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成果及论文

精选论文(第一作者 “#”字样,通讯作者“*”字样)         

  1. Liu, Li-Ping#, Dong-Xu Zheng#, Zheng-Fang Xu, Hu-Cheng Zhou, Yun-Cong Wang, Hang Zhou, Jian-Yun Ge, Daisuke Sako, Mi Li, Kazunori Akimoto, Yu-Mei Li*, and Yun-Wen Zheng*. Transcriptomic and Functional Evidence Show Similarities between Human Amniotic Epithelial Stem Cells and Keratinocytes, Cells. 2022; 11(1):70. https://doi.org/10.3390/cells11010070
  2. Hang Zhou#, Yun Wang#, Li-Ping Liu*, Yu-Mei Li*, Yun-Wen Zheng*, Gene Editing in Pluripotent Stem Cells and Their Derived Organoids, Stem Cells International, vol. 2021, 8130828,  14 pages, 2021.  https://doi.org/10.1155/2021/8130828
  3. Sun H#, Zhang Y-X, Li Y-M*. Generation of Skin Organoids: Potential Opportunities and Challenges. Front Cell Dev Biol. 2021 Nov 4;9:709824. doi: 10.3389/fcell.2021.709824. PMID: 34805138; PMCID: PMC8600117.
  4. Wang Y#, Cao D, Chen SL, Li YM, Zheng YW*, Ohkohchi N. Current trends in three-dimensional visualization and real-time navigation as well as robot-assisted technologies in hepatobiliary surgery. World J Gastrointest Surg. 2021 Sep 27;13(9):904-922. doi: 10.4240/wjgs.v13.i9.904. PMID: 34621469; PMCID: PMC8462083.
  5. Zhang YX#, Liu LP, Jin M, Sun H, Zhang HL, Li YM*. Direct Reprogramming of Mouse Fibroblasts into Melanocytes. J Vis Exp. 2021 Aug 27;(174). doi: 10.3791/62911. PMID: 34515686.
  6. Cao D#, Ge JY#, Wang Y, Oda T, Zheng YW*. Hepatitis B virus infection modeling using multi-cellular organoids derived from human induced pluripotent stem cells. World J Gastroenterol. 2021 Aug 7;27(29):4784-4801. doi: 10.3748/wjg.v27.i29.4784. PMID: 34447226; PMCID: PMC8371505.
  7. Xu MX#, Liu LP#, Li YM*, Zheng YW*. The Opportunities and Challenges regarding Induced Platelets from Human Pluripotent Stem Cells. Stem Cells Int. 2021 May 1;2021:5588165. doi: 10.1155/2021/5588165. PMID: 34054969; PMCID: PMC8112939.
  8. Fang M#, Liu LP#, Zhou H, Li YM*, Zheng YW*. Practical choice for robust and efficient differentiation of human pluripotent stem cells. World J Stem Cells. 2020;12(8):752-760. doi:10.4252/wjsc.v12.i8.752
  9. Zhou H#, Liu LP, Fang M, Li YM*, Zheng YW*. A potential ex vivo infection model of human induced pluripotent stem cell-3D organoids beyond coronavirus disease 2019. Histology and Histopathology. 2020 Oct;35(10):1077-1082. doi: 10.14670/hh-18-223.
  10. Liu LP#, Guo NN, Li YM*, Zheng YW*,**. Generation of Human iMelanocytes from Induced Pluripotent Stem Cells through a Suspension Culture System[J]. STAR Protocols, 2020: 100004. (**Lead contact).
  11. Guo NN#, Liu LP#, Zheng YW*, Li YM*. Inducing human induced pluripotent stem cell differentiation through embryoid bodies: A practical and stable approach. World J Stem Cells 2020. 12(1): 25-34. doi: 10.4252/wjsc.v12.i1.25 (invited review)
  12. Sun L#, Wang Y#, Cen J, Ma X, Cui L, Qiu Z, Zhang Z, Li H, Yang RZ, Wang C, Chen X, Wang L, Ye Y, Zhang H, Pan G, Kang JS, Ji Y, Zheng YW*, Zheng S*, and Hui L*. Modeling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes. Nat Cell Biol 2019.21(8):1015-26.doi:10.1038/s41556-019-0359-5.
  13. Furuya K#, Zheng YW*, Sako D, Iwasaki K, Zheng DX, Ge JY, Liu LP, Furuta T, Akimoto K, Yagi H, Hamada H, Isoda H, Oda T and Ohkohchi N. Enhanced hepatic differentiation in the subpopulation of human amniotic stem cells under 3D multicellular microenvironment. World J Stem Cells 2019. 11(9):705-21. doi: 10.4252/wjsc.v11.i9.705.
  14. Ge JY#, Zheng YW*, Liu LP, Isoda H and Oda T. Impelling force and current challenges by chemicals in somatic cell reprograming and expansion beyond hepatocytes. World J Stem Cells 2019. 11(9):650-65. doi: 10.4252/wjsc.v11.i9.650. (invited review)
  15. Guo NN#, Liu LP#, Zhang YX, Cai YT; Guo Y, Zheng YW*, Li YM*. Early prediction of the differentiation potential during the formation of human iPSC-derived embryoid bodies. Biochem Biophys Res Commun 2019. 516(3):673-79. doi: 10.1016/j.bbrc.2019.06.081.
  16. Liu LP#, Zheng YW*. Predicting differentiation potentials of human pluripotent stem cells: Possibilities and challenges. World J Stem Cells 2019.11(7): 375-82. doi: 10.4252/wjsc.v11.i7.375 (invited editorial).
  17. Liu LP#, Li YM#,*, Guo NN, Li S, Ma XL, Zhang YX, Gao YM, Huang JL, Zheng DX, Wang LY, Xu H, Hui L*, Zheng YW*,**. Therapeutic potential of patient iPSC-derived iMelanocytes in autologous transplantation. Cell Rep 2019. 27(2):455-466.e5. doi: 10.1016/j.celrep.2019.03.046. (**Lead contact)
  18. Nie YZ#, Zheng YW#,*, Miyakawa K, Murata S, Zhang RR, Sekine K, Ueno Y, Takebe T, Wakita T, Ryo A, Taniguchi H*. Recapitulation of hepatitis B virus-host interactions in liver organoids from human induced pluripotent stem cells. EBioMedicine 2018; 35:114-23 doi:10.1016/j.ebiom.2018.08.014 (Cover image).
  19. Zhang YX#, Liu LP#, Li M, Huang JL, Xu H, Chen XD, Zhu WY, Cai YP, Guo NN, Chen ZQ, Zheng YW*, Li YM*, Development of Individualized Induced Pluripotent Stem Cells from Fibroblasts of Keloid Lesions in Patients, Transplant Proc 2018, 50(9):2868-71. doi: 10.1016/j.transproceed.2018.04.008.
  20. Wang LY#, Liu LP#, Ge JY, Yuan YY, Sun LL, Xu H, Huang PY, Hui LJ, Isoda H, Ohkohchi N, Li YM*, Zheng YW*, A multiple-cell microenvironment in a three-dimensional system enhances direct cellular reprogramming into hepatic organoids, Transplant Proc 2018. 50(9): 2864-7. doi:10.1016/j.transproceed.2018.03.076.
  21. Zhang RR#, Zheng YW#,*, Li B, Nie YZ, Ueno Y, Tsuchida T, Taniguchi H*. Hepatic stem cells with self-renewal and liver repopulation potential are harbored in CDCP1-positive subpopulations of human fetal liver cells. Stem Cell Res Ther 2018. 9(1):29. Doi:10.1186/s13287-017-0747-3.
  22. Nie YZ#, Zheng YW#,*, Ogawa M, Miyagi E, Taniguchi H*. Human liver organoids generated with single donor-derived multiple cells rescue mice from acute liver failure. Stem Cell Res Ther 2018. 9(1):5. DOI:10.1186/s13287-017-0749-1.
  23. Iwasaki K#, Zheng YW*, Murata S, Ito H, Nakayama K, Kurokawa T, Sano N, Nowatari T, Villareal MO, Nagano Y, Isoda H, Matsui H, Ohkohchi N. Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer. World J Gastroenterol 2016. 22(44):9765-74. DOI: 10.3748/wjg.v22.i44.9765
  24. Zhang RR#, Zheng YW#,*, Taniguchi H. Generation of a humanized mouse liver by using human hepatic stem cells. J Vis Exp 2016. (114) ,e54167 ,doi:10.3791/54167.
  25. Zhang RR#, Zheng YW#,*, Li B, Tsuchida T, Ueno Y, Nie YZ, Taniguchi H*. Human hepatic stem cells transplanted into a fulminant hepatic failure Alb-TRECK/SCID mouse model exhibit liver reconstitution and drug metabolism capabilities. Stem Cell Res Ther 2015. 6: 49.
  26. Guan HB#, Nie YZ#, Zheng YW#,*, Takiguchi K, Yu HW, Zhang RR, Li B, Tsuchida T, Taniguchi H*. Acyclic retinoid induces differentiation and apoptosis of murine hepatic stem cells. Stem Cell Res Ther 2015. 6: 51.
  27. Zheng YW#, Tsuchida T#, Shimao T, Li B, Takebe T, Zhang RR, Sakurai Y, Ueno Y, Sekine K, Ishibashi N, Imajima M, Tanaka T, and Taniguchi H*: The CD133+CD44+ Precancerous Subpopulation of Oval Cells is a Therapeutic Target for Hepatocellular Carcinoma. Stem Cells Dev 2014. 23:2237-49.
  28. Ozawa M#, Ichikawa Y#, Zheng YW#, Oshima T, Miyata H, Nakazawa K, Guan HB, Shiozawa M, Akaike M, Watanabe K, Ota M, Fujii S, Kunisaki C, Ishikawa T, Tanaka K, Akiyama H, Endo I, and Taniguchi H*. Prognostic significance of CD44 variant 2 upregulation in colorectal cancer. Br J Cancer 2014. 111(2):365-74. doi: 10.1038/bjc.2014.253.
  29. Zheng YW#, Nie YZ#, Tsuchida T, Zhang RR, Aoki K, Sekine K, Ogawa M, Takebe T, Ueno Y, Sakakibara H, Hirahara F, Taniguchi H*. The evidence of sophisticatedly heterogeneous population of human umbilical vein endothelial cells. Transplant Proc 2014. 46, 1251-3 (*equal contribution) doi: 10.1016/j.transproceed.2013.11.077.
  30. Tsuchida T#, Zheng YW#, Zhang RR, Takebe T, Ueno Y, Sekine K, Taniguchi H*. The development of humanized liver with Rag1 knockout rats. Transplant Proc 2014. 46, 1191-3 (*equal contribution) doi: 10.1016/j.transproceed.2013.12.026.
  31. Takebe T#, Sekine K, Enomura M, Koike H, Kimura M, Ogaeri T, Zhang RR, Ueno Y, Koike N, Zheng YW, Aoyama S, Adachi Y, Taniguchi H*. Vascularised and functional human liver from an iPSC-derived organ bud transplant. Nature 2013. 499(7459):481-4. doi: 10.1038/nature12271
  32. Zheng YW#, Nie YZ#, Taniguchi H*. Cellular Reprogramming and Hepatocellular Carcinoma Development. World J Gastroenterol 2013. 19(47):8850-60 (*equal contribution). doi: 10.3748/wjg.v19.i47.8850.
  33. Li B#, Zheng YW*. Uncover the Black Box of Reprogramming in the Post-Yamanaka Era. OA Biotechnol 2013, 2(1):5. (invited review).

专著

  1. Liu LP#, Li YM, Guo NN, Wang LY, Isoda H, Ohkohchi N, Taniguchi H and Zheng YW*. Generation of liver organoids and their potential applications. In Stem Cells and Cancer in Hepatology: From Essentials to Application (edited by Zheng YW). ELSEVIER May 24, 2018. ISBN 9780128123010.

  2. Xu H#, Zheng YW*, Liu Q, Liu LP, Luo FL, Zhou HC, Isoda H, Ohkohchi N and Li YM*. Reactive Oxygen Species in Skin Repair, Regeneration, Aging, and Inflammation. In Reactive Oxygen Species (ROS) in Living Cells (edited by Cristiana Filip).InTechOpen (December 20th 2017). ISBN 978-953-51-5822-6.

  3. Zhang RR, Zheng YW*, Taniguchi H*. Three-Dimensional Culture Systems and Humanized Liver Models Using Hepatic Stem Cells for Enhanced Toxicity Assessment. In Stem Cells in Toxicology and Medicine (edited by Sahu SC). Johns Wiley and Sons. Dec, 2016, pp145-54. ISBN: 978-1-119-13541-8, DOI: 10.1002/9781119135449.ch8.

  4. Huang PY, Li B, Zheng YW*. Role of Stem Cells in the Gastrointestinal Tract and in the Development of Cancer. In Stem Cells in Toxicology and Medicine (edited by Sahu SC). Johns Wiley and Sons. Dec, 2016, pp363-74. ISBN: 978-1-119-13541-8, DOI: 10.1002/9781119135449.ch19

  5. Li YM*, Ma H, Zheng YW*. Potential Medical Applications with Current Biotechnology in A Text Book of Biotechnology (edited by Zahoorullah S). SMGroup, 2015, pp1-14

专利

  1.  李遇梅;张怡萱;刘莉萍;郑允文;一种小鼠胚胎成纤维细胞直接重编程为黑素细胞的方法,2021-07-12,中国,202110785524.6
  2.  郑允文;葛剑云;刘莉萍;Fah基因缺失动物的程序化慢性肝损伤维持及其在制备异源化肝脏模型中的应用;2020-11-30,中国,202011379101.6
  3.  Liu, Li ping; Li, Yu mei; Zheng, Yun wen; Guo, Ning ning; 3D SUSPENSION METHOD FOR GENERATING AUTOLOGOUS MELANOCYTE BY INDUCING IPS CELLS AND APPLICATION THEREOF, 2019-11-12, 美国, 16613054
  4.  李遇梅; 周沪程; 刘莉萍; 罗凤林; 一种点涂器, 2019-04-22, 中国, ZL2019 20548582.5 (授权)
  5.  刘莉萍; 李遇梅; 郑允文; 郭宁宁; 一种3D悬浮诱导iPS细胞生成自体黑素细胞的方法及应用, 2018-05-04, 中国, 201810419157.6 (授权)
  6.  李遇梅; 张怡萱; 李淑; 刘莉萍; 许辉; 惠利健; 郑允文; 一种成纤维细胞诱导分化为多功能干细胞的方法, 2016-4-20, 中国, 201510987834.0 (授权)