姓名：王为
头衔：瓯江实验室助理研究员
研究兴趣和方向
1）表型、行为与神经精神疾病的遗传学基础、表观遗传学/突触可塑性/神经环路机制；
2）应激、成瘾的神经环路研究；
3）基因和表观遗传治疗、神经和网络调控在神经精神疾病中的调控作用；
4）应用Patch-seq技术解析大脑，并拓展其在神经/精神疾病中的应用。
学习与工作经历
1) 2007.09-2012.06，泸州医学院，临床医学，学士
2) 2013.09- 2016.06，重庆医科大学，儿科学，硕士
3) 2016.07-2020.06，纽约州立大学布法罗分校，生理与生物物理学，研究实习员
4) 2020.07-2022.07，得克萨斯A&M大学，神经科学与实验治疗学，研究实习员
5) 2022.08 -2023.08，贝勒医学院，神经科学，研究实习员
6) 2023.08 -至今，温州医科大学，再生调控与眼脑健康浙江省实验室， 助理研究员
代表性论著(*共同第一作者)
1) Wang W*, Xie XY*, Zhuang X, Huang Y, Tan T, Gangal H, Huang Z, Purvines W, Wang X, Stefanov A, Chen R, Rodriggs L, Chaiprasert A, Yu E, Vierkant V, Hook M, Huang Y, Darcq E, Wang J (2023) Striatal μ-opioid receptor activation triggers direct-pathway GABAergic plasticity and induces negative affect. Cell Reports. 42(2):112089. PMID: 36796365.
2) Wang W, Tan T, Cao Q, Zhang F, Rein B, Duan WM, Yan Z (2022) Epigenetic treatment of behavioral and synaptic deficits in a mouse model of 16p11.2 deletion syndrome. The International Journal of Neuropsychopharmacology. 25(10):877-889. PMID: 35907244.
3) Wang W*, Cao Q*, Tan T, Yang FW, Williams J, Yan Z (2021) Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model. Aging Cell. 20(10):e13456. PMID: 34547169.
4) Wang W*, Rein B*, Zhang F, Tan T, Zhong P, Qin L, Yan Z (2018) Chemogenetic activation of prefrontal cortex rescues synaptic and behavioral deficits in a mouse model of 16p11.2 deletion syndrome. J. Neurosci. 38(26):5939-5948. PMID: 29853627.
5) Wang W*, Tan T*, Yu Y*, Huang Z, Du Y, Han H, Dong Z (2018) Inhibition of AMPAR endocytosis alleviates pentobarbital-induced spatial memory deficits and synaptic depression. Behavioural Brain Research. 339:66-72. PMID: 29162383.
6) Tan T*, Wang W*, Xu J, Huang Z, Wang YT, Dong Z (2018) Low-frequency rTMS ameliorates autistic-like behaviors in rats induced by neonatal isolation through regulating the synaptic GABA transmission. Frontiers in cellular neuroscience. 12:46. PMID: 29541022.
7) Peng Y*, Wang W*, Tan T, He W, Dong Z, Wang YT, Han H (2016). Maternal sleep deprivation at different stages of pregnancy impairs the emotional and cognitive functions and suppresses hippocampal long-term potentiation in the offspring rats. Mol Brain. 9:17. PMID: 26876533.
8) Wang W*, Tan T*, Tu M, He W, Dong Z, Han H (2015) Acute pentobarbital treatment impairs spatial learning and memory and hippocampal long-term potentiation in rats. Physiol Behav. 149:169-73. PMID: 26056078.
主持项目
2026.01-2028.12 神经发育期Ctnnb1缺陷导致认知障碍的皮层-丘脑环路机制研究（32500517，C类）
学术活动
1) Wang J, Wang W, Xie XY, Zhuang XW, Huang YF, Tan T, Gangal H, Huang ZB, Purvines W, Wang XH, Stefanov A, Chen RF, Yu E, Hook M, Huang Y, Darcq E (2022) Striatal m-Opioid Receptor Activation Triggers Direct-Pathway GABAergic Plasticity and Induces Negative Affect. SFN 2022, San Diego (会议报告)
2) Wang W, Xie XY, Zhuang XW, Tan T, Huang ZB, Gangal H, Huang YF, Purvines W, Wang XH, Hook M, Huang Y, Wang J (2021) Chronic Opioid Administration Potentiates Striatopallidal and Striatonigral GABAergic Transmission, Neuroscience 2021, online, 2021-11-08至2021-11-11 (会议报告)
3) Wang W, Cao Q, Tan T, Yang FW, Williams J, Yan Z (2020) Epigenetic Treatment of Behavioral and Physiological Deficits in a Tauopathy Mouse Model, SfN Global Connectome virtual event, online, 2021-01-11至2021-01-13 (会议报告)
4) Wang W, Cao Q, Tan T, Yang FW, Williams J, Yan Z (2020) Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model. Neuroscience across Texas, Texas (会议报告)
5) Wang W, Tan T, Chen L, Dong Z (2015) A study on mechanisms of modulating neonatal isolation induced autistic-like behaviors by low frequency rTMS, Regional Asia Pacific IMFAR 2015, Shanghai, 2015-11-06至2015-11- 08 (会议报告)
6) Wang W, Tan T, He W, Tu M, Dong Z (2015) The effects of amyloid beta1-42 on neural excitability and ion channel, The 5th International Ion Channel Conference, Luzhou, 2015-06-26 至 2015-6-30 (会议报告)
联系方式：wangwei@ojlab.ac.cn