Independent Work

2025

59."Site-Selective Defluorinative Functionalization of Unactivated Alkenes Enabled by Cobalt/Photoredox Relay Catalysis"

Shuaikang Ren, Guangying Huang, Yuyang Bai, Shengqing Zhu*, and Lingling Chu*, ACS Catal. 2026, 16(1), 636–645.

 

58."Catalytic Asymmetric Synthesis of Chiral Allenylic Fluorides Enabled by Multiple Radical Sorting"

Yingying Li, Xian Gong, Ye Yuan, Yuyang Bai, Dr. Huan Li, Prof. Dr. Lingling Chu^*, Angew. Chem. Int. Ed. 2025, e202518286

 

57."Photochemical Nickel-Catalyzed Hydrocyanation of Unactivated Alkenes Using Isonitriles"

Yi Lu, Zhonghou Huang, Weidong Meng^*, Shengqing Zhu^*, Lingling Chu^*，Chin. J. Chem. 2025, 43, 3437-3443

56. "Enantioselective Carbonylative Coupling Reactions: Merging Nickel-Based Selectivity and Photoredox Reactivity"

 Ling Li, Zhen Hu, Shuaikang Ren, Bruce A. Arndtsen*, Lingling Chu*,   J. Am. Chem. Soc. 2025, 147 (31),  28206–28214.

55.  “Divergent Carbocyanation and Hydrocyanation of Alkynes Enabled by Photoinduced Nickel-Catalyzed Homolytic Bond Cleavage of C(sp3)–N Bond in Isonitriles”

Zhuzhu Zhang , Jian Qin , Shengqing Zhu, Lingling Chu^∗, Synlett, 2025,  36(11), 1461-1468.

* Invited synpacts

54. "Photocatalyzed Dicyanation of Alkenes Enabled by Phosphorous Radical Cation Addition"

Jing Li, Yanyan Zhang, Shengqing Zhu,* Lingling Chu^*  Chem. Eur. J. 2025, e202501154

53. "Photocatalytic Amine-Promoted Selective Hydrochlorination and sp³ C–O Acylation of Alkyne-Tethered Methyl Ethers with Aldehydes"

Liping Huo, Shengqing Zhu, Yaheng Zhao, Xiaoyu Zhao and Lingling Chu^*    Org. Lett. 2025, 27, 3548–3553

52."Nickel-Catalyzed Cyanation of Vinyl Triflates with Isonitrile as a Nucleophilic CN Source"

Yuntong Hu, Jian Qin, Shengqing Zhu*, Lingling Chu*   Adv. Synth. Catal. 2025, 367, e202500200

51."Atroposelective Three-Component (Fluoro)methylative Alkylation of Terminal Alkynes"

Yaheng Zhao, Liping Huo, Xiaoyu Zhao, and Lingling Chu*  ACS Catal. 2025, 15, 63−71.

2024

50."Radical Alkylcyanation of 1,6-Enynes with Isonitriles as Bifunctional Reagents"

Zhonghou Huang, Jian Qin, Yuntong Hu, Shengqing Zhu*, and Lingling Chu*, Org. Lett., 2024,  26 , 10763–10768.

49. "Metallaphotoredox-Catalyzed Three-Component Asymmetric Cross-Electrophile Coupling for Chiral Boronate Synthesis"

Xiaofang Li, Yuntong Hu, Zhonghou Huang, Shengqing Zhu, Feng-Ling Qing, Lingling Chu^*  ACS Catal. 2024, 14 (20), 15790–15798

48."Photoinduced Nickel-Catalyzed Homolytic C(sp³)–N Bond Activation of Isonitriles for Selective Carbo- and Hydro-Cyanation of Alkynes"

Jian Qin, Yingying Li, Yuntong Hu, Zhonghou Huang, Weihang Miao, and Lingling Chu* J. Am. Chem. Soc. 2024, 146, 27583–27593

Highlighted by Synfacts 2024; 20(12): 1287

47. "Regio- and enantioselective hydrofluorination of internal alkenes via nickel-catalyzed hydrogen atom transfer"

Fan Chen, Xiaoyu Zhao, Weihang Miao, Yingying Li, Ye Yuan, and Lingling Chu*. Chin. Chem. Lett. 2025, 36(5), 110239.

46. "Selective Hydrofunctionalization of Alkenyl Fluorides Enabled by Nickel-Catalyzed Hydrogen Atoms and Group Transfer: Reaction Development and Mechanistic Study"

Fan Chen^#, Qianwei Zhang^#, Yingying Li, Zhi-Xiang Yu*, and Lingling Chu*. J. Am. Chem. Soc. 2024, 146, 11418–11431. 

Highlighted by 

Organic Chemistry Portal; 

Synfacts 2024; 20(07): 0724

45. “Defluorinative Alkylboration of Alkenes Enabled by Dual Photoredox and Copper Catalysis”

Fan, Y.; Huang, Z.; Lu, Y. Zhu, S^*.;* Chu, L.*. Angew. Chem. Int. Ed. 2024, 63, e202315974.

Highlighted by 

Synfacts 2024; 20(04): 0380

44."Two-Carbon Homologation of Aldehydes: An Efficient Route to Difluoromethyl Alkynes"

Liang Shao , Shuaikang Ren , Jing Li , Chuqian Tang , Shengqing Zhu∗ , Lingling Chu∗  Synlett, Doi: 10.1055/a-2487-3686

2023

43. " Divergent 1,2-carboallylation of terminal alkynes enabled by metallaphotoredox catalysis with switchable triplet energy transfer"

Qin, J.; Zhang, Z.; Lu, Y. Zhu, S.; Chu, L.*. Chem. Sci. 2023,14, 12143-12151.

‍42.“Visible-light-induced defluorinative allylation of difluoromethyl ketones using alkylamines as bifunctional agents.”

‍Jiao, X.; Huang, Z.; Meng, W.; Zhu, S.*;  Chu, L.*.Org. Chem. Front. 2023, 10, 4542-4549.

# 2023 Organic Chemistry Frontiers HOT articles

41. "Nickel-Catalyzed Markovnikov-Selective Hydrodifluoromethylation of Alkynes Using BrCF₂H."

Pan, S.; Chen, F.; Zhang, Y.; Shao, L.;Chu, L.*. Angew. Chem. Int. Ed. 2023, 62, e202305426.

40. "Site- and Stereoselective Synthesis of Alkenyl Chlorides by Dual Functionalization of Internal Alkynes via Photoredox/Nickel Catalysis."

Huo, L.; Li, X,; Zhao, Y.; Li, L.; Chu, L.*. J. Am. Chem. Soc. 2023, 145 , 9876–9885. 

39. "Recent Advances in Nickel-Catalyzed Asymmetric Acylation Reactions."

Zhang, Y.; Zhang, Z.; Zhu, S*.; Chu, L.*. Chin. J. Org. Chem. 2023, 43, 1023-1035.

# Invited review

38. "Ligand-controlled stereodivergent alkenylation of alkynes to access functionalized trans- and cis-1,3-dienes"

Long, T.^#; Zhu, C.^#; Li, L.; Shao, L.; Zhu, S.; Rueping, M.;*Chu, L.* Nat. Commun. 2023, 14, 55.

37. "Exploring visible light for carbon–nitrogen and carbon–oxygen bond formation via nickel catalysis"

36. "Three-component enantioselective alkenylation of organophosphonates via nickel metallaphotoredox catalysis" 

Li, X.^#; Yuan, M.^#; Chen, F.; Huang, Z.; Qing, F.-L.; Gutierrez, O.;* Chu, L.* Chem, 2023, 9(1), 154-169.

2022

35. "Light-Induced Divergent Cyanation of Alkynes Enabled by Phosphorus Radicals"

34. "Selective Three-Component Reductive Alkylalkenylation of Unbiased Alkenes via Carbonyl-Directed Nickel Catalysis"

Wang, F.; Pan, S.; Zhu, S.; Chu, L.* ACS Catal. 2022, 12, 9779–9789.

33. "Metallaphotoredox-Enabled Intermolecular Carbobromination of Alkynes with Alkenyl Bromides"

Yu, W.; Jiao, X.; Fan, Y.; Zhu, S.;* Chu, L.*  Adv. Synth. Catal. 2022, 364, 1239-1244.

32. "Catalyst-Free Intermolecular Sulfonyl/Fluoromethyl Heteroarylation of Vinyl Ethers via Visible-Light-Induced Charge Transfer"

Long, T.; Pan, S.; Zhu, S.; Chu, L.*  Chem. Eur. J. 2022, 28, e202104080

31. "Selective Fluoromethyl Couplings of Alkynes via Nickel Catalysis"

Li, H.; Wang, F.; Zhu, S.; Chu, L.*  Angew. Chem. Int. Ed. 2022, 61, e202116725.

30. "Selective Ni-catalyzed cross-electrophile coupling of alkynes, fluoroalkyl halides, and vinyl halides" 
Dai, Y.; Wang, F.; Zhu, S.; Chu, L.* Chin. Chem. Lett. 2022, 33, 4074-4078.

 # Special issue for "Fluorine Chemistry"

2021

29. "Divergent Aminocarbonylations of Alkynes Enabled by Photoredox/Nickel Dual Catalysis"
Zhao, X.; Feng, X.; Chen, F.; Zhu, S.; Qing, F.-L.; Chu, L.* Angew. Chem. Int. Ed. 2021, 60 (51), 26511-26517.

28. "Recent Advances in Photoredox/Nickel Dual-Catalyzed Difunctionalization of Alkenes and Alkynes" 
Xu, L.; Wang, F.; Chen, F.; Zhu, S.; Chu, L.* Chin. J. Org. Chem. 2021, 41, DOI: 10.6023/cjoc202109002.

# Invited review

27. "Catalytic three-component dicarbofunctionalization reactions involving radical capture by nickel”

Zhu, S,-Q.; Zhao, X.; Li, H.; Chu, L.* Chem. Soc. Rev. 2021, 50, 10836-10856.

# This article is part of the themed collection: Radical Chemistry

26. "Reductive hydrobenzylation of terminal alkynes via photoredox and nickel dual catalysis”
Zhao, X.; Zhu, S,-Q.; Qing, F.-L.; Chu, L.* Chem. Commun.  2021, 57, 9414-9417.

# This article is part of the themed collection: 2021 Emerging Investigators

25. "Radical 1,2-addition of bromoarenes to alkynes via dual photoredox and nickel catalysis”
Xu, L.; Zhu, S,-Q.; Huo, L,-P.; Chen, F.; Yu, W.; Chu, L.* Org. Chem. Front. 2021, 8, 2924-2931.

24. “Photoinduced triiodide-mediated [3+2] cycloaddition of N-tosyl aziridines and alkenes”
Li, Y.; Chen, F.; Zhu, S.; Chu, L.* Org. Chem. Front. 2021, 8, 2196-2202.

23. "Dual Photoredox-/Palladium-Catalyzed Cross-Electrophile Couplings of Polyfluoroarenes with Aryl Halides and Triflates"

Qin, J.; Zhu, S.; Chu, L.* Organometallics, 2021, 40, 2246-2252.

# This article is part of the "Organometallic Solutions to Challenges in Cross-Coupling" special issue.

22. "Borates as a Traceless Activation Group for Intermolecular Alkylarylation of Ethylene through Photoredox/Nickel Dual Catalysis"
Feng, X.; Guo, L.; Zhu, S.; Chu, L.* Synlett. 2021, 32, 1519-1524.

# cluster "Modern Nickel-Catalyzed Reactions"

21. "Silver‐Enabled General Radical Difluoromethylation Reaction with TMSCF₂H"
Yang, J.^#; Zhu, S.^#; Wang, F.; Qing, F.-L.; Chu, L.* Angew. Chem. Int. Ed. 2021, 60, 4300-4306.

20. "Organic-photoredox-catalyzed three-component sulfonylative pyridylation of styrenes"
Wang, F.; Qin, J.; Zhu, S.; Chu, L.* RSC Adv. 2021, 11, 142-146.

2020
19. "General Method for Enantioselective Three-Component Carboarylation of Alkenes Enabled by Visible-Light Dual Photoredox/Nickel Catalysis"

Guo, L.^#; Yuan, M.^#; Zhang, Y.; Wang, F.; Zhu, S.; Osvaldo Gutierrez*; Chu, L.* J. Am. Chem. Soc. 2020, 142, 20390-20399.

18. "Synergistic Catalysis for Stereodivergent Synthesis of trans- and cis-Skipped Dienes"
Wang, F.; Zhu, S.*; Chu, L.* Synlett. 2020, 31, 1741-1746.

# Invited Synpact

17. "Enantioselective Three-Component Fluoroalkylarylation of UnactivatedOlefins Through Nickel-Catalyzed Cross-Electrophile Coupling"
Tu, H.^#; Wang, F.^#; Huo, L.; Li, Y.; Zhu, S.; Zhao, X.; Li, H.; Qing, F.-L.; Chu, L.* J. Am. Chem. Soc. 2020, 142, 9604-9611.

16. "Sequential C-O Decarboxylative Vinylation/C-H Arylation of Cyclic Oxalates via Nickel-Catalyzed Multicomponent Radical Cascade"
Li, H.^#; Guo, L.^#; Feng, X.; Huo, L.; Zhu, S.; Chu, L.* Chem. Sci. 2020, 11, 4904-4910.

15. "Recent advances in photoredox and nickel dual-catalyzed cascade reactions: pushing the boundaries of complexity"
Zhu, C.; Yue, H.-F.; Chu, L.; Rueping, M. Chem. Sci. 2020, 11, 4051-4064.

# Invited review

14. "Recent Advances in Nickel-Catalyzed Three-Component Difunctionalization of Unactivated Alkenes"
Tu, H.-Y.; Zhu, S.*; Qing, F.-L.; Chu, L.* Synthesis 2020, 52, 1346-1356.

# Invited review

13. "Visible‐Light‐Enabled Stereodivergent Synthesis of (E)‐ and (Z)‐1,4‐Dienes via Photoredox/Nickel Dual Catalysis"
Song, F.#; Wang, F.#; Guo, L.; Feng, X.; Zhang, Y.; Chu, L.* Angew. Chem. Int. Ed. 2020, 59(1), 177-181.

# Hot paper

2019

12. "Bisphosphonium salt: an effective photocatalyst for the intramolecular hydroalkoxylation of olefins"
Cheng, H.; Wang, X.; Chang, L.; Chen, Y.-L.; Chu, L.*; Zuo, Z.-W.* Sci. Bull. 2019, 64, 1896-1901.

11. "Selective, Intermolecular Alkylarylation of Alkenes via Photoredox/Nickel Dual Catalysis"
Guo, L.^#; Tu, H.-Y.^#; Zhu, S.-Q.; Chu, L.* Org. Lett. 2019, 21, 4771-4776.

10. "Photoredox-catalyzed branch-selective pyridylation of alkenes for the expedient synthesis of Triprolidine"
Zhu, S.; Qin, J.; Wang, F.; Li, H.; Chu, L.* Nat. Commun. 2019, 10, 749.

9. "Intermolecular, redox-neutral azidoarylation of alkenes via photoredox catalysis"
Chen, J.^#; Zhu, S.^#; Qin, J.; Chu, L.* Chem. Commun. 2019, 55, 2336-2339.

2018
8. "Solvent-tuned chemoselective carboazidation and diazidation of alkenes via iron catalysis"
Xu, L.; Chen, J.; Chu, L.* Org. Chem. Front. 2018, 6, 512-516.

7. “A four-component radical cascade trifluoromethylation reaction of alkenes enabled by an electron-donor–acceptor complex”
Tu, H.-Y.; Zhu, S.; Qing, F.-L.; Chu, L.* Chem. Commun. 2018, 54, 12710-12713.

6. "Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling"
Chen, D.; Xu, L.; Long, T.; Zhu, S.; Yang, J.; Chu, L.* Chem. Sci. 2018, 9, 9012-9017.

5. "syn-Selective Alkylarylation of Terminal Alkynes via the Combination of Photoredox and Nickel Catalysis"
Guo, L.; Song, F.; Zhu, S.; Li, H.; Chu, L.* Nat. Commun. 2018, 9, 4543.

4. "Ligand-Accelerated, Branch-Selective Oxidative Cyanation of Alkenes"
Yang, J.; Li, H.; Qin, J.; Song, F.; Zhang, J.; Qing, F.-L.; Chu, L.* Sci. Bull. 2018, 63, 1479-1484.

3. "Intermolecular selective carboacylation of alkenes via nickel-catalyzed reductive radical relay"
Zhao, X.^#; Tu, H.-Y.^#; Guo, L.; Zhu, S.; Qing F.-L.; Chu, L.* Nat. Commun. 2018, 9, 3488.

2. "Catalytic, Metal-free Sulfonylcyanation of Alkenes via Visible Light Organophotoredox Catalysis"
Sun, J.^#; Li, P.^#; Guo, L.; Yu, F.; He, Y.-P.*; Chu, L.* Chem. Commun. 2018, 54, 3162-3165.

2017
1. "Visible-light-induced Halogenation of Aliphatic C-H Bonds"
Tu, H.; Zhu, S.; Qing, F.-L.; Chu, L.* Tetrahedron Lett. 2017, 59, 173-179.

# Invited review

Prior to DHU

24. "Silver-Mediated Oxidative Trifluoromethylation of Phenols: Direct Synthesis of Aryl Trifluoromethyl Ethers"
Liu, J.-B.; Chen, C.; Chu, L.; Chen, Z.-H.; Xu, X.-H.; Qing, F.-L.* Angew. Chem. Int. Ed. 2015, 54, 11839-11842.

23. "Merging Photoredox and Nickel Catalysis: The Direct Synthesis of Ketones via the Decarboxylative Arylation of α-Oxo Acids"
Chu, L.; Lipshultz, J. M.; MacMillan, D. W. C.* Angew. Chem. Int. Ed. 2015, 54, 7929−7933 (Very Important Paper).

22. "Carboxylic Acids as A Traceless Activation Group for Conjugate Additions: A Three-Step Synthesis of (±)-Pregabalin"
Chu, L.; Ohta, C.; Zuo, Z.; MacMillan, D. W. C.* J. Am. Chem. Soc. 2014, 136, 10886−10889.

21. "Merging Photoredox with Nickel Catalysis: Coupling of α-Carboxyl sp³-Carbons with Aryl Halides"
Zuo, Z.; Ahneman, D.; Chu, L.; Terrett, J.; Doyle, A. G.*; MacMillan, D.W. C.* Science 2014, 345, 437−440.

20. "Oxidative Trifluoromethylation and Trifluoromethylthiolation Reactions Using (Trifluoromethyl)trimethylsilane as A Nucleophilic CF₃ Source"
Chu, L.; Qing, F.-L.* Acc. Chem. Res. 2014, 47, 1513−1522.

19. "Direct introduction of ethoxycarbonyldifluoromethyl-group to heteroarenes with ethyl bromodifluoroacetate via visible-light photocatalysis"
Lin, Q.; Chu, L.; Qing, F.-L.* Chin. J. Chem. 2013, 31, 885-891.

18. "Copper-Mediated Oxidative Difluoromethylenation of Aryl Boronic Acids with a-Silyldifluoromethylphosphonates: A New Method for Aryldifluorophosphonates"
Jiang, X.; Chu, L.; Qing, F.-L.* New J. Chem. 2013, 37, 1736−1741.

17. "Total Synthesis of the Trifluoromethylated Analog of Isoaltholactone: 5-Trifluoromethylisoaltholactone"
Chen, J.-L.; Chu, L.; Qing, F.-L.* J. Fluorine Chem. 2013, 152, 70−76.

16. "Electrophilic Trifluoromethylthiolation of Allylsilanes with Trifluoromethanesulfanamide"
Liu, J.; Chu, L.; Qing, F.-L.* Org. Lett. 2013, 15, 894−897.

15. "Silver-Catalyzed Hydrotrifluoromethylation of Unactivated Alkenes with CF₃SiMe₃"
Wu, X.; Chu, L.; Qing, F.-L.* Angew. Chem. Int. Ed. 2013, 52, 2198−2202.

14. "PhI(OAc)₂-mediated Oxidative Trifluoromethylation of Arenes with CF₃SiMe₃ under Metal-free Conditions"
Wu, X.; Chu, L.; Qing, F.-L.* Tetrahedron Lett. 2013, 54, 249−251.

13. "Synthesis of γ-Fluoroalkylated Allylic Amines Derivatives via Palladium-catalyzed Overman Rearrangement"
Jiang, X.-Y.; Chu, L.; Wang, R.-W.; Qing, F.-L.* Tetrahedron Lett. 2012, 53, 6853−6857.

12. "Metal-Free Oxidative Trifluoromethylthiolation of Terminal Alkynes with CF₃SiMe₃ and Elemental Sulfur"
Chen, C.; Chu, L.; Qing, F.-L.* J. Am. Chem. Soc. 2012, 134, 12454−12457.

11. "Copper-Mediated Oxidative Cross-Coupling Reaction of Terminal Alkynes with α-Silyldifluoromethylphosphonates: An Efficient Method for α,α-Difluoropropargylphosphonates"
Jiang, X.; Chu, L.; Qing, F.-L.* Org. Lett. 2012, 14, 2870−2873.

10. "Copper-Catalyzed Oxidative Trifluoromethylation of Terminal Alkenes Using Nucleophilic CF₃SiMe₃: Efficient C(sp³)–CF₃ Bond Formation"
Chu, L.; Qing, F.-L.* Org. Lett. 2012, 14, 2106−2109.

9. "Copper-Catalyzed Aerobic Oxidative Trifluoromethylation of H-Phosphonates Using Trimethyl(trifluoromethyl)silane"
Chu, L.; Qing, F.-L.* Synthesis 2012, 44, 1521−1525.

8. "Copper-Catalyzed Oxidative Trifluoromethylation of Terminal Alkynes and Aryl Boronic Acids Using (Trifluoromethyl)trimethylsilane"
Jiang, X.; Chu, L.; Qing, F.-L.* J. Org. Chem. 2012, 77, 1251−1257.

7. "Copper-Catalyzed Oxidative Trifluoromethylthiolation of Aryl Boronic Acids with TMSCF₃ and Elemental Sulfur"
Chen, C.; Xie, Y.; Chu, L.; Wang, R. Zhang, X. Qing, F.-L.* Angew. Chem. Int. Ed. 2012, 51, 2492−2495.

6. "Copper-Catalyzed Direct C-H Oxidative Trifluoromethylation of Heteroarenes"
Chu, L.; Qing, F.-L.* J. Am. Chem. Soc. 2012, 134, 1298−1304.

5. "Copper-Mediated Oxidative Trifluoromethylation of Boronic Acids"
Chu, L.; Qing, F.-L.* Org. Lett. 2010, 12, 5060–5063.

4. "Copper-Mediated Aerobic Oxidative Trifluoromethylation of Terminal Alkynes with Me₃SiCF₃"
Chu, L.; Qing, F.-L.* J. Am. Chem. Soc. 2010, 132, 7262−7263.

3. "Benzoyl Peroxide (BPO)-promoted Oxidative Trifluoromethylation of Tertiary Amines with Trimethyl(trifluoromethyl)silane"
Chu, L.; Qing, F.-L.* Chem. Commun. 2010, 46, 6285−6287.

2. "Cu(II)-Mediated Methylthiolation of Aryl C−H Bonds with DMSO"
Chu, L.; Yue, X.; Qing, F.-L.* Org. Lett. 2010, 12, 1644−1647.

1. "CuBr-Catalyzed Oxidative Difluoromethylation of Tertiary Amines with Difluoroenol Silyl Ethers"
Chu, L.; Zhang, X.; Qing, F.-L.* Org. Lett. 2009, 11, 2197−2200.