of Diverse Oxindoles Enabled by the Versatile Heck Reaction of Carbamoyl Chlorides. Org. Lett. 2020, 22, 3915.
5. Huang, W.; Wang, Y.; Weng, Y.; Qu, J.*; Chen, Y.* Nickel-Catalyzed Formal Aminocarbonylation of Unactivated Alkyl Iodides with Isocyanides. Org. Lett. 2020, 22, 3245.
4. Li, X.+; Zhang, C. +; Wang, C.; Ye, W.; Zhang, Q.; Zhang, Z.; Su, J.; Chen, Y.*; Tian, H. Modular synthesis of (C-10 to C-13)-substituted-9,14-diaryl-9,14-dihydrodibenzo[a,c]phenazines via a subsequent Buchwald–Hartwig amination and C–H amination strategy. Chem. Common. 2020, 56, 2260.
3. Weng, Y.; Zhang, C.; Tang, Z.; Shrestha, M.; Huang, W.; Qu, J.*; Chen, Y.* Nickel-Catalyzed Allylic Carbonylative Coupling of Alkyl Zinc Reagents with tert-Butyl Isocyanide. Nat. Commun. 2020, 11, 392.
2. Ye, W.; Li, X.; Ding, B.; Wang, C.; Shrestha, M.; Ma, X.; Chen, Y.* Tian, H. Facile Synthesis of Nitrogen-Containing Six-Membered Benzofuzed Phenophosphazinine Oxides and Studies of the Photophysical Properties. J. Org. Chem. 2020, 85, 3879.
1. Wu, X.; Li, X.; Huang, W.; Wang, Y.; Xu, H.; Cai, L.; Qu, J.*; Chen, Y.* Direct Transformation of Aryl-2-Pyridyl Esters to Secondary Benzylic Alcohols by Nickel Relay Catalysis. Org. Lett. 2019, 21, 2453.
Publications prior to ECUST:
1. Chen, Y.; Huang, D.; Zhao, Y.; Newhouse, T. R.* Allyl-Palladium Catalyzed Ketone Dehydrogenation Enables Telescoping with Enone a,b-Vicinal Difunctionalization. Angew. Chem. Int. Ed. 2017, 56, 8258.
2. Chen, Y.; Turlik, A.; Newhouse, T. R.* Amide a, b-Dehydrogenation Using Allyl-Palladium Catalysis and a Hindered Monodentate Anilide. J. Am. Chem. Soc. 2016, 138, 1166.
3. Chen, Y.; Romaire, J. P.; Newhouse, T. R.* Palladium-Catalyzed a, b-Dehydrogenation of Esters and Nitriles. J. Am. Chem. Soc. 2015, 137, 5875.
4. Chen, Y.; Chen, M.; Liu, Y.* Gold-Catalyzed Cyclization of 1,6-Diyne-4-en-3-ols: Stannyl Transfer from 2-Tributylstannylfuran Through Au/Sn Transmetalation. Angew. Chem. Int. Ed. 2012, 51, 6181.
5. Chen, Y.; Chen, M.; Liu, Y.* Gold-Catalyzed Cascade Cyclizations of 1,6-Diynyl Carbonates to Benzo[b]fluorenes Involving Hydroarylation of Oxocarbenium Ion Intermediates and Decarboxylative Etherification. Angew. Chem. Int. Ed. 2012, 51, 6493.
6. Chen, Y.; Wang, L.; Sun, N.; Xie, X.; Zhou, X.; Chen, H.; Li, Y.*; Liu, Y.* Gold(I)-Catalyzed Furan-yne Cyclizations Involving 1,2-Rearrangement: Efficient Synthesis of Functionalized 1-Naphthols and Its Application to the Synthesis of Wailupemycin G. Chem. Eur. J. 2014, 20, 12015.
7. Chen, Y.; Wang, L.; Li, Y.*; Liu, Y.* Grignard Reagent Acceleration of the Intramolecular Diels-Alder Reaction of Furans with Unactivated Alkynes: Toward Structurally Complex Oxabicyclic Alkene. Chem. Eur. J. 2011, 17, 12582.
8. Chen, Y.; Li, G.; Liu, Y.* Gold-Catalyzed Cascade Friedel-Crafts/Furan-Yne Cyclization/Heteroenyne Metathesis for the Highly Efficient Construction of Phenanthrene Derivatives. Adv. Syn. Catal. 2011, 353, 392.
9. Chen, Y.; Liu, Y.* A New Gold-Catalyzed Approach to Multisubstituted Fulvenes via Cycloisomerization of Furan/Ynes. J. Org. Chem. 2011, 76, 5274.
10. Chen, Y.; Lu, Y.; Li, G.; Liu, Y.* Gold-catalyzed Cascade Friedel-Crafts/Furan-Alkyne Cycloisomerizations for the Highly Efficient Synthesis of Arylated (Z)-Enones or –Enals. Org. Lett. 2009, 11, 3838.
11. Turlik, A.; Chen, Y.; Scruse, A. C.; Newhouse, T. R.* Convergent Total Synthesis of Principinol D, a Rearranged Kaurane Diterpenoid. J. Am. Chem. Soc. 2019, 141, 8088.
12. Zhao, Y.; Chen, Y.; Newhouse, T. R.* Allyl-Palladium Catalyzed a,b-Dehydrogenation of Carboxylic Acid via Enediolates. Angew. Chem. Int. Ed. 2017, 56, 13122.
13. Chen, M.; Chen, Y.; Sun, N.; Zhao, J. Liu, Y.*; Li, Y.* Gold-Catalyzed Oxidative Ring Expansion of 2-Alkynyl-1,2-Dihydropyridine or -quinolines: Highly Efficient Synthesis of Functionalized Azepine or Benzazepine Scaffolds. Angew. Chem. Int. Ed. 2015, 54, 1200.
14. Schuppe, A. W.; Huang, D.; Chen, Y.; Newhouse, T. R. Total Synthesis of (–)-Xylogranatopyridine B via a Palladium-Catalyzed Oxidative Stannylation of Enones. J. Am. Chem. Soc. 2018, 140, 2062.
