课题和项目：
在研项目：
1. 国家自然科学基金面上项目、青春期应激导致暴力/抑郁性别差异的BNST及环路机制研究（82471536）、2025-2028（49万）在研
2. 国家自然科学基金青年科学基金项目（C类）、神经发育期Ctnnb1缺陷导致认知障碍的皮层-丘脑环路机制研究（32500517）、2026-2028（30万）在研（课题组成员：王为）
3. 教育部海外引才专项、孤独症高风险基因致病机制及无创干预研究、2024-2026（XXX万）在研
4. 温州市瓯越创新团队、压力应激与精神健康创新团队（2024R2002）、2025-2027（100万）在研
5. 温州市重大科技创新攻关项目、基于整合生物学的精神分裂症精准诊疗标志物筛选与机制研究（ZY2023006）、2024-2026（40万）在研
6. 瓯江实验室启动项目、孤独症高风险基因致病机制及无创干预研究(OJQD2022002)、2022-2027（XXX万）在研
7. 横向课题、低强度脉冲超声神经调控安全性实验（OJHX202401）、202501-202512（11万）在研
已结题科研项目：
1. 国家自然科学基金青年科学基金项目、rTMS调节AD认知功能的突触可塑性机制研究、2015-2017（22万）结题
2. 重庆医科大学附属儿童医院杰出青年计划B类人才、rTMS调节孤独症的机制研究，2015-2016（75万）结题
3. 中国博士后科学基金第56批面上资助“西部地区博士后人才资助计划”、rTMS调节AD认知功能的突触可塑性机制研究，2014-2016（5万）结题
4. 2014年“重庆市博士后科研项目特别资助”项目、低频rTMS调节AD认知功能的突触可塑性机制研究，2014-2016（10万）结题
5. 天津医科大学“211工程”博士创新基金、rTMS修复Aβ模型大鼠记忆损伤的机制研究，2010-2013（8万）结题
代表论著 (*通讯作者，†共同第一作者)
Google Scholar Citations: 1,900; h-index: 25; i10-index: 33
2025
1. Yiqing Wu†, Yonghe Tang†, Yufei Mei†, Wei Wang†, Qiangfeng Dun, Tingting Gao, Xinzhou Lyv, Feiyan Zhou, Yuanyu Fu, Zhuowen Zhao, Jingyu Dai, Juntao Zhu, Yan Wang, Chuang Yang, Haisu Chen, Panpan Wang, Jinan Xu, Huanxin Chen, Zhongxia Shen, Hang Zhao, Yiduo Kou, Yan Lyv, Hongjun Luo, Hui Li, Wenhong Luo, Jianhua Cheng, Ping Zhang*, Tao Tan* and Zhiqian Tong*. (2025) Decoding Depression: Stress-derived formaldehyde initiates depressive symptoms in mouse and human. Molecular Psychiatry. (2025/10/10 accept) (中科院1区，IF 10.1)
2. Xiaohua Zhang†, Yuanjie Zhao†, Xinlin Chen, Wenhua Shen, Li Huang, Tao Tan*. Suppression of astrocytic PirB alleviates Aβ-induced excitotoxicity and cognitive deficits via EAAT expression. GLIA. (2025/12/4 accept)（中科院2区，IF 5.1）
3. Jingyao Gao, Tong Ye, Xingwang Chen, Jie Yang, Shumin Wu, Wei Wang, Zhipei Liu, Li Huang, Weihong Song*, Tao Tan*. (2025) Advances in chemogenetics: a review of DREADDs and its application in psychiatric disorders. Molecular Psychiatry. 2025 Oct 17. doi: 10.1038/s41380-025-03305-5. (中科院1区，IF 10.1)
4. Gao J†, Wu S†, Yang J, Ye T, Yang J, Shen W, Chen X, Huang L, Pang R, Lin P, Lin J, Zhou Y, Wang W, Tan T*. Comprehensive behavioral characterization and impaired hippocampal synaptic transmission in R1117X Shank3 mutant mice. Translational Psychiatry. 2025 Aug 9;15(1):274. doi: 10.1038/s41398-025-03505-1. (中科院2区，IF 6.2)
5. Liu S, Liu X, Duan Y, Huang L, Ye T, Gu N*, Tan T*, Zhang Z*, Sun J*. (2025). PIEZO2 is the underlying mediator for precise magnetic stimulation of PVN to improve autism-like behavior in mice. Journal of Nanobiotechnology. 2025 Jul 8;23(1):494. doi: 10.1186/s12951-025-03557-x. (中科院1区，IF 12.6)
6. Liu S†, Yang Q†, Zhu P, Liu X, Lu Q, Yang J, Gao J, Han H, Zhang Z*, Gu N*, Tan T*, Sun J*. (2025) Precise Magnetic Stimulation of the Paraventricular Nucleus Improves Sociability in a Mouse Model of ASD. Neuroscience Bulletin. 2025 Aug 4. doi: 10.1007/s12264-025-01444-x (中科院2区，IF 5.8)
7. Luo Q, Ye X, Xu J, Sun Z, Wang P, Chen H, Gao T, Deng Q, Wang Z, Wang Q, Chen X, Zhao Z, Wu Y, Yang C, Lyv W, Lyv X, Li Y, Zhao H, Jiang K, Gu Z, Lin J, Sun Y, Tan T*, Xu H*, Tong Z*. (2025). Low-intensity pulsed ultrasound enhances delivery of 30 nm Q10 for improving mental and memory disorder in APP/PS1 mice. Drug Delivery and Translational Research. 2025 Feb 24. doi: 10.1007/s13346-025-01814-y. (中科院2区，IF 5.7)
8. Ni T†, Sun Y†, Li Z†, Tan T†, Han W, Li M, Zhu L, Xiao J, Wang H, Zhang W, Ma Y, Wang B, Wen D, Chen T, Tubbs J, Zeng X*, Yan J*, Gui H*, Sham P, Guan F*. (2025). Integrated Transcriptome Analysis Reveals Novel Molecular Signatures for Schizophrenia Characterization. Advanced Science. 2025 Jan;12(2):e2407628. doi: 10.1002/advs.202407628. (中科院1区，IF 14.1)
9. Ma C, Ye Y, Shi X, Li N, Mu Z, Tan T, Yin H, Dai J, Liu Y, Chen H*. (2025). Photobiomodulation mitigates blood-brain barrier disruption in APP/PS1 mouse model of Alzheimer's disease by activating the AMPK pathway. Alzheimer's Research & Therapy. 2025 Jun 23;17(1):141. doi: 10.1186/s13195-025-01787-7. (中科院1区，IF 7.6)
10. Chen H*, Li N, Liu N, Zhu H, Ma C, Ye Y, Shi X, Luo G, Dong X, Tan T, Wei X*, Yin H*. (2025). Photobiomodulation modulates mitochondrial energy metabolism and ameliorates neurological damage in an APP/PS1 mousmodel of Alzheimer’s disease. Alzheimer's Research & Therapy. 2025 Apr 5;17(1):72. doi: 10.1186/s13195-025-01714-w. (中科院1区，IF 7.6)
11. Qiu W, Chen R, Pan L, Li Y, Xu Y, Li Y, Guo A, Huang W, Tan T, Li P, Xie Ch, Xu H, Lin L, Wang X*. (2025). Edaravone dexborneol exerts anti-epileptic effects on rodent temporal lobe epilepsy by promoting NMDAR deactivation and inhibiting oxidative stress. Phytomedicine. 2025 May;140:156558. doi: 10.1016/j.phymed.2025.156558. (中科院1区，IF 6.7)
2024
1. Tan T, Palumbo S* (2024): Editorial: Reviews in emotional and behavioral dyscontrol in neurological disorders. Frontiers in Behavioral Neuroscience. 2024 Jul 22;18:1447287. doi: 10.3389/fnbeh.2024.1447287. (中科院3区，IF 2.6)
2. Zhao K, Zhou X, Chen M, Gou L, Mei D, Gao C, Zhao S, Luo S, Wang X*, Tan T*, Zhang Y*. (2024). Neuroprotective Effects of CXCR2 Antagonist SB332235 on Traumatic Brain Injury Through Suppressing NLRP3 Inflammasome. Neurochemical Research. 2024 Jan;49(1):184-198. doi: 10.1007/s11064-023-04021-8. (中科院3区，IF 4.4)
3. Chen Y†, Gu Y†, Wang B†, Wei A†, Dong N, Jiang Y, Liu X, Zhu L, Zhu F, Tan T, Jing Z, Mao F, Zhang Y, Yao J, Yang Y, Wang H, Wu H, Li H, Zheng C, Duan X, Huo J, Wu X, Hu S, Zhao A, Li Z, Cheng X, Qin Y, Song Q, Zhan S, Qu Q, Guan F*, Xu H*, Kang X*, Wang C*. (2024). Synaptotagmin-11 deficiency mediates schizophrenia-like behaviors in mice via dopamine over-transmission. Nature Communications. 2024 Dec 4;15(1):10571. doi: 10.1038/s41467-024-54604-4. (中科院1区，IF 15.7)
2023
1. Lin P, Yang J, Wu S, Ye T, Zhuang W, Wang W, Tan T*. (2023). Current trends of high-risk gene Cul3 in neurodevelopmental disorders. Frontiers in Psychiatry. 2023 Jul 28;14:1215110. doi: 10.3389/fpsyt.2023.1215110. (中科院3区，IF 4.7)
2. Zhuang W, Ye T, Wang W, Song W, Tan T*. (2023). CTNNB1 in neurodevelopmental disorders. Frontiers in Psychiatry. 2023 Mar 16;14:1143328. doi: 10.3389/fpsyt.2023.1143328. (中科院3区，IF 4.7)
3. Chen H*, He T, Li M, Wang C, Guo C, Wang W, Yu B, Huang J, Cui L, Guo P, Yuan Y, Tan T*. (2023) Cell-type-specific synaptic modulation of mAChR on SST and PV interneurons. Frontiers in Psychiatry. 2023 Jan 12;13:1070478. doi: 10.3389/fpsyt.2022.1070478. (中科院3区，IF 4.7)
4. Wang X†*, Mei D†, Gou L, Zhao S, Gao C, Guo J, Luo S, Guo B, Yang Z, Wang Q*, Tan T*, Zhang Y*. (2023). Functional Evaluation of a Novel GRIN2B Missense Variant Associated with Epilepsy and Intellectual Disability. Neuroscience. 2023 Aug 21;526:107-120. doi: 10.1016/j.neuroscience.2023.06.018. (中科院3区，IF 3.3)
5. Wang W, Xie X, Zhuang X, Huang Y, Tan T, Gangal H, Huang Z, Purvines W, Wang X, Stefanov A, Chen R, Rodriggs L, Chaiprasert A, Yu E, Vierkant V, Hook M, Huang Y, Darcq E, Wang J*. (2023). Striatal μ-opioid receptor activation triggers direct-pathway GABAergic plasticity and induces negative affect. Cell Reports. 2023 Feb 28;42(2):112089. doi: 10.1016/j.celrep.2023.112089. (中科院1区，IF 8.8)
已发表的其余论著（2023以前）：
1. Tan T, Wang W, Liu T, Zhong P, Conrow-Graham M, Tian X, Yan Z*. (2021). Neural circuits and activity dynamics underlying sex-specific effects of chronic social isolation stress. Cell Reports. 2021 Mar 23;34(12):108874. doi: 10.1016/j.celrep.2021.108874. (中科院1区，IF 9.99)
2. Tan T, Wang W, Williams J, Ma K, Cao Q, Yan Z*. (2019). Stress Exposure in Dopamine D4 Receptor Knockout Mice Induces Schizophrenia-Like Behaviors via Disruption of GABAergic Transmission. Schizophrenia Bulletin. 2019 Sep 11;45(5):1012-1023. doi: 10.1093/schbul/sby163. (中科院1区，IF 7.9)
3. Rapanelli M†, Tan T†, Wang W, Wang X, Wang ZJ, Zhong P, Frick L, Qin L, Ma K, Qu J, Yan Z*. (2021). Behavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3. Molecular Psychiatry. 2021 May;26(5):1491-1504. doi: 10.1038/s41380-019-0498-x. (中科院1区，IF 15.9)
4. Tan T†, Zhang Y†, Luo W†, Lv J†, Han C, Hamlin JNR, Luo H, Li H, Wan Y, Yang X, Song W*, Tong Z*. (2018). Formaldehyde induces diabetes-associated cognitive impairments. FASEB Journal. 2018 Jul;32(7):3669-3679. doi: 10.1096/fj.201701239R. (中科院2区，IF 5.6)
5. Tan T, Wang W, Xu H, Huang Z, Wang YT, Dong Z*. (2018). Low-frequency rTMS ameliorates autistic-like behaviors in rats induced by neonatal isolation through regulating the synaptic GABA transmission. Frontiers in Cellular Neuroscience. 2018 Feb 28;12:46. doi: 10.3389/fncel.2018.00046. (中科院2区，IF 4.3)
6. Ai L†, Tan T†, Tang Y†, Yang J, Cui D, Wang R, Wang A, Fei X, Di Y, Wang X, Yu Y, Zhao S, Wang W, Bai S, Yang X, He R, Lin W, Han H, Cai X, Tong Z*. (2019). Endogenous formaldehyde is a memory-related molecule in mice and humans. Communications Biology.2019 Nov 29;2:446. doi: 10.1038/s42003-019-0694-x. (中科院1区，IF 4.2)
7. Qin L, Williams JB, Tan T, Liu T, Cao Q, Ma K, Yan Z*. (2021). Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures. Nature Communications. 2021 Nov 15;12(1):6589. doi: 10.1038/s41467-021-26972-8. (中科院1区，IF 17.7)
8. Wang W, Cao Q, Tan T, Yang F, Williams JB, Yan Z*. (2021). Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model. Aging Cell. 2021 Oct;20(10):e13456. doi: 10.1111/acel.13456. (中科院1区，IF 11)
9. Rein B, Tan T, Yang F, Wang W, Williams J, Zhang F, Mills A, Yan Z*. (2021). Reversal of synaptic and behavioral deficits in a 16p11.2 duplication mouse model via restoration of the GABA synapse regulator Npas4. Molecular Psychiatry. 2021 Jun;26(6):1967-1979. doi: 10.1038/s41380-020-0693-9. (中科院1区，IF 15.9)
10. Wang W, Rein B, Zhang F, Tan T, Zhong P, Qin L, Yan Z*. (2018). Chemogenetic activation of prefrontal cortex rescues synaptic and behavioral deficits in a mouse model of 16p11.2 deletion syndrome. Journal of Neuroscience. 2018 Jun 27;38(26):5939-5948. doi: 10.1523/JNEUROSCI.0149-18.2018. (中科院1区，IF 6.1)
11. Zhu B, Zhao L, Luo D, Xu D, Tan T, Dong Z, Tang Y, Min Z, Deng X, Sun F, Yan Z, Chen G*. (2018). Furin promotes dendritic morphogenesis and learning and memory in transgenic mice. Cellular and Molecular Life Sciences. 2018 Jul;75(13):2473-2488. doi: 10.1007/s00018-017-2742-3. (中科院1区，IF 7)
12. Wei J, Zhong P, Qin L, Tan T, Yan Z*. (2018). Chemogenetic Restoration of the Prefrontal Cortex to Amygdala Pathway Ameliorates Stress-Induced Deficits. Cerebral Cortex. 2018 Jun 1;28(6):1980-1990. doi: 10.1093/cercor/bhx104. (中科院2区，IF6.3)
13. Huang, Z., Tan, T., Du, Y., Chen, L., Fu, M., Yu, Y., ... & Dong, Z*. (2017). Low-frequency repetitive transcranial magnetic stimulation ameliorates cognitive function and synaptic plasticity in APP23/PS45 mouse model of Alzheimer's disease. Frontiers in Aging Neuroscience, 9, 292. (Co-first)
14. Wei Wang, Tao Tan, Yanzhi Yu, Zhilin Huang, Yehong Du, Huili Han, Zhifang Dong*. (2017). Inhibition of AMPAR endocytosis alleviates pentobarbital-induced spatial memory deficits and synaptic depression. Behav Brain Res. (Co-first)
15. Guo D, Gan J, Tan T, et al. (2018) Neonatal exposure of ketamine inhibited the induction of hippocampal long-term potentiation without impairing the spatial memory of adult rats. Cognitive Neurodynamics, 1-7. (Co-first)
16. Wei Wang, Tao Tan, Man Tu, Wenting He, Zhifang Dong and Huili Han*. (2015). Acute Pentobarbital Treatment Impairs Spatial Learning and Memory and Hippocampal Long-Term Potentiation in Rats, Physiol Behav, 149 169-73. (Co-first)
17. Tao Tan, Jiacun Xie, Tiaotiao Liu, Xiaojia Chen, Xiaobo Zheng, Zhiqian Tong, Xin Tian*. (2013). Low frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) reverses Aβ1-42 mediated memory deficit in rats. Experimental Gerontology, Volume 48, Issue 8, Pages 786-794, 2013.
18. Tao Tan, Jiacun Xie, Zhiqian Tong, Tiaotiao Liu, Xiaojia Chen, Xin Tian*(2013). Repetitive transcranial magnetic stimulation increases excitability of hippocampal CA1 pyramidal neurons. Brain Research, Volume 1520, Pages 23-35.
19. Tan, Tao, Bao-Liang Zhang and Xin Tian*. (2011). Chronic Effects of Oligomeric Abeta1-42 on Hippocampal Synaptic Plasticity in Vivo. Acta physiologica Sinica 63, no. 3: 225-32.
20. Huang, X., Chen, Y. Y., Shen, Y., Cao, X., Li, A., Liu, Tao, T, Q., ... & Arias-Carrion, O*. (2017). Methamphetamine abuse impairs motor cortical plasticity and function. Molecular Psychiatry, 22(9), 1274.
21. Peng, Y., W. Wang, T. Tan, W. He, Z. Dong, Y. T. Wang and H. Han (2016). "Maternal sleep deprivation at different stages of pregnancy impairs the emotional and cognitive functions, and suppresses hippocampal long-term potentiation in the offspring rats." Mol Brain 9(1): 17.
22. Zhou, Limin; Bai, Yanjie; Li, Yanxi; Liu, Xueliang; Tan, Tao; Meng, Shasha; He, Wenting; Wu, Xiaobin; Dong, Zhifang. (2016). Overexpression of MCPH1 inhibits uncontrolled cell growth by promoting cell apoptosis and arresting the cell cycle in S and G2/M phase in lung cancer cells. Oncology Letters, 11, 1, 365-372.
23. Chen, L., W. Wang, T. Tan, H. Han and Z. Dong*. (2015). Gaba Receptors in the Central Nucleus of the Amygdala Are Involved in Pain- and Itch-Related Responses. J Pain.
24. Zhifang Dong, Huili Han, Tao Tan, Yutian Wang*, etc. (2014). Long-term potentiation decay and memory loss are mediated by AMPAR endocytosis. J Clin Invest, p. 1-14.
25. Xiaoyan Wu, Yanrui Bai, Tao Tan, Zhifang Dong*, etc. (2014). Lithium ameliorates autistic-like behaviors induced by neonatal isolation in rats. Front Behav Neurosci, 8: p. 1-12.
26. Liu, T., W. Bai, H. Yi, T. Tan, J. Wei, J. Wang and X. Tian (2014). Functional connectivity in a rat model of Alzheimer's disease during a working memory task. Curr Alzheimer Res 11(10): 981-991.
27. Liu Aili, Li Yize, Tan Tao, Tian Xin*, (2014). Early exposure to sevoflurane inhibits Ca2+ channels activity in hippocampal CA1 pyramidal neurons of developing rats. Brain Research, 1557: p. 1-11.
28. Chen, Xiaojia; Tan, Tao; Liu, Tiaotiao; Tian, Xin. (2013). Changes of IA and IK from the pyramidal neurons at hippocampal CA1 during the early development of rats. Sheng li xue bao:[Acta physiologica Sinica], 65, 2, 193-200
29. GUO, D. Y., TAN, T., TIAN, X., & WANG, G. L. (2012). Effect of ketamine injected into cerebro ventriles on synaptic plasticity of hippocampus in adult SD rats. Journal of Tianjin Medical University, 2, 016.
30. GUO, Dong-yong; TAN, Tao; TIAN, Xin; WANG, Guo-lin. (2012). Neonatal ketamine exposure-induced cognitive dysfunction persists into adulthood in rats, Chinese Journal of Anesthesiology. 32, 4, 420-422
31. Zhang, B., Chen, X., Lin, Y., Tan, T., Yang, Z., Dayao, C., ... & Zhang, J. (2011). Impairment of synaptic plasticity in hippocampus is exacerbated by methylprednisolone in a rat model of traumatic brain injury. Brain Research, 1382, 165-172.
32. Zhang, B. L., Chen, X., Tan, T., Yang, Z., Carlos, D., Jiang, R. C., & Zhang, J. N. (2011). Traumatic brain injury impairs synaptic plasticity in hippocampus in rats. Chinese Medical Journal-Beijing, 124(5), 740.
33. Bei, Fang; Tan, Tao; Tian, Xin. (2011). Diabetes suppresses hippocampal synaptic plasticity in rats, International Journal of Biomedical Engineering. 34, 3, 150-153
34. Bei, Fang; Tan, Tao; Tian, Xin. (2010). Study on the Use of Water Maze to Test the Change of Spatial Memory Ability in Diabetic Rats, International Journal of Biomedical Engineering. 6, 321-325
