personal profile

Yali Zhang, female, Associate Professor, Master Professor, Department of Biochemistry and Molecular Biology, School of Medicine, Nantong University, Nantong, China, graduated from Zhejiang University in 2012 with a Ph.D. degree in Biochemistry and Molecular Biology, and will conduct research on the application of phosphorylated proteomics to disease mechanism as a visiting scholar in the group of Prof. Weiguo Tao at the Department of Biochemistry and Molecular Biology, Purdue University, USA, from 2019 to 2020. She has presided over one national, one provincial and one municipal project, and published 10 SCI research papers as the first author or corresponding author.

Specialised Research Area:

To study the effect of phosphorylation level of protein phosphatase 2A (PP2A) regulatory subunit B on the structure and biological function of PP2A and its role in the induction of hepatotoxicity and neurotoxicity by exogenous substances using PP2A as a target protein.

published paper

1.Yin H, Fan X, Zhang Y, Zhao N, Zhao X, Yin K, Zhang Y*. An Integrated Study on the Differential Expression of the FOX Gene Family in Cancer and Their Response to Chemotherapy Drugs. Genes (Basel). 2022, 13(10):1754.

2.Wang X, Xiao P, Wang R, Luo C, Zhang Z, Yu S, Wu Q, Li Y, Zhang Y*, Zhang H, Zhao X. Relationships between urinary metals concentrations and cognitive performance among U.S. older people in NHANES 2011-2014. Front Public Health. 2022, 10:985127.

3. Zhang Y*, Zhu P, Wu X, Yuan T, Su Z, Chen S, Zhou Y, Tao WA. Microcystin-LR Induces NLRP3 Inflammasome Activation via FOXO1 Phosphorylation, Resulting

in Interleukin-1β Secretion and Pyroptosis in Hepatocytes. Toxicol Sci. 2021 6;179(1):53-69.

4. Zhang Y*, Fan X, Su Z, Yuan T, Yin H, Gu H, Zuo Y, Chen S, Zhou H, Su G. Pretreatment with metformin prevents microcystin-LR-induced tau hyperphosphorylation via mTOR-dependent PP2A and GSK-3β activation. Environ Toxicol. 2021 36(12):2414-2425.

5. Zhang Y*, Yuan T, Su Z, Wang X, Wang Y, Ni Y, Zuo Y, Gu H. Reduced methylation of PP2Ac promotes ethanol-induced lipid accumulation through FOXO1 phosphorylation in vitro and in vivo. Toxicol Lett. 2020, 331:65-74.

6. Zhang Y*, Zhang J, Wang E, Qian W, Fan Y, Feng Y, Yin H, Li Y, Wang Y, Yuan T. Microcystin-Leucine-Arginine Induces Tau Pathology Through Bα Degradation via Protein Phosphatase 2A Demethylation and Associated Glycogen Synthase Kinase-3β Phosphorylation. Toxicol Sci. 2018,162(2):475-487.

7. Zhang Y, Chen Y, Sun L, Liang J, Guo Z, Xu L. Protein phosphatases 2A as well as reactive oxygen species involved in tributyltin-induced apoptosis in mouse livers. Environ Toxicol. 2014 ,29(2):234-42.

8. Zhang YL, Sun FT, Zhang Z, Chen XX, Liu AX, Pan JJ, Peng F, Zhou S, Sun LJ. Comprehensive expression analysis suggests functional overlapping of human FOX transcription factors in cancer. Asian Pac J Cancer Prev. 2014;15(23):10475-81.

9. Zhang Y, Guo Z, Xu L. Tributyltin induces a G2/M cell cycle arrest in human amniotic cells via PP2A inhibition-mediated inactivation of the ERK1/2 cascades. Environ Toxicol Pharmacol. 2014 Mar;37(2):812-8.

10. Zhang Y, Liang J, Sun L, Guo Z, Xu L. Inhibition of PP2A and the consequent activation of JNK/c-Jun are involved in tributyltin-induced apoptosis in human amnionic cells. Environ Toxicol. 2013 Jul;28(7):390-400.