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  • Modification of thread-based microfluidic device with polysiloxanes for the development of a sensitive and selective immunoassay
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-13
    Jane Ru Choi, Azadeh Nilghaz, Lei Chen, Keng C. Chou, Xiaonan Lu
    更新日期:2018-01-13
  • Smart Hydrogel-based Optical Fiber SPR Sensor for pH Measurements
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-13
    Yong Zhao, Ming Lei, Shi-Xuan Liu, Qiang Zhao

    A hydrogel-coated optical fiber surface plasmon resonance (SPR) sensor based on MMF-SMF-MMF structure has been fabricated for pH measurements. When the solutions with difference pH values contacting the sensing probe, the amount of the dissociated carboxylic ions in the hydrogel will change according to the pH value of the solution. This process will modify the volume and refractive index of the hydrogel, which results in a shift of the SPR wavelength. The experimental sensor is able to indicate pH variations in a wide pH range from 1 to 12, and the maximum pH sensitivity of the proposed sensor can reach 13 nm/pH at higher pH region (8–10 pH). The influence of temperature (in the range of 20 °C–40 °C) on SPR wavelength is found to be weak. Further, the sensor possesses remarkable repeatability and excellent stability. Due to the wide measuring range and simple fabrication process, the sensor is promising to be used for the pH measurements.

    更新日期:2018-01-13
  • Pt-In2O3 Mesoporous Nanofibers with Enhanced Gas Sensing Performance towards ppb-level NO2 at Room Temperature
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-12
    Yunshi Liu, Xing Gao, Feng Li, Geyu Lu, Tong Zhang, Nicolae Barsan
    更新日期:2018-01-13
  • Graphene oxide functionalized long period fiber grating for highly sensitive hemoglobin detection
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-12
    C. Liu, B.J. Xu, L. Zhou, Z. Sun, H.J. Mao, J.L. Zhao, L. Zhang, X. Chen

    We present graphene oxide (GO) nanosheets functionalized long period grating (LPG) for ultrasensitive hemoglobin sensing. The sensing mechanism relies on the measurement of LPG resonant intensity change induced by the adsorption of hemoglobin molecules onto GO, where GO as a bio-interface linkage provides the significant light-matter interaction between evanescent field and target molecules. The deposition technique based on chemical-bonding associated with physical-adsorption was developed to immobilize GO nanosheets on cylindrical fiber device. The surface morphology was characterized by scanning electron microscope, atomic force microscopy, and Raman spectroscopy. With relatively thicker GO coating, the refractive index (RI) sensitivity of GO-LPG was extremely enhanced and achieved −76.5 dB/RIU, −234.2 dB/RIU and +1580.5 dB/RIU for RI region of 1.33-1.38, 1.40-1.44 and 1.45-1.46, respectively. The GO-LPG was subsequently implemented as an optical biosensor to detect human hemoglobin giving a sensitivity of 1.9 dB/(mg/mL) and a detectable concentration of 0.05 mg/mL, which was far below the hemoglobin threshold value for anemia defined by World Health Organization. The proposed GO-LPG architecture can be further developed as an optical biosensing platform for anemia diagnostics and biomedical applications.

    更新日期:2018-01-13
  • 更新日期:2018-01-13
  • A novel natural surface-enhanced Raman spectroscopy (SERS) substrate based on graphene oxide-Ag nanoparticles-Mytilus coruscus hybrid system
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-12
    Zhengyi Lu, Yanjun Liu, Minghong Wang, Chao Zhang, Zhen Li, Yanyan Huo, Zhe Li, Shicai Xu, Baoyuan Man, Shouzhen Jiang

    Recently, biological materials have attracted more and more attentions on preparing the surface-enhanced Raman spectroscopy (SERS) substrate with the conspicuous SERS performance. Herein, we demonstrate a simply facile and inexpensive approach to fabricate a novel natural SERS substrate based on graphene oxide-Ag nanoparticles-Mytilus coruscus (GO-AgNPs-M.c.). The surface-enhanced resonance Raman spectroscopy (SERRS) signals of the Rhodamine 6G (R6G) on the GO-AgNPs-M.c. hybrids exhibit the much better SERRS performances in terms of the sensitivity, the signal reproducibility and the antioxidant stability than that on the AgNPs-M.c. one. The well electric field enhancement contribution is likewise confirmed in theory via the COMSOL software. Moreover, the successful detection of trace malachite green (MG) and methylene blue (MB) indicates the well feasibility for multi-molecules detection on the GO-AgNPs-M.c. hybrids. Thus, this inexpensive and high-efficiency natural SERS substrate have great potential for the considerable biochemical SERS applications and broaden the way for preparing multiple SERS platforms derived from other natural materials.

    更新日期:2018-01-13
  • LABEL-FREE GOLD NANOPARTICLE-BASED SENSING OF CYSTEINE: NEW PECULIARITIES AND PROSPECTS
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-12
    Vladimir V. Apyari, Viktoria V. Arkhipova, Andrei I. Isachenko, Pavel A. Volkov, Stanislava G. Dmitrienko, Irina I. Torocheshnikova
    更新日期:2018-01-13
  • Fluorescent-Magnetic Janus Nanorods for Selective Capture and Rapid Identification of Foodborne Bacteria
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-12
    Zhi-min Chang, Zheng Wang, Dan Shao, Juan Yue, Meng-meng Lu, Li Li, Mingfeng Ge, Dian Yang, Ming-qiang Li, Huize Yan, Qiaobing Xu, Wen-fei Dong
    更新日期:2018-01-13
  • A wireless-electrodeless quartz crystal microbalance with dissipation DMMP sensor
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-12
    Daqi Chen, Kaihuan Zhang, Hui Zhou, Guokang Fan, You Wang, Guang Li, Ruifen Hu

    Highly sensitive chemical warfare agents (CWAs) detection is demanded against the usage of the CWAs for war or terrorism aims. A dimethyl methylphosphonate (DMMP), simulant for sarin, monitoring sensor based on a homemade wireless-electrodeless quartz crystal microbalance with dissipation (QCM-D) was developed. With this noncontact configuration, deterioration of the sensing ability cause by the electrodes and drilling on the gas chamber for wire lead was avoided. Nano-structured hollow ball-like indium oxide (In2O3) was synthesized using a facile hydrothermal method and then decorated with cubic gold particles (In2O3-Au). Both of them were applied as the sensing films to detect DMMP. The In2O3-Au based QCM-D sensor exhibited 2.1 Hz/ppm to DMMP range from 5 ppm to 50 ppm, which was 400% higher compared to the undecorated one. Moreover, with the simultaneously monitored dissipation value, desorption processes of DMMP was further investigated and the overshoot that appear in some researches was explained in terms of visco-elastic variations in mechanical stiffness. The results suggest that the wireless-electrodeless QCM-D could be a promising strategy for observation of materials under dynamic conditions.

    更新日期:2018-01-13
  • 更新日期:2018-01-13
  • A novel electrochemical sensor for glucose detection based on Ag@ZIF-67 nanocomposite
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-11
    Wei Meng, Yuanyuan Wen, Lei Dai, Zhangxing He, Ling Wang

    In this paper, we demonstrated the first application of a Co-based porous metal-organic framework (MOF) ZIF-67 as the glucose electrochemical sensor. The ZIF-67 modified glassy carbon electrode (GCE) showed an excellent catalytic activity towards glucose oxidation. Meanwhile, to improve the electrocatalytic performance of the modified electrode, a novel Ag@ZIF-67 nanocomposite was fabricated through a sequential deposition-reduction method. The Ag@ZIF-67/GCE exhibited an enhanced catalytic activity towards glucose oxidation. The electrocatalytic performance of Ag@ZIF-67 with different Ag loadings was investigated, and the results indicated that with the Ag contents increasing from 0% to 0.5%, the response time of the modified electrode was shorten by more than two times, and the sensitivity was increased by two times and a half. The Ag-0.5%@ZIF-67GCE exhibited excellent electrocatalytic performances in the glucose concentration range of 2–1000 μM, including a high sensitivity of 0.379 μA μM−1 cm−2, a low detection limit of 0.66 μM (S/N = 3) as well as good selectivity and stability.

    更新日期:2018-01-12
  • High-throughput production of satellite-free droplets through a parallelized microfluidic deterministic lateral displacement device
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-11
    Naotomo Tottori, Takasi Nisisako

    We present a parallel numbering-up device for microfluidic production of satellite droplet-free emulsions. The device consists of two stacked layers made of polydimethylsiloxane (PDMS). The bottom layer combines eight parallel sets of a microfluidic droplet generator (MFDG) and deterministic lateral displacement (DLD) array for size-based separation of main and satellite droplets. The top layer has input reservoirs to supply both the disperse and continuous phases evenly to the eight channels of the bottom layer. We employed 3D flow simulations to find the reservoirs most suitable for equal inflow distribution. Water-in-oil (W/O) droplets comprised of main droplets (∼67.4 μm in diameter) and satellite droplets (1–20 μm) were generated in the parallelized MFDGs, and they were then completely separated through the DLD arrays having a critical diameter of Dc = 37.1 μm. Thus, we confirmed production of satellite droplet-free emulsion droplets at 0.2 ml/h, eight times the processing throughput of single device (=0.025 ml/h) without decrease in performance.

    更新日期:2018-01-12
  • Superhydrophilic ZnO nanoneedle array: Controllable in situ growth on QCM Transducer and enhanced humidity sensing properties and mechanism
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-11
    Xiaoli Cha, Fanfei Yu, Yu Fan, Jiafan Chen, Luyu Wang, Qun Xiang, Zhiming Duan, Jiaqiang Xu

    Humidity sensors have attracted intensive interest due to their significant air humidity monitoring values. But it is still a challenge in achieving highly sensitive and accurate humidity sensors with a rapid and convenient method. And only few studies examined the relationship between the sensing and the wetting behavior of sensing materials. Here, we propose a novel strategy for designing humidity sensor by using superhydrophilic ZnO nanoneedle array. Via this smart design, superhydrophilic ZnO nanoneedle array was first in-situ grown on the electrode of quartz crystal microbalance (QCM) transducers by a facile chemical deposition method in solution. The design admits the water molecule easily reach the internal and outer surface of the array, further form multi-molecular-layer adsorption mode on the surface based on a physical adsorption effect between water molecule and superhydrophilic ZnO nanoneedle array. The characterization and sensing results show that the sensors constructed from superhydrophilic ZnO nanoneedles with a defined morphology exhibit enhanced humidity sensing properties including high sensitivity (21.4 Hz/%RH, at 95%RH), fast response/recovery speed (2s/2s, at 33%RH), well reproducibility, and narrow hysteresis (Maximum 2%RH) compared with the hydrophilic ZnO seeds and the superhydrophobic ZnO nanoneedles. Finally, the humidity sensing mechanism was also discussed in detail.

    更新日期:2018-01-12
  • Study of the NO2 sensing mechanism of PEDOT-RGO film using in situ Raman Spectroscopy
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-11
    K.J. Dunst, K. Trzciński, B. Scheibe, M. Sawczak, P. Jasiński

    In this work, the mechanism of the NO2 reaction with PEDOT-RGO composite film has been investigated via in situ Raman spectroscopy. Reduced graphene oxide (RGO), poly(3,4-ethylenedioxytiophene)-reduced graphene oxide (PEDOT-RGO) and poly(3,4-ethylenedioxytiophene)/ClO4− (PEDOT/ClO4−) films were fabricated using an electrodeposition method method and used as resistance sensors of gaseous nitrogen dioxide. The experimental results indicate that NO2 causes overoxidation of the PEDOT polymer (PEDOT/ClO4− film) which leads to resistance increase and irreversible response. In contrast, the PEDOT-RGO response in the presence of NO2 is reversible. During short NO2 exposure, PEDOT from the PEDOT-RGO composite does not react to the gas but the presence of RGO in the PEDOT-RGO composite does not affect the overoxidation potential. It was found that the nitrogen dioxide reacts more readily to reduced graphene oxide, thus RGO “protects” the polymer against the adverse overoxidation process.

    更新日期:2018-01-12
  • 更新日期:2018-01-12
  • Enhancement of Mass Transfer Coefficient Towards Carbon Nanotube Nanoelectrode Array
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-11
    Rongzhou Lin, Tuti Mariana Lim, Tuan Tran

    The mass transfer of analytes is a major limiting factor of electrochemical response at vertically-aligned carbon nanotube nanoelectrode arrays (VCNs). In this study, the dependence of the mass transfer coefficient on the array diameter and force convection is studied experimentally. The mass transfer coefficient is shown to increase 2 folds by reducing the array diameter from 2 mm to 50μm, while it increases 20 folds by introducing force convection at the flow rate 2000 μL·min−1. The VCNs used with channel flow voltammetry exhibit low limit of detection (5 nM), high sensitivity, and wide linear range for detecting both K3Fe(CN)6 and dopamine. The VCNs can be used on lab-on-a-chip systems for analytical applications. It is anticipated a combined approach of reducing array diameter and introducing forced convection can be used to significantly improve electrochemical responses of other nanoelectrode arrays.

    更新日期:2018-01-12
  • Detection of tuberculosis in patients with the use of portable SPR device
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-10
    M. Trzaskowski, A. Napiórkowska, E. Augustynowicz-Kopeć, T. Ciach

    Tuberculosis (TB) is still one of the important causes of death worldwide. Its detection is challenging and new tools for TB diagnostics are highly needed. In this work, we investigated a possibility of using surface plasmon resonance (SPR) phenomenon in detection of TB bacteria in sputum. For this purpose we designed a portable SPR apparatus. We compared its performance with a standard desktop SPR platform designed to work in laboratory by measuring response to Ag85 − TB secretory protein. We examined samples of suspended Mycobacterium tuberculosis cultures and sputum samples of TB patients. The device was able to detect M. tuberculosis secretory protein (Ag85) in concentration of 10 ng/ml which was comparable to the desktop SPR equipment. It has been also able to detect TB bacteria cultures in concentration of 1*104 cfu/ml with no significant interfering response from two other bacteria species. Finally, detection of bacteria in sputum of confirmed tuberculosis patients has been demonstrated.

    更新日期:2018-01-11
  • Carbon nanotube isolation layer enhancing in-liquid quality-factors of thin film bulk acoustic wave resonators for gravimetric sensing
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-10
    Girish Rughoobur, Hisashi Sugime, Mario DeMiguel-Ramos, Teona Mirea, Shan Zheng, John Robertson, Enrique Iborra, Andrew John Flewitt

    A thickness longitudinal mode (TLM) thin film bulk acoustic resonator biosensor is demonstrated to operate in water with a high quality-factor, Q. This is achieved using a layer of carbon nanotubes (CNTs) on top of the resonator which has a significantly different acoustic impedance to either the resonator or liquid whilst being susceptible to the binding of biological molecules. This allows the resonance to be decoupled from direct energy loss into the liquid, although still retaining mass sensitivity. AlN solidly mounted resonators (SMRs) having a thickness shear mode (TSM) at 1.1 GHz and TLM at 1.9 GHz are fabricated. CNTs with different forest densities are grown by chemical vapor deposition on the active area with Fe as catalyst and resulting devices compared. High forest density CNTs are shown to acoustically decouple the SMRs from the water and in-liquid TLM Q values higher than 150 are recorded even exceeding TSM SMRs without CNTs. The TLM Q in water is remarkably improved from 3 to 160 for the first time by dense CNT forests, rendering the large-scale fabrication of TLM SMRs for liquid-phase sensing applications possible. Despite this partial isolation, SMRs with CNT forests ∼15 μm tall can still detect binding of bovine serum albumin.

    更新日期:2018-01-11
  • Diaminomaleonitrile based chromo-fluorescent receptor molecule for selective sensing of Mn(II) and Zn(II) ions
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-10
    Suman Swami, Arunava Agarwala, Debasis Behera, Rahul Shrivastava

    A new class of chemosensors (L1-L3) based on sequential coupling of 2,3-diaminomaleonitrile, 4-formyl-1-substituted phenyl-pyrazole-3-carboxylate and 2-hydroxy-1-naphthaldehyde through imine linkages were successfully designed and synthesized. The synthesized chemosensors showed quick colorimetric response with excellent selectivity and sensitivity towards detection of Mn2+ and Zn2+ ions in preference of other cations. Along with this, chemosensors also serve as fluorescent turn ‘off’ and turn ‘on’ switch for detection of Mn2+ and Zn2+ ion respectively. Analytical characterization were evaluated using UV–vis titration, fluorescent titration and Job’s plot methods which revealed that sensor interact with Mn2+ and Zn2+ ion in 1:1 and 1:2 binding stoichiometry respectively.

    更新日期:2018-01-10
  • Ultrasensitive colorimetric assay melamine based on in situ reduction to formation of CQDs-silver nanocomposite
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-10
    Wei-Feng Wang, Yin Qiang, Xian-Hua Meng, Jun-Li Yang, Yan-Ping Shi

    In this work, the in situ reduction of Ag+ by carbon quantum dots (CQDs) to the formation of CQDs-silver nanocomposite (CQDs-silver NPs) was exploited to develop a facile and ultrasensitive colorimetric sensor platform. Due to the high affinity between Ag and melamine, melamine could significantly induce the well-dispersed CQDs-silver NPs aggregation. Consequently, the solution color of CQDs-silver NPs changed from bright yellow to red. Based on this finding, we proposed a new colorimetric method to qualitatively and quantitatively detect melamine by the naked eyes and UV–vis spectroscopy, respectively. Under the optimum conditions, the linearity of melamine with the solution absorbance (ΔR) was plotted in the concentration range of 1 × 10−10–1 × 10−8 g/mL (y = 0.55 + 0.049x, R = 0.9596) and 2.5 × 10−8–5 × 10−7 g/mL (y = 3.43 + 0.42x, R = 0.9961). The developed method showed excellent detection sensitivity for melamine with the detection limit as low as 7.9 × 10−12 g/mL (eq. 65.3 pmol L−1). Finally, the developed method was employed to detect the amount of melamine in cow milk and milk powderand a recovery of 87.6 to 116%, and RSD of 1.6 to 3.9% was achieved.

    更新日期:2018-01-10
  • A selective ‘turn-on’ fluorescent chemosensor for detection of Al3+ in aqueous medium: experimental and theoretical studies
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-09
    Mukesh Kumar, Amit Kumar, Md. Serajul Haque Faizi, Santosh Kumar, Mantu Kumar Singh, Sumanta Kumar Sahu, Shyam Kishor, Rohith P. John
    更新日期:2018-01-10
  • Novel Hydroxyl-substituted Perylene-3,4,9,10-tetracarboxylic Acid Diimides for Selective Recognition of Fluoride
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-09
    Ran Wang, Yongshan Ma, Jianfeng Zhao, Andong Zhang, Shufan Yang, Han Shen, Gang Li, Zhiqiang Shi
    更新日期:2018-01-10
  • Graphene oxide supported liposomes for efficient label free electrochemical DNA biosensing
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-09
    Habibulla Imran, Palinci Nagarajan Manikandan, Venkataraman Dharuman

    Liposome and graphene are studied towards the development of biocompatible materials for DNA sensing and target delivery applications. In this study, liposomes are supported on various graphene materials on gold surface by physisorption without using thiol self-assembled monolayers. Reduced graphene oxides (rGO) are prepared by chemical (ascorbic acid and hydrazine) and electrochemical reduction methods Studies indicate that the bilayer formation of cationic 1,2-dioleoyltrimethylammoniumpropane (DOTAP) on the graphite, graphene, graphene oxide and chemically reduced GO is due to thick layers of these materials. The thin layered rGO produced through mild electrochemical reduction in the acidic medium (favors selective reduction of hydroxyl and epoxide functional group) is suitable for the tethering intact vesicle structure of the DOTAP confirmed by different surface characterizing techniques. The intact vesicle structure is applied for label free sensing of DNA in the dynamic range from 10−15 to 10−9 M to demonstrate the feasibility of the sensor for molecular diagnosis.

    更新日期:2018-01-10
  • A facile fluorescence lateral flow biosensor for glutathione detection based on quantum dots-MnO2 nanocomposites
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-09
    Juan Chen, Zhongming Huang, Hongmin Meng, Lin Zhang, Danyang Ji, Juanzu Liu, Fei Yu, Lingbo Qu, Zhaohui Li
    更新日期:2018-01-10
  • Development of rapid method to assess microbial quality of minimally processed pomegranate arils using FTIR.
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-09
    Vanshika Adiani, Sumit Gupta, Rupali Ambolikar, Prasad S. Variyar

    Fourier transform infrared spectroscopy (FTIR) spectra were correlated with microbial quality of minimally processed pomegranate (Punica granatum) arils stored at 10 °C using chemometrics. FTIR data processed in three ways i.e. FTIR spectrum, first derivative for FTIR spectrum and peak integrated data of FTIR spectrum was used as independent variables for preparing regression models by partial Least Square Regression (PLS-R) and artificial neural networks (ANN) for predicting the total viable count (TVC) and yeast and mold count (Y&M). Models built with both ANN and PLS-R using FTIR data demonstrated a high correlation value of R2 > 0.85. Analysis of PLS-R results suggested the production of alcohols and acids with utilization of sugars during storage. This is a first report demonstrating use of FTIR as a nondestructive rapid method for microbial quality analysis of minimally processed fruits.

    更新日期:2018-01-10
  • Enhanced H2 gas sensing properties by Pd-loaded urchin-like W18O49 hierarchical nanostructures
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-09
    Rui Zhou, Xiaoping Lin, Dongyang Xue, Fengyi Zong, Jianmin Zhang, Xiaochuan Duan, Qiuhong Li, Taihong Wang
    更新日期:2018-01-10
  • 更新日期:2018-01-10
  • DNA-based dual fluorescence signals on and ratiometric mercury sensing in fetal calf serum with simultaneous excitation
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-09
    Fenghua Geng, Xiangyu Jiang, Yongxiang Wang, Congying Shao, Kefeng Wang, Peng Qu, Maotian Xu

    Compared to the single emission intensity based sensors, the ratiometric fluorescence assay has achieved improved sensitivity and accuracy by providing built-in correction. However, the dual signals on and ratiometric methods have rarely been reported. Here, a novel strategy for constructing dual fluorescence signals on and ratiometric mercury sensing system is proposed using two kinds of fluorescence dyes (4',6-diamidino-2-phenylindole (DAPI) and N-methylmesoporphyrin IX (NMM)) and two DNA sequences with both thymine (T)-rich and guanine (G)-rich at two ends. In the presence of Hg2+, T-rich segments cooperatively coordinate with Hg2+ due to the specific and strong affinity between T–T mismatched base pairs and Hg2+, which causes the formation of the split G-quadruplex by two G-rich segments at the other ends. So, both the fluorescent dyes of DAPI and NMM selectively intercalate into dsDNA and G-quadruplex DNA separately, and their fluorescence at 455 nm and 610 nm were enhanced accordingly. Under the experimental conditions employed here, the ratiometric signal was proportional to the Hg2+ concentrations from 0.05 to 3 μM. The limit of detection (LOD) was estimated to be 8 nM based on 3s/m rule. The Hg2+ concentration in FCS has been successfully determined, further demonstrating the potential utility of the novel system.

    更新日期:2018-01-09
  • Highly sensitive electrochemiluminescence biosensor for cholesterol detection based on AgNPs-BSA-MnO2 nanosheets with superior biocompatibility and synergistic catalytic activity
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-09
    Da-Peng Yang, Weiwei Guo, Zhengfa Cai, Yisong Chen, Xingsheng He, Chusen Huang, Junyang Zhuang, Nengqin Jia

    Monitoring the level of cholesterol in blood serum is a critical approach for diseases surveillance. In this work, we reported on the successful construction of a new electrochemiluminescence (ECL) sensor for cholesterol detection by employing the Ag-(bovine serum albumin) BSA-MnO2 nanosheets for cholesterol oxidase (ChOx) immobilization and catalytic amplification of ECL signal. The AgNPs-BSA-MnO2 nanosheets were synthesized by using BSA as protective agent, which greatly facilitated the immobilization of ChOx due to the existing amino group donated by BSA. The structure and properties of the AgNPs-BSA-MnO2 nanosheets were characterized by a series of techniques, including transmission electron microscope (TEM), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), powder X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FT-IR). Importantly, experiment results indicated that the synergistic effect of AgNPs with MnO2 nanosheets could provide excellent catalytic ability towards ROSs generation and thus to efficiently amplify the ECL signal of luminol-H2O2 system. Under optimal conditions, the ECL intensity increased with the increasing cholesterol concentration in a dynamic range from 0.21 μM to 1667 μM with a limit of detection (LOD) of 0.07 μM (3σ).

    更新日期:2018-01-09
  • Development of a high-sensitive electrochemical detector with micro-stirrer driven by surface acoustic waves
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-08
    Hiroaki Sakamoto, Hiroki Kitanishi, Satoshi Amaya, Tsunemasa Saiki, Yuichi Utsumi, Shin-ichiro Suye

    We developed a highly sensitive electrochemical detector with a micro-stirrer driven by surface acoustic waves (SAWs) for micro total analysis systems. The detector, fabricated on a LiNbO3 wafer by microfabrication technology, consisted of a three-electrode system for electrochemical measurement and interdigital transducers (IDTs) for stirring the aqueous solution by SAWs. In an amperometry experiment with ferrocenecarboxylic acid and potassium phosphate buffer solution (total volume: 50 μL), the oxidation current was measured while the solution was stirred by SAWs generated by applying 1.4 W electric power to the IDTs. Under this condition, the oxidation current was about 13 times larger than that without SAW-stirring. Furthermore, the diffusion rate of analyte molecules evaluated by the Cottrell relation from amperometry measurements increased 12-fold by using the SAW micro-stirrer.

    更新日期:2018-01-09
  • 更新日期:2018-01-09
  • Detection of protein aggregate morphology through single antifouling nanopore.
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-08
    Nicoletta Giamblanco, Diego Coglitore, Jean-Marc Janot, Pierre Eugène Coulon, Benoît Charlot, Sébastien Balme
    更新日期:2018-01-09
  • Polyaniline (PAni) Optical Sensor in Chloroform Detection
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-08
    Irma Zulayka Mohamad Ahad, Sulaiman Wadi Harun, Seng Neon Gan, Sook Wai Phang
    更新日期:2018-01-08
  • 更新日期:2018-01-08
  • Electrochemical determination of paracetamol based on Au@graphene core-shell nanoparticles doped conducting polymer PEDOT nanocomposite
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-08
    Mengru Li, Wei Wang, Zhuo Chen, Zhiling Song, Xiliang Luo

    Conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) possesses high electrical conductivity but limited catalytic activity, and doping with suitable nanomaterial to fabricate multifunctional electrical substrate is an ideal approach to broaden the application of PEDOT. Herein, Au@graphene (AG) core-shell nanoparticles with high conductivity, catalytic activity and stability, were synthesized and doped into PEDOT to build PEDOT/AG nanocomposite material by a facile electrodeposition method. The PEDOT/AG composite exhibited high conductivity and excellent catalytic activity toward the redox of paracetamol, and owing to the presence of AG nanoparticles, the electrochemical signals and peak profiles of paracetamol at the PEDOT/AG modified electrode were significantly improved. Under optimum conditions, the PEDOT/AG modified electrode exhibited high sensitivity to paracetamol over a wide linear range of concentrations from 0.15 μM to 5.88 mM, with a detection limit of 41 nM (S/N = 3). Furthermore, the fabricated sensor exhibited high selectivity and long-term stability, and was capable of detecting paracetamol in real pharmaceutical samples with satisfying accuracy.

    更新日期:2018-01-08
  • Potentiometric textile-based pH sensor
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-07
    M.L. Zamora, J.M. Dominguez, R.M. Trujillo, C.B. Goy, M.A. Sanchez, R.E. Madrid

    Determining the pH of sweat provides valuable information for athletes and patient monitoring. This work presents a textile-based, highly sensitive pH sensor for pH determination. Three conductive fabrics (Argenmesh, Ristop silver and Stainless steel mesh (SSM)) were modified with a pH sensitive electrodeposited Iridium Oxide Film (EIROF). The three electrodeposited fabrics were characterized by impedance measurements. The Stainless Steel Mesh showed the best sensitivity to pH changes and therefore was selected for further experiments. Two configurations of this fabric were evaluated, looking for improvement in pH sensitivity and temperature dependence. The best result was obtained with the configuration that maximizes the contact surface between the stainless steel fibers, showing an error of 0.15% in the pH measurement of a buffer solution. This configuration was also used to perform in vivo measurements, obtaining an error of 4% when compared to the measurements performed with a commercial pH test strip. The implementation of sensor into textiles brings some advantages such as comfort, biocompatibility and washability, among others; making the future incorporation of a sensor into a garment very possible.

    更新日期:2018-01-07
  • Microstructured optical fiber based chloride ion sensing method for concrete health monitoring
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-06
    Liyun Ding, Zhijie Li, Qingjun Ding, Xiang Shen, Yinquan Yuan, Jun Huang

    Chloride erosion is the main factor to decrease durability of concrete, it is fairly important to control and monitor chloride in concrete structure. A new sensor based on a suspended core optical fiber was developed to detect the chloride in concrete, in which lucigenin is selected as a fluorescence sensitive material for chloride. A novel type of the sol-gel membrane was introduced to immobilize lucigenin onto the inner wall of the suspended core optical fiber with dip-coating method. The properties of the sol-gel membrane were characterized by scanning electron microscope (SEM) and Fourier transforming infrared (FT-IR), andenergyof evanescent field the suspended core optical fiber was calculated by using COMSOL. The fluorescence fluctuations of the optic fiber sensor are chloride concentration-dependent andthe relationship between relative fluorescence intensity and chloride concentration followsthe Stern–Volmerequation.The linear calibration formulas I0/I = 1 + 1.463[Cl−] (R2 = 0.973) and I0/I = 1 + 1.982[Cl−](R2 = 0.984)withthe detection limit of 0.02Mare obtained through detecting standard KCl solution and concrete simulated pore solution of KCl (pH = 13.5), respectively.Besides, specificity of the sensorisalso tested.

    更新日期:2018-01-07
  • 更新日期:2018-01-06
  • Modification of Microfluidic Paper-Based Devices with Dye Nanomaterials Obtained by Encapsulation of Compounds in Y and ZSM5 Zeolites
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-06
    Ana Raquel Bertão, Nuno Pires, António M. Fonseca, Olívia S.G.P. Soares, Manuel F.R. Pereira, Tao Dong, Isabel C. Neves
    更新日期:2018-01-06
  • A real-time simultaneous measurement on a microfluidic device for individual bacteria discrimination
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-06
    Hirotoshi Yasaki, Takao Yasui, Takeshi Yanagida, Noritada Kaji, Masaki Kanai, Kazuki Nagashima, Tomoji Kawai, Yoshinobu Baba

    Rapid detection of pathogenic bacteria is one of the important social issues for preventing and identifying cause of problems affecting human health. Ionic current sensing through pores has shown the ability to electrically measure bacteria. However, there is an inherent limitation to discriminate chemical characteristics of bacteria for existing ionic current sensing methods Here we propose a real-time simultaneous measurement method, which combines ionic current sensing and fluorescence observation on a microfluidic device. Our method can detect not only the size of individual bacteria passing through a micropore but also observe their stainability based on chemical properties of bacterial cell surface within 300 ms. We succeeded in discriminating each bacterium in a solution mixture including contaminant particles by combining highly accurate ionic current sensing which can detect a size difference of 70 nm, and fluorescence observation which can discriminate internal structures such as those that define bacteria as gram-positive or gram-negative. Our method can be applied to not only on-site bacteria detection but also to screening technology.

    更新日期:2018-01-06
  • H2S sensing characteristics of Ni-doped CaCu3Ti4O12 films synthesized by a sol-gel method
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-06
    Arisara Boontum, Ditsayut Phokharatkul, Jose H. Hodak, Anurat Wisitsoraat, Satreerat K. Hodak

    The problem of detecting the toxic hydrogen sulfide (H2S) gas at part per million levels in air by means of simple solid state gas sensors is relevant to environmental and gas processing industries. In this work, high-performance H2S gas sensors are developed based on nickel-doped calcium copper titanate (Ni-doped CCTO) thin films synthesized by a sol-gel method. From gas-sensing measurements, the response of Ni-doped CCTO sensing films increased substantially with increasing Ni doping level from 1.5 to 7.3 wt%, revealing a catalytic effect of Ni on the surface reactions with adsorbed H2S molecules. In particular, 7.3 wt% Ni-doped CCTO sensors offered a high response of 120 for 10 ppm of H2S at the optimal operating temperature of 250 °C, an order of magnitude higher than that of undoped one. In addition, the response time dropped significantly from ∼80 s to ∼4 s while the recovery time slightly improved as the Ni doping content increased from 0 to 7.3 wt%. Moreover, the Ni-doped CCTO sensors exhibited good reproducibility and high H2S selectivity against ethanol, H2, NO2 and NH3. Therefore, the Ni-doped CCTO sensors are highly promising for sensitive and selective detections of H2S.

    更新日期:2018-01-06
  • 更新日期:2018-01-06
  • Colorimetric sensing of mercury (II) ion based on anti-aggregation of gold nanoparticles in the presence of hexadecyl trimethyl ammonium bromide
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-06
    Xiaoxiao Sun, Ruxin Liu, Qingwen Liu, Qing Fei, Guodong Feng, Hongyan Shan, Yanfu Huan

    A new specific and sensitive colorimetric sensor based on anti-aggregation of unmodified gold nanoparticles (AuNPs) for mercury ion detection was studied by forming Au-Hg alloys deposited onto the surface of AuNPs. In the protocol, hexadecyl trimethyl ammonium bromide (CTAB) could cause the aggregation of AuNPs and induced the color change from red to blue due to the strong electrostatic attraction between CTAB and citrate ion capped gold nanoparticles. In the presence of Hg2+, citrate ion capped AuNPs reduced Hg2+ to Hg and then formed Hg-Au alloys, which could inhibit the aggregation of AuNPs caused by CTAB to some extent. Based on these findings, Hg2+ was detected by a blue-to-red color change of AuNPs solution containing CTAB. Also, the limit of detection (LOD) was 11.9 nM by UV–vis spectroscopy, which was lower than the guideline concentration of Hg2+ (30 nM) in drinking water set by the World Health Organization (WHO). And the results showed the absorbance ratios A650/A520 had a good linear correlation with the Hg2+ concentration from 0 to 680 nM, which could be used for the quantitative detection of Hg2+. This method was successfully used to detect Hg2+ in tap water sample.

    更新日期:2018-01-06
  • 更新日期:2018-01-06
  • Hybrid Nanoarchitecturing of Hierarchical Zinc Oxide Wool-Ball-Like Nanostructures with Multi-Walled Carbon Nanotubes for Achieving Sensitive and Selective Detection of Sulfur Dioxide
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-06
    Ni Luh Wulan Septiani, Yusuf Valentino Kaneti, Brian Yuliarto, Nugraha, Hermawan Kresno Dipojono, Toshiaki Takei, Jungmok You, Yusuke Yamauchi
    更新日期:2018-01-06
  • On-Chip Microelectrode Array and In-Situ Transient Calibration for Measurement of Transient Concentration Gradients Near Surfaces of 2D Cell Cultures
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-05
    Siddarth V. Sridharan, Jose F. Rivera, James K. Nolan, Muhammad A. Alam, Jenna L. Rickus, David B. Janes

    Amperometric microelectrode arrays (MEAs) interrogate the concentration at multiple positions simultaneously and with sufficient sampling rates, thus being able to capture fast transient gradients. However, sensitivity variability issues in amperometric MEAs degrade the reliability of the measurements, particularly at the small concentration scales found in physiological studies. This paper describes the development of on-chip platinum amperometric MEAs and in-situ transient calibration for reliable measurement of physiological transient concentration gradients. The designed MEA geometry facilitates positioning near a 2D cell culture setup, and the proposed in-situ transient calibration minimizes the effects of sensitivity variability, thus allowing for calculation of gradients based on concentration differences between closely spaced electrodes. The effectiveness of the MEA and the in-situ transient calibration was evaluated by measuring controllably-generated gradients, and then calculating the difference between experimental and simulated data using normalized time analysis. Gradients generated by periodic uptake intervals as fast as 150 ms followed by recovery intervals of 60 s were measured over a spatial range of 70 μm, with spatial resolution of 35 μm, and sampling time and measurement time of 10 ms. Transient gradients of hydrogen peroxide were also measured above the surface of a 2D cell culture of human astrocytes, thus demonstrating the approach in actual physiological measurements.

    更新日期:2018-01-06
  • 更新日期:2018-01-06
  • Multifunctional Aptamer Probe Mediated Cascade Amplification for Label-free Detection of Adenosine
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-05
    Wei Li, Jiewei Sun, Huijuan Wang, Lei Wang, Wei Jiang

    Herein, a multifunctional aptamer probe mediated cascade amplification strategy has been constructed for sensitive and label-free detection of adenosine. First, the multifunctional aptamer probe was designed with an aptamer for adenosine identification and a template for cascade amplification. These two regions could partially hybridize with each other and formed a stem-loop structure. Thus, in the absence of adenosine, the probe could be inhibited by itself and the interference signals could be reduced effectively. In the presence of adenosine, the probe identified the adenosine, resulting in the conformational transformation and the release of the template. Then, the 3′-end of the probe-adenosine complex acted as primer to trigger the cascade amplification of strand displacement amplification (SDA) and catalytic hairpin assembly (CHA), yielding a lot of G-quadruplex. Finally, by inserting N-methy mesoporphyrin IX (NMM), an enhanced and label-free fluorescence signal was achieved. This strategy suggested a high sensitivity with a detection limit of 1.3 × 10−7 mol/L that attributes to the low interference signals of the probe and the amplification capability of the cascade amplification. Moreover, adenosine analysis in human urines was performed, indicating that this method was reliable and could be further used in the early clinical diagnosis and medical research.

    更新日期:2018-01-06
  • Functionalised CuO nanostructures for the detection of organophosphorus pesticides: A non-enzymatic inhibition approach coupled with nano-scale electrode engineering to improve electrode sensitivity
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-05
    Mawada Mohamed Tunesi, Nazar Kalwar, Malik Waseem Abbas, Selcan Karakus, Razium Ali Soomro, Ayben Kilislioglu, Muhammad Ishaq Abro, Keith Richard Hallam
    更新日期:2018-01-06
  • Human Influenza Virus Detection Using Sialyllactose-Functionalized Organic Electrochemical Transistors
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-05
    Wenfeng Hai, Tatsuro Goda, Hiroaki Takeuchi, Shoji Yamaoka, Yukichi Horiguchi, Akira Matsumoto, Yuji Miyahara
    更新日期:2018-01-05
  • Boronic acid functionalized fiber-optic SPR sensors for high sensitivity glycoprotein detection
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-05
    Siyu Qian, Yang Zhang, Huizhen Yuan, Wei Ji, Yun Liu, Jianzhang Zhao, Ming Han, Wei Peng

    Boronic acid and its derivatives have shown special capability to cis-diols groups such as glycoprotein and carbohydrate, which has been widely investigated and applied in practical disease diagnosis. Fiber-optic surface plasmon resonance (SPR) sensors with tiny size are very accurate and convenient tools for monitoring the surface interaction in real time. In this paper, phenylboronic acids (PBA) were formed on the sensing surface by coating the fiber surface with a self-assembled monolayer (SAM) with long and short alkyl groups. Compared with commercial available 4-mercaptophenyboronic acid, PBA with long carbon chain provided more flexible space in binding process and achieved much higher sensitivity to glycoprotein. Furthermore, PBA SAM showed much stronger response for Concanavalin A (ConA) than the traditional protein-protein interaction. The limit of detection for ConA was as low as 0.29 nM by L-PBA SAM modified fiber-optic SPR sensors. Finally, we tested different regeneration solutions to remove glycoprotein from the sensor surface and found that only acidic environment was not enough and the protein denaturant such as ethanol or urea was essential for glycoprotein dissociation.

    更新日期:2018-01-05
  • Layered assembly of NiMn-layered double hydroxide on graphene oxide for enhanced non-enzymatic sugars and hydrogen peroxide detection
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-04
    Jie Zhou, Mengke Min, Yun Liu, Jian Tang, Weihua Tang

    Metal-based non-enzymatic sensors have been intensively explored for rapid and efficient detection of biological molecules. Here, we demonstrate the facile assembly of NiMn-layered double hydroxide (NiMn-LDH) on graphene oxide (GO) (NiMn-LDH/GO) for sugars and hydrogen peroxide (H2O2) monitoring. The hybrids can be easily and large-scale prepared via a simple co-precipitation and hydrothermal approach. Under optimal preparation conditions, NiMn-LDH/GO hybrids exhibit a remarkable sensitivity for glucose oxidation (839.2 μA mM−1 cm−2) and H2O2 reduction (96.82 μA mM−1 cm−2), along with a low detection limit of 1.2 μM and 4.4 μM, respectively. With regard to glucose detection, the linear response range covered four orders of magnitude from 2 μM to 3.386 mM with a correlation coefficient of 0.998. Such versatile sensor is also suitable for detecting other sugars (sucrose, mannitol and erythritol). The delicate non-enzymatic sensor possessed rapid response (reach to ready-state in less than 10 s), good selectivity and reproducibility toward sugars and H2O2 detection, which will boost the exploration of layered metallic nanomaterials in electrochemical sensors.

    更新日期:2018-01-05
  • 更新日期:2018-01-05
  • Sensitive Detection of Pesticides by a Highly Luminescent Metal-organic Framework
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-04
    Xiahong Xu, Yuna Guo, Xiangyun Wang, Wang Li, Peipei Qi, Zhiwei Wang, Xinquan Wang, Sundaram Gunasekaran, Qiang Wang
    更新日期:2018-01-05
  • 更新日期:2018-01-05
  • An improved method of preparing iridium oxide electrode based on carbonate-melt oxidation mechanism
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-04
    Yiwen Pan, Zhentao Sun, Hangqi He, Yifan Li, Long You, Hao Zheng

    pH is a fundamental parameter in understanding the chemical processes in many fields. Based on the strong oxidative characteristic of the molten lithium carbonate (Li2CO3), an advanced iridium oxide electrode preparation approach is developed by adding sodium peroxide (Na2O2) powder into a Li2CO3 melt in a semi-closed/closed reactor at a high temperature to increase the regional peroxide (O22−) ion concentration in the iridium-melt interface. The iridium oxide film (IROF) of prepared electrodes has a dense and uniform surface with small and cone-shaped particles. Open-circuit tests show that electrodes exhibit a near-Nernstian pH response with good linearity, fast response, high stability (a slight periodic fluctuation of potential change with standard deviation <0.65 mV in 48 h), good reversibility in the pH range of 2.00–10.00, and anti-interference to low concentration of oxidants. Besides, electrodes show a stable response in seawater, indicating the major ions in seawater do not influence their performances. In addition, prepared electrodes from the same batch show consistency in terms of sensitivity and the intercept of the standard curve (E°'), while electrodes from different batches vary in E°', which could be attributed to the hardness in controlling identical synthetic conditions among fabrications of different batches.

    更新日期:2018-01-05
  • Titanium dioxide-Polyaniline/Silk fibroin microfiber sensor for pork freshness evaluation
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-04
    Yongqiang Shi, Zhihua Li, Jiyong Shi, Fang Zhang, Xucheng Zhou, Yahui Li, Mel Holmes, Wen Zhang, Xiaobo Zou
    更新日期:2018-01-05
  • 更新日期:2018-01-05
  • 更新日期:2018-01-05
  • Protonated carbon nitride induced hierarchically ordered Fe2O3/H-C3N4/rGO architecture with enhanced electrochemical sensing of nitrite
    Sens Actuators B Chem. (IF 5.401) Pub Date : 2018-01-04
    Shuang Wang, Maoxiang Liu, Shanshan He, Shupeng Zhang, Xuchu Lv, Haiou Song, Jun Han, Duozhe Chen
    更新日期:2018-01-05
Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
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