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A dual-mode biosensor coupling electrochemical and fluorescent measurements of single nucleotide polymorphism with enzyme-free cascade amplification Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-03-01 Jing Ye, Mengyao Chai, Ma Luo, Qi Liang, Minzhi Fan, Yuheng Liao, Yunshan Zhang, Xiaoyu Zhao, Lin Weng, Diming Zhang
Enzyme-free amplification techniques empower the easy-operable and cost-effective analysis of single nucleotide polymorphisms (SNPs), which garnered considerable extensive attention. However, the sensitivity and reliability of enzyme-free amplification technology are limited to meet the needs of biomedical diagnosis. Herein, we develop a dual-mode biosensing strategy that combines target-induced double
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A new rapid-release SMA-activated micropump with incorporated microneedle arrays and polymeric nanoparticles for optimized transdermal drug delivery Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-28 Mostafa Sedky, Ahmed Ali, Mona Abdel-Mottaleb, Mohamed Serry
Recent research in Transdermal drug delivery (TDD) systems has predominantly focused on microneedles (MNs) and nanoencapsulated drugs, which offer painless, gradual drug release but may not cater to quick-release drug demands. This study introduces an innovative approach to expedite the TDD process by merging a new rapid-release micropump, MNs, and nanoencapsulation into a modular framework. The fabrication
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In situ monitor l-Dopa permeability by integrating electrochemical sensor on the Blood-Brain Barrier chip Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-28 Jiaxue Liang, Hang Qi, Feng Zhu, Shuqi Chen, Bohua Liu, Chongling Sun, Yanyan Wang
Real-time monitoring the drugs penetration into brain is crucial for clinical therapy of neurodegenerative diseases. In this study, a Blood-Brain Barrier-electrochemical sensing (BBB-ES) platform combining BBB on chip model and electrochemical sensing system was proposed, which facilitated stable BBB growth under fluidic conditions and realized real-time detection of L-Dopa across the BBB. Based on
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Rational design of 1D/2D heterostructured ZnSnO3/ZnO/Ti3C2TX MXene nanocomposites for enhanced acetone gas sensing performance Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-28 Buting Sun, Yongling Ding, Qi Wang, Peng Song
In this paper, one-dimensional ZnSnO/ZnO nanofibers prepared by electrospinning were attached to two-dimensional TiCT MXene sheets by electrostatic self-assembly technology to obtain 1D/2D heterostructured ZnSnO/ZnO/TiCT MXene composites. Its chemical composition, morphology and structure were analyzed by various methods. The results show that the diameter of ZnSnO/ZnO nanofibers is about 400nm, and
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Characterization and optimization of a quantitative colorimetric acetylcholine esterase inhibition assay for biochip integration demonstrated by neurotoxicity evaluation of malathion Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-28 Mateo G. Vasconez Martinez, Noemi Parato, Silvia Schobesberger, Florian Selinger, Eva I. Reihs, Sarah Spitz, Martin Frauenlob, Peter Ertl, Christian Resch, Gerald Bauer, Günter Povoden, Mario Rothbauer
Organophosphates (OPs) and carbamates as insecticides, nematicides, fungicides, and herbicides are constantly increasing. Their neurotoxic nature requires careful usage, and misuse can lead to fatalities. OPs classified as 'Class 1′ toxic compounds irreversibly inhibit cholinesterases due to their molecular structure resembling the natural acetylcholine substrate, leading to toxic events in the human
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Ultra-sensitive fluorescent immunoassay based on bright AIE nanoparticle for biomarkers detection and quantification Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-28 Yaxin Hu, Song Cheng, Lidan Chen, Li Xie, Haihai Fu, Zhaohui Sun, Rong Hu, Yong Liu, Zhiming Wang, Ben Zhong Tang
Fluorescence immunoassay (FIA) is one of the most immunoassay diagnosis methods in clinic for biomarker quantification in recent years. The development of reliable FIA strategy with high-sensitivity, large-rang and outstanding efficiency for biomarkers rapid diagnosis, especially in complicated samples, is still a great challenge. Herein, an ultra-sensitive FIA combined with magnetic separation was
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Doping/breath figure method triggered reversible diethylchlorophosphate vapor sensing Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-27 Simeng Zang, Huafeng Wu, Huizi Li, Wei Xu, Zhengqi Shen, Wenxing Xu, Bo Wang, Qingguo He, Jiangong Cheng, Yanyan Fu
Aggregation-caused quenching (ACQ) is the key reason why thin-film fluorescence sensing studies have lagged. A facile two-step strategy combining doping with breath figure method (BF) is capable to suppress the ACQ effect without sacrificing the sensing property of the molecule. In this work, two long-wavelength fluorescent probes, MeBOPHY-1 and MeBOPHY-2, were synthesized by introducing one or two
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Electrical Capacitance-based Cancer Cell Viability Monitoring Device for Accelerated Drug Development Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-27 Goeun Park, Sunggu Kang, Yein Kwon, Jeongyun An, Hanbin Park, Min-Ho Lee, Taek Lee
Cell-based assays are important for drug development. Among these, the cell viability assay damages the cells due to the use of toxic reagents, is time-consuming, and has multi-step protocols requiring technical expertise. In this study, a rapid capacitance-based electrical drug monitoring system that can replace existing cell viability assays is presented. This system evaluates the anticancer effects
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Insitu controllable synthesis of MoO3 nanoflakes and its temperature-dependent dual selectivity for detection of ethanol and isopropanol Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-27 Wen Li, Hao Xu, Aiwu Wang, Xuelan Cheng, Jidong Shi, Aihua Zhong, Yujie Ma, Liaoyuan Zhang, Zhiyong Fan, Fang Xu
Nanostructures significantly affect the performance of metal oxide semiconductor (MOS) based gas sensors. Herein, we proposed a method of inducing sulfur-doping (S-doping) in the synthesis to control the morphology of MoO nanoflakes. The MoO nanoflakes prepared with increased S-doping have morphologies with decreased thickness, increased aspect ratio, increased surface area and increased surface chemisorbed
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A mart-responsive photoacoustic sensor based on metal-organic framework as bioreactor for in situ visualization of hydrogen sulfide and tracking of drug-induced liver injury by NIR-II imaging Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-27 Shulong Wang, Yanni Luo, Jianniao Tian, Fanggui Ye, Zhihui Luo, Shulin Zhao
Metformin is currently the most commonly used oral drug for the treatment of diabetes. However, excessive use can up-regulate hydrogen sulfide (HS) levels in the liver, which subsequently leads to severe liver injury and hepatotoxicity. Therefore, using endogenous HS as a target molecule of an intelligent triggering sensor, a nano-probe that can recognize HS with high specificity, and achieve non-invasive
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The effect of high ethanol concentration on E-nose response for diabetes detection in exhaled breath: Laboratory studies Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-27 Anna Paleczek, Artur Rydosz
The growing number of people with diabetes has paved the way for the creation of non-invasive devices to measure blood glucose levels and enable the detection of diabetes non-invasively, for example, through exhaled air. This paper presents the development of a breath detection system using multiple sensors (e-nose system) for the non-invasive estimation of blood glucose levels. The system employs
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Improving Performance of SALDI-MS by Regulating Density of Plasmonic Nanoparticles Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-27 Jingtong Zhai, Yalei Wang, Jiaxin Lu, Chunning Chen, Jiaqi Liu, Hongkun Zhao, Nan Lu
Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) emerges as an effective method for analyzing small molecules. At the current stage, its application is still limited by its detection sensitivity. According to the mechanism of SALDI-MS, the sensitivity highly depends on the laser desorption/ionization (LDI) efficiency. In this study, we adjust the localized surface plasmon resonance
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The pre-high-level temperature modulation: gas detection strategy to improve the response speed of semiconductor sensor Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-27 Hanyang Ji, Hongmin Zhu, Renze Zhang, Zhenyu Yuan, Fanli Meng
With the rapid development of the Internet of Things, gas detection has become an important part of ensuring industrial process and information security. In recent years, dynamic temperature modulation mode has been widely used in semiconductor gas sensors to improve their selectivity. This mode has no definition of response time so far and is not optimized from the perspective of response speed. In
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Coordination Nanosheets based Molecular Computing for Detection and Differentiation of High-Energy Explosives TATB and FOX-7. Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-27 Vishwakarma Ravikumar Ramlal, Akansha Singh, Aniruddha Das, Rabindranath Lo, Amal Kumar Mandal
Detection and differentiation of explosives is an issue of immediacy for security and environmental monitoring. At present, the most operated explosive system combines primary and secondary explosives. Although various advances are presently equipped for identifying primary explosives, the insensitive nature of secondary explosives makes their detection and differentiation challenging. Here, we report
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Programmable 3D DNA nanotweezers combined with frozen gold probes for the detection of ochratoxin A Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-27 Rui Zhang, Ruipeng Chen, Yujing Ma, Han Cui, Jiaqi Lin, Shuyue Ren, Jun Liang, Zhixian Gao
Mycotoxins constitute a group of toxic small-molecule secondary metabolites formed by fungi under specific temperature and humidity conditions. The toxicity of ochratoxin A (OTA) is second only to aflatoxin B1 (AFB1), which has nephrotoxicity, hepatotoxicity, immunotoxicity and other toxicological effects on humans and animals, seriously endangering the health of human and animal bodies. Thus, developing
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A highly specific two-photon fluorescent probe for pantetheinase and its biological applications Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-24 Yuxing Lin, Ruixue Xu, Zhao Ma, Xiaoyu Chen, Ke Wang, Xuyu Song, Lei Zhang, Minyong Li, Huiqing Yuan
Pantetheinase is an enzyme that catalyzes the hydrolysis of pantetheine, releasing pantothenic acid (vitamin B5) and cysteamine as byproducts, which is associated with many physiological and pathological processes. In this work, a two-photon fluorescent probe PA-BAN for pantetheinase based on N-butyl-4-amino-1,8-naphthalimide fluorophore scaffold, was designed, synthesized, and developed for sensing
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Ultra-dense SnO2 QDs-decorated MXene nanosheets with high water dispersibility for rapid NH3 sensing at room temperature Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-24 Eunyeong Yang, Ki Hong Park, Taegon Oh, Seon Joon Kim
The demand for sensitive and rapidly detecting gas sensors is increasing across various industries, ranging from environmental monitoring to medical diagnostics. Various harmful gases pose significant health risks, necessitating detection below permissible exposure limits where metal oxide semiconductor (MOS) gas sensors have garnered attention due to their sensitivity, rapid response, and cost-effectiveness
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Fiber-optic trace gas sensing based on graphite excited photoacoustic wave Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-24 Xiao Han, Chenxi Li, Min Guo, Xinyu Zhao, Zhengzhi Wang, Hongchao Qi, Ke Chen
A fiber-optic trace gas sensing system based on photoacoustic (PA) effect of solids is reported. The modulated laser light absorbed by the gas is incident on a graphite sheet. The graphite sheet and cantilever are enclosed together to form an optical power detector based on PA effect of solids. This scheme is different from the traditional PA trace gas detection, achieving the separation of the gas
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Synchronously manipulating absorption and nonradiative transition of croconaine via donor engineering for efficient NIR-II photothermal theranostics Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-23 Jian Li, Xinhui Su, Nian Liu
Organic molecules with strong absorption in the near-infrared (NIR)-II region are highly desired for cancer photothermal theranostics. However, it remains challenges to construct NIR-II photothermal agents with desired optical properties. This study reports a donor engineering approach to simultaneously manipulate the absorption and nonradiative transitions of croconaine dyes. By introducing different
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Nanocube-shaped In2O3@TiO2 core-shell based chemiresistive-type sensors for formaldehyde detection at room temperature Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-23 Su Zhang, Yansheng Li, Tiefeng Wu, Zhichao Zhao, Qiuxia Feng, Xiaogan Li
InO@TiO core-shell nanocubes were successfully prepared via hydrothermal method and subsequent water bath method. The characterization results show that the size of the InO@TiO nanocomposites is 250–350 nm. The InO@TiO nanocomposites based sensor presents excellent sensing response to formaldehyde at ppb level. The response of InO@TiO nanocomposites based sensor to 1 ppm formaldehyde is about 5.3 at
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Temperature-insensitive cascaded micro-ring resonator silicon photoelectric sensor based on wavelength interrogation for HSA detection Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-23 Zhaoyu Wang, Mingyu Li, Xin Chen, Kaihao Zhao, Jiamei Gu, Jian-Jun He, Qiu-Shun Li, Wen-Fei Dong
Silicon-based optical biosensors have garnered significant interest since their inception. They are, however, susceptible to temperature fluctuations in a controlled environment. In order to address this issue, we provide a solution including the utilization of a silicon-on-insulator (SOI) cascaded micro-ring resonators (CMRR) biosensor that is designed to be insensitive to temperature changes. It
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A sensing platform for highly sensitive immunoassay based on metal-enhanced fluorescence of CdSe@ZnS Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-23 Fangfang Chen, Yihan Li, Ziwei Ma, Ning Li, Chunxia Chen, Huaibin Shen, Dangdang Xu, Min Liu, Yufeng Yuan, Lin Song Li
Insufficient sensitivity caused by low radiative intensity of employed fluorescent material is the main obstacle toward early accurate diagnosis of fatal diseases when applying fluorescence analysis. Herein, we have developed a dual amplification procedure to overcome this issue. We first synthesize high-quality CdSe@ZnS@SiO core/shell quantum dots (QDs) with type-I band alignment to confine the carrier
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Three-in-one lateral flow aptasensor based on magnetic nanoparticles for on-site detection of ochratoxin A in Astragalus membranaceus Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-23 Yangjiayi Xiang, Gou Wu, Cong Hu, Hongmei Liu, Yan Li
The prevalence and significant health risks associated with mycotoxin contamination in traditional Chinese medicines underscore the need for on-site detection methods. The complexity of matrices necessitates sample pretreatment before analysis, leading to prolonged analysis times and intricate procedures. In this study, we employed aptamer-modified magnetic nanoparticles (aptamer-MNPs) as labels and
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Construction of bayberry-like Cu2O/CuO and detection of trace Cl2 at low temperature Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-23 Yuanyuan Wu, Xianfa Zhang, Xiaoli Cheng, Yingming Xu, Shan Gao, Lihua Huo
The effective detection of toxic and harmful gases is of great significance for protecting the environment and human health. The construction of heterostructures plays a crucial role in improving gas sensing performance of sensitive materials. In this study, an one-step solvothermal method was used to directly synthesize ∼2 μm bayberry-like CuO/CuO. Due to the formation of heterostructures, the gas
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Oxygen plasma treatment-enhanced humidity sensing performance of MoS2 nanoparticles-anchored nitrogen-doped laser-induced graphene Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-23 Chen Li, Jijun Xiong, Jiang Zhao
The monitoring of humidity has elicited considerable interest in diverse fields. Nevertheless, the intricate nature of preparatory procedures employed for humidity sensors poses a formidable challenge in the pursuit of a streamlined, expeditious, and highly efficient technique for fabricating humidity-sensitive materials. Herein, the fundamental formation principle of polyimide (PI) film serves as
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MOF-derived Co3O4-ZnO heterostructure for 3-methyl-1-butanol detection Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-22 Gustavo S.M. Santos, Bruna S. de Sá, Tarcísio M. Perfecto, Diogo P. Volanti
Microbial volatile organic compounds (MVOCs) detection with a fast response and high selectivity is barely studied. The challenge is developing a material that matches these factors in different sensing conditions, such as operating temperature and humidity. In this study, we searched for a better way to improve the gas sensing properties of cobalt oxide (CoO), synthesizing a MOF-derived (ZIF-67-ZIF-8)
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A signal-amplification electrochemical aptasensor based on porous Pt nanotubes and tetrahedral DNA nanostructures for ultrasensitive detection of citrinin Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-22 Shi Tang, Baoshan He, Jun Yang, Yao Liu, Ying Liang, Jinshui Wang, Huali Jin, Min Wei, Wenjie Ren, Zhiguang Suo, Yiwei Xu
A highly sensitive and accurate electrochemical aptasensor integrated tetrahedral DNA nanostructures (TDN) and porous platinum nanotubes (p-PtNTs) for citrinin (CIT) detection was constructed in this study. The TDN, the probe support material, was hybridized with an aptamer (Apt) to create a TDN-Apt anchored to the electrode surface. This effectively controls the distance between probes and reduces
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Fluorescent Dual-Signal Immunosensor Combined with Machine Learning Algorithm for Accuracy Discrimination of Natural Brucella Infection and Vaccination Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-22 Deying Zou, Jiang Chang, Shiying Lu, Pan Hu, Kai Zhang, Cheng Han, Feng Li, Yansong Li, Dan Chi, Mengyan Cheng, Jianfeng Xu, Xiaoli Sun, Zengshan Liu, Honglin Ren
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Autoluminescent Met-AuNCs mediated coreactant-free electrochemiluminescent biosensor based on DNA walker cascade signal amplification for Vibrio parahaemolyticus detection Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-22 Luting Yan, Yuhao Zhang, Qi Guo, Lei Tian, Falan Li, Qingqing Yang, Yanyan Zhang
Most electrochemiluminescent (ECL) biosensors currently necessitate coreactants that affect sensor detection accuracy and increase sensor construction complexity. This study detailed the creation of an ECL biosensor without coreactant, utilizing Methionine-capped Au nanoclusters (Met-AuNCs) as luminophore and a Pb-dependent DNAzyme-mediated DNA walker signal amplification strategy to detect Vibrio
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Triethylamine gas sensor based on Zn2SnO4 polyhedron decorated with Au nanoparticles and density functional theory investigation Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-22 Caixuan Sun, Junkai Shao, Guofeng Pan, Xueli Yang
The effective detection of toxic and harmful triethylamine (TEA) gases is of great significance for the living environment and personal safety. Therefore, it is necessary to develop a high-quality TEA sensor that can respond quickly and has high response and low detection limits. In this work, Au nanoparticles (NPs) were successfully loaded onto the surface of the ZnSnO (ZSO) polyhedron by hydrothermal
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Pesticide Uptake and Translocation in Plants Monitored in situ via Laser Ablation Dielectric Barrier Discharge Ionization Mass Spectrometry Imaging Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-22 Xue You, Qiao Lu, Xiaokang Guan, Zhouyi Xu, Renato Zenobi
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Bacteria proliferation-mediated cascade amplification for visually ultrasensitive detection of extracellular vesicles Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-22 Jingjing Li, Wen Bi, Yanfeng Gao, Shurong Qin, Jingjing Yang, Yujun Song, Bangshun He
In molecular diagnostics, there exist challenges in effectively isolating and sensitively detecting biomarkers such as extracellular vesicles (EVs) visually. Within this study, we propose a highly sensitive and specific point-of-care testing (POCT) strategy that utilizes the rapid capture of as a surrogate, coupled with volumetric bar-chart chips (V-chip) for EVs markers quantification. Firstly, the
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Hydrophilic redox buffers for textile-based potentiometric sensors Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-22 Eliza J. Herrero, Takumi Goto, Philippe Bühlmann
One of the barriers to the more widespread use of ion-selective electrodes (ISEs) in resource-limited areas is the need for frequent recalibration of such devices. The incorporation of a redox buffer to minimize the effect of redox-active impurities in the system has previously been shown to significantly improve reproducibility. To date, however, there have been no examples of redox buffers compatible
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U-disk portable photoelectrochemical sensor based on bifunctional poly(o-phenylenediamine) for on-site detection of erythromycin Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-22 Qi Zheng, Yang Chen, Yuyan Cao, Yuhui He, Kening Lu, Nengqin Jia
Developing portable sensing platform with robust signal intensity is essential for on-site detection. Here, a bifunctional poly(-phenylenediamine) (PoPD)-involved portable photoelectrochemical (PEC) sensor is proposed for detecting erythromycin (Ery). Firstly, the PoPD polymer-semiconductor acts as a molecularly imprinted polymer for specific recognition of Ery and simultaneously serves as a key PEC-active
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A sub-second QCM humidity sensor with low hysteresis base on Nafion thin film Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-21 Xing Ding, Haochi Ying, Xiangdong Chen
In this paper, we developed a QCM humidity sensor with Nafion thin film coated on its electrode. An impedance-based QCM measurement system proposed in our previous work was used for measurement without oscillators. The experimental results indicate that the obtained QCM sensor has an ultrafast response speed (0.6/0.9 s) and very low hysteresis (1.61% RH). This may be related to the low amount of Nafion
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A benzothiazole derivative for differentiating mitochondrial G-quadruplex formation between normal and tumor cells Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-21 Ranran Sun, Hongxia Sun, Xiongjun Ye, Dawei Yang, Boyang Zhang, Yan Liu, Ruiyang Bai, Fanru Zhong, Li Yao, Yalin Tang
Emerging studies demonstrates that mitochondrial G-quadruplex (G4) may be a prospective diagnostic and therapeutic target for cancer. Fluorescent probes targeting mitochondrial G4 are crucial for in-depth research on G4 function and mechanism and developing new diagnostic techniques. Here, we report a benzothiazole derivative named ThT-E, which can be prepared with high yield through only one step
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Fabrication of biocompatible and biodegradable cloth-based sweat sensors using polylactic acid (PLA) via stencil transparent film-printing Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-21 Benjarat Tasangtong, Kunwarin Sirichan, Chanakarn Hasoon, Piyaporn Na Nongkhai, Nadnudda Rodthongkum, Yupaporn Sameenoi
Cloth-based sensors are gaining attention for creating microfluidic wearable sensors for continuous monitoring of sweat biomarkers because of their flexibility, low cost, and natural hydrophilicity making them suitable for integration into everyday products. Here, we present a novel, low-cost and simple fabrication approach to create a cloth-based sensor ready for use as a sweat sensor while being
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Dual-mode aptasensor based on a coumarin–benzothiazole fluorescent and colorimetric probe for label-free and visual detection of ochratoxin A Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-21 Yue Mou, Yanfei Zhang, Meiyun Chen, Xinru Lin, Jiaheng Zhang, Jiaona Han, Xingyu Luo
Ochratoxin A (OTA) is regarded as a harmful mycotoxin that severely influences human health by increasing the risk of diseases. Although conventional quantitative methods for OTA detection have been developed, there remain drawbacks of limited signal transduction, bulky instrument requirements, high cost, and sophisticated sample pretreatment. Herein, we successfully synthesize a coumarin-benzothiazole
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Red-emissive silicon nanodots with highly biocompatible for mitochondrial dynamic tracking and blood-brain barrier penetration imaging Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-20 Yulu Liu, Lei Cao, Tongtong Zhu, Haiyang Yan, Panyong Wang, Xinpei Pang, Li Li, Qian Mei, Wen-Fei Dong, Minghui Zan
As one of the most indispensable organelles in eukaryotic cells, mitochondria are the primary site of cellular energy acquisition. Visual monitoring of mitochondria is an important way to understand mitochondrial morphology and cellular activities. However, it is difficult to achieve long-term localization and tracking due to the poor photostability of commercial mitochondria-targeted dyes. In this
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Dual-FRET aptasensor for rapid screening of Ochratoxin A in food samples Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-20 Chengxia Xie, Xianming Li, Quanwei Yu, Minjin Wang, Bin Yang, Binwu Ying, Peng Wu
Simple, low cost, and sensitive OTA screening method is important for food safety control. The discovery of the OTA aptamer enabled the development of various aptasensors, but the structural change caused by target binding is not appreciable enough, thus limiting the sensitivity. The introduction of various nanomateirals could amplify the structure change, but such aptasensors are difficult to be standardized
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Decentralized touch-based micronutrition sensor towards personalized nutrition: Parallel detection of sweat ascorbic acid and zinc ions Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-20 Sumeyye Seker, Dionysios Soulis, Jong-Min Moon, Anastasios Economou, Joseph Wang
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Gas Discrimination and Concentration Prediction Based on Sensing Features Deriving from Molecular Interfacial Interactions Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-20 Zhengmao Cao, Xiaoyan Gao, Zijian Zhang, Wu Wang, Jianping Sheng, Jieyuan Li, Yanjuan Sun, Fan Dong
The chemresistive sensing process derives from the interfacial interactions between the gaseous molecule and the sensing material’s surface. However, the deeper understanding of gas-solid interfacial interactions during gas sensing is still a formidable challenge. In this study, we combine diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) and Raman spectroscopy to systemically investigate
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Soil pesticides pollution detection and specific recognition using electronic nose Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-20 Cheng Kong, Lili Ren, Xiaohu Shi, Zhiyong Chang
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Polyethyleneimine cross-linked BSA with enhanced antifouling capability for electrochemical detection of cancer antigen 125 in complex biofluids Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-19 Rong Li, Kunpeng Yu, Gao-Chao Fan, Zhen Song, Xiliang Luo
Biofouling is a major challenge in the practical application of electrochemical biosensors, and the exploration of antifouling materials to fabricate low-fouling sensing interfaces has attracted increasing attention. Herein, a composite material with enhanced antifouling capability was prepared through cross-linking bovine serum albumin (BSA) with polyethyleneimine (PEI). The PEI cross-linked BSA (BSA-PEI)
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A fluorescence-electrochemistry dual-mode imprinted sensing platform constructed by boric acid-functionalized MOF@COF core-shell composite for sensitive detection of glycoprotein Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-19 Wei Hu, Fubin Pei, Bin Du, Jiang Wang, Muwen Liang, Lidong Yang, Bing Liu, Xihui Mu, Zhaoyang Tong
A novel imprinted material for glycoprotein detection was prepared based on metal-organic framework (MOF)/covalent-organic framework (COF) hybrid composite (MOF@COF-B(OH)) with fluorescent properties and boric component that facilitated glycoprotein imprinting. The MOF@COF-B(OH) exhibited improved fluorescence emission from MOF due to efficient excited-state intramolecular proton transfer (ESIPT).
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Dual-modal aptasensor based on multifunctional acridone derivative for rapid detection of exosomal proteins and cancer diagnosis Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-19 Yaokun Xia, Gengzhen Zhu, Lijuan Zhao, Caixia Yan, Zening Huang, Jun He, Xiao Li, Qingwei Zhao
Molecular profiling of exosomes is a promising non-invasive approach for cancer diagnosis. However, the rapid, robust, and sensitive detection of exosomal proteins remains challenging. In this study, we develop a dual-modal aptamer sensor (aptasensor) using reversible exosomes isolation and 2-sulfo-acridone (2-SA) mediated signal amplification for the colorimetric and fluorescent detection of exosomal
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Peptide self-assembly (PSA) nanoparticle-based nanoscale organic framework (PSAOF): A smart photochemical assays for pyrethroid Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-19 Ying Zhang, Dianwei Zhang, Huilin Liu, Baoguo Sun
Profiting from the unique photoluminescence features, covalent organic frameworks (COFs) have been developed vigorously as an advanced chemical sensing platform, whereas their selectivity and sensitivity remain a big challenge. Herein, a peptide self-assembly (PSA) nanoparticle-based nanoscale organic framework (PSAOF) was constructed through a novel modulation strategy for sensing pesticides. The
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Biodegradable poly(3-hydroxybutyrate-co-4-hydroxybutyrate)/curcumin composite film as a smart indicator of food spoilage Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-17 Yun Hyeok Choi, Jun Tae Kim, Min Hee Kim, Won Ho Park
Due to the global issue of food wastage, smart packaging technologies have been garnering growing attention in the food industry. These technologies provide comprehensive information throughout the food distribution process, including maintaining freshness, regulating temperature and humidity of food products. In this study, we developed an intelligent indicator film composed of microbial aliphatic
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A NIR iridium(III) complex-based reversible probe for assessing AD progression and screening anti-AD drugs through visualization of the “Cu2+-H2S seesaw” phenomenon in Alzheimer’s disease Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-17 Chaolong Liu, Meichun Qin, Shouheng Xu, Yanan Yuan, Ke Li, Jianguo Tang
The progression of Alzheimer’s disease (AD) is accompanied by the increase of copper ions (Cu) concentration and decrease of hydrogen sulfide (HS) level in brain tissue, thus, reversible detection of Cu and HS is regarded as an important strategy for the diagnosis and intervention of AD. However, reliable tools for reversible tracking of Cu and HS and demonstrate their dynamic changes in AD are still
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Ultrasensitive cancer cell sensing based on tapered optical fiber operating near the dispersion turning point Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-17 Qiang Zhang, Junlei Zhao, Anqi Han, Xiaonan Zhang, Mingya Yang, Hui Li, Benli Yu, Guosheng Zhang, Sheng Zhou
Cancer cell screening is very important for its treatment and prognosis. The screening techniques are required with high sensitivity and specific recognition. Here, an ultrasensitive tapered optical fiber (TOF) biosensor for cancer cell sensing is proposed. The unique property of the dispersion turning point (DTP) in the TOF is utilized to greatly improve the sensing sensitivity. Combined with numerical
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Integrating liquid chromatography-electrochemical detection-surface Enhanced Raman Spectroscopy on microfluidic chip for phenylurea herbicides analysis Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-16 Xu Wang, Ziyang Guo, Dongtang Zhang, Yong Yan, Yaqing Yu, Biao Du, Zhengdong Zhang, Xiayan Wang
The widespread use of phenylurea herbicides (PHs) is a serious threat to human health and environmental safety. These pollutants usually have similar molecular structures but distinct toxicities. Therefore, developing rapid detection methods to analyze PHs quantitatively and qualitatively is highly desirable. This study fabricated a microfluidic glass liquid chromatography (LC) coupled with electrochemical
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Modulating the majority charge carrier type and performance of organic heterojunction ammonia sensors by increasing peripheral fluorination of the silicon phthalocyanine sublayer Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-16 Benjamin King, Sujithkumar Ganesh Moorthy, Eric Lesniewska, Rita Meunier-Prest, Marcel Bouvet, Benoît H. Lessard
Silicon phthalocyanines (R-SiPcs) are an emerging class of high-performance organic semiconductors which have recently found application in highly sensitive and selective bilayer organic heterojunction devices for ammonia (NH) sensing. We report bilayer heterojunction devices based on axially-substituted bis(pentafluorophenoxy)silicon phthalocyanines of increasing peripheral fluorination ((FPhO)-FSiPc)
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Using orientational transition of acetone-doped liquid crystal triggered by vanillin as a naked-eye vanillin sensor Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-16 Kai Lin, Ao Xia, Qiang Liao, Kun-Lin Yang
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Corn stigma template-assisted synthesis of single crystal MoO3 elliptical nanosheets for chemiresistive detection of dibutylamine vapor Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-15 Shi-Kai Shen, Yu-Ying Xin, Xian-Fa Zhang, Xin Zhou, Zhao-Peng Deng, Ying-Ming Xu, Li-Hua Huo, Shan Gao
The fabrication of chemoresistive sensor for the sensing detection of hazardous organoamines has recently aroused wide interest. However, there is no report on dibutylamine (DBA) to date. For this aim, two MoO materials were simply prepared by calcining corn stigma bio-template immersed in ammonium molybdate solution. Among, MoO-600 hierarchical structure calcined at 600C is cross-linked by relatively
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A cofactor self-supplying and self-feedback DNAzyme nanodevice for cascade-amplified imaging of mRNA in living cells and in vivo Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-15 Xiaohong Zhong, Yifang He, Ming Shi, Yong Huang, Kexin Liang, Beilei Wang, Jing Hua, Liangliang Zhang, Shulin Zhao, Hong Liang
In vivo imaging of tumor-related mRNA has prosperous prospects for tumor diagnosis. Given the low expression levels of tumor-related mRNA at early stages of cancer, its in vivo amplified imaging still requires more efforts. Herein, we report a novel cofactor self-supplying and self-feedback DNAzyme (Dz) nanodevice (SFDND) for imaging of tumor-related mRNA in vitro and in vivo with cascade signal amplification
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A highly sensitive flexible humidity sensor based on a wafer-level composite material of carbon-quantum-dots@nanofiber clusters Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-15 Yuefang Zhao, Mao Li, Na Zhou, Shaohang Xu, Meng Shi, Chengjun Huang, Haiyang Mao
A novel composite material composed of carbon-quantum-dots@nanofiber clusters (CQDs@NFCs) is successfully developed in wafer level, taking it as a sensitive material, a flexible humidity sensor is also developed. Since the composite material is superhydrophilic and contains a super large number of nanopores of different sizes, capillary condensation is able to take place within the composite material
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A mitochondria-targeting fluorescent probe for the dual-emission fluorescence-enhanced detection of hydrogen sulfide and turn-on detection of hydrazine Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-15 Yu-Man Tian, Shuang-Shuang Liu, Wei-Na Wu, Xiao-Lei Zhao, Yuan Wang, Yun-Chang Fan, Zhi-Hong Xu, Tony D. James
A fluorescent probe (probe ) with selectivity and sensitivity for HS and NH has been developed. Probe exhibits dual-excitation and dual-emission fluorescence response to HS and fluorescence enhancement toward NH with distinct naked-eye color changes. Moreover, probe displayed low detection limits for HS and NH of 0.90nM and 23.6nM, respectively. The reaction mechanism of probe toward HS and NH was
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Enhanced electrochemiluminescence immunosensor using MIL-53(Fe) as co-reaction promoter of Ru(bpy)32+/PEI system for the detection of carcinoembryonic antigen Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-15 Wenwen Jiang, Wenjin Liang, Chulei Zhao, Wenjin Lai, Bing Cong, Shaopeng Zhang, Mingzhe Jiang, Hongling Li, Chenglin Hong
At present, tumor markers are becoming an increasingly important factor in the diagnosis and treatment of cancer. In this study, an attractive sandwich-type electrochemiluminescence sensor was established for the monitoring of embryonic antigen (CEA),on account of the Ru(bpy)/PEI luminescence system and the faclitation of PEI by MIL-53 (Fe) metal–organic frameworks. In order to achieve the effect of
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Discovery of an indolium-based, turn-on fluorescent ligand that represses the Neuroblastoma RAS expression by targeting the 5′-UTR G-quadruplex structure Sens. Actuators B Chem. (IF 8.4) Pub Date : 2024-02-15 Xiao-Dong Wang, Yong-Si Liu, Ming-Hao Hu
The RNA G-quadruplex (RG4) at 5′-UTRs of Neuroblastoma () mRNA is considered to modulate the NRAS translation, providing new opportunities for interfering with NRAS hyperactivation. Therefore, targeting this RG4 structure by small molecules seems to be an alternative strategy for treating cancers with NRAS mutations or overexpression. In this study, we have developed a promising fluorescent ligand