代表性论文列表

2024年

1. Glycopolymer with Sulfated Fucose and 6′-Sialyllactose as a Dual-Targeted Inhibitor on Resistant Influenza A Virus Strains

   Ping Zhang, Chenning Li, Xiaoyao Ma, Jinfeng Ye, Depeng Wang, Hongzhi Cao, Guangli Yu, Wei Wang*, Xun Lv*, and Chao Cai*

    ACS Macro Lett,. 2024, 13, 874–881. https://doi.org/10.1021/acsmacrolett.4c00221

2. Anti-tumor and anti-metastasis of water-soluble sulfated β-glucan derivatives from Saccharomyces cerevisiae

        Jia Li, Mengmeng Zheng, Zhe Wang, Yang Liu, Qingfeng Niu, Han Zhou, Depeng Wang, Jike Song, Hongsheng Bi*, Bin Guo*, Guangli Yu*, Chao Cai*

           Carbohyd. Polym., 2024, 122466. https://doi.org/10.1016/j.carbpol.2024.122466

3. Immune-enhancing activity of compound polysaccharide on the inactivated influenza vaccine 

    Yang Zhang#, Depeng Wang#, Daotong Tan, Anqi Zou, Zhe Wang, Hao Gong, Yu Yang, Lishan Sun, Xiaoliang Lin, Ming Liang, Yi Yu, Xiaoxi He*,  Guangli  Yu, Wei Wang*, Chao Cai* 

     Carbohyd. Polym., 2024, 336, 122080.  https://doi.org/10.1016/j.carbpol.2024.122080

4. Nanopore-regulated in situ polymerization for synthesis of homogeneous heparan sulfate with low dispersity

     Meng Qiao#, Zhe Wang#, Junjie Zhang, Yanqi Li, Liang-An Chen, Fuming Zhang, Jonathan S. Dordick, Robert J. Linhardt, Chao Cai*, He Huang, Xing Zhang*

     Carbohyd. Polym., 2024, 122297. https://doi.org/10.1016/j.carbpol.2024.122297

5. A Strain-Promoted Divergent Chemical Steroidation Unveils Potent Anti-Inflammatory Pseudo-Steroidal Glycosides.

      Han Ding, Xiao-Lin Zhang, Aoxin Guo, Qian Ping Lee, Chao Cai, Ming Li, Hongzhi Cao, and Xue-Wei Liu*.

      J. Am. Chem. Soc., 2024, 146, 11811–11822. https://doi.org/10.1021/jacs.4c00537

6. Structural Elucidation of Glycosaminoglycans in the Tissue of Flounder and Isolation of Chondroitin Sulfate C. 

      Zhe Wang, Weiwen Wang, Hao Gong, Yudi Jiang, Renjie Liu, Guangli Yu*, Guoyun Li*, Chao Cai*. 

      Mar. Drugs., 2024, 22, 198. https://doi.org/10.3390/md22050198

2023年

1. The sol-gel property of a triple-helix polysaccharide from Auricularia auricula-judae and the protective effect on DSS-induced ulcerative colitis. 

     Ziwei Gao#, Na Hu#, Peng Cao#, Jingjing Cheng, Wenxiu Qiu, Qi Wang, Xinyan Chen, Cong Chang, Chao Cai*, Yan Meng*, Xiaojuan Xu*. 

     Food Frontiers., 2024, 5, 867-879. https://doi.org/10.1002/fft2.361

2. In Situ Probing of the Intrinsic Adhesion Strength of Single Anaerobic Microbial Cells. 

     Jian-Lu Duan, Lei Wu, Ping Zhang, Jing-Ya Ma, Xiao-Dong Sun, Xiao-Yu Liu, Fan-Shu Geng, Mei-Yan Liu, Yu-Chen Sun, Chao Cai, Zhen Yan, and Xian-Zheng Yuan*

     Anal. Chem., 2023, 95, 8325–8331. https://doi.org/10.3390/md22050198

2021年

1. Recent progress and advanced technology in carbohydrate-based drug development. 

      Lin Pan#, Chao Cai#,  Chanjuan Liu, Di Liu, Guoyun Li, Robert J. Linhardt, Guangli Yu*. 

      Curr. Opin. Biotech., 2021, 69, 191-198. https://doi.org/10.1016/j.copbio.2020.12.023

2. Recent advances in the chemical synthesis of marine acidic carbohydrates. 

     Xinru Li#, Chao Cai*, Depeng Wang, Ping Zhang and Guangli Yu. 

      Curr. Org. Chem., 2021, 25, 1-12. https://doi.org/10.2174/1385272824999201230120805

2020年

1. End-functionalised glycopolymers as glycosaminoglycan mimetics inhibit HeLa cell proliferation.

      Chendong Yang^#, Lei Gao^#, Meng Shao, Chao Cai*, Lihao Wang, Yifan Chen, Jianghua Li, Fei Fan, Yubing Han, Ming Liu*, 

      Robert J. Linhardt   and Guangli Yu*.  

      Polym. Chem., 2020, 11, 4714-4722. https://doi.org/10.1039/D0PY00384K

2. Odd-numbered agaro-oligosaccharides alleviate type 2 diabetes mellitus and related colonic microbiota dysbiosis in mice.

      Xueliang Wang^#, Zimei Yang, Xu Xu, Hao Jiang*, Chao Cai*, Guangli Yu*. 

      Carbohyd. Polym., 2020, 240, 116261. https://doi.org/10.1016/j.carbpol.2020.116261

3. Purification, structural characterization, and immunomodulatory activity of the polysaccharides from 

    Ganoderma lucidum.

      Jia Li^#, Feifei Gu^#, Chao Cai*, Minghua Hu, Luodi Fan, Jiejie Hao*, Guangli Yu*.  

             Int. J. Biol. Macromol., 2020, 143, 806-813. https://doi.org/10.1016/j.ijbiomac.2019.09.141

4. Collaborative assembly of doxorubicin and galactosyl diblock glycopolymer for targeted delivery of 

     hepatocellular carcinoma. 

      Jianghua Li^#, Yang Zhang^#, Chao Cai^#*, Xiaozhi Rong, Meng Shao, Jiarui Li, Chendong Yang, Guangli Yu*.

             Biomater. Sci., 2020, 8, 189–200. https://doi.org/10.1039/C9BM01604J

2019年

1. Chemoenzymatic synthesis of heparan sulfate mimetic glycopolymers and their interactions with 

    the receptor for advanced glycation end-product.

      Jun Li^#, Chao Cai*, Lihao Wang, Chendong Yang, Hao Jiang, Miaomiao Li, Ding Xu, Guoyun Li, Chunxia Li, Guangli Yu*.  

      ACS Macro Lett., 2019, 8, 1570-1574. https://doi.org/10.1021/acsmacrolett.9b00780

2. Synthesis and properties of functional glycomimetics through click grafting of fucose onto chondroitin sulfates.

      Fei Fan^#, Ping Zhang, Lihao Wang, Tiantian Sun, Chao Cai*, Guangli Yu*. 

      Biomacromolecules, 2019, 20, 3798-3808. https://doi.org/10.1021/acs.biomac.9b00878

3. Concise chemoenzymatic synthesis of heparan sulfate analogues as potent BACE-1 inhibitors.

      Jun Li^#, Jiarui Li, Tiantian Sun, Chao Cai*, Meng Shao, Guangli Yu*.

      Carbohyd. Polym., 2019, 217, 232-239.https://doi.org/10.1016/j.carbpol.2019.04.047

4. Recent advances in pharmaceutical potential of brown algal polysaccharides and their derivatives. 

      Jun Li^#, Chao Cai*, Chendong Yang, Jianghua Li, Tiantian Sun, Guangli Yu.

      Curr. Pharm. Design, 2019, 25, 1290-1311. DOI: 10.2174/1381612825666190618143952

5. Alkaline extraction, structural characterization, and bioactivities of (1→6)-β-d-glucan from 

    Lentinus edodes. 

      Jia Li^#, Chao Cai*, Mengmeng Zheng, Jiejie Hao, Ya Wang, Minghua Hu, Luodi Fan, Guangli Yu*.

      Molecules, 2019, 24, 1610. https://doi.org/10.3390/molecules24081610

6. Heavy heparin: a stable isotope‐enriched, chemoenzymatically‐synthesized, poly‐component drug.

      Brady F. Cress^#, Ujjwal Bhaskar, Deepika Vaidyanathan, Asher Williams, Chao Cai, Xinyue Liu, Li Fu, Vandhana M-Chari, Fuming Zhang, 

      Shaker A. Mousa, Jonathan S. Dordick, Mattheos A. G. Koffas, Robert J. Linhardt*. 

      Angew. Chem. Int. Ed., 2019, 58, 5962 –5966. https://doi.org/10.1002/anie.201900768

2018年

1. Synthesis of fucoidan-mimetic glycopolymers with well-defined sulfation patterns via emulsion

     ring-opening metathesis polymerization.

       Fei Fan^#, Chao Cai*, Wei Wang, Lei Gao, Jun Li, Jia Li, Feifei Gu, Tiantian Sun, Jianghua Li, Chunxia Li, and Guangli Yu*.

       ACS Macro Lett., 2018, 7, 330-335. https://doi.org/10.1021/acsmacrolett.8b00056

2. Effect of anomeric configuration on stereocontrolled α-glycosylation of L-Fucose.

      Lihao Wang^#, Fei Fan#, Haotian Wu, Lei Gao, Ping Zhang, Tiantian Sun, Chendong Yang, Guangli Yu, Chao Cai*.

      Synlett, 2018, 29, 2701-2706. DOI: 10.1055/s-0037-1611311

3. Chitosan-based nanomaterials for drug delivery. 

     Jianghua Li^#, Chao Cai*, Jiarui Li, Jun Li, Jia Li, Tiantian Sun, Lihao Wang, Haotian Wu, Guangli Yu.

      Molecules, 2018, 23, 2661. https://doi.org/10.3390/molecules23102661

2017年

1. Microwave-assisted synthesis of glycopolymers by ring-opening metathesis polymerization (ROMP) 

     in an emulsion system.

      Fei Fan^#, Chao Cai*, Lei Gao, Jun Li, Ping Zhang, Guoyun Li, Chunxia Li, and Guangli Yu*.

      Polym. Chem., 2017, 8, 6709-6719.  https://doi.org/10.1039/C7PY01415E

2. Spongy bilayer dressing composed of chitosan-Ag nanoparticles and chitosan-Bletilla striata 

    polysaccharide for wound healing applications.

      Lang Ding^#, Xindi Shan, Xiaoliang Zhao, Hualian Zha, Xiaoyu Chen, Jianjun Wang, Chao Cai*, Xiaojiang Wang, Guoyun Li, Jiejie Hao, Guangli Yu*.  

     Carbohydr. Polym., 2017, 157, 1538-1547.https://doi.org/10.1016/j.carbpol.2016.11.040

2015年

1. Green solvents in carbohydrate chemistry: from raw materials to fine chemicals.

     Angeles Farrán^#, Chao Cai, Manuel Sandoval, Yongmei Xu, Jian Liu, María J. Hernáiz*, and Robert J. Linhardt*. 

    Chem. Rev., 2015, 115, 6811-6853. https://doi.org/10.1021/cr500719h

2. Click-coated, heparinized, decellularized vascular grafts.

     Sashka Dimitrievska^#, Chao Cai, Amanda Weyers, Jenna L. Balestrini, Tylee Lin, Sumati Sundaram, Go Hatachi, David A. Spiegel, 

      Themis R. Kyriakides, Jianjun Miao, Guoyun Li, Laura E. Niklason, Robert J. Linhardt*.  

      Acta Biomater., 2015, 13, 177-187. https://doi.org/10.1016/j.actbio.2014.11.015

2014年

1.  Fluorous-assisted chemoenzymatic synthesis of heparan sulfate oligosaccharides. 

      Chao Cai^#, Demetria Dickinson, Lingyun Li, Sayaka Masuko, Matt Suflita, Victor Schultz, Shawn Nelson, Ujjwal Bhaskar, Jian Liu, Robert J. Linhardt*.

      Org. Lett., 2014, 16, 2240-2243. https://doi.org/10.1021/ol500738g

2. Homogeneous low-molecular-weight heparins with reversible anticoagulant activity. 

     Yongmei Xu^#, Chao Cai, Kasemsiri Chandarajoti, Po-Hung Hsieh, Lingyun Li, Truong Q. Pham, Erica M. Sparkenbaugh, Juzheng Sheng, Nigel S. Key, 

     Rafal Pawlinski, Edward N. Harris, Robert J. Linhardt* and Jian Liu*. 

     Nat. Chem. Biol., 2014, 10, 248-250. https://doi.org/10.1038/nchembio.1459

2013年

1. Towards the chemoenzymatic synthesis of heparan sulfate oligosaccharides: Oxidative cleavage of p-nitrophenyl 

     group with ceric ammonium salts.

      Chao Cai^#, Lingyun Li, Cate Harvey, Jian Liu, Robert J. Linhardt*. 

      Tetrahedron Lett., 2013, 54, 4471-4474. https://doi.org/10.1016/j.tetlet.2013.06.044

2. Preparation and application of a “clickable” acceptor for enzymatic synthesis of heparin oligosaccharides.

     Chao Cai#, Kristi Edgar, Jian Liu, Robert J. Linhardt*.  

     Carbohyd. Res., 2013, 372, 30-34. https://doi.org/10.1016/j.carres.2013.02.010

2011年

1. Semi-synthesis of chondroitin sulfate-E from chondroitin sulfate-A.

     Chao Cai#, Kemal Solakyildirim, Bo Yang, Julie M. Beaudet, Amanda Weyers, Robert J. Linhardt, Fuming Zhang*.  

     Carbohyd. Polym., 2011, 87, 822-829. https://doi.org/10.1016/j.carbpol.2011.08.075

2010年

1. Stereoselective total synthesis of (−)-Cleistenolide.

     Chao Cai#, Jun Liu, Yuguo Du* and Robert J. Linhardt.  

     J. Org. Chem., 2010, 75, 5754-5756. https://doi.org/10.1021/jo101059e