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Serotonin Signaling through Lipid Membranes ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-18 Liubov S. Kalinichenko, Johannes Kornhuber, Steffen Sinning, Jana Haase, Christian P. Müller
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Structures and Dynamics of β-Rich Oligomers of ATTR (105–115) Assembly ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-14 Liqun Liang, Yuqi Zhang, Yanyan Zhu, Juxia Bai, Yangyang Ni, Junfeng Wan, Haiyan Yue, Qingjie Zhao, Huiyu Li
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Research Report: A Link between Sertraline Treatment and Susceptibility to (Mis)information ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-14 Michal Piksa, Karolina Noworyta, Jan Piasecki, Aleksander Gundersen, Jonas Kunst, Mikolaj Morzy, Rafal Rygula
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Investigating a Novel Neurodegenerative Disease Toxic Mechanism Involving Lipid Binding Specificity of Amyloid Oligomers ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-15 Sarah S. Hirschbeck, Edward T. Lindberg, Joshua H. Jang, MaKenna R. Jacob, Kristi L. Lazar Cantrell, Thanh D. Do
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Influence of Cigarette Aerosol in Alpha-Synuclein Oligomerization and Cell Viability in SH-SY5Y: Implications for Parkinson’s Disease ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-14 Yu-Xin Shen, Pe-Shuen Lee, Ming-Chu Teng, Jhih-Hong Huang, Chia C. Wang, Hsiu-Fang Fan
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Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-13 Lieve van Veggel, Tamara A.M. Mocking, Hubert J. Sijben, Rongfang Liu, Marina Gorostiola González, Majlen A. Dilweg, Jeroen Royakkers, Anna Li, Vijay Kumar, Yin Yao Dong, Alex Bullock, David B. Sauer, Hanne Diliën, Gerard J.P. van Westen, Rudy Schreiber, Laura H. Heitman, Tim Vanmierlo
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Patient-Derived Blood-Brain Barrier Model for Screening Copper Bis(thiosemicarbazone) Complexes as Potential Therapeutics in Alzheimer’s Disease ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-13 Joanna M. Wasielewska, Kathryn Szostak, Lachlan E. McInnes, Hazel Quek, Juliana C. S. Chaves, Jeffrey R. Liddell, Jari Koistinaho, Lotta E. Oikari, Paul S. Donnelly, Anthony R. White
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Alleviating Severe Cytoskeletal Destruction of Spinal Motor Neurons: Another Effect of Docosahexaenoic Acid in Spinal Cord Injury ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-12 Qinqin Pei, Qiurong Zhao, Chunhui Lang, Shilong Feng, Juanjuan Meng, Guangjiao Tan, Wei Cui, Cheng Zhang, Xiaohe Luo, Lixin Xu, Jian Chen
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Rational Design of TDP-43 Derived α-Helical Peptide Inhibitors: An In Silico Strategy to Prevent TDP-43 Aggregation in Neurodegenerative Disorders ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-11 Muthu Raj Salaikumaran, Pallavi P. Gopal
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Kynurenines Dynamics in the Periphery and Central Nervous System Steers Behavioral Deficits in Rats under Hypobaric Hypoxia ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-10 Kalyani Verma, Amitabh, Dipti N. Prasad, M. Prasanna Kumar Reddy, Ekta Kohli
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Aryl Hydrocarbon Receptor Involvement in the Sodium-Dependent Glutamate/Aspartate Transporter Regulation in Cerebellar Bergmann Glia Cells ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-07 Janisse Silva-Parra, Leticia Ramírez-Martínez, Cecilia Palafox-Gómez, Cristina Sandu, Esther López-Bayghen, Libia Vega, Guillermo Elizondo, Jaqueline Loaeza-Loaeza, Daniel Hernández-Sotelo, Luisa C. Hernández-Kelly, Marie-Paule Felder-Schmittbuhl, Arturo Ortega
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18F-Labeled PET Tracers Specific for Adenosine A2A Receptor: Design, Synthesis, and Biological Evaluation ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-08 Tingyu Yang, Wei Zheng, Xuebo Cheng, Hualong Chen, Zeng Jiang, Ziyue Yu, Lu Zhang, Yi Xie, Lianjie Du, Xuan Ge, Jiahuai Zhang, Leilei Yuan, Yajing Liu, Zehui Wu
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Nav1.7 Modulator Bearing a 3-Hydroxyindole Backbone Holds the Potential to Reverse Neuropathic Pain ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-06 Yuwei Wang, Jirong Shu, Haoyi Yang, kemiao Hong, Xiangji Yang, Weijie Guo, Jie Fang, Fuyi Li, Tao Liu, Zhiming Shan, Taoda Shi, Song Cai, Jian Zhang
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Discovery, Structure-Based Modification, In Vitro, In Vivo, and In Silico Exploration of m-Sulfamoyl Benzoamide Derivatives as Selective Butyrylcholinesterase Inhibitors for Treating Alzheimer’s Disease ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-07 Xin Lu, Yueqing Li, Qianwen Guan, Huajing Yang, Yijun Liu, Chenxi Du, Lei Wang, Qinghua Wang, Yuqiong Pei, Liang Wu, Haopeng Sun, Yao Chen
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Neuroprotection Role of Vitamin C by Upregulating Glutamate Transporter-1 in Auditory Cortex of Noise-Induced Tinnitus Animal Model ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-07 Wanxin Cao, Shan Xiong, Wenliang Ji, Huan Wei, Furong Ma, Lanqun Mao
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Phytic Acid Maintains Peripheral Neuron Integrity and Enhances Survivability against Platinum-Induced Degeneration via Reducing Reactive Oxygen Species and Enhancing Mitochondrial Membrane Potential ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-06 Arjun Prasad Tiwari, Bayne Albin, Khayzaran Qubbaj, Prashant Adhikari, In Hong Yang
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EB1 Increases the Dynamics of Tau Droplets and Inhibits Tau Aggregation: Implications in Tauopathies ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-06 Anuradha Venkatramani, Anvesh Ashtam, Dulal Panda
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4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H3 Receptors and Cholinesterases ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-05 Beata Michalska, Marek Dzięgielewski, Justyna Godyń, Tobias Werner, Marek Bajda, Tadeusz Karcz, Katarzyna Szczepańska, Holger Stark, Anna Więckowska, Krzysztof Walczyński, Marek Staszewski
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Deciphering the Association of Epstein–Barr Virus and Its Glycoprotein M Peptide with Neuropathologies in Mice ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-04 Annu Rani, Priyanka Patra, Tarun Prakash Verma, Anamika Singh, Ajay Kumar Jain, Neha Jaiswal, Sanjeev Narang, Nitish Mittal, Hamendra Singh Parmar, Hem Chandra Jha
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Reversible Morphological Remodeling of Prefrontal and Hippocampal Serotonergic Fibers by Fluoxetine ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-04 Serena Nazzi, Marta Picchi, Sara Migliarini, Giacomo Maddaloni, Noemi Barsotti, Massimo Pasqualetti
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Modulation of Primary and Secondary Processes in Tau Fibril Formation by Salt-Induced Dynamics ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-03 Arshad Abdul Vahid, Muhammed Shafeek Oliyantakath Hassan, Allwin Ebenezer Sahayaraj, Ann Teres Babu, Safwa T. Kizhakkeduth, Vinesh Vijayan
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A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-28 Sean Chia, Rodrigo Lessa Cataldi, Francesco Simone Ruggeri, Ryan Limbocker, Itzel Condado-Morales, Katarina Pisani, Andrea Possenti, Sara Linse, Tuomas P. J. Knowles, Johnny Habchi, Benedetta Mannini, Michele Vendruscolo
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Sex-Specific Transcriptomic Changes in the Villous Tissue of Placentas of Pregnant Women Using a Selective Serotonin Reuptake Inhibitor ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-29 Laura Staal, Torsten Plösch, Theodora Kunovac Kallak, Inger Sundström Poromaa, Bregje Wertheim, Jocelien D. A. Olivier
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Potential Metabolite Biomarkers of Multiple Sclerosis from Multiple Biofluids ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-29 Fatema Bhinderwala, Heidi E. Roth, Mary Filipi, Samantha Jack, Robert Powers
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A Toxicogenic Interaction between Intracellular Amyloid-β and Apolipoprotein-E ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-29 Arpan Dey, Aditi Verma, Uchit Bhaskar, Bidyut Sarkar, Mamata Kallianpur, Vicky Vishvakarma, Anand Kant Das, Kanchan Garai, Odity Mukherjee, Kunihiko Ishii, Tahei Tahara, Sudipta Maiti
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Reduction of Amyloid-β Production without Inhibiting Secretase Activity by MS-275 ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-28 Yachiyo Mitsuishi, Masaki Nakano, Hirotatsu Kojima, Takayoshi Okabe, Masaki Nishimura
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New Multitarget Molecules Derived from Caffeine as Potentiators of the Cholinergic System ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-26 Juan Pablo Munafó, Brunella Biscussi, Diego Obiol, Marcelo Costabel, Cecilia Bouzat, Ana Paula Murray, Silvia Antollini
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Extracellular Vesicles Slow Down Aβ(1–42) Aggregation by Interfering with the Amyloid Fibril Elongation Step ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-26 Vesa Halipi, Nima Sasanian, Julia Feng, Jing Hu, Quentin Lubart, David Bernson, Daniel van Leeuwen, Doryaneh Ahmadpour, Emma Sparr, Elin K. Esbjörner
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Beyond CSF and Neuroimaging Assessment: Evaluating Plasma miR-145-5p as a Potential Biomarker for Mild Cognitive Impairment and Alzheimer’s Disease ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-26 Qingfeng Wen, Mandy Melissa Jane Wittens, Sebastiaan Engelborghs, Marcel H. M. van Herwijnen, Maria Tsamou, Erwin Roggen, Bert Smeets, Julian Krauskopf, Jacco Jan Briedé
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Spectral Fluorescence Pathology of Protein Misfolding Disorders ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-26 Anastasiia A. Stepanchuk, Peter K. Stys
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Identification of an Antagonist Targeting G Protein and β-Arrestin Signaling Pathways of 5-HT7R ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-22 Jeong Hyun Jeong, Haeun Lee, Doyoung Kim, Eunseo Park, Jiwan Woo, Yakdol Cho, Gyochang Keum, Ansoo Lee, Taek Kang, Jeongjin Kim, Hyunah Choo, Sanghee Lee, Byungsun Jeon
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Comparison of Behavioral Effects of GABAergic Low- and High-Efficacy Neuroactive Steroids in the Zebrafish Larvae Assay ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-22 Allison L. Germann, Yuanjian Xu, Douglas F. Covey, Alex S. Evers, Gustav Akk
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Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid Composition ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-20 František Sedlák, Aleš Kvasnička, Barbora Marešová, Radana Brumarová, Dana Dobešová, Kateřina Dostálová, Karolína Šrámková, Martin Pehr, Pavel Šácha, David Friedecký, Jan Konvalinka
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Evidence for a Role of 5-HT-glutamate Co-releasing Neurons in Acute Stress Mechanisms ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-20 L. Sophie Gullino, Cara Fuller, Poppy Dunn, Helen M. Collins, Salah El Mestikawy, Trevor Sharp
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SCFAs Supplementation Rescues Anxiety- and Depression-like Phenotypes Generated by Fecal Engraftment of Treatment-Resistant Depression Rats ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-21 Mani Surya Kumar Palepu, Siva Nageswara Rao Gajula, Malleshwari K, Rajesh Sonti, Manoj P. Dandekar
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Uncovering Structure–Activity Relationships of Phenethylamines: Paving the Way for Innovative Mental Health Treatments ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-21 Sedat Karabulut, Harpreet Kaur, James W. Gauld
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A Bright Future? A Perspective on Class C GPCR Based Genetically Encoded Biosensors ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-21 Margulan Otanuly, Martin Kubitschke, Olivia Andrea Masseck
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Edge Substitution Effects of Histidine Tautomerization Behaviors on the Structural Properties and Aggregation Properties of Aβ(1–42) Mature Fibril ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-20 Yaru Shi, Yue Sun, Changgui Li, Shuo Wang, Jinping Wang, Hu Shi
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Behavioral and Neurophysiological Implications of Pathological Human Tau Expression in Serotonin Neurons ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-20 Nazmus S. Khan, Juan Uribe Isaza, Nahid Rouhi, Naila F. Jamani, Shaista Jabeen, Amisha K. Gill, Mio Tsutsui, Frank Visser, Derya Sargin
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Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-19 Claudia Mugnaini, Antonella Brizzi, Marco Paolino, Enrico Scarselli, Riccardo Castelli, Modesto de Candia, Nicola Gambacorta, Orazio Nicolotti, Magdalena Kostrzewa, Poulami Kumar, Ali Mokhtar Mahmoud, Vittoria Borgonetti, Monica Iannotta, Andrea Morace, Nicoletta Galeotti, Sabatino Maione, Cosimo D. Altomare, Alessia Ligresti, Federico Corelli
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Amyloidogenic Propensity of Metabolites in the Uric Acid Pathway and Urea Cycle Critically Impacts the Etiology of Metabolic Disorders ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-18 Monisha Patel, Ankita Jaiswal, Anam Naseer, Ankita Tripathi, Aayushi Joshi, Tarun Minocha, Aanand Kautu, Shilpi Gupta, Khashti Ballabh Joshi, Manoj Kumar Pandey, Randhir Kumar, Kshatresh Dutta Dubey, Aamir Nazir, Sandeep Verma, Nidhi Gour
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Molecular Pharmacology of Selective NaV1.6 and Dual NaV1.6/NaV1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-15 Samuel J. Goodchild, Noah Gregory Shuart, Aaron D. Williams, Wenlei Ye, R. Ryley Parrish, Maegan Soriano, Samrat Thouta, Janette Mezeyova, Matthew Waldbrook, Richard Dean, Thilo Focken, Mohammad-Reza Ghovanloo, Peter C. Ruben, Fiona Scott, Charles J. Cohen, James Empfield, JP Johnson
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Mass Spectrometric Imaging of Anionic Phospholipids Desorbed from Human Hippocampal Sections: Discrimination between Temporal and Nontemporal Lobe Epilepsies ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-14 Supratim Mondal, Abhijit Nandy, Geetha Dande, Krishna Prabhu, Rajesh Ramanna Valmiki, Debasish Koner, Shibdas Banerjee
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Omega-3 and -6 Fatty Acids Alter the Membrane Lipid Composition and Vesicle Size to Regulate Exocytosis and Storage of Catecholamines ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-12 Chaoyi Gu, Mai H. Philipsen, Andrew G. Ewing
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In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-12 Meng-Hua M. Tsai, Li Chen, Michael H. Baumann, Meritxell Canals, Jonathan A. Javitch, J. Robert Lane, Lei Shi
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Transient Adenosine Modulates Serotonin Release Indirectly in the Dorsal Raphe Nuclei ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-09 Kailash Shrestha, B. Jill Venton
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New Alpha9 nAChR Ligands Based on a 5-(Quinuclidin-3-ylmethyl)-1,2,4-oxadiazole Scaffold ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-09 Clelia Dallanoce, Katrin Richter, Clare Stokes, Claudio Papotto, Hina Andleeb, Ganesh A. Thakur, Andrew Kerr, Veronika Grau, Roger L. Papke
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Design, Synthesis, and Biological Investigation of Quinazoline Derivatives as Multitargeting Therapeutics in Alzheimer’s Disease Therapy ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-08 Akash Verma, Digambar Kumar Waiker, Neha Singh, Anima Roy, Namrata Singh, Poorvi Saraf, Bhagwati Bhardwaj, Sairam Krishnamurthy, Surendra Kumar Trigun, Sushant Kumar Shrivastava
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The Surprising Nonlinear Effects of S100A9 Proteins in the Retina ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-07 Efrat Naaman, Amanda Qarawani, Rony Ben-Zvi Elimelech, Michal Harel, Shahaf Sigal-Dror, Shadi Safuri, Vytautas Smirnovas, Ieva Baronaite, Nina V. Romanova, Ludmilla A. Morozova-Roche, Shiri Zayit-Soudry
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Novel Substituted Pyrimidine Derivatives as Potential Anti-Alzheimer’s Agents: Synthesis, Biological, and Molecular Docking Studies ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-06 Swati Pant, Ranjith Kumar K, Preeti Rana, Tulika Anthwal, Syed Mastan Ali, Mohan Gupta, Monika Chauhan, Sumitra Nain
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High-Resolution NMR Structures of Intrastrand Hairpins Formed by CTG Trinucleotide Repeats ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-06 Liqi Wan, Axin He, Jinxing Li, Pei Guo, Da Han
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Coronal ApoE Protein Combines with LRP1 to Inactivate GSK3β That Mitigates Silica Nanoparticle-Induced Brain Lesion ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-05 Wei Wei, Hang Sun, Bingwei Yang, Erqun Song, Yang Song
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Unraveling the Interplay of Extracellular Domain Conformational Changes and Parathyroid Hormone Type 1 Receptor Activation in Class B1 G Protein-Coupled Receptors: Integrating Enhanced Sampling Molecular Dynamics Simulations and Markov State Models ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-05 Mengrong Li, Xiaoxiao Zhang, Shu Li, Jingjing Guo
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Atomic Force Microscopy Applied to the Study of Tauopathies ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-02 Maria do Socorro do Nascimento Amorim, Álefe Roger Silva França, Ralph Santos-Oliveira, Jonas Rodrigues Sanches, Thamys Marinho Melo, Bruno Araújo Serra Pinto, Leandro R. S. Barbosa, Luciana Magalhães Rebelo Alencar
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Spatial Neurolipidomics at the Single Amyloid-β Plaque Level in Postmortem Human Alzheimer’s Disease Brain ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-01 Wojciech Michno, Andrew Bowman, Durga Jha, Karolina Minta, Junyue Ge, Srinivas Koutarapu, Henrik Zetterberg, Kaj Blennow, Tammaryn Lashley, Ron M. A. Heeren, Jörg Hanrieder
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Caged Zn2+ Photolysis in Zebrafish Whole Brains Reveals Subsecond Modulation of Dopamine Uptake ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-02-01 Piyanka Hettiarachchi, Sayuri Niyangoda, Austin Shigemoto, Isabel J. Solowiej, Shawn C. Burdette, Michael A. Johnson
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Paeonol Derivative, 6′-Methyl Paeonol, Attenuates Aβ-Induced Pathophysiology in Cortical Neurons and in an Alzheimer’s Disease Mice Model ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-01-30 Pin-Jung Chen, Chien-An Yao, Po-Chung Chien, Han-Jung Tsai, Yi-Ru Chen, Jen-Hua Chuang, Pei-Li Chou, Guan-Chiun Lee, Wenwei Lin, Yenshou Lin
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Inhibition of GluN2D-Containing NMDA Receptors Protects Dopaminergic Neurons against 6-OHDA-Induced Neurotoxicity via Activating ERK/NRF2/HO-1 Signaling ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-01-26 Jin-Bao Zhang, Fen Wang, Yu-Ting Tang, Meng-Zhu Pang, Dan Li, Chun-Feng Liu
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Optical Control of Adenosine A2A Receptor Using Istradefylline Photosensitivity ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-01-26 Anaëlle Dumazer, Xavier Gómez-Santacana, Fanny Malhaire, Chris Jopling, Damien Maurel, Guillaume Lebon, Amadeu Llebaria, Cyril Goudet
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Characterization of Hair Metabolome in 5xFAD Mice and Patients with Alzheimer’s Disease Using Mass Spectrometry-Based Metabolomics ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-01-25 Chih-Wei Chang, Jen-Yi Hsu, Yu-Tai Lo, Yu-Hsuan Liu, Onanong Mee-inta, Hsueh-Te Lee, Yu-Min Kuo, Pao-Chi Liao