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成果及论文


53. Wansen Xie, Jinmiao Zhou, Wei Liu, Tianren Qin, Xiaoyu Yang*, Divergent asymmetric synthesis of heterohelicenes via sequential organocatalyzed Povarov reaction and aromatization, Cell Rep. Phy. Sci. 2024, DOI:10.1016/j.xcrp.2024.101993

52. Jinmiao Zhou, Mengyao Tang, Xiaoyu Yang*, Catalytic Asymmetric Synthesis of Inherently Chiral Saddle-Shaped Dibenzo[b,f][1,5]diazocines, Chin. J. Chem. 2024, 42, 1953-1959. (Invited as Emerging Investigators in 2024, selected as Breaking Report)


51. Zidan Ye, Wansen Xie, Donglei Wang, Hua Liu, and Xiaoyu Yang*, Atroposelective Synthesis of Diarylamines via Organocatalyzed Electrophilic Amination, ACS Catal. 2024, 14, 4958-4967.


50. Mengyao Tang, Mengyao Yuan, Shibin Hong, Qianwen Jiang, Huanchao Gu, and Xiaoyu Yang*, Kinetic Resolution of Sulfoximines via Asymmetric Organocatalyzed Formation of Benzothiadiazine-1-oxides, Org. Lett. 2024, DOI:10.1021/acs.orglett.4c00266.


49. Dekun Zhang#, Jinmiao Zhou#, Tianren Qin, Xiaoyu Yang*,  Asymmetric synthesis of saddle-shaped eight-membered azaheterocycles via (dynamic) kinetic resolution, Chem. Catal. 2024, 4, 100827.


48. Qianwen Jiang, Dekun Zhang, Mengyao Tang, Hua Liu, Xiaoyu Yang*, (Parallel) kinetic resolution of 3,3-disubstituted indolines via organocatalyzed reactions with azodicarboxylates, Sci. China Chem. 2024, 67, 973-980.

47. Mengyao Tang, Xiaoyu Yang,* One-step synthesis of indole atropisomers with vicinal diaxes via Co-catalyzed C–H activation, Chem. Catal. 2023, 3, DOI:10.1016/j.checat.2023.100754. (Invited preview)


46. Guosong Shen , Faqian He, Wansen Xie, Huanchao Gu, and Xiaoyu Yang*, Diastereodivergent Asymmetric [4 + 2] Cycloaddition of In Situ Generated ortho-Quinone Methides and Allenyl Ketones Enabled by Chiral Phosphoric Acid Catalysis, ACS Catal. 2023, 13, 12472–12480.


45. Mengyao Tang and Xiaoyu Yang*, Catalytic Enantioselective Synthesis of Inherently ChiralMolecules: Recent Advances, Eur. J. Org. Chem. 2023, e202300738. (invited review)


44. Shaoze Yu, Hanyang Bao, Dekun Zhang and Xiaoyu Yang*, Kinetic resolution of substituted amido[2.2]paracyclophanes via asymmetric electrophilic amination, Nat. Commun. 2023, 14, 5239.


43. Zidan Ye, Wei Liu, Huanchao Gu, and Xiaoyu Yang*, Enantioselective Dearomatization of Substituted Phenols via Organocatalyzed Electrophilic Amination, Org. Lett. 2023, 25, 5838–5843.


42. Wei Liu,# Tianren Qin,# Wansen Xie, Jinmiao Zhou, Zidan Ye and Xiaoyu Yang*, Enantioselective Synthesis of Azahelicenes through Organocatalyzed Multicomponent Reactions, Angew. Chem. Int. Ed. 2023, 62, e202303430.


41. Qianwen Jiang, Wansen Xie and Xiaoyu Yang*, Asymmetric Synthesis of Highly Sterically Congested α-Tertiary Amines via Organocatalyzed Kinetic Resolution, Chem. Commun. 2023, 59, 4762-4765. (Invited as 2023 Pioneering Investigators)


40. Hanyang Bao, Yunrong Chen, Xiaoyu Yang*, Catalytic Asymmetric Synthesis of Axially Chiral Diaryl Ethers through Enantioselective Desymmetrization, Angew. Chem. Int. Ed. 2023, 62, e202300481.


39. Dekun Zhang,# Ying-Bo Shao,# Wansen Xie, Yunrong Chen, Wei Liu, Hanyang Bao, Faqian He, Xiao-Song Xue*, and Xiaoyu Yang* Remote Enantioselective Desymmetrization of 9,9-Disubstituted 9,10-Dihydroacridines through Asymmetric Aromatic Aminations, ACS Catal. 202212, 14609–14618


38. Wei Liu, Tianren Qin, Wansen Xie, Xiaoyu Yang* Catalytic Enantioselective Synthesis of Helicenes, Chem. Eur. J. 2022, 28, e202202369 (Invited Review)


37. Shaoze Yu, Guosong Shen, Faqian He and Xiaoyu Yang* Asymmetric Synthesis of Planar-chiral Macrocycles via Organocatalyzed Enantioselective Macrocyclization, Chem. Commun. 2022, 58, 7293-7296.


36. Jinglei Xie#, Zheng Guo#, Wei Liu, Dekun Zhang, Yu-Peng He*, Xiaoyu Yang* Kinetic Resolution of 1,2-Diamines via Organocatalyzed Asymmetric Electrophilic Aminations of Anilines, Chin. J. Chem. 2022, 40, 1674-1680.


35. Yunrong Chen, Wei Liu, Xiaoyu Yang*, Recent Advances in Kinetic Resolution of Tertiary Alcohols, Chin. J. Org. Chem., 2022, 42, 679-697. (Invited Review, Cover Paper) 

  


34. Donglei Wang,# Ying-Bo Shao,# Yunrong Chen, Xiao-Song Xue*, Xiaoyu Yang*, Enantioselective Synthesis of Planar-Chiral Macrocycles through Asymmetric Electrophilic Aromatic Amination. Angew. Chem. Int. Ed. 202261,  e2022010.


33. Wei Liu , Donglei Wang , Dekun Zhang , Xiaoyu Yang* Catalytic Kinetic Resolution and Desymmetrization of Amines, Synlett 2022, 33, 1788-1812 (Invited account)


32. Qianwen Jiang, Tianren Qin and Xiaoyu Yang*, Asymmetric Synthesis of Hydroquinazolines Bearing C4-Tetrasubstituted Stereocenters via Kinetic Resolution of α-Tertiary Amines, Org. Lett. 2022, 24, 625–630.


31. Faqian He, Guosong Shen and Xiaoyu Yang*, Asymmetric Aminations and Kinetic Resolution of Acyclic α-Branched YnonesChin. J. Chem. 2022, 40, 15.


30. Jiawen Wang,# Faqian He# and Xiaoyu Yang*, Asymmetric construction of acyclic quaternary stereocenters via direct enantioselective additions of α-alkynyl ketones to allenamides, Nat. Commun. 2021, 12, 6700. (Highlighted by Synfacts 2022,  10.1055/s-0041-1737523)


29. Yunrong Chen*, Xueqian Ye, Faqian He and Xiaoyu Yang*, Asymmetric synthesis of oxazolines bearing α-stereocenters through radical addition–enantioselective protonation enabled by cooperative catalysis, Org. Chem. Front. 2021, 8, 5804-5809.


28. Zheng Guo, Jinglei Xie, Tao Hu,  Yunrong Chen,* Houchao Tao*  and  Xiaoyu Yang*, Kinetic resolution of N-aryl β-amino alcohols via asymmetric aminations of anilines, Chem. Commun. 2021, 57, 9394-9397.


27. Faqian He, Jiawen Wang,   Fang Zhou,   Houchao Tao*  and  Xiaoyu Yang*, Regio- and enantioselective amination of acyclic branched α-alkynyl ketones: asymmetric construction of N-containing quaternary stereocenters,  Org. Chem. Front. 2021, 8, 5377-5382.


26. Mengyao Tang, Huanchao Gu, Shunlong He, Subramani Rajkumar, Xiaoyu Yang* Asymmetric Enamide-Imine Tautomerism in the Kinetic Resolution of Tertiary Alcohols, Angew. Chem. Int. Ed. 2021, 60, 21334 – 21339. (Hot Paper) (Hightlighted by Synfacts 2021, 17, 1144)


25. Qi Wei, Qingyun Zhang, Longjun Xiang, Shihao Zhang, Jianpeng Liu, Xiaoyu Yang, Youqi Ke*, and Zhijun Ning* Giant Spin Splitting in Chiral Perovskites Based on Local Electrical Field Engineering,J. Phys. Chem. Lett. 2021, 12,  6492–6498.


24. Yongkai Pan,# Donglei Wang,# Yunrong Chen, DeKun Zhang, Wei Liu, and Xiaoyu Yang*, Kinetic Resolution of α-Tertiary Propargylic Amines through Asymmetric Remote Aminations of Anilines, ACS Catal. 2021, 11, 8843-8848.


23.  Chaofan Zhu , Wei Liu, Fei Zhao, Yunrong Chen*, Houchao Tao*, Yu-Peng He*,  Xiaoyu Yang* Kinetic Resolution of 2,2-Disubstituted Dihydroquinolines through Chiral Phosphoric Acid-Catalyzed C6-Selective Asymmetric Halogenations Org. Lett. 2021,  23, 4104–4108.


22. Dekun Zhang, Yunrong Chen, Yongning Lai, Xiaoyu Yang* Enantioselective desymmetrization of 2-substituted and 2,2-disubstituted 1,3-propanediamines via asymmetric para-aminations of anilines, Cell Rep. Phy. Sci. 20212, 100413.


21. Wei Liu, Xiaoyu Yang*, Recent Advances in (Dynamic) Kinetic Resolution and Desymmetrization Catalyzed by Chiral Phosphoric Acids, Asian J. Org. Chem. 2021, 10, 692-710.(invited review, VIP paper)


20. Yunrong Chen, Chaofan Zhu, Zheng Guo, Wei Liu, Xiaoyu Yang* Asymmetric Synthesis of Hydroquinolines with α,α-Disubstitution via Organocatalyzed Kinetic Resolution, Angew. Chem. Int. Ed.2021, 60, 5268 –5272.



19. Jiawen Wang#, Sujuan Zheng#, Subramani Rajkumar, Jinglei Xie, Na Yu, Qian Peng* and Xiaoyu Yang* Chiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies, Nat. Commun. 2020, 11, 5527. ("Featured in Org. Chem. Highlights: C-C Bond Formation").


18. Yongkai Pan, Qianwen Jiang, Subramani Rajkumar, Chaofan Zhu, Jinglei Xie, Shaoze Yu, Yunrong Chen, Yu-Peng He* and Xiaoyu Yang*  Kinetic Resolution of 2-N-Acylamido Tertiary Allylic Alcohols: Asymmetric Synthesis of Oxazolines, Adv. Syn. Catal. 2021, 363, 200-207 (VIP paper)


17. Wei Liu, Qianwen Jiang, Xiaoyu Yang*, Versatile Method for Kinetic Resolution of Protecting-Group-Free BINAMs and NOBINs through Chiral Phosphoric Acid Catalyzed Triazane Formation, Angew. Chem. Int. Ed., 2020, 59, 23598 – 23602


16. Xueqian Ye,  Yongkai Pan,  Yunrong Chen,  Xiaoyu Yang*, Enantioselective Construction of Sulfur‐Containing Tetrasubstituted Stereocenters via Asymmetric Functionalizations of α‐Sulfanyl Cyclic Ketones, Adv. Syn. Catal. 2020, 362, 3374-3379.


15. Shunlong He, Huanchao Gu, Yu-Peng He*, and Xiaoyu Yang*,Asymmetric Aza-Diels–Alder Reactions of in Situ Generated β,β-Disubstituted α,β-Unsaturated N–H Ketimines Catalyzed by Chiral Phosphoric Acids,Org. Lett.2020, 22, 5633–5639.


14. Donglei Wang, Qianwen Jiang and Xiaoyu Yang*,Atroposelective synthesis of configurationally stable nonbiaryl N-C atropisomers through direct asymmetric aminations of 1,3-benzenediamines, Chem Commun, 2020, 56, 6201-6204. (Selected as “Chem Commun HOT Articles" by editors)


13.  Subramani Rajkumar#,  Mengyao Tang# and  Xiaoyu Yang*Chiral Phosphoric Acid‐Catalyzed Kinetic Resolution of 2‐Amido Benzyl Alcohols: Asymmetric Synthesis of 4H‐3,1‐Benzoxazines, Angew. Chem. Int. Ed., 2020, 59, 2333 –2337


12. Donglei Wang#, WeiLiu#, MengyaoTang, NaYu, XiaoyuYang*, Atroposelective Synthesis of Biaryl Diamines and Amino Alcohols via Chiral Phosphoric Acid Catalysed para-Aminations of Anilines and Phenols, iScience, 2019, 22, 195-205


11.  Xueqian Ye, Yongkai Pan and Xiaoyu Yang*Direct enantioselective Mannich reactions of α-azido cyclic ketones: asymmetric construction of chiral azides possessing an α-quaternary stereocenter, Chem. Commun. 2020, 56, 98-101.

Graphical abstract: Direct enantioselective Mannich reactions of α-azido cyclic ketones: asymmetric construction of chiral azides possessing an α-quaternary stereocenter

10. Subramani Rajkumar#, Shunlong He# and Xiaoyu Yang* Kinetic Resolution of Tertiary 2-Alkoxycarboxamido-Substituted Allylic Alcohols by Chiral Phosphoric Acid Catalyzed Intramolecular Transesterification. Angew. Chem. Int. Ed. 2019, 58, 10315-10319

     

9. Wei Liu, Subramani Rajkumar, Weihu Wu, Ziyu Huang, and Xiaoyu Yang*, Asymmetric Synthesis of β-Indolyl Cyclopentanones and Cyclopentylamides with an All-Carbon Quaternary Stereocenter via Chiral Phosphoric Acid Catalyzed Friedel–Crafts Alkylation Reactions, Org. Lett. 2019, 21, 3563-3567

        


8.  Subramani Rajkumar #, Jiawen Wang #, Xiaoyu Yang*, Asymmetric Transformations of α-Hydroxy Enamides Catalyzed by Chiral Brønsted Acids,  Synlett 2019, 30, DOI: 10.1055/s-0037-1612078 (invited synpact paper)


7. Subramani Rajkumar#, Jiawen Wang#, Sujuan Zheng, Donglei Wang, Xueqian Ye, Xuejiao Li, Qian Peng,* and Xiaoyu Yang*, Regioselective and Enantioselective Synthesis of β-Indolyl Cyclopentenamides by Chiral Anion Catalysis. Angew. Chem. Int. Ed. 2018, 57, 13489 –13494


  • 6.     Shixian Lin#; Xiaoyu Yang#, S. Jia, A.M. Weeks, M. Hornsby, P.S. Lee, R.V. Nichiporuk, A.T. Iavarone, J.A. Wells, F.D. Toste, C.J. Chang, Redox-based reagents for chemoselective methionine bioconjugation. Science 2017, 355, 597-602 (# 共同第一作者)


Selected works before joining ShanghaiTech:

5.     Xiaoyu Yang and F. Dean Toste*.  Asymmetric addition of α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid. Chem. Sci. 2016, 7, 2653-2656.

4.     Xiaoyu Yang, F. Dean Toste*. Direct Asymmetric Amination of α-Branched Cyclic Ketones Catalyzed by a Chiral Phosphoric Acid. J. Am. Chem. Soc. 2015, 137, 3205-3208.

3.     Xiaoyu Yang#, Tao Wu#, Robert J. Phipps, F. Dean Toste*.Advances in Catalytic Enantioselective Fluorination, Mono, Di, and Trifluoromethylation, and Trifluoromethylthiolation Reactions. Chem. Rev. 2015, 115, 826-870.

2.     Xiaoyu Yang#, Robert J. Phipps#, F. Dean Toste*. Asymmetric Fluorination of α-Branched Ketones Enabled by a Synergistic Combination of Chiral Anion Phase-Transfer Catalysis and Enamine Catalysis using Protected Amino Acids. J. Am. Chem. Soc. 2014, 136, 5225-5228.

1.     Xiaoyu Yang, Boqiao Fu, and Biao Yu*.Total Synthesis of Landomycin A, a Potent Antitumor Angucycline Antibiotic. J. Am. Chem. Soc. 2011, 133, 12433-12435.