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Functionalization of Alkenes with Difluoromethyl Nitrile Oxide to Access the Difluoromethylated Derivatives Org. Lett. (IF 5.2) Pub Date : 2024-03-18 Bohdan A. Chalyk, Oleksandr Zginnyk, Andrii V. Khutorianskyi, Pavel K. Mykhailiuk
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Accessing 3,4-Dihydroquinolinone from N-Arylacrylamides via Tetralone-Mediated Energy Transfer and 1,3-Hydrogen Shift Org. Lett. (IF 5.2) Pub Date : 2024-03-18 Yongbo Tan, Jing Zhao, Guo-Jun Deng, Xiaochen Ji, Huawen Huang
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Utilization of High-Throughput Experimentation (HTE) and ChemBeads Toward the Development of an Aryl Bromide and Benzyl Bromide Photoredox Cross-Electrophile Coupling Org. Lett. (IF 5.2) Pub Date : 2024-03-18 Michal P. Glogowski, Noel Cercizi, Tessa Lynch-Colameta, Lance H. Ridgers, James P. Phelan, Ann M. Rowley, Martin P. Rauch
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Chemical Synthesis of Δ-4,5 Unsaturated Heparan Sulfate Oligosaccharides for Biomarker Discovery Org. Lett. (IF 5.2) Pub Date : 2024-03-18 Apoorva Joshi, Pradeep Chopra, Andre Venot, Geert-Jan Boons
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Selective Late-Stage Functionalization of Tryptophan-Containing Peptides To Facilitate Bioorthogonal Tetrazine Ligation Org. Lett. (IF 5.2) Pub Date : 2024-03-18 Nagaraju Mupparapu, Basir Syed, Diem N. Nguyen, Thao H. Vo, Angelica Trujillo, Sherif I. Elshahawi
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Decarboxylative Sulfonylation of Carboxylic Acids under Mild Photomediated Iron Catalysis Org. Lett. (IF 5.2) Pub Date : 2024-03-15 Yuanqi Dong, Ni Xiong, Zhouting Rong, Rong Zeng
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N-Iminopyridinium Compounds in Giese Reaction: Photoinduced Homolytic N–N and C–C Bond Cleavage for Cyanoalkyl Radical Generation Org. Lett. (IF 5.2) Pub Date : 2024-03-15 Gyuri Han, Jihyun You, Junhyeon Choi, Eun Joo Kang
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Synthesis of Bufadienolide Cinobufagin via Late-Stage Singlet Oxygen Oxidation/Rearrangement Approach Org. Lett. (IF 5.2) Pub Date : 2024-03-15 Colin Tichvon, Eugene Zviagin, Zoey Surma, Pavel Nagorny
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Pd-Catalyzed Enantioselective Creation of All-Carbon Quaternary Center with 2,3-Allenylic Carbonates Org. Lett. (IF 5.2) Pub Date : 2024-03-15 Jie Lin, Minqiang Jia, Xu Song, Hao Yu, Shengming Ma
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Palladium-Catalyzed 1,2-Alkynylarylation of Vinyl Arenes with Haloalkynes and Arylboronic Acids Org. Lett. (IF 5.2) Pub Date : 2024-03-15 Ruize Ma, Songjia Fang, Huanfeng Jiang, Wanqing Wu
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Palladium-Catalyzed Dearomative Heck/Suzuki Coupling of C2-Deuterated or C2-Nonsubstituted Indoles Org. Lett. (IF 5.2) Pub Date : 2024-03-15 Wei-Yang Gao, Gao-Yang Yu, Yan-Yu Li, Ren-Xiao Liang, Xin Hong, Yi-Xia Jia
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Synthesis of [2.2]Paracyclophane-Fused Heterocycles via Palladium-Catalyzed C–H Activation/Annulation of [2.2]Paracyclophanecarboxamides with Arynes Org. Lett. (IF 5.2) Pub Date : 2024-03-15 Chongqing Pan, Hongwei Sun, Yonglei Du, Wenbin Wang, Lingling Xu, Yu Hu, Manzhou Zhu
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Regio- and Chemoselective Double Allylic Substitution of Alkenyl vic-Diols Org. Lett. (IF 5.2) Pub Date : 2024-03-15 Bocheng Chen, Lucas Pagès, Raphaël Dollet, Cyrille Kouklovsky, Sébastien Prévost, Aurélien de la Torre
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Catalytic Asymmetric Dearomatization of 2,3-Disubstituted Indoles by a [4 + 2] Cycloaddition Reaction with In Situ Generated Vinylidene ortho-Quinone Methides: Access to Polycyclic Fused Indolines Org. Lett. (IF 5.2) Pub Date : 2024-03-15 Amit Shikari, Chandrakanta Parida, Subhas Chandra Pan
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Asymmetric Deoxygenative Functionalization of Secondary Amides with Vinylpyridines Enabled by a Triple Iridium-Photoredox-Chiral Phosphoric Acid System Org. Lett. (IF 5.2) Pub Date : 2024-03-15 Xiyike Deng, Feng Jiang, Xiaoming Wang
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Biomimetic Total Synthesis of Bimagnolignan: A Natural Anti-Breast Cancer Agent Org. Lett. (IF 5.2) Pub Date : 2024-03-14 Yu-Hong Liu, Yu-Ting Liao, Xiao-Dan Shao, Zhu-Ya Yang, Dashan Li, Lu Liu, Li-Dong Shao
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Light-Driven Three-Component Carbonylation of Aryl Halides Using Abundant Metal Carbonyl Org. Lett. (IF 5.2) Pub Date : 2024-03-13 Quansheng Mou, Tongyu Han, Mingxin Liu
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Intramolecular Nitrone Interrupted Click Reaction Org. Lett. (IF 5.2) Pub Date : 2024-03-14 Tejas A. Pothi, Chepuri V. Ramana
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Photoinduced Decarboxylative Borylation of N-Hydroxyphthalimide Esters with Hypoboric Acid Org. Lett. (IF 5.2) Pub Date : 2024-03-13 Bálint Nagy, Zsombor Gonda, Tamás Földesi, Péter Pál Fehér, András Stirling, Gergely L. Tolnai, Zoltán Novák
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Stereoselective Fluorosulfonylation of Vinylboronic Acids for (E)-Vinyl Sulfonyl Fluorides with Copper Participation Org. Lett. (IF 5.2) Pub Date : 2024-03-13 Jianquan Hong, Chunxiang Li, Kui Zhao, Xiaoyu Wang, Ruilong Feng, Xifei Chen, Chongbin Wei, Xinxin Gong, Feng Zheng, Changge Zheng
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Concave P-Stereogenic Phosphorodiamidite Ligands for Enantioselective Rh(I) Catalysis Org. Lett. (IF 5.2) Pub Date : 2024-03-12 Nidal Saleh, Céline Besnard, Jérôme Lacour
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Continuous Flow Synthesis of Benzotriazin-4(3H)-ones via Visible Light Mediated Nitrogen-Centered Norrish Reaction Org. Lett. (IF 5.2) Pub Date : 2024-03-11 Jorge García-Lacuna, Marcus Baumann
We report a new protocol for the synthesis of substituted benzotriazin-4(3H)-ones which are underrepresented heterocyclic scaffolds with important pharmacological properties. Our method exploits acyclic aryl triazine precursors that undergo a photocyclization reaction upon exposure to violet light (420 nm). Continuous flow reactor technology is exploited to afford excellent yields in only 10 min residence
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Phosphine-Promoted Ring Opening/Recyclization of Cyclopropyl Ketones to Access Hydrofluorenones Org. Lett. (IF 5.2) Pub Date : 2024-03-12 Jay Prakash Maurya, S. S. V. Ramasastry
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Synthesis of Unnatural Amino Acids via Ni/Ag Electrocatalytic Cross-Coupling Org. Lett. (IF 5.2) Pub Date : 2024-03-11 Gabriele Laudadio, Philipp Neigenfind, Rajesh Chebolu, Vanna D. Blasczak, Shambabu Joseph Maddirala, Maximilian D. Palkowitz, Philippe N. Bolduc, Michael C. Nicastri, Ravi Kumar Puthukanoori, Bheema Rao Paraselli, Phil S. Baran
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Baldwin and Whitehead’s Manzamine Alkaloids Biosynthesis Hypothesis Involves a Finely Tuned Reactivity of Acrolein: Automated Extraction of Reactivity Patterns from LC-MS2 Data Org. Lett. (IF 5.2) Pub Date : 2024-03-11 Axel Leblond, Alexandre Nguyen, Charlotte Alcover, Karine Leblanc, Jean-François Gallard, Delphine Joseph, Erwan Poupon, Mehdi A. Beniddir
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Visible-Light-Induced trans-Hydroboration of Diaryl Alkynes Utilizing Excited State of Borate Complexes Org. Lett. (IF 5.2) Pub Date : 2024-03-11 Takahiro Komaki, Yu Sato, Masanobu Uchiyama, Ken Tanaka, Yuki Nagashima
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Rhodium(I)-Catalyzed Defluorinative Bisarylation of Monofluorodienes with Boronic Acids Org. Lett. (IF 5.2) Pub Date : 2024-03-11 Min Li, Gavin Chit Tsui
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Nickel-Catalyzed Deoxygenative Amidation of Alcohols with Carbamoyl Chlorides Org. Lett. (IF 5.2) Pub Date : 2024-03-11 Lele Wang, Zhongxian Li, Yang Zhou, Jun Zhu
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Brønsted Acid-Catalyzed Diastereoselective Synthesis of Spiroisoindolinones from Enamides Org. Lett. (IF 5.2) Pub Date : 2024-03-11 Miro Halaczkiewicz, Arianit Maraj, Harald Kelm, Georg Manolikakes
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Pd–NHC (NHC = N-Heterocyclic Carbene)-Catalyzed B-Alkyl Suzuki Cross-Coupling of 2-Pyridyl Ammonium Salts by N–C Activation: Application to the Discovery of Agrochemical Molecular Hybrids Org. Lett. (IF 5.2) Pub Date : 2024-03-11 Yanqing Gao, Yuge Hu, Jiuhui Ye, Zhiqing Ma, Juntao Feng, Xili Liu, Peng Lei, Michal Szostak
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One-Pot Synthesis of Polycyclic Sultams Enabled by Gold-Catalyzed Hydroamination of o-Alkynylbenzenesulfonamides and Subsequent Iodine(III)-Mediated Counteranion-Assisted Intramolecular Annulation Org. Lett. (IF 5.2) Pub Date : 2024-03-08 Lijun Zhang, Zhiguang Song
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Iron-Catalyzed Cyanide-Free Synthesis of Alkyl Nitriles: Oxidative Deconstruction of Cycloalkanones with Ammonium Salts and Aerobic Oxidation Org. Lett. (IF 5.2) Pub Date : 2024-03-07 Hong Xin, Mingyu Yang, Cheng Guan, Jialong Li, Pin Gao, Xu Yang, Xin-Hua Duan, Li-Na Guo
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Stereocontrolled Construction of Spirooxindole-Containing 5,6,7,8-Tetrahydropyrrolo[1,2-a]pyridine via Michael/Friedel–Crafts Domino Reaction Promoted by Secondary Amine-Squaramide Org. Lett. (IF 5.2) Pub Date : 2024-03-08 Pengxuan Yin, Zijie Zhou, Lingsheng Shi, Chengzhi Xiang, Ling Ye, Min Han, Zhichuan Shi, Zhigang Zhao, Xuefeng Li
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High anti Diastereoselectivity in a Tandem Oxyhomologation–Coupling Protocol for the Preparation of Amides and Peptides Incorporating α-Hydroxy β-Amino Acids Org. Lett. (IF 5.2) Pub Date : 2024-03-08 Xuefeng He, Régis Guillot, Sandrine Deloisy, David J. Aitken
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Photodriven Radical Perfluoroalkylation–Thiolation of Unactivated Alkenes Enabled by Electron Donor–Acceptor Complex Org. Lett. (IF 5.2) Pub Date : 2024-03-08 Lixin Liu, Qian Wang, Yuanhua Li, Min Liu, Bifu Liu, Qiang Li, Kejun Feng
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Air Induced Phosphoryl Radical Mediated Stereoselective Hydrosulfonylation of Alkynes via Halogen Atom Transfer: Ingress of Z-Vinyl Sulfones Org. Lett. (IF 5.2) Pub Date : 2024-03-08 Shashikant Tiwari, Manisha Kumari, Diwan S. Rawat
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FluoroFusion: NHC-Catalyzed Nucleophilic Aromatic Substitution Reaction Unveils Functional Perfluorinated Diarylmethanones Org. Lett. (IF 5.2) Pub Date : 2024-03-08 Cheng-Lin Chan, Shao-Chi Lee, Pei-Shan Lin, Radyn Vanessa Phaz P. Tapales, Jia-Syuan Li, Chun-An Lai, Jyh-Tsung Lee, Chien-Hung Li, Hsuan-Hung Liao
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Electrochemical Formation of Oxazolines by 1,3-Oxyfluorination of Non-activated Cyclopropanes Org. Lett. (IF 5.2) Pub Date : 2024-03-08 Madara Darzina, Aigars Jirgensons
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Silver-Catalyzed Decarboxylative Remote Fluorination via a Zwitterion-Promoted 1,4-Heteroaryl Migration Org. Lett. (IF 5.2) Pub Date : 2024-03-08 Xiaofei Xie, Jie Li, Weinan Li, Yan Li, Kang Guo, Yingguang Zhu, Kang Chen
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Electrochemical Continuous-Flow Scholl Reaction toward Polycyclic Aromatic Hydrocarbons Org. Lett. (IF 5.2) Pub Date : 2024-03-08 Wei-Zhen Wang, Qiang Wang, Xinglei He, Yi-Han Shen, Zi’ang Zhai, Ruiying Zhang, Yuanming Li, Ke-Yin Ye
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Dirhodium(II)/DPPM Catalyzed 1,2-Hydrosilylation of Conjugated Dienes with Tertiary Silanes Org. Lett. (IF 5.2) Pub Date : 2024-03-08 Liqun Yang, Xiaoyu Wu, Wenkui Lu, Yan Lu, Zhaoguo Zhang
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Directing-Group-Assisted Non-Strained Ether C–O Bond Homolysis Mediated by Low-Valent Titanium Org. Lett. (IF 5.2) Pub Date : 2024-03-08 Takuya Suga, Ryusei Takada, Masaya Sakamoto, Yutaka Ukaji
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Direct, Selective α-Aryloxyalkyl Radical Cyanation and Allylation of Aryl Alkyl Ethers Org. Lett. (IF 5.2) Pub Date : 2024-03-07 Iain Robb, John A. Murphy
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Direct Catalytic Enantioselective Conjugate Addition of α-Substituted Benzyl Nitriles to Alkyl Acrylates Org. Lett. (IF 5.2) Pub Date : 2024-03-07 Sadhanendu Samanta, Jin Cui, Yasunari Otsuka, Takumi Watanabe, Masakatsu Shibasaki
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Synthesis of γ-Oxo-phosphonates via N-Heterocyclic Carbene-Catalyzed Acylphosphorylation of Alkenes Org. Lett. (IF 5.2) Pub Date : 2024-03-07 Jia-Nan Mo, Shengbin Sun, Huiwei Xu, Hanyu Shu, Jiannan Zhao
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Palladium-Catalyzed Heck/Suzuki Tandem Reaction of (Z)-1-Iodo-1,6-dienes and Organoboronic Acids Org. Lett. (IF 5.2) Pub Date : 2024-03-07 Shuling Yu, Zhengneng Jin, Xiaofeng Tong, Linjun Qi
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Ru(II)-Catalyzed Divergent C–H Alkynylation Cascade with Bifunctional α-Alcohol Haloalkynes Org. Lett. (IF 5.2) Pub Date : 2024-03-07 Qiaoya Zhang, Yinling Li, Yabo Chen, Jiahua Jiang, Yuan Liu, Jiye Luo, Yang Gao, Yanping Huo, Qian Chen, Xianwei Li
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Skeletal Editing of Benzene Motif: Photopromoted Transannulation for Synthesis of DNA-Encoded Seven-Membered Rings Org. Lett. (IF 5.2) Pub Date : 2024-03-07 Yue Zhang, Jia-ying Xue, Xiao-can Su, Wen-jie Xiao, Jing-yi Lv, Wen-xia Shi, Yong Zou, Ming Yan, Xue-jing Zhang
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Copper-Mediated Cyclization of Terminal Alkynes with CF3-Imidoyl Sulfoxonium Ylides To Construct 5-Trifluoromethylpyrroles Org. Lett. (IF 5.2) Pub Date : 2024-03-07 E Mi, Li Zhou, Yixin Tong, Xiaodong Qiu, Xiaobao Zeng, Jinlong Li, Biao Xiong
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Palladium-Catalyzed Directed Carbon–Carbon Bond Activation of Aryl Nitriles for Cyano Transfer Org. Lett. (IF 5.2) Pub Date : 2024-03-07 Lin Tan, Yang Pan, Qing-Ying Zeng, Zhen-Yu Wang, Hui Xu, Hui-Xiong Dai
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Photoredox-Catalyzed Alkene Amination: C(sp2)–H/N–H Radical–Radical Cross Dehydrogenative Coupling Org. Lett. (IF 5.2) Pub Date : 2024-03-07 Chen Jin, Cailin Ning, Yating Sui, Bingxin Zhang, Xinxin Li, Ling Pan, Qun Liu, Yifei Li
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Photocatalyst-Free Activation of Sulfamoyl Chlorides for Regioselective Sulfamoyl-Oximation of Alkenes via Hydrogen Atom Transfer (HAT) and Halogen-Atom Transfer (XAT) Relay Strategy Org. Lett. (IF 5.2) Pub Date : 2024-03-07 Wei Li, Zhihua Huang, Deliang Zhong, Huaifeng Li
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Enantioselective Phase-Transfer-Catalyzed Synthesis of Spirocyclic Azetidine Oxindoles Org. Lett. (IF 5.2) Pub Date : 2024-03-06 Alexander J. Boddy, Aditya K. Sahay, Emma L. Rivers, Andrew J. P. White, Alan C. Spivey, James A. Bull
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Photoredox-Catalyzed Alkylarylation of N-Aryl Bicyclobutyl Amides with α-Carbonyl Alkyl Bromides: Access to 3-Spirocyclobutyl Oxindoles Org. Lett. (IF 5.2) Pub Date : 2024-03-06 Jian-Hong Fan, Jing Yuan, Peng-Fei Xia, Jiao Zhou, Long-Jin Zhong, Peng-Fei Huang, Yu Liu, Ke-Wen Tang, Jin-Heng Li
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Dynamic Thermodynamic Resolution of Racemic 1,1′-Binaphthyl-2,2′-diol (BINOL) Org. Lett. (IF 5.2) Pub Date : 2024-03-06 Omer Shaashua, Dennis Pollok, Alina Dyadyuk, Alexander I. Shames, Siegfried R. Waldvogel, Doron Pappo
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Synthesis of the [6–6–7–5–5] Pentacyclic Core of Calyciphylline N Org. Lett. (IF 5.2) Pub Date : 2024-03-04 Zhiwen Zhao, Guowei Deng, Chuang-Chuang Li
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Expanding the Scope of Alkynes in C–H Activation: Weak Chelation-Assisted Cobalt-Catalyzed Synthesis of Indole C(4)-Acrylophenone via C–O Bond Cleavage of Propargylic Ethers Org. Lett. (IF 5.2) Pub Date : 2024-03-05 Pranav Shridhar Mahulkar, Sofaya Joshi, Shyam Kumar Banjare, Lamphiza O Najiar, Ponneri C. Ravikumar
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Modular Strategy for Constructing para-Cage[n]arenes, meta-Cage[n]arenes, and meta-Bimacrocyclic-Arenes Org. Lett. (IF 5.2) Pub Date : 2024-03-05 Gang Wu, Sheng-Yi Zhuang, Jiabin Xing, Qihan Lin, Zhan-Ting Li, Dan-Wei Zhang
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Chemical Synthesis of a Branched Nonasaccharide Fragment from Helicobacter pylori Lipopolysaccharide Org. Lett. (IF 5.2) Pub Date : 2024-03-05 Ling Li, Xiao-Chen Yin, Yuan-Yuan Jiang, Yi-Fei Xia, Xia Wang, Jiao Li, Hong Li, Yong Qin, Jin-Song Yang
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An Intermolecular Hydroarylation of Unactivated Arylcyclopropane via Re2O7/HFIP-Mediated Ring Opening Org. Lett. (IF 5.2) Pub Date : 2024-03-05 Liqun Hu, Yao Xiang, Xiao-Bing Lan, Youwei Xie