个人简介:王晓珂,女,华中科技大学公共卫生学院医学博士,美国马里兰大学医学院博士后。现任职于南通大学公共卫生学院职业医学与环境毒理学系,系主任,教授,硕士生导师。先后主持了国家自然科学基金青年基金、江苏省自然科学基金青年基金和江苏省高校自然科学基金面上项目等多项省部级课题。近年来以第一作者和通讯作者身份在《Particle and Fibre Toxicology》、《Toxicological Sciences》、《Environmental Pollution》、《ACS Nano》和《Free Radical Biology and Medicine》等期刊发表SCI论文20余篇,中科院二区及以上论文10篇。目前担任江苏省毒理学会基础毒理青年委员会委员,江苏省环境诱变剂协会理事,江苏省环境卫生学专业委员会委员,南通市医学会内分泌学会委员。
获得奖项:
1.南通大学优秀教育工作者
2.南通大学优秀本科毕业论文指导教师
3.南通市“226高层次人才工程”培养对象
研究方向:
主要从事环境毒理学研究,具体研究方向为孕期环境污染物暴露对肥胖、糖尿病和非酒精性脂肪肝等慢性病发生的影响及相关分子机制研究。
学术兼职:
1.江苏省毒理学会基础毒理青年委员会委员
2.江苏省环境诱变剂协会理事
3.江苏省环境卫生学专业委员会委员,
4.南通市医学会内分泌学会委员
科研项目:
1.国家自然科学基金委员会,青年基金项目,21407082,孕期PM2.5暴露对子代肥胖发生的影响及机制研究,2015.01- 2017.12,24万元,结题,主持
2.江苏省自然科学基金委员会,青年基金项目,BK20140426,以人群诱导多功能干细胞等位基因不平衡表达研究砷毒性敏感性差异,2014.07至2016.06,20万元,结题,主持
3.国家自然科学基金委员会,青年基金项目,81703255,肺泡上皮细胞p62聚集在超细颗粒物诱导肺纤维化中的作用及机制研究,2018.01至2020.12,20万元,结题,参与
4.国家自然科学基金委员会,青年基金项目,21607082,滤泡辅助性T细胞在DEHP与PM2.5联合暴露诱导哮喘中的用及机制研究作,2017.01-2019.12,20万元,结题, 参与
5.市科技局,BK2014034, 孕期PM2.5暴露对子代肥胖发生的影响及机制研究,2014.07-2016.06,3.0万元,结题,主持
6.市科技局,JC2019016, 出生前PM2.5暴露对非酒精性脂肪肝发生的影响及机制研究,2019.07-2021.06,3.0万元,结题,主持
7.通市科技局, 面上项目, MS22022081, 南通市售海产品中微塑料的污染特征分析及纳米微塑料暴露对非酒精性脂肪肝发生的影响,2022.07-2024.06, 10万元, 结题, 主持
论文代表作
1. Xiaoke Wang#; Zixuan Zhao#; Xin Wang; Wenxuan Hu; Chao Luo; Xiuyu Chu; Muzhou Qian; Rui Wang; Shali Yu; Qiyun Wu; Juan Tang; Xinyuan Zhao., 2023. Effects of polystyrene nanoplastic gestational exposure on mice. Chemosphere 324, 138255. https://doi.org/10.1016/j.chemosphere.2023.138255. (中科院二区,IF: 8.943)
2. Tang Juan; Bu Wenxia; Hu Wenxuan; Zhao Zixuan; Liu Lei; Luo Chao; Wang Rui; Fan Susu;Yu Shali; Wu Qiyun*; Wang Xiaoke*; Zhao Xinyuan*, 2023. Ferroptosis Is Involved in Sex-Specific Small Intestinal Toxicity in the Offspring of Adult Mice Exposed to Polystyrene Nanoplastics during Pregnancy. ACS Nano 17(3), 2440-2449. https://doi.org/10.1021/acsnano.2c09729. (中科院一区,IF: 18.027)
3. Wang Xiaoke#; Yang Yuxue#; Zhu Piaoyu; Wu Yifan; Jin Yang; Yu Shali; Wei Haiyan; Qian Muzhou; Cao Weiming; Xu Shenya; Liu Yingqi; Chen Gang; Zhao Xinyuan*, 2019a. Prenatal exposure to diesel exhaust PM(2.5) programmed non-alcoholic fatty liver disease differently in adult male offspring of mice fed normal chow and a high-fat diet. Environ Pollut 255(Pt 1), 113366. https://doi.org/10.1016/j.envpol.2019.113366. (中科院二区,IF: 9.988)
4. Wang Xiaoke#; Zhu, Piaoyu#;; Xu Shenya; Liu Yuting; Jin Yang; Yu Shali; Wei Haiyan; Li Jinlong; Zhang Qinglin; Hasegawa Takahiro; Yao Chenjuan; Yoshimura Hiroshi; Wu Qiyun; Zhao Xinyuan*, 2019b. Antimony, a novel nerve poison, triggers neuronal autophagic death via reactive oxygen species-mediated inhibition of the protein kinase B/mammalian target of rapamycin pathway. Int J Biochem Cell Biol 114, 105561. https://doi.org/10.1016/j.biocel.2019.105561. (中科院二区,IF: 5.652)
5. Chen Minjie#; Wang Xiaoke#; Hu Ziying; Zhou Huifen; Xu Yanyi; Qiu Lianglin; Qin Xiao bo; Zhang Yuhao; Ying Zhekang*, 2017. Programming of mouse obesity by maternal exposure to concentrated ambient fine particles. Part Fibre Toxicol 14(1), 20. https://doi.org/10.1186/s12989-017-0201-9. (中科院一区,IF: 9.112)
6. Wang Xiaoke#; Chen Minjie; Zhong Mianhua; Hu Ziying; Qiu Lianglin; Rajagopalan Sanjay; Fossett Nancy G.; Chen Lung-chi; Ying Zhekang*, 2017. Exposure to Concentrated Ambient PM2.5 Shortens Lifespan and Induces Inflammation-Associated Signaling and Oxidative Stress in Drosophila. Toxicol Sci 156(1), 199-207. https://doi.org/10.1093/toxsci/kfw240. (中科院二区,IF: 4.109)
7. Xu Shenya; Yang Zeyun; Zhi Ye; Yu Shali; Zhang Tao; Jiang Junkang; Tang Jun; He Hongsen; Lu Ming; Wang Xiaoke*; Wu Qiyun*; Zhao Xinyuan*, 2021. The effects of antimony on Alzheimer's disease-like pathological changes in mice brain. Sci Total Environ 760, 143235. https://doi.org/10.1016/j.scitotenv.2020.143235. (中科院一区,IF: 10.753)
8. Wei Haiyan#, Hu Qiaoyun#, Wu Junxia, Yao Chenjuan, Xu Lingfei, Xing Fenjun, Zhao Xinyuan, Yu Shali, Wang Xiaoke*, Chen Gang*, 2018. Molecular mechanism of the increased tissue uptake of trivalent inorganic arsenic in mice with type 1 diabetes mellitus. Biochem Biophys Res Commun 504(2), 393-399. https://doi.org/10.1016/j.bbrc.2018.06.029. (中科院四区,IF: 3.322)
9. Zhao Xinyuan#, Jin Yang#, Yang Lijia, Hou Zhengxing, Liu Yingqi, Sun Tianyu, Pei Jiaxin, Li Jinlong, Yao Chenjuan, Wang Xiaoke*, Chen Gang*, 2018. Promotion of SIRT1 protein degradation and lower SIRT1 gene expression via reactive oxygen species is involved in Sb-induced apoptosis in BEAS-2b cells. Toxicol Lett 296, 73-81. https://doi.org/10.1016/j.toxlet.2018.07.047. (中科院三区,IF: 4.271)
10. Zhao Xinyuan, Jin Yang, Yang Lijia, Hou Zhengxing, Liu Yingqi, Sun Tianyu, Pei Jiaxin, Li Jinlong, Yao Chenjuan, Wang Xiaoke*, Chen Gang*, 2017. Antimony trichloride induces a loss of cell viability via reactive oxygen species-dependent autophagy in A549 cells. Int J Biochem Cell Biol 93, 32-40. https://doi.org/10.1016/j.biocel.2017.10.007. (中科院二区,IF: 5.652)