代表性论文列表

2025年

1. GSH-Responsive GalNAc-Conjugated Glycopolymer for Targeted Survivin siRNA Delivery in Hepatocellular Carcinoma Therapy

    Mengfei Yin, Lihao Wang, Yang Liu, Jingjing Chen, Hongming Gao, Jinlong Xu, Yuxin Guo, Xinying Cui, Guangli Yu and Chao Cai*

     ACS Macro Lett., 2025, 14, 589–596.  https://doi.org/10.1021/acsmacrolett.5c00121

2. Synthesis of Fucoidan-Biomimetic Glycopolymers with Flexible Skeletons for Enhanced Anti-Herpes Virus Efficacy

    Ping Zhang, Han Yan, Zhihe Liang, Peng Zhang, Xiao-Hua Li, Xian-Zheng Yuan, Guangli Yu*, Wei Wang*, Chao Cai*

     ACS, Nano., 2025. https://doi.org/10.1021/acsnano.4c15060

2024年

1. Chemical synthesis of a trisaccharide fragment of a fucosylated glucuronomannan isolated from brown algae

    Gong Hao, Le Zhang, Wenhan Guo, Huixin Qiu, Guangli Yu, and Chao Cai*

     J. Carbohyd. Chem., 2024, 1-21. https://doi.org/10.1080/07328303.2024.2410797

2. A novel esterase regulates Klebsiella pneumoniae hypermucoviscosity and virulence

   Lijun Wang, Zhe Wang, Hua Zhang, Qian Jin, Shuaihua Fan, Yanni Liu, Xueting Huang, Jun Guo, Chao Cai*, Jing-Ren Zhang*, Hui Wu*

   PLoS Pathog,. 2024, 20: e1012675. https://doi.org/10.1371/journal.ppat.1012675

3. Ganoderma lucidum polysaccharide alleviates cognitive dysfunction by inhibiting neuroinflammation via NLRP3/NF-κB signaling pathway

    Yudi Jiang, Zhe Wang, Wanshuai Wang, Yang Liu, Yang Meng, Yaozhong Wang, Minghao Fan*, Chao Cai*

    J. Ethnopharmacol,. 2024, 228, 119065. https://doi.org/10.1016/j.jep.2024.119065 

4. Structural properties, bioactivities, structure-activity relationships and bio-applications of polysaccharides from Auricularia auricula: A review

   Jun Tang, Zihan He, Baohui Zhang, Jingjing Cheng, Wenxiu Qiu, Xinyan Chen, Cong Chang, Qi Wang, Junjie Hu*, Chao Cai*, Yan Meng*

   Int. J. Biol. Macromol., 2024, 280, 135941. https://doi.org/10.1016/j.ijbiomac.2024.135941

5. Glycopolymer with Sulfated Fucose and 6′-Sialyllactose as a Dual-Targeted Inhibitor on Resistant Influenza A Virus Strains

   Ping Zhang, Chenning Li, Xiaoyao Ma, Jinfeng Ye, Depeng Wang, Hongzhi Cao, Guangli Yu, Wei Wang*, Xun Lv*, and Chao Cai*

    ACS Macro Lett,. 2024, 13, 874–881. https://doi.org/10.1021/acsmacrolett.4c00221

6. Anti-tumor and anti-metastasis of water-soluble sulfated β-glucan derivatives from Saccharomyces cerevisiae

        Jia Li, Mengmeng Zheng, Zhe Wang, Yang Liu, Qingfeng Niu, Han Zhou, Depeng Wang, Jike Song, Hongsheng Bi*, Bin Guo*, Guangli Yu*, Chao Cai*

           Carbohyd. Polym., 2024, 122466. https://doi.org/10.1016/j.carbpol.2024.122466

7. Immune-enhancing activity of compound polysaccharide on the inactivated influenza vaccine 

    Yang Zhang#, Depeng Wang#, Daotong Tan, Anqi Zou, Zhe Wang, Hao Gong, Yu Yang, Lishan Sun, Xiaoliang Lin, Ming Liang, Yi Yu, Xiaoxi He*,  Guangli  Yu, Wei Wang*, Chao Cai* 

     Carbohyd. Polym., 2024, 336, 122080.  https://doi.org/10.1016/j.carbpol.2024.122080

8. Nanopore-regulated in situ polymerization for synthesis of homogeneous heparan sulfate with low dispersity

     Meng Qiao#, Zhe Wang#, Junjie Zhang, Yanqi Li, Liang-An Chen, Fuming Zhang, Jonathan S. Dordick, Robert J. Linhardt, Chao Cai*, He Huang, Xing Zhang*

     Carbohyd. Polym., 2024, 122297. https://doi.org/10.1016/j.carbpol.2024.122297

9. A Strain-Promoted Divergent Chemical Steroidation Unveils Potent Anti-Inflammatory Pseudo-Steroidal Glycosides.

      Han Ding, Xiao-Lin Zhang, Aoxin Guo, Qian Ping Lee, Chao Cai, Ming Li, Hongzhi Cao, and Xue-Wei Liu*.

      J. Am. Chem. Soc., 2024, 146, 11811–11822. https://doi.org/10.1021/jacs.4c00537

10. Structural Elucidation of Glycosaminoglycans in the Tissue of Flounder and Isolation of Chondroitin Sulfate C. 

      Zhe Wang, Weiwen Wang, Hao Gong, Yudi Jiang, Renjie Liu, Guangli Yu*, Guoyun Li*, Chao Cai*. 

      Mar. Drugs., 2024, 22, 198. https://doi.org/10.3390/md22050198

2023年

1. The sol-gel property of a triple-helix polysaccharide from Auricularia auricula-judae and the protective effect on DSS-induced ulcerative colitis. 

     Ziwei Gao#, Na Hu#, Peng Cao#, Jingjing Cheng, Wenxiu Qiu, Qi Wang, Xinyan Chen, Cong Chang, Chao Cai*, Yan Meng*, Xiaojuan Xu*. 

     Food Frontiers., 2024, 5, 867-879. https://doi.org/10.1002/fft2.361

2. In Situ Probing of the Intrinsic Adhesion Strength of Single Anaerobic Microbial Cells. 

     Jian-Lu Duan, Lei Wu, Ping Zhang, Jing-Ya Ma, Xiao-Dong Sun, Xiao-Yu Liu, Fan-Shu Geng, Mei-Yan Liu, Yu-Chen Sun, Chao Cai, Zhen Yan, and Xian-Zheng Yuan*

     Anal. Chem., 2023, 95, 8325–8331. https://doi.org/10.3390/md22050198

2021年

1. Recent progress and advanced technology in carbohydrate-based drug development. 

      Lin Pan#, Chao Cai#,  Chanjuan Liu, Di Liu, Guoyun Li, Robert J. Linhardt, Guangli Yu*. 

      Curr. Opin. Biotech., 2021, 69, 191-198. https://doi.org/10.1016/j.copbio.2020.12.023

2. Recent advances in the chemical synthesis of marine acidic carbohydrates. 

     Xinru Li#, Chao Cai*, Depeng Wang, Ping Zhang and Guangli Yu. 

      Curr. Org. Chem., 2021, 25, 1-12. https://doi.org/10.2174/1385272824999201230120805

2020年

1. End-functionalised glycopolymers as glycosaminoglycan mimetics inhibit HeLa cell proliferation.

      Chendong Yang^#, Lei Gao^#, Meng Shao, Chao Cai*, Lihao Wang, Yifan Chen, Jianghua Li, Fei Fan, Yubing Han, Ming Liu*, 

      Robert J. Linhardt   and Guangli Yu*.  

      Polym. Chem., 2020, 11, 4714-4722. https://doi.org/10.1039/D0PY00384K

2. Odd-numbered agaro-oligosaccharides alleviate type 2 diabetes mellitus and related colonic microbiota dysbiosis in mice.

      Xueliang Wang^#, Zimei Yang, Xu Xu, Hao Jiang*, Chao Cai*, Guangli Yu*. 

      Carbohyd. Polym., 2020, 240, 116261. https://doi.org/10.1016/j.carbpol.2020.116261

3. Purification, structural characterization, and immunomodulatory activity of the polysaccharides from 

    Ganoderma lucidum.

      Jia Li^#, Feifei Gu^#, Chao Cai*, Minghua Hu, Luodi Fan, Jiejie Hao*, Guangli Yu*.  

             Int. J. Biol. Macromol., 2020, 143, 806-813. https://doi.org/10.1016/j.ijbiomac.2019.09.141

4. Collaborative assembly of doxorubicin and galactosyl diblock glycopolymer for targeted delivery of 

     hepatocellular carcinoma. 

      Jianghua Li^#, Yang Zhang^#, Chao Cai^#*, Xiaozhi Rong, Meng Shao, Jiarui Li, Chendong Yang, Guangli Yu*.

             Biomater. Sci., 2020, 8, 189–200. https://doi.org/10.1039/C9BM01604J

2019年

1. Chemoenzymatic synthesis of heparan sulfate mimetic glycopolymers and their interactions with 

    the receptor for advanced glycation end-product.

      Jun Li^#, Chao Cai*, Lihao Wang, Chendong Yang, Hao Jiang, Miaomiao Li, Ding Xu, Guoyun Li, Chunxia Li, Guangli Yu*.  

      ACS Macro Lett., 2019, 8, 1570-1574. https://doi.org/10.1021/acsmacrolett.9b00780

2. Synthesis and properties of functional glycomimetics through click grafting of fucose onto chondroitin sulfates.

      Fei Fan^#, Ping Zhang, Lihao Wang, Tiantian Sun, Chao Cai*, Guangli Yu*. 

      Biomacromolecules, 2019, 20, 3798-3808. https://doi.org/10.1021/acs.biomac.9b00878

3. Concise chemoenzymatic synthesis of heparan sulfate analogues as potent BACE-1 inhibitors.

      Jun Li^#, Jiarui Li, Tiantian Sun, Chao Cai*, Meng Shao, Guangli Yu*.

      Carbohyd. Polym., 2019, 217, 232-239.https://doi.org/10.1016/j.carbpol.2019.04.047

4. Recent advances in pharmaceutical potential of brown algal polysaccharides and their derivatives. 

      Jun Li^#, Chao Cai*, Chendong Yang, Jianghua Li, Tiantian Sun, Guangli Yu.

      Curr. Pharm. Design, 2019, 25, 1290-1311. DOI: 10.2174/1381612825666190618143952

5. Alkaline extraction, structural characterization, and bioactivities of (1→6)-β-d-glucan from 

    Lentinus edodes. 

      Jia Li^#, Chao Cai*, Mengmeng Zheng, Jiejie Hao, Ya Wang, Minghua Hu, Luodi Fan, Guangli Yu*.

      Molecules, 2019, 24, 1610. https://doi.org/10.3390/molecules24081610

6. Heavy heparin: a stable isotope‐enriched, chemoenzymatically‐synthesized, poly‐component drug.

      Brady F. Cress^#, Ujjwal Bhaskar, Deepika Vaidyanathan, Asher Williams, Chao Cai, Xinyue Liu, Li Fu, Vandhana M-Chari, Fuming Zhang, 

      Shaker A. Mousa, Jonathan S. Dordick, Mattheos A. G. Koffas, Robert J. Linhardt*. 

      Angew. Chem. Int. Ed., 2019, 58, 5962 –5966. https://doi.org/10.1002/anie.201900768

2018年

1. Synthesis of fucoidan-mimetic glycopolymers with well-defined sulfation patterns via emulsion

     ring-opening metathesis polymerization.

       Fei Fan^#, Chao Cai*, Wei Wang, Lei Gao, Jun Li, Jia Li, Feifei Gu, Tiantian Sun, Jianghua Li, Chunxia Li, and Guangli Yu*.

       ACS Macro Lett., 2018, 7, 330-335. https://doi.org/10.1021/acsmacrolett.8b00056

2. Effect of anomeric configuration on stereocontrolled α-glycosylation of L-Fucose.

      Lihao Wang^#, Fei Fan#, Haotian Wu, Lei Gao, Ping Zhang, Tiantian Sun, Chendong Yang, Guangli Yu, Chao Cai*.

      Synlett, 2018, 29, 2701-2706. DOI: 10.1055/s-0037-1611311

3. Chitosan-based nanomaterials for drug delivery. 

     Jianghua Li^#, Chao Cai*, Jiarui Li, Jun Li, Jia Li, Tiantian Sun, Lihao Wang, Haotian Wu, Guangli Yu.

      Molecules, 2018, 23, 2661. https://doi.org/10.3390/molecules23102661

2017年

1. Microwave-assisted synthesis of glycopolymers by ring-opening metathesis polymerization (ROMP) 

     in an emulsion system.

      Fei Fan^#, Chao Cai*, Lei Gao, Jun Li, Ping Zhang, Guoyun Li, Chunxia Li, and Guangli Yu*.

      Polym. Chem., 2017, 8, 6709-6719.  https://doi.org/10.1039/C7PY01415E

2. Spongy bilayer dressing composed of chitosan-Ag nanoparticles and chitosan-Bletilla striata 

    polysaccharide for wound healing applications.

      Lang Ding^#, Xindi Shan, Xiaoliang Zhao, Hualian Zha, Xiaoyu Chen, Jianjun Wang, Chao Cai*, Xiaojiang Wang, Guoyun Li, Jiejie Hao, Guangli Yu*.  

     Carbohydr. Polym., 2017, 157, 1538-1547.https://doi.org/10.1016/j.carbpol.2016.11.040

2015年

1. Green solvents in carbohydrate chemistry: from raw materials to fine chemicals.

     Angeles Farrán^#, Chao Cai, Manuel Sandoval, Yongmei Xu, Jian Liu, María J. Hernáiz*, and Robert J. Linhardt*. 

    Chem. Rev., 2015, 115, 6811-6853. https://doi.org/10.1021/cr500719h

2. Click-coated, heparinized, decellularized vascular grafts.

     Sashka Dimitrievska^#, Chao Cai, Amanda Weyers, Jenna L. Balestrini, Tylee Lin, Sumati Sundaram, Go Hatachi, David A. Spiegel, 

      Themis R. Kyriakides, Jianjun Miao, Guoyun Li, Laura E. Niklason, Robert J. Linhardt*.  

      Acta Biomater., 2015, 13, 177-187. https://doi.org/10.1016/j.actbio.2014.11.015

2014年

1.  Fluorous-assisted chemoenzymatic synthesis of heparan sulfate oligosaccharides. 

      Chao Cai^#, Demetria Dickinson, Lingyun Li, Sayaka Masuko, Matt Suflita, Victor Schultz, Shawn Nelson, Ujjwal Bhaskar, Jian Liu, Robert J. Linhardt*.

      Org. Lett., 2014, 16, 2240-2243. https://doi.org/10.1021/ol500738g

2. Homogeneous low-molecular-weight heparins with reversible anticoagulant activity. 

     Yongmei Xu^#, Chao Cai, Kasemsiri Chandarajoti, Po-Hung Hsieh, Lingyun Li, Truong Q. Pham, Erica M. Sparkenbaugh, Juzheng Sheng, Nigel S. Key, 

     Rafal Pawlinski, Edward N. Harris, Robert J. Linhardt* and Jian Liu*. 

     Nat. Chem. Biol., 2014, 10, 248-250. https://doi.org/10.1038/nchembio.1459

2013年

1. Towards the chemoenzymatic synthesis of heparan sulfate oligosaccharides: Oxidative cleavage of p-nitrophenyl 

     group with ceric ammonium salts.

      Chao Cai^#, Lingyun Li, Cate Harvey, Jian Liu, Robert J. Linhardt*. 

      Tetrahedron Lett., 2013, 54, 4471-4474. https://doi.org/10.1016/j.tetlet.2013.06.044

2. Preparation and application of a “clickable” acceptor for enzymatic synthesis of heparin oligosaccharides.

     Chao Cai#, Kristi Edgar, Jian Liu, Robert J. Linhardt*.  

     Carbohyd. Res., 2013, 372, 30-34. https://doi.org/10.1016/j.carres.2013.02.010

2011年

1. Semi-synthesis of chondroitin sulfate-E from chondroitin sulfate-A.

     Chao Cai#, Kemal Solakyildirim, Bo Yang, Julie M. Beaudet, Amanda Weyers, Robert J. Linhardt, Fuming Zhang*.  

     Carbohyd. Polym., 2011, 87, 822-829. https://doi.org/10.1016/j.carbpol.2011.08.075

2010年

1. Stereoselective total synthesis of (−)-Cleistenolide.

     Chao Cai#, Jun Liu, Yuguo Du* and Robert J. Linhardt.  

     J. Org. Chem., 2010, 75, 5754-5756. https://doi.org/10.1021/jo101059e