一、 基金项目
1. 国家自然科学基金面上项目，2025-2028，在研，主持
2. 国家自然科学基金青年项目，2022-2024，结题，主持
3. 苏州市姑苏创新创业领军人才，2023-2026，在研，主持
4. 苏州瑞博生物技术公司合作课题，2024-2026，在研，主持
5. 江苏省双创博士，2022-2023
6. 教育部老年病与免疫重点实验室内部协作基金，2024-2025，在研，主持
7. 卫生部糖复合物重点实验室，开放课题基金，2016-2017，已结题，主持
二、 文章
20.Guran, A#, Ji Y#, Fang P, Pan KT, Urlaub H, Avkiran M, Lenz C, Weeks K. L. PP2A-B56alpha is a key determinant of cardiac protein phosphorylation and functional responses to beta-adrenergic signalling. J Mol Cell Cardiol Plus, 2025 Jun. 12: p. 100301.
19. Fang P#*, Yu XM#(苏大本科生), Ding MY, Cong QF, Jiang HY, Shi Q, Zhao WW, Zheng WM, Li YN, Ling, ZX, Kong WJ, Yang PY, Shen HL*. Ultradeep N-glycoproteome Atlas of Mouse Reveals Spatiotemporal Signatures of Brain Aging and Neurodegenerative Diseases. Nat Commun, 2025 Jul 1. 16. Article number: 5568. online.
18.Zhang ZC, Liu YY(苏大2022级硕士), Chen T, Fang P*, Kong WJ*. Recent advances in the electrochemical synthesis of oligosaccharides and glycosides. Green Synthesis and Catalysis. 2025 Jun 13.
17.Kong, WJ*#, Wu HB, Chen JY, Liao RZ, Liu YY(苏大2022级硕士), Luo ZP, Pires Vilela I, Fang P, Himo F,* Backvall J. E*. Palladium-Catalyzed Site-Selective Regiodivergent Carbocyclization of Di- and Trienallenes: A Switch between Substituted Cyclohexene and Cyclobutene. J Am Chem Soc, 2025 Mar 19. 147(11): p. 9909-9918.
16. Fang P, Ji Y, Oellerich T, Urlaub H*, Pan KT*. Strategies for Proteome-Wide Quantification of Glycosylation Macro- and Micro-Heterogeneity. Int J Mol Sci. 2022 Jan 30; 23(3):1609.
15. Song Y#, Zan W#, Qin L, Han S, Ye L, Wang M, Jiang B, Fang P, Liu Q, Shao C, Gong Y, Li P. Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation. Mol Metab. 2022 Feb; 56:101423.
14. Fang P, Ji Y, Silbern I, Viner R, Oellerich T, Pan KT, Urlaub H*. Evaluation and Optimization of High-Field Asymmetric Waveform Ion-Mobility Spectrometry for Multiplexed Quantitative Site-Specific N-Glycoproteomics. Anal Chem. 2021 Jun 16. doi: 10.1021/acs.analchem.1c00802.
13. Wensien M#, von Pappenheim FR#, Funk LM, Kloskowski P, Curth U, Diederichsen U, Uranga J, Ye J, Fang P, Pan KT, Urlaub H, Mata RA, Sautner V, Tittmann K*. A lysine-cysteine redox switch with an NOS bridge regulates enzyme function. Nature. 2021 May;593(7859):460-464.
12. Güran A#, Ji Y#, Fang P, Pan KT, Urlaub H, Avkiran M, Lenz C. Quantitative Analysis of the Cardiac Phosphoproteome in Response to Acute β-Adrenergic Receptor Stimulation In Vivo.Int J Mol Sci.2021 Nov 22;22(22).
11. Silbern I, Fang P, Ji Y, Christof L, Urlaub H, Pan KT. Relative Quantification of Phosphorylated and Glycosylated Peptides from the Same Sample Using Isobaric Chemical Labelling with a Two-Step Enrichment Strategy. Methods Mol Biol.2021;2228:185-203. (Book chapter)
10. Fang P#, Ji Y#, Silbern I, Doebele C, Ninov M, Lenz C, Oellerich T, Pan KT*, Urlaub H*. A streamlined pipeline for multiplexed quantitative site-specific N-glycoproteomics. Nat Commun. 2020 Oct 19;11(1):5268.
9. Ukmar-Godec T#, Fang P#, Ibáñez de Opakua A#, Henneberg F, Godec A, Pan KT, Cima-Omori MS, Chari A, Mandelkow E, Urlaub H, Zweckstetter M. Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Sci Adv. 2020 Jul;6(30): eaba3916.
8. Fang P#, Xie J#, Sang S, Zhang L, Liu M, Yang L, Xu Y, Yan G, Yao J, Gao X, Qian W, Wang Z, Zhang Y*, Yang P*, Shen H*. Multilayered N-Glycoproteome Profiling Reveals Highly Heterogeneous and Dysregulated Protein N-Glycosylation Related to Alzheimer's Disease. Anal Chem. 2020 Jan 7;92(1):867-874.
7. Xue Y, Xie J, Fang P, Yao J, Yan G, Shen H*, Yang P*. Study on behaviors and performances of universal N-glycopeptide enrichment methods. Analyst.2018 Apr 16;143(8):1870-1880.
6. Liu MQ#, Zeng WF#, Fang P#, Cao WQ#, Liu C#, Yan GQ, Zhang Y, Peng C, Wu JQ, Zhang XJ, Tu HJ, Chi H, Sun RX, Cao Y, Dong MQ, Jiang BY, Huang JM, Shen HL, Wong CCL*, He SM*, Yang PY*. pGlyco 2.0 enables precision N-glycoproteomics with comprehensive quality control and one-step mass spectrometry for intact glycopeptide identification. Nat Commun. 2017 Sep 5;8(1):438. （高被引）
5. Fang P, Wang XJ, Xue Y, Liu MQ, Zeng WF, Zhang Y, Zhang L, Gao X, Yan GQ, Yao J, Shen HL*, Yang PY*. In-depth mapping of the mouse brain N-glycoproteome reveals widespread N-glycosylation of diverse brain proteins. Oncotarget. 2016 Jun 21;7(25):38796-38809.
4. Zeng WF#, Liu MQ#, Zhang Y, Wu JQ, Fang P, Peng C, Nie A, Yan G, Cao W, Liu C, Chi H, Sun RX, Wong CC*, He SM*, Yang P*. pGlyco: a pipeline for the identification of intact N-glycopeptides by using HCD- and CID-MS/MS and MS3.Sci Rep.2016 May 3;6:25102.
3. Fang P, Liu M, Xue Y, Yao J, Zhang Y, Shen H*, Yang P*. Controlling nonspecific trypsin cleavages in LC-MS/MS-based shotgun proteomics using optimized experimental conditions. Analyst. 2015 Nov 21;140(22):7613-21.
2. Li H, Shen H, Yan G, Zhang Y, Liu M, Fang P, Yu H*, Yang P*. Site-specific structural characterization of O-glycosylation and identification of phosphorylation sites of recombinant osteopontin. Biochim Biophys Acta.2015 Jun;1854(6):581-91.
1. Li H, Wei L*, Fang P, Yang P*. Recent advances in the fabrication and detection of lectin microarrays and their application in glycobiology analysis. Analytical Methods.2014 January.
