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成果及论文




#第一作者,*通讯作者)

  - 2022年 

30. Guo TA#, Lai HY#, Li C, Li Y, Li YC, Jin YT, Zhang ZZ, Huang HB, Huang SL*, Xu Y*. Plasma Extracellular Vesicle Long RNAs Have Potential as Biomarkers in Early Detection of Colorectal Cancer. Front Oncol. 2022 Apr 8;12:829230

29. Yin Y#, Liu B#, Cao Y, Yao S, Liu Y, Jin G, Qin Y, Chen Y, Cui K, Zhou L, Bian Z, Fei B, Huang S*, Huang Z*. Colorectal Cancer-Derived Small Extracellular Vesicles Promote Tumor Immune Evasion by Upregulating PD-L1 Expression in Tumor-Associated Macrophages. Advanced Science. 2022 Jan 17;9(9):2102620.

28. Ye S#, Li Q#, Wu Y, Jiang W, Zhou S, Zhou X, Yang W, Tu X, Shan B, Huang S*, Yang H*. Integrative genomic and transcriptomic analysis reveals immune subtypes and prognostic markers in ovarian clear cell carcinoma. Br J Cancer. 2022 May;126(8):1215-1223.

27. Huang B#, Li Q#, Geng Q, Lao J, Guo J, Huang S*, Xu D*. ASTE1 frameshift mutation triggers the immune response in Epstein-Barr virus-associated gastric cancer. Signal Transduct Target Ther. 2022 Jan 5;7(1):4.

26. Lai H#, Li Y#, Zhang H, Hu J, Liao J, Su Y, Li Q, Chen B, Li C, Wang Z, Li Y, Wang J, Meng Z*, Huang Z*Huang S*. exoRBase 2.0: an atlas of mRNA, lncRNA and circRNA in extracellular vesicles from human biofluids. Nucleic Acids Res. 2022 Jan 7;50(D1):D118-D128

  2021年 

25. Su Y#, Li Y#, Guo R#, Zhao J, Chi W, Lai H, Wang J, Wang Z, Li L, Sang Y, Hou J, Xue J, Shao Z, Chi Y, Huang S*, Wu J*. Plasma extracellular vesicle long RNA profiles in the diagnosis and prediction of treatment response for breast cancer. NPJ Breast Cancer. 2021 Dec 10;7(1):154

24. Chen S#, Lai H#, Zhao J, Chen B, Li Y, Li Y, Li Q, Zheng Q, Huang S*, Zhu X*. The viral expression and immune status in human cancers and insights into novel biomarkers of immunotherapy. BMC Cancer. 2021 Nov 5;21(1):1183.

23. Li Y#, Li Y#, Yu S#, Qian L, Chen K, Lai H, Zhang H, Li Y, Zhang Y, Gu S, Meng Z, Huang S*, Wang P*. Circulating EVs long RNA-based subtyping and deconvolution enable prediction of immunogenic signatures and clinical outcome for PDAC. Mol Ther Nucleic Acids. 2021 Sep 24;26:488-501.

22. Li Y#, Chen B#, Zhao J, Li Q, Chen S, Guo T, Li Y, Lai H, Chen Z, Meng Z, Guo W*, He X*Huang S*. Advanced Science. HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein. 2021 May 1;8(13):2001701.

21. Qin Li#, Hongyan Lai#, Yuchen Li, Bing Chen, Siyuan Chen, Yan Li, Zhaohui Huang, Zhiqiang Meng, Peng Wang, Zhixiang Hu*Shenglin Huang*. RJunBase: a database of RNA splice junctions in human normal and cancerous tissues. Nucleic Acids Research. 2021;49(D1):D201-D211.

2020年 

20. Qiupeng Zheng#, Jingjing Zhao#, Hui Yu, Huajie Zong, Xigan He, Yiming Zhao, Yan Li, Yu Wang, Yichao Bao, Yuchen Li, Bing Chen, Weijie Guo, Yilin Wang, Zhiao Chen, Yingjun Zhao, Lu Wang*, Xianghuo He*, Shenglin Huang*. Tumor-specific Transcripts are Frequently Expressed in Hepatocellular Carcinoma with Clinical Implication and Potential Function. Hepatology. 2020;71(1):259-274. Epub 2019 Aug 12.

19. Yu S#, Li Y#, Liao Z#, Wang Z#, Wang Z, Li Y, Qian L, Zhao J, Zong H, Kang B, Zou WB, Chen K, He X, Meng Z, Chen Z*, Huang S*, Wang P*. Plasma extracellular vesicle long RNA profiling identifies a diagnostic signature for the detection of pancreatic ductal adenocarcinoma. Gut. 2020;69(3):540-550.

18. Ziteng Li#, Siyuan Chen#, Wanjing Feng, Yixiao Luo, Hongyan Lai, Qin Li, Bingqiu Xiu, Yuchen Li, Yan Li, Shenglin Huang*, Xiaodong Zhu*. A pan-cancer analysis of HER2 index revealed transcriptional pattern for precise selection of HER2-targeted therapy. EBioMedicine. 2020 Dec;62:103074.

17. Ziteng Li, Xiaodong Zhu, Shenglin Huang*. Extracellular vesicle long non-coding RNAs and circular RNAs: Biology, functions and applications in cancer. Cancer Lett. 2020 Oct 1;489:111-120. (Invited Review)

16. Wu Y#, Zhao Y#, Huan L, Zhao J, Zhou Y, Xu L, Hu Z, Liu Y, Chen Z, Wang L, Huang S*, He X*, Liang L*. An LTR Retrotransposon-Derived Long Noncoding RNA lncMER52A Promotes Hepatocellular Carcinoma Progression by Binding p120-Catenin. Cancer Res. 2020;80(5):976-987.

15. Chen S, Zhu X, Huang S*. Clinical applications of extracellular vesicle long RNAs. Crit Rev Clin Lab Sci. 2020 Dec;57(8):508-521. (Invited Review)

14. Yang LF, Yang F, Zhang FL, Xie YF, Hu ZX, Huang SL*, Shao ZM*, Li DQ*. Discrete functional and mechanistic roles of chromodomain Y-like 2 (CDYL2) transcript variants in breast cancer growth and metastasis. Theranostics. 2020;10(12):5242-5258.

- 2019年 -

13. Xiu B#, Chi Y#, Liu L#, Chi W, Zhang Q, Chen J, Guo R, Si J, Li L, Xue J, Shao ZM, Wu ZH*, Huang S*, Wu J*. LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription. Mol Cancer. 2019;18(1):187.

12. Yuchen Li#, Jingjing Zhao#, Shulin Yu, Zhen Wang, Xigan He, Yonghui Su, Tianan Guo, Haoyue Sheng, Jie Chen, Qiupeng Zheng, Yan Li, Weijie Guo, Xiaohong Cai, Guohai Shi, Jiong Wu, Lu Wang, Peng Wang*, Xianghuo He*, Shenglin Huang*. Extracellular vesicles long RNA sequencing reveals abundant mRNA, circRNA and lncRNA in human blood as biomarkers for cancer diagnosis. Clinical Chemistry. 2019;65(6):798-808.

11. Jingjing Zhao#, Qin Li#, Yuchen Li, Xianghuo He, Qiupeng Zheng*, Shenglin Huang*. ASJA: Assembling Splice Junctions Analysis. Computational and Structural Biotechnology Journal, 2019;17:1143-1150.

- 2018年 -

10. Guo W#, Hu Z#, Bao Y, Li Y, Li S, Zheng Q, Lyu D, Chen D, Yu T, Li Y, Zhu X, Ding J, Zhao Y, He X*, Huang S*. A LIN28B Tumor-Specific Transcript in Cancer. Cell Reports. 2018; 22(8):2016-2025.

9. Shengli Li, Yuchen Li, Bing Chen, Jingjing Zhao, Shulin Yu, Yan Tang, Qiupeng Zheng, Yan Li, Peng Wang, Xianghuo He, Shenglin Huang*. exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes. Nucleic Acids Research. 2018;46:D106–D112. 

8. Shengli Li, Jiwei Zhang, Shenglin Huang*, Xianghuo He*. Genome-wide analysis reveals that exon methylation facilitates its selective usage in the human transcriptome. Briefings in Bioinformatics. 2018;19(5):754-764. 

- 2017年前 -

7. Chen B, Huang S*. Circular RNA: An emerging non-coding RNA as a regulator and biomarker in cancer. Cancer Letters. 2018;418:41-50. (Invited Review)

6. Jie Chen#, Yan Li#, Qiupeng Zheng, Chunyang Bao, Jian He, Bing Chen, Dongbin Lyu, Biqiang Zheng, Yu Xu, Ziwen Long, Ye Zhou, Huiyan Zhu, Yanong Wang, Xianghuo He, Yingqiang Shi*, Shenglin Huang*. Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Cancer Letters. 2017; 388: 208-19. 

5. Dongbin Lyu, Shenglin Huang*. The emerging role and implication of human exonic circular RNA. RNA Biology. 2017;14(8):1000-1006. (Invited Review)

4. Qiupeng Zheng#, Chunyang Bao#, Weijie Guo, Shuyi Li, Jie Chen, Bin Chen, Yanting Luo, Dongbin Lyu, Yan Li, Guohai Shi, Linhui Liang, Jianren Gu, Xianghuo He*, Shenglin Huang*. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nature Communications. 2016; 7:11215.

3. Chunyang Bao#, Yan Li#, Lin Huan, Yuannv Zhang, Fangyu Zhao, Qifeng Wang, Linhui Liang, Jie Ding, Li Liu, Taoyang Chen, Jinjun Li, Ming Yao, Shenglin Huang*, Xianghuo He*. NF-kB signaling relieves negative regulation by miR-194 in hepatocellular carcinoma by suppressing the transcription factor HNF-1a. Science Signaling. 2015;8(387):ra75. 

2. Yan Li#, Qiupeng Zheng#, Chunyang Bao, Shuyi Li, Weijie Guo, Jiang Zhao, Di Chen, Jianren Gu, Xianghuo He*, Shenglin Huang*. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Research. 2015;25(8):981-4. 

1. Zheng Q#, Cai X#, Tan MH, Schaffert S, Arnold CP, Gong X, Chen CZ*, Huang S*. Precise gene deletion and replacement using the CRISPR/Cas9 system in human cells. Biotechniques. 2014;57(3):115-24.