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成果及论文

主要学术成绩

3年来,累计在Nature ChemistryNature CommunicationAdvanced Functional MaterialsBiosensors & Bioelectronics等国际著名期刊上发表论文40余篇。申请中国发明专利12项,PCT国际专利2项。

基金项目

1、 国家自然科学基金面上项目:仿生ECM聚谷氨酸/透明质酸水凝胶的可控梯度层状构筑及软骨修复研究(31771049),主持,2018.01-2021.12

2、江苏省重点研发计划项目:3D打印构建聚氨基酸仿生组织工程皮肤(BE2018731),主持,2018.07-2021.06

3、材料化学工程国家重点实验室自主课题:仿生设计的多重梯度水凝胶的可控构筑及介导BMSCs成软骨分化研究(ZK201806),主持,2018.07-2021.06

代表性论文

1)Soumen De, Bo Chi, Thierry Granier, Ting Qi, Victor Maurizot, Ivan Huc*. Designing cooperatively folded abiotic uni- and multimolecular helix bundles. Nature Chemistry, 2018,10,51-56. (共同一作, SCI Top期刊,IF=25.87

2)Rui Wang, Jingzhe Li, Wei Chen, Tingting Xu, Shifeng Yun, Zheng Xu, Zongqi Xu, Takashi Sato, Bo Chi*, Hong Xu*. A biomimetic mussel-inspired ɛ-Poly-L-lysine hydrogel with robust tissue-anchor and anti-infection capacityAdv. Funct. Mater., 2017, 27: 1604894.

3)Tingting Xu, Rong Yang, Rong Yang, Wei Chen, Shuai Liu, Xin Liu, Xiaojun Cai, Hong Xu*Bo Chi*, Bionic Poly(γ‐Glutamic Acid) Electrospun Fibrous Scaffolds for Preventing Hypertrophic Scars. Advanced Healthcare Materials., 2019: 1900123.

4)Wei Chen, Rui Wang, Tingting Xu, Xuebin Ma, Zhong Yao, Bo Chi*, Xu, Hong* A mussel-inspired poly(γ-glutamic acid) tissue adhesive with high wet strength for wound closure. Journal of Materials Chemistry B, 2017, 5, 5668-5678.

5) Xuebin Ma, Tingting Xu, Wei Chen, Hongye Qin, Bo Chi*, Zhiwen Ye.  Injectable hydrogels based on the hyaluronic acid and poly (γ-glutamic acid) for controlled protein delivery. Carbohydrate Polymers, 2018, 179, 100-109.

6)Rong Yang, Xiaoxue Wang, Shuai Liu, Wenjie Zhang, Penghui Wang, Xin Liu, Yanhan Ren, Xiaoyan Tan*, Bo Chi*. Bioinspired poly (γ-glutamic acid) hydrogels for enhanced chondrogenesis of bone marrow-derived mesenchymal stem cells. International journal of biological macromolecules, 2020, 142: 332-344.

7)Shuai Liu, Yajie Pu, Rong Yang, Xin Liu, Penghui Wang, Xiaoxue Wang, Yanhan Ren, Xiaoyan Tan, Zhiwen Ye*, Bo Chi*. Boron-assisted dual-crosslinked poly (γ-glutamic acid) hydrogels with high toughness for cartilage regeneration. International Journal of Biological Macromolecules,2020.

      8)Shuai Liu, Yajie Pu, Rong Yang, Xin Liu, Penghui Wang, Xiaoxue Wang, Yanhan Ren, Xiaoyan Tan, Zhiwen Ye*Maurizot, Victor*Bo  Chi*. Mussel-inspired Dual-crosslinking Hyaluronic Acid/ε-polylysine Hydrogel with Self-healing and Antibacterial Properties for Wound Healing. ACS Applied Materials & Interfaces, 2020. 

 



PCT专利

        1.  E-polylysine hydrogel and preparation methord and application thereof. Hong Xu, Bo Chi, Rui Wang, Xiaohai Feng, Sha Li, Jinfeng Liang, Pingkai Ouyang.          US9833539 B2

        2.  Hydrogel based on γ-polyglutamic acid and ε-polylysine crosslinked polymer, and preparation method therefor.  Hong Xu, Bo Chi, Jun Xia, Sha Li, Xiaohai          Feng. WO 2015/058633 A1