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成果及论文

28. Yunrong Chen*, Xueqian Ye, Faqian He and Xiaoyu Yang*, Asymmetric synthesis of oxazolines bearing α-stereocenters through radical addition–enantioselective protonation enabled by cooperative catalysis, Org. Chem. Front. 2021, DOI: 10.1039/D1QO00970B


27. Zheng Guo, Jinglei Xie,   Tao Hu,  Yunrong Chen,*   Houchao Tao*  and  Xiaoyu Yang*, Kinetic resolution of N-aryl β-amino alcohols via asymmetric aminations of anilines, Chem. Commun. 2021, 57, 9394-9397.


26. Mengyao Tang, Huanchao Gu, Shunlong He, Subramani Rajkumar, Xiaoyu Yang* Asymmetric Enamide-Imine Tautomerism in the Kinetic Resolution of Tertiary Alcohols, Angew. Chem. Int. Ed. 2021, 60, 21334 – 21339. (Hot Paper)


25. Qi Wei, Qingyun Zhang, Longjun Xiang, Shihao Zhang, Jianpeng Liu, Xiaoyu Yang, Youqi Ke*, and Zhijun Ning* Giant Spin Splitting in Chiral Perovskites Based on Local Electrical Field Engineering,J. Phys. Chem. Lett. 2021, 12,  6492–6498.


24. Yongkai Pan, Donglei Wang, Yunrong Chen, DeKun Zhang, Wei Liu, and Xiaoyu Yang*, Kinetic Resolution of α-Tertiary Propargylic Amines through Asymmetric Remote Aminations of Anilines, ACS Catal. 2021, 11, 8843-8848.


23.  Chaofan Zhu , Wei Liu, Fei Zhao, Yunrong Chen*, Houchao Tao*, Yu-Peng He*,  Xiaoyu Yang* Kinetic Resolution of 2,2-Disubstituted Dihydroquinolines through Chiral Phosphoric Acid-Catalyzed C6-Selective Asymmetric Halogenations Org. Lett. 2021,  23, 4104–4108.


22. Dekun Zhang, Yunrong Chen, Yongning Lai, Xiaoyu Yang* Enantioselective desymmetrization of 2-substituted and 2,2-disubstituted 1,3-propanediamines via asymmetric para-aminations of anilines, Cell Rep. Phy. Sci. 20212, 100413.


21. Wei Liu, Xiaoyu Yang*, Recent Advances in (Dynamic) Kinetic Resolution and Desymmetrization Catalyzed by Chiral Phosphoric Acids, Asian J. Org. Chem. 2021, 10, 692-710.(invited review, VIP paper)


20. Yunrong Chen, Chaofan Zhu, Zheng Guo, Wei Liu, Xiaoyu Yang* Asymmetric Synthesis of Hydroquinolines with α,α-Disubstitution via Organocatalyzed Kinetic Resolution, Angew. Chem. Int. Ed.2021, 60, 5268 –5272.



19. Jiawen Wang#, Sujuan Zheng#, Subramani Rajkumar, Jinglei Xie, Na Yu, Qian Peng* and Xiaoyu Yang* Chiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies, Nat. Commun. 2020, 11, 5527. ("Featured in Org. Chem. Highlights: C-C Bond Formation").


18. Yongkai Pan, Qianwen Jiang, Subramani Rajkumar, Chaofan Zhu, Jinglei Xie, Shaoze Yu, Yunrong Chen, Yu-Peng He* and Xiaoyu Yang*  Kinetic Resolution of 2-N-Acylamido Tertiary Allylic Alcohols: Asymmetric Synthesis of Oxazolines, Adv. Syn. Catal. 2021, 363, 200-207 (VIP paper)


17. Wei Liu, Qianwen Jiang, Xiaoyu Yang*, Versatile Method for Kinetic Resolution of Protecting-Group-Free BINAMs and NOBINs through Chiral Phosphoric Acid Catalyzed Triazane Formation, Angew. Chem. Int. Ed., 2020, 59, 23598 – 23602


16. Xueqian Ye,  Yongkai Pan,  Yunrong Chen,  Xiaoyu Yang*, Enantioselective Construction of Sulfur‐Containing Tetrasubstituted Stereocenters via Asymmetric Functionalizations of α‐Sulfanyl Cyclic Ketones, Adv. Syn. Catal. 2020, 362, 3374-3379.


15. Shunlong He, Huanchao Gu, Yu-Peng He*, and Xiaoyu Yang*,Asymmetric Aza-Diels–Alder Reactions of in Situ Generated β,β-Disubstituted α,β-Unsaturated N–H Ketimines Catalyzed by Chiral Phosphoric Acids,Org. Lett.2020, 22, 5633–5639.


14. Donglei Wang, Qianwen Jiang and Xiaoyu Yang*,Atroposelective synthesis of configurationally stable nonbiaryl N-C atropisomers through direct asymmetric aminations of 1,3-benzenediamines, Chem Commun, 2020, 56, 6201-6204. (Selected as “Chem Commun HOT Articles" by editors)


13.  Subramani Rajkumar#,  Mengyao Tang# and  Xiaoyu Yang*Chiral Phosphoric Acid‐Catalyzed Kinetic Resolution of 2‐Amido Benzyl Alcohols: Asymmetric Synthesis of 4H‐3,1‐Benzoxazines, Angew. Chem. Int. Ed., 2020, 59, 2333 –2337


12. Donglei Wang#, WeiLiu#, MengyaoTang, NaYu, XiaoyuYang*, Atroposelective Synthesis of Biaryl Diamines and Amino Alcohols via Chiral Phosphoric Acid Catalysed para-Aminations of Anilines and Phenols, iScience, 2019, 22, 195-205


11.  Xueqian Ye, Yongkai Pan and Xiaoyu Yang*Direct enantioselective Mannich reactions of α-azido cyclic ketones: asymmetric construction of chiral azides possessing an α-quaternary stereocenter, Chem. Commun. 2020, 56, 98-101.

Graphical abstract: Direct enantioselective Mannich reactions of α-azido cyclic ketones: asymmetric construction of chiral azides possessing an α-quaternary stereocenter

10. Subramani Rajkumar#, Shunlong He# and Xiaoyu Yang* Kinetic Resolution of Tertiary 2-Alkoxycarboxamido-Substituted Allylic Alcohols by Chiral Phosphoric Acid Catalyzed Intramolecular Transesterification. Angew. Chem. Int. Ed. 2019, 58, 10315-10319

     

9. Wei Liu, Subramani Rajkumar, Weihu Wu, Ziyu Huang, and Xiaoyu Yang*, Asymmetric Synthesis of β-Indolyl Cyclopentanones and Cyclopentylamides with an All-Carbon Quaternary Stereocenter via Chiral Phosphoric Acid Catalyzed Friedel–Crafts Alkylation Reactions, Org. Lett. 2019, 21, 3563-3567

        


8.  Subramani Rajkumar #, Jiawen Wang #, Xiaoyu Yang*, Asymmetric Transformations of α-Hydroxy Enamides Catalyzed by Chiral Brønsted Acids,  Synlett 2019, 30, DOI: 10.1055/s-0037-1612078 (invited synpact paper)


7. Subramani Rajkumar#, Jiawen Wang#, Sujuan Zheng, Donglei Wang, Xueqian Ye, Xuejiao Li, Qian Peng,* and Xiaoyu Yang*, Regioselective and Enantioselective Synthesis of β-Indolyl Cyclopentenamides by Chiral Anion Catalysis. Angew. Chem. Int. Ed. 2018, 57, 13489 –13494


  • 6.     Shixian Lin#; Xiaoyu Yang#, S. Jia, A.M. Weeks, M. Hornsby, P.S. Lee, R.V. Nichiporuk, A.T. Iavarone, J.A. Wells, F.D. Toste, C.J. Chang, Redox-based reagents for chemoselective methionine bioconjugation. Science 2017, 355, 597-602 (# 共同第一作者)


Selected works before joining ShanghaiTech:

5.     Xiaoyu Yang and F. Dean Toste*.  Asymmetric addition of α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid. Chem. Sci. 2016, 7, 2653-2656.

4.     Xiaoyu Yang, F. Dean Toste*. Direct Asymmetric Amination of α-Branched Cyclic Ketones Catalyzed by a Chiral Phosphoric Acid. J. Am. Chem. Soc. 2015, 137, 3205-3208.

3.     Xiaoyu Yang#, Tao Wu#, Robert J. Phipps, F. Dean Toste*.Advances in Catalytic Enantioselective Fluorination, Mono, Di, and Trifluoromethylation, and Trifluoromethylthiolation Reactions. Chem. Rev. 2015, 115, 826-870.

2.     Xiaoyu Yang#, Robert J. Phipps#, F. Dean Toste*. Asymmetric Fluorination of α-Branched Ketones Enabled by a Synergistic Combination of Chiral Anion Phase-Transfer Catalysis and Enamine Catalysis using Protected Amino Acids. J. Am. Chem. Soc. 2014, 136, 5225-5228.

1.     Xiaoyu Yang, Boqiao Fu, and Biao Yu*.Total Synthesis of Landomycin A, a Potent Antitumor Angucycline Antibiotic. J. Am. Chem. Soc. 2011, 133, 12433-12435.