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  • Benefits of the soluble and insoluble fractions of bitter gourd in mice fed a high-fat diet
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-12
    Jie Xu, Ke Cao, Zhihui Feng, Jiankang Liu

    Background Bitter gourd (BG) fruit powder was previously showed to prevent high-fat diet (HFD)-induced metabolic disorders in mice. In current study, we investigated the beneficial difference of the water soluble (S-BG) and insoluble fractions (IS-BG) of bitter gourd. Results Compared to normal chow diet, the HFD induced greater body weight gain and increased fat mass accompanied by impaired insulin sensitivity, elevated serum lipids and inflammation. Supplementation of BG, S-BG, and IS-BG showed similar beneficial effects and restored the metabolic changes in mice. Interestingly, BG showed no effect on fat mass, which was decreased by both S-BG and IS-BG. Additionally, S-BG and IS-BG inhibited the SREBP-1/FAS pathway, thereby decreasing liver cholesterol accumulation, while only BG showed improvement on mitochondrial activity. Conclusion These results further support the position that bitter gourd has multiple active ingredients and that both fractions have beneficial effects on metabolic disorders.

    更新日期:2018-01-13
  • Whey protein hydrolysates as a source of bioactive peptides for functional foods – Biotechnological facilitation of industrial scale-up
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-10
    Anja Dullius, Márcia Inês Goettert, Claucia Fernanda Volken de Souza

    Whey proteins, which possess the highest nutritional quality of all food proteins, are an optimal source of functional food ingredients. Enzymatic hydrolysis of whey proteins liberates fragments that can promote health benefits in the immune, cardiovascular, nervous and gastrointestinal systems. Industrial production of peptide-based food ingredients requires overcoming several challenges in product development to achieve economically viable downstream processes. We suggest hybrid strategies currently utilized in biopharmacy that are based on computational modelling combined with heuristics and mechanistic modelling, thus minimizing the time- and cost-intensive trial and error approach. Additionally, we propose an application of a cost performance indicator during early decisions at the laboratory scale, which can lead to optimal downstream processing of bioactive, peptide-based food ingredients. This review summarizes the requirements of industrial processes regarding peptide release and stability, depending on several process parameters, and considers some enrichment techniques for whey-derived peptides that are potentially applicable to industry.

    更新日期:2018-01-12
  • Plant foods for the prevention and management of colon cancer
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-10
    Jun Tao, Ya Li, Sha Li, Hua-Bin Li
    更新日期:2018-01-12
  • Luteolin inhibits ER-α expression through ILK inhibition is regulated by a pathway involving Twist and YB-1
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-10
    Ying-Chao Lin, Liang-Chih Liu, Chi-Tang Ho, Chao-Ming Hung, Tzong-Der Way

    Increasing evidence supports the anti-estrogenic and/or anti-proliferative properties of luteolin, which is a natural flavonoid existing in herbs, vegetables and fruits. However, the molecular mechanisms responsible for these effects are only partially explored. In the present study, estrogen receptor-alpha (ER-α) was identified as a potential molecular target for luteolin. Our data indicated that treatment with luteolin engendered suppression of ER-α protein and mRNA expression in ER-α-positive breast cancer cells. Y-box binding protein-1 (YB-1) is a known transcriptional regulator of ER-α expression. In this studies it was demonstrated that luteolin decreased YB-1 protein and mRNA expression. Integrin-linked kinase (ILK) is able to phosphorylate many downstream effectors that have the potential to regulate YB-1 transcription. We provided evidence for a mechanism by which luteolin suppressed YB-1 expression through the downregulation of ILK/Akt/STAT3-regulated Twist expression in ER-α-positive breast cancer cells. Our data also showed that luteolin inhibited cancer migration and invasion through the inhibition of epithelial-mesenchymal transition (EMT). Taken together, these data indicate that the antitumorigenic effects of luteolin in ER-α-positive breast cancer cells may arise from its ability to reduce ER-α expression.

    更新日期:2018-01-12
  • 更新日期:2018-01-12
  • 更新日期:2018-01-12
  • Modulatory impact of selected ellagitannins on the viability of human breast cancer cells
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-10
    Izabela Berdowska, Bogdan Zieliński, Jolanta Saczko, Mirosław Sopel, Andrzej Gamian, Izabela Fecka

    The impact of agrimoniin, sanguiin H-6, rugosins D and A, tellimagrandin I, and pedunculagin on Adriamycin-resistant (MCF-7/Adr) and wild-type (MCF-7/wt) human breast cancer cell lines was evaluated with MTT assay. An inhibitory effect on MCF-7/wt cells viability grew stronger with the number of functional units: hexahydroxydiphenoyl (HHDP) group – releasable in the form of ellagic acid (EA), and HHDP derivatives (releasable in the form of EA derivatives). Thus agrimoniin (with five units) was the most active, pedunculagin and rugosin D (with two units each) exhibited medium impact, and rugosin A and tellimagrandin I (both with 1 unit) were the least active. Sanguiin H-6 was the only compound which inhibited MCF-7/Adr cells. It might be hypothesized that the characteristic for sanguiin H-6 structural sanguisorboyl unit contributed to the effect on MCF-7/Adr cells.

    更新日期:2018-01-12
  • Non-extractable polyphenols of green tea and their antioxidant, anti-α-glucosidase capacity, and release during in vitro digestion
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-10
    Shuaishuai Yan, Hongjun Shao, Zhihao Zhou, Qi Wang, Luhua Zhao, Xingbin Yang

    The extractable and non-extractable polyphenols (EPP and NEPP) of green tea were characterized. The results showed that the total polyphenolic content of NEPP was 4 times lower than that of EPP, and polyphenolic profiles of NEPP and EPP were also remarkably different, both qualitatively and quantitatively. Furthermore, the antioxidant activity of NEPP, determined by DPPH radical dot , ABTS and FRAP assays, was lower compared with EPP, but higher than vitamin C. Meanwhile, NEPP also exhibited α-glucosidase inhibitory effect (IC50 1.96 ± 0.21 µg/mL) in a noncompetitive manner. Additionally, an in vitro digestion of the green tea residues after EPP extraction led to the release of NEPP, in which gallocatechin, epigallocatechin, catechin, and epicatechin, along with caffeine, were the most abundant compounds. The results of this study indicated that NEPP of green tea are untapped natural sources of antioxidants and α-glucosidase inhibitors.

    更新日期:2018-01-12
  • Fortified yogurt with vitamin D as a cost-effective food to prevent diabetes: A randomized double-blind clinical trial
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-10
    Roghayeh Mostafai, Reza Mohammadi, Seyed Mostafa Nachvak, Mansour Rezaei, Yahya Pasdar, Hadi Abdollahzad, Fatemeh Rezvanmadani, Shima Moradi, Mojgan Morvaridzadeh, Parisa Niazi, Khosrow Adeli
    更新日期:2018-01-12
  • Selective oncolytic effect in Epstein-Barr virus (EBV)-associated gastric carcinoma through efficient lytic induction by Euphorbia extracts
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-10
    Dong-eun Kim, Sunhee Jung, Hyung Won Ryu, Miri Choi, Mingu Kang, Hyunju Kang, Heung Joo Yuk, Hyejeong Jeong, Jiyeon Baek, Jae-Hyoung Song, Janghwan Kim, Hyojeung Kang, Sang-Bae Han, Sei-Ryang Oh, Sungchan Cho

    Lytic induction of latent Epstein-Barr virus (EBV) has been considered as a therapeutic approach for efficient treatment of EBV-associated malignancies. Here, we established a robust assay system quantitatively measuring EBV lytic induction and identified three Euphorbia extracts as strong inducers from a screen of Korean medicinal plant extracts library. Expression of lytic genes were efficiently induced by each Euphorbia extract in SNU-719 (EBV-positive gastric carcinoma cells). Euphorbia pekinensis, out of three extracts, exhibited the most potent lytic-inducing activity. Importantly, treatment with E. pekinensis extract led to an obvious cytotoxic effect on SNU-719 cells, but little on MKN-74 cells (EBV-negative gastric carcinoma cells), indicating the selective oncolytic effect on EBV-positive gastric carcinoma. We further revealed that lytic-inducing activity of E. pekinensis was mediated by PKC/MEK signal. Moreover, we defined two structural analogs of PMA with strong lytic-inducing activity, suggesting their therapeutic applicability for the treatment of EBV-associated gastric carcinoma.

    更新日期:2018-01-12
  • A bioactive polysaccharide TLH-3 isolated from Tricholoma lobayense protects against oxidative stress-induced premature senescence in cells and mice
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-10
    Wen-Juan Pan, Qiu-Ying Ding, Ya Wang, Dan-Dan Wang, Yong-Ming Lu, Wei-Wei Yang, Zheng-Nan Cai, Xiao-Du Cheng, Wen-Na Zhang, Yan Chen

    To inform rational therapeutics to alleviate many senescence-related diseases in terms of the pathogenic pathways, we investigated the protective mechanisms of TLH-3 against premature senescence in tert-butyl hydroperoxide (t-BHP)-induced human embryonic lung fibroblast (HELF) cells model and d-galactose-induced premature aging mice model. We demonstrate that TLH-3 ameliorated t-BHP-induced premature senescence, which is characterized by decreased senescence-associated β-galactosidase (SA-β-Gal) positive cells containing decreased senescence effector p53 level, via up-regulating bcl-2 and down-regulated bax and caspase-3 protein expression to block t-BHP-induced inappropriate apoptosis. Furthermore, d-galactose-induced mice exhibit senescence hallmark features such as increased senescence-associated secretory phenotype characterized by increased interleukin-6 (IL-6) secretion. TLH-3 diminished age-dependent increase in circulating IL-6, lipofuscin pigment (LPF) and advanced glycation endproducts (AGEs) accumulation, the monoamine oxidase (MAO) activity and the intensity of nuclear p53 staining, which was up-regulated by d-galactose stimulation in premature aging mice. Meanwhile, TLH-3 attenuated d-galactose-induced histopathological lesions in premature aging mice.

    更新日期:2018-01-12
  • Serum metabolomics analysis for biomarker of Lactobacillus plantarum NCU116 on hyperlipidaemic rat model feed by high fat diet
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-11
    Chuan Li, Jun Cao, Shao-Ping Nie, Ke-Xue Zhu, Tao Xiong, Ming-Yong Xie

    A metabolomics method based on ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) was used to investigate the effect of Lactobacillus plantarum NCU116 on the metabolites of hyperlipidaemic rat model feed by high-fat diet. Nine potential biomarkers (Pantothenic Acid, 5-Hydroxyindole acetaldehyde, Glycocholic Acid, Biliverdin IX, l-Leucine, 2-Phenylethanol glucuronide, Taurocholic acid, Indoleacrylic acid and 2-Arachidonoylglycerol) were identified and the pathway features were analyzed by Mass Profiler Professional (MPP) software. Meanwhile, clustering of principal components analysis (PCA), partial least squares-discriminant analysis (PLS-DA) and hierarchical clustering analysis (HCA) produces and biological pathways including tryptophan metabolism, bile secretion, fatty acid biosynthesis, glucose homeostasis, protein digestion and absorption were affected by L. plantarum NCU116. This study demonstrated that L. plantarum NCU116 improved hyperlipidaemic rats via metabolism pathways of amino acids, bile, fatty acids and glucose.

    更新日期:2018-01-12
  • In vitro antitumor and hypotensive activity of peptides from olive seeds
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-11
    Romy Vásquez-Villanueva, Laura Muñoz-Moreno, M. José Carmena, M. Luisa Marina, M. Concepción García

    Peptides with molecular weights below 3 kDa from the hydrolysis of olive seed proteins with Thermolysin (OS-3 kDa) have demonstrated a high in vitro hypotensive effect. This fraction has been further fractionated by semipreparative RP-HPLC to obtain 8 fractions. ACE inhibitor capacity of fractions was evaluated observing the highest capacity in fraction F5. Peptides in fraction F5 were identified by RP-HPLC- and HILIC-ESI-Q-ToF and cytotoxic effect was assessed in different cell lines. Peptide LLPSY, present in this faction, was synthesized and characterized. Despite antihypertensive capacity was not as high as in fraction F5, a significant anti-proliferative capacity on two different cancer cell lines was observed. Additional studies to assess antitumor activity confirmed that this peptide showed capability to increase the adhesion capacity of tumor cells, to decrease the migration capacity of cancer cells, and to arrest cell cycle on S phase.

    更新日期:2018-01-12
  • Liver-specific metabolomics characterizes the hepatoprotective effect of saponin-enriched Celosiae Semen extract on mice with nonalcoholic fatty liver disease
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-12
    Feng-Jie Liu, Dan Liang, Lan-Yun Miao, Ping Li, Hui-Jun Li

    Celosiae Semen, derived from the seeds of Celosia argentea L., has a long history of therapeutic uses for liver diseases in China and Japan. Phytochemical researches revealed a series of saponins from Celosiae Semen, which showed a variety of important pharmacological properties such as anti-hyperlipidemia and hepatoprotection. However, the exact protection mechanism is still looking forward to further elucidation. In present study, a liver-specific metabolomics approach based on gas chromatography-mass spectrometry (GC–MS) was applied to investigate the hepatoprotective effect of saponin-enriched Celosiae Semen extract (SECSE) under high-fat diet (HFD) induced nonalcoholic fatty liver disease (NAFLD). Orthogonal partial least squares discriminant analysis (OPLS-DA) was used to identify different metabolic profiles of liver from C57BL/6 mice. At the meantime, serum biochemical analysis and liver histopathological examination were performed. The results suggested that SECSE has effective protection to NAFLD, which is associated with energy metabolism, amino acid metabolism and lipid metabolism.

    更新日期:2018-01-12
  • Lactobacillus gasseri SF1183 protects the intestinal epithelium and prevents colitis symptoms in vivo
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-12
    B. Di Luccia, A. Mazzoli, R. Cancelliere, R. Crescenzo, I. Ferrandino, A. Monaco, A. Bucci, G. Naclerio, S. Iossa, E. Ricca, L. Baccigalupi

    Lactobacillus gasseri SF1183 belongs to a subpopulation of bacteria tightly associated to the human ileal epithelium. Cells of SF1183 survive and grow in simulated intestinal and gastric conditions, have a strong antimicrobial activity against Gram-positives and Gram-negatives and secrete molecule(s) sensed by human intestinal cells. We report that the oral administration of SF1183 cells had a protective effect in a murine model of DSS (Dextran-Sulfate-Sodium)-induced colitis. The analysis of the intestinal microbial composition indicated that several bacterial genera were differently represented in the intestine of DSS-treated animals. An overall similar alteration was observed in the microbiota of DSS-treated animals that received SF1183, suggesting that the beneficial role of the probiotic was not played through a reshuffling of the intestinal flora. Based on our in vivo data we propose the SF1183 strain of L. gasseri as a new anti-inflammatory probiotic, potentially useful as a therapeutic agent for the treatment of IBDs.

    更新日期:2018-01-12
  • Cytoprotective effect and purification of novel antioxidant peptides from hazelnut (C. heterophylla Fisch) protein hydrolysates
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-12
    Chunlei Liu, Dayong Ren, Jingjing Li, Li Fang, Ji Wang, Jingsheng Liu, Weihong Min

    In the present study, antioxidant fraction (C2) has been obtained from a hazelnut processing by-product. The C2 exhibited strong antioxidant and cytoprotective effect against Ang II induced oxidant injury via up-regulation of SOD and heme oxygenase-1 (HO-1) levels and down-regulation of xanthine oxidase-1 (XO-1) level to inhibit the production of ROS synthesis in human umbilical vein endothelial cells (HUVECs). LC-ESI-MS/MS results revealed that C2 was found to include six novel peptides and their amino acid sequences were ADGF (408.16 Da), AGGF (350.16 Da), AWDPE (616.25 Da), DWDPK (659.29 Da), ETTL (462.23 Da), and SGAF (380.17 Da). All six synthetic peptides showed excellent antioxidant activity. Especially, the ADGF peptide exhibited the highest ABTS radical scavenging activity and DPPH radical scavenging ability among them. Therefore, the peptides isolated from wild hazelnut protein hydrolysates may be used as potential antioxidants in the food and drug industries.

    更新日期:2018-01-12
  • Phyllodulcin, a natural functional sweetener, improves diabetic metabolic changes by regulating hepatic lipogenesis, inflammation, oxidative stress, fibrosis, and gluconeogenesis in db/db mice
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-10
    Eunju Kim, Jae-Ho Shin, Pu Reum Seok, Min-Soo Kim, Sang-Ho Yoo, Yuri Kim

    Phyllodulcin, an isocoumarin derivatives and well-known natural sweetener derived from Hydrangea macrophylla var, was evaluated for its roles in diabetes-related metabolic and genetic changes by regulating glucose homeostasis in the liver. C57BL/KsJ-db/db mice received 20 mg/kg body weight (b.w.) stevioside (SVS 20), 10 mg/kg b.w. phyllodulcin (P 10), or 20 mg/kg b.w. phyllodulcin (P 20) for four weeks. Water and food intake were significantly lower in the phyllodulcin supplemented group compared with the diabetic group. Phyllodulcin supplementation suppressed the levels of fasting blood glucose, HbA1c, and plasma and hepatic triglyceride level. Phyllodulcin improved hepatic lipogenesis, while also suppressing inflammation and oxidative stress. Phyllodulcin inhibited hepatic fibrosis and regulated liver glucose homeostasis. Thus, these results indicate the potential of phyllodulcin to serve as a therapeutic agent to improve global hepatic function and metabolic abnormalities of diabetic conditions and the necessity to be better explored.

    更新日期:2018-01-10
  • Oat globulin peptides regulate antidiabetic drug targets and glucose transporters in Caco-2 cells
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-10
    Feng Wang, Yanyan Zhang, Tongtong Yu, Jiatai He, Jin Cui, Jingnan Wang, Xiangning Cheng, Junfeng Fan
    更新日期:2018-01-10
  • C-phycocyanin reduces inflammation by inhibiting NF-κB activity through downregulating PDCD5 in lipopolysaccharide-induced RAW 264.7 macrophages
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-10
    Shuai Hao, Yan Yan, Weiwei Huang, Fei Gai, Junpo Wang, Liyun Liu, Chengtao Wang

    C-phycocyanin (C-PC), a type of functional food colourant, plays a significant role in regulating inflammatory responses. However, its underlying anti-inflammatory mechanism remains unknown. Previously, we have established a 35S in vivo/vitro labelling analysis for dynamic proteomic (SiLAD) technology. Unlike traditional proteomic methods, SiLAD exclusively detects synthesis rates instead of accumulated amounts through 35S pulse labelling of newly synthesized proteins, providing a high sensitive way for analysing protein alterations. In this work, we applied SiLAD to explore the anti-inflammatory mechanism of C-PC. We found that the protein synthesis rates were specifically detected and visualised. Strikingly, network analysis suggested programmed cell death 5 protein (PDCD5) was involved in C-PC mediated anti-inflammatory process. Phenotyping experiments demonstrated that C-PC could reduce inflammation through down-regulating PDCD5-NF-κB signaling. These results provided important information for the regulation of C-PC, and offered a novel perspective for regulatory mechanism of functional food.

    更新日期:2018-01-10
  • 更新日期:2018-01-10
  • Plasma lipid lowering effect by a novel chia seed based nutraceutical formulation
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-10
    Gian Carlo Tenore, Domenico Caruso, Giuseppe Buonomo, Maria D'Avino, Roberto Ciampaglia, Ettore Novellino
    更新日期:2018-01-10
  • Structure characterization of two novel polysaccharides from Colocasia esculenta (taro) and a comparative study of their immunomodulatory activities
    J. Funct. Foods (IF 3.144) Pub Date : 2018-01-10
    Huixian Li, Zhou Dong, Xiaojia Liu, Huamin Chen, Furao Lai, Mengmeng Zhang

    Two fractions of non-starch polysaccharides termed TPS-1 and TPS-2 were sequentially purified from the corms of Colocasia esculenta. Structural characterizations of TPS-1 and TPS-2 were determined. The average molecular weight of TPS-1 and TPS-2 were estimated to be 10.502 and 10.191 kDa, respectively. TPS-1 consisted of Rha (8.5%), Xyl (0.73%), Glc (88.57%), and Gal (2.56%), while TPS-2 consisted of Rha (3.54%), Arf (1.6%), Glc (87.92%), and Gal (6.94%). The presence of glycosidic linkages in the two fractions of polysaccharides were identified and were significantly different. TPS-2 exhibited a higher immunomodulatory activity than TPS-1 through an immunostimulation assay promoting NO, TNF-α, and IL-6 production in RAW 264.7 cells. Furthermore, TPS-2 could significantly enhance the phagocytosis ability of macrophages. The membrane receptors of TPS-2 were identified to be TLR2, TLR4, GR, and SR. Taken together, TPS-1 and TPS-2 could be considered as novel potential immunostimulants of food and pharmaceutical supplements for hypoimmunity.

    更新日期:2018-01-10
  • Prepared Rehmanniae Radix oligosaccharide regulates postprandial and diabetic blood glucose in mice
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-27
    Chen-Yuan Chiu, Wei-Hsiang Hsu, Hui-Kang Liu, Shing-Hwa Liu, Yun-Lian Lin
    更新日期:2017-12-31
  • Inhibitory effects of punicalagin from Punica granatum against type II collagenase-induced osteoarthritis
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-27
    Chia-Jung Lee, Lih-Geeng Chen, Wen-Li Liang, Ming-Shium Hsieh, Ching-Chiung Wang

    Pomegranate (Punica granatum) is a heath with abundant hydrolysable tannin in its peel. This study demonstrated that POMx (70% acetone extract of pomegranate peels) significantly reduced interleukin (IL)-1β-induced inducible nitric oxide synthase, cyclooxygenase-2, and matrix metalloproteinase-13 protein expression in primary rat chondrocytes (PRCs). In the type II collagenase-induced osteoarthritis rat model, POMx (150 mg/kg) recovered the weight-bearing ratio changes in experimental animals, suggesting the alleviation of knee-related inflammation and nociception. Therefore, the major compound, punicalagin, was isolated from POMx. Punicalagin also significantly reduced IL-1β-induced inflammatory factors in PRCs and exerted significant antiosteoarthritis effects in the vivo model after 28-d treatment (concentration: 0.50 mg/kg). However, the IC50 values of POMx and punicalagin against prostaglandin E2 production were 83.2 and 36.0 μg/mL, respectively, and the concentration of punicalagin in POMx was 19.1%. Altogether, POMx can be used to develop functional foods for knee-related diseases, and punicalagin can act as an active ingredient.

    更新日期:2017-12-31
  • Phenolic compounds from Syzygium jambos (Myrtaceae) exhibit distinct antioxidant and hepatoprotective activities in vivo
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-27
    Mansour Sobeh, Ahmed Esmat, Ganna Petruk, Mohamed A.O. Abdelfattah, Malak Dmirieh, Daria Maria Monti, Ashraf B. Abdel-Naim, Michael Wink
    更新日期:2017-12-31
  • 更新日期:2017-12-31
  • NF-κB/twist mediated regulation of colonic inflammation by lupeol in abating dextran sodium sulfate induced colitis in mice
    J. Funct. Foods (IF 3.144) Pub Date : 
    Nirmal Kumar Kasinathan, Bharathraja Subramaniya, Niranjali Devaraj Sivasithamparam

    Due to the idiopathic inflammation of the gastrointestinal tract and ulcerative colitis, there is an increased risk of colorectal cancer in inflammatory bowel disease (IBD) patients. Chemoprevention remains vital and much interest has been focused on targetable inflammatory proteins associated with IBD. Dextran sodium sulfate (DSS) induced colitis mimics human IBD in mouse, which is used as a model to determine the action of Lupeol (a triterpene), found in certain fruits and Indian herbs, in the healing of colitis. DSS causes chronic inflammation of the colonic epithelium by altering mucosal immune system i.e. mucins and inflammatory proteins namely TNF-α, IL 1 and 2 and NF-κB. Lupeol supplement to colitis mice, showed colonic regeneration by altering the MUC 1 & 2 gene expression. Lupeol also modulates TWIST gene expression, NF-κB, mediated inflammation and assists down regulation of TNF-α and IL genes. Thus Lupeol has potent colonic healing activity and also acts as an anti-inflammatory agent in controlling colitis.

    更新日期:2017-12-31
  • Royal jelly is an effective and relatively safe alternative approach to blood lipid modulation: A meta-analysis
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-27
    Amir Hadi, Ameneh Najafgholizadeh, Elham Smadi Aydenlu, Zahra Shafiei, Fatemeh Pirivand, Sahar Golpour, Makan Pourmasoumi
    更新日期:2017-12-27
  • Isolation of activating factors of serotonin N-acetyltransferase from rice peptides
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-26
    Chie Moritani, Kayoko Kawakami, Akiko Fujita, Koji Kawakami, Hiroshi Shimoda, Tadashi Hatanaka, Seiji Tsuboi

    Serotonin N-acetyltransferase (AA-NAT), which converts serotonin to N-acetylserotonin, is a rate-limiting enzyme for melatonin synthesis. We previously reported that intracellular redox conditions regulate AA-NAT activity by switching an intramolecular disulfide bridge in a glutathione (GSH)-dependent manner; thus, increased GSH levels can activate AA-NAT. Here, we found that commercially available rice peptides increased intracellular GSH levels and attenuated H2O2-induced inactivation of AA-NAT activity in COS7 cells expressing AA-NAT constitutively. Purification of the peptides using a Sep-Pak C18 cartridge and three rounds of reversed-phase HPLC, followed by sequence analysis by mass spectrometry, led to the identification of three peptides. Two of these peptides (Pep2, VVTFGPSGLTTEVK; Pep3, YQQQFQQFLPEGQSQSQK) prevented inactivation of AA-NAT activity by H2O2. Only Pep3 increased intracellular GSH levels and prevented the decrease in the reduced/oxidised GSH ratio induced by H2O2. These results suggest that Pep3 activates AA-NAT by increasing intracellular GSH levels, which switches the intramolecular disulfide bond of AA-NAT.

    更新日期:2017-12-27
  • Particle size determines the anti-inflammatory effect of wheat bran in a model of fructose over-consumption: Implication of the gut microbiota
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-26
    Francesco Suriano, Audrey M. Neyrinck, Joran Verspreet, Marta Olivares, Sophie Leclercq, Tom Van de Wiele, Christophe M. Courtin, Patrice D. Cani, Laure B. Bindels, Nathalie M. Delzenne
    更新日期:2017-12-27
  • Anti-metastatic activity of Agrocybe aegerita galectin (AAL) in a mouse model of breast cancer lung metastasis
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-26
    Qing Yang, Yalin Yin, Yongfu Pan, Xiangdong Ye, Bo Xu, Wenhui Yu, Haolong Zeng, Hui Sun

    Agrocybe aegerita galectin (AAL) has been reported to possess anti-tumor activity in tumor cells. The anti-metastasis activity of AAL in breast cancer and its possible mechanisms involved were investigated in this study. A bio-distribution assay showed AAL was highly absorbed by the lung. Administration of AAL (0.75 mg/kg twice or 1.5 mg/kg once) significantly inhibited pulmonary metastases of 4T1 cells and prolonged survival time of tumor-bearing mice. The binding between AAL and 4T1 cells relied on the carbohydrates recognition of AAL. AAL showed anti-proliferation activity against 4T1 cells with an IC50 of 4.11 M for 24 h treatment and 0.75 M for 48 h treatment. AAL induced apoptosis of 4T1 cells in a Caspase-3/7-dependent manner. Moreover, AAL inhibited migration and invasion of 4T1 cells, and decreased MMP 9 activity was found to be involved. This study would help to enhance the use of A. aegerita in nutritional and medicinal application.

    更新日期:2017-12-27
  • Protective effects of a phenolic glycoside compound curculigoside on H2O2-induced oxidative stress and cytotoxicity in normal human breast epithelial cells
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-26
    Hong-Tai Chang, Chung-Ren Jan, Wei-Zhe Liang

    Oxidative stress has been implicated in the development of many diseases including cancer. Curculigoside, a phenolic glycoside, has been reported to protect various models against damage induced by oxidative stress. However, the protective effect of curculigoside on oxidative stress in normal human breast cells remains unclear. This study evaluated whether curculigoside protected MCF 10A human breast epithelial cells from H2O2-induced cytotoxicity and explored its underlying mechanisms. The H2O2-induced oxidative stress of cell models was demonstrated by decreased percentages of cell viability, increased levels of ROS, reduced activities in antioxidant enzymes, and inhibition of the expressions of antioxidant proteins. More importantly, pre-treatment with curculigoside significantly inhibited the H2O2-induced apoptosis in this cell model. Together, curculigoside significantly prevented the cytotoxic effects of H2O2, suggesting that it protected the cells against H2O2-induced oxidative damage. Our findings provide new insight into the cytoprotective effects of curculigoside and the possible mechanisms underlying these effects.

    更新日期:2017-12-27
  • 更新日期:2017-12-27
  • Mushroom polysaccharides from Ganoderma lucidum and Poria cocos reveal prebiotic functions
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-26
    Imran Khan, Guoxin Huang, Xiaoang Li, Waikit Leong, Wenrui Xia, W.L. Wendy Hsiao

    Ganoderma lucidum and Poria cocos are the medicinal mushrooms that have been used as traditional Chinese medicines and consumed as functional foods. We hypothesized that these mushroom polysaccharides could contribute to health benefits, in part, by modulating gut microbiota (GM). In this study, mushroom polysaccharides derived from fruiting bodies and mycelia were administrated daily (750 mg/kg) to 6 weeks-old C57BL/6J mice for 15 days. Then, mice GM was evaluated using ERIC-PCR and 16S amplicon sequencing. A total of 2.59 million high-quality reads (>200 bp) were processed and evaluated for GM profiling. Polysaccharides reduced OTUs diversity and significantly (p < .01) remodeled GM compositions. Bacteria that have been reported for anti-obesity, SCFA-producer, polysaccharides/xylan degradation, and lactic acid production were significantly (p < .05) abundant in mice treated with polysaccharides. We conclude that these polysaccharides act as prebiotics to modulate GM composition thereby potentially contribute to the health promotion effects of G. lucidum and P. cocos.

    更新日期:2017-12-27
  • Sulforaphane inhibits human bladder cancer cell invasion by reversing epithelial-to-mesenchymal transition via directly targeting microRNA-200c/ZEB1 axis
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Lei Huang, Bao-Long Li, Can-Xia He, Yao-Jie Zhao, Xiu-Li Yang, Bo Pang, Xiao-Hong Zhang, Yu-Juan Shan

    Sulforaphane (SFN), one of the isothiocyanates, abundantly existed in quite a few of cruciferous vegetables and exhibits effective anticancer activities in our previous experiments. However, its effects on bladder cancer cell invasion and metastasis have only begun to be explored. Here, we investigated the effect of microRNA on bladder cancer cell invasion and the underlying molecular mechanism. According to the gene chip results, SFN obviously increased microRNA-200c (miR-200c) expression, one of the short noncoding RNAs that acts as considerable modulator in epithelial mesenchymal transition (EMT). Moreover, SFN dose-dependently induced EMT hallmark E-cadherin and down-regulated vimentin and transcriptional repressor ZEB1 at the level of transcription and translation, and these effects can be reversed by miR-200c inhibitor transfection. Remarkably, Transwell assay showed that cell invasiveness ability can be eradicated by silencing of ZEB1. Therefore, these findings firmly suggest that SFN inhibited bladder cancer cell invasion through reversing EMT via targeting miR-200c/ZEB1 axis.

    更新日期:2017-12-27
  • Modulation of gut microbiota and gut-generated metabolites by bitter melon results in improvement in the metabolic status in high fat diet-induced obese rats
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Juan Bai, Ying Zhu, Ying Dong

    The anti-obesity property of bitter melon powder (BMP) was investigated using a high-fat diet (HFD) obesity model. Obese rats were fed a HFD and treated with BMP for 8 weeks. We observed that BMP could effectively retard the body weight gain and improve the insulin sensitivity compared to the HFD group (p < .05). BMP also showed reduced endotoxin load as lipopolysaccharide-binding protein (LBP) level in the system. 16S rRNA sequencing indicated that BMP dramaticlly increased the relative abundance of Blautia and Allobaculum at the genus level. Metabolomic data revealed that dietary BMP changed metabolic profiles, including the metabolism of organic acids, amino acids and sugars. Additionally, some significant correlations was observed between specific gut microbiota at the genus level and effective biomarkers. These results reveal that the inhibition of insulin resistance and anti-inflammatory effect of BMP in obesity are illustrated with the restoration of gut microbiota and gut-generated metabolites.

    更新日期:2017-12-27
  • Kinetic approach to study the relation between in vitro lipid digestion and carotenoid bioaccessibility in emulsions with different oil unsaturation degree
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-23
    S.H.E. Verkempinck, L. Salvia-Trujillo, L.G. Moens, C. Carrillo, A.M. Van Loey, M.E. Hendrickx, T. Grauwet
    更新日期:2017-12-27
  • Polyphenols of mulberry fruits as multifaceted compounds: Compositions, metabolism, health benefits, and stability—A structural review
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Ibrahim Khalifa, Wei Zhu, Kai-kai Li, Chun-mei Li

    Mulberry (Morus sp.) fruits provide high levels of anthocyanins, quercetin glycoside, and chlorogenic acid. Recently, mulberry’s polyphenols and their functionalities are spotlighted in different ex vivo and in vivo studies. Meanwhile, the deficiency of systematic knowledge on the health effects and polyphenols composition greatly hinders the development of mulberry as a sustainable fruit. This review briefly summarises the polyphenol compositions, metabolism, health benefits, and their stability in different mulberry production steps. These claimed health effects include anti-oxidative, anti-cancer, anti-diabetes, anti-obesity, and other related effects. However, although the current evidence is promising, further clinical studies are needed to evaluate the role of mulberries' polyphenols to support human health. Besides, the mechanisms by which they confer the health benefits, the bioavailability studies on mulberry’s polyphenols are also scarce. We compile the research findings from the available literatures within the last two decades, and we also suggest some future perspectives in this review.

    更新日期:2017-12-27
  • Phenolic compounds within banana peel and their potential uses: A review
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Hang T. Vu, Christopher J. Scarlett, Quan V. Vuong

    A large quantity of bananas is produced annually and its peel, which accounts for about one third of the fruit weight, is mostly discarded as waste. The peel has been traditionally used for the treatment of various ailments. This by-product is rich in phenolics with over 40 individual compounds identified. However, composition and levels of these compounds are influenced by various factors, including varieties, maturity, cultivation conditions, and pre-treatments. Phenolics within banana peels have been found to possess potent antioxidant and antimicrobial properties, and linked with various health benefits. Therefore, it is worthwhile to recover phenolics from this by-product for further utilisation in food and pharmaceutical industries. This review comprehensively highlights the phenolic compounds as well as major factors affecting their presence within the banana peel, reviews the current applications of this by-product, outlines its potential uses in food and pharmaceutical industries and finally proposes a trend for future studies.

    更新日期:2017-12-27
  • Citrus waste derived nutra-/pharmaceuticals for health benefits: Current trends and future perspectives
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Neelima Mahato, Kavita Sharma, Mukty Sinha, Moo Hwan Cho
    更新日期:2017-12-27
  • Bioactive properties of Sambucus nigra L. As a functional ingredient for food and pharmaceutical industry
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Karolina Młynarczyk, Dorota Walkowiak-Tomczak, Grzegorz P. Łysiak
    更新日期:2017-12-27
  • Role of probiotics in the management of lung cancer and related diseases: An update
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Anshul Sharma, Buddolla Viswanath, Young-Seo Park
    更新日期:2017-12-27
  • Antiviral potential of curcumin
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Dony Mathew, Wei-Li Hsu
    更新日期:2017-12-27
  • Curcumin - A promising nutritional strategy for chronic kidney disease patients
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Livia de Almeida Alvarenga, Viviane de Oliveira Leal, Natália Alvarenga Borges, Aline Silva de Aguiar, Gerd Faxén-Irving, Peter Stenvinkel, Bengt Lindholm, Denise Mafra
    更新日期:2017-12-27
  • Effect of butyrate and fermentation products on epithelial integrity in a mucus-secreting human colon cell line
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Ditte Søvsø Gundelund Nielsen, Bent Borg Jensen, Peter Kappel Theil, Tina Skau Nielsen, Knud Erik Bach Knudsen, Stig Purup

    Butyrate produced by microbial fermentation of dietary fibres beneficially affect the colonic epithelium. Here we enhanced butyrate production through in vitro incubations of different sources of arabinoxylan (AX) with butyrogenic bacteria (Butyrivibrio fibrisolvens, Eubacterium rectale) to explore their potential synbiotic effects on the intestinal epithelial barrier function. B. fibrisolvens incubated with AX produced the highest butyrate levels (15 mM). Sodium-butyrate (1–10 mM) and fermentation products (5% v/v) from B. fibrisolvens increased the barrier function in a human colonic epithelial cell line. This was associated with regulation of different genes involved in epithelial integrity, mucus secretion, apoptosis, oxidative stress, and butyrate transport. In conclusion, butyrate in concentrations that can be achieved by dietary intervention in vivo enhanced the epithelial barrier function in vitro. B. fibrisolvens might be a potential new probiotic for increasing colonic butyrate production in humans, specifically in synbiotic combination with AX, a common DF component of food cereals.

    更新日期:2017-12-27
  • 更新日期:2017-12-27
  • Impact of resveratrol, epicatechin and rosmarinic acid on fluorescent AGEs and cytotoxicity of cookies
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Juanying Ou, Jing Teng, Hani S. El-Nezami, Mingfu Wang
    更新日期:2017-12-27
  • Impact of microbiota on the use and effects of isoflavones in the relief of climacteric symptoms in menopausal women – A review
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Naice E.S. Monteiro, Lívia D. Queirós, Danielle B. Lopes, Adriana O. Pedro, Gabriela A. Macedo

    Menopause is a natural event that occurs in women around the age of 50 years, causing irregularities in the menstrual cycle until its complete end, due to the hormonal deficit, especially estrogen, that causes several unpleasant urogenital and vasomotor symptoms. Hormone replacement therapy has many benefits, but should be prescribed with caution in women with a history of stroke, thromboembolic events, certain types of cancer, or increased risk (genetic predisposition) for these events, so many women seek alternatives to hormonal therapy. Phytoestrogens, especially isoflavones, have many benefits in the climacteric phase, due to the similarity of their chemical structure with the hormone estradiol (E2), reducing the rate of menopause side effects and resulting in symptom relief. Furthermore, the isoflavones may still have their effects potentiated by an intestinal microbiota modulated with probiotic strains, which act on metabolism and increase the bioavailability of these phytoestrogens, and can benefit menopausal women's health.

    更新日期:2017-12-22
  • 更新日期:2017-12-22
  • Development of dried probiotic apple cubes incorporated with Lactobacillus casei NRRL B-442
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Sueli Rodrigues, Luís C.A. Silva, Antonio Mulet, Juan A. Cárcel, Fabiano A.N. Fernandes

    This work presents the development of a probiotic dried apple snack consisting of dried apple cubes impregnated with Lactobacillus casei NRRL B-442. Apple cubes were impregnated with probiotic microorganisms and dried under different temperatures (10–60 °C), with or without application of ultrasound. The viability of Lactobacillus casei in the dried apple snack was evaluated studying the effects of drying conditions and ultrasound application (as a drying enhancing technology). A mathematical model was developed to predict the drying kinetics and the inactivation of Lactobacillus casei. Drying and microorganism inactivation rates increased with increasing process temperature and with ultrasound application. The concentration of probiotics in the apple snacks was similar to the concentration of microorganisms in commercial probiotic dairy products when the apples were dried at 60 °C or when ultrasound-assisted air-drying was applied, thus proving that the production of dried probiotic apple snacks is possible and technically viable.

    更新日期:2017-12-22
  • Effect of the consumption of a synbiotic diet mousse containing Lactobacillus acidophilus La-5 by individuals with metabolic syndrome: A randomized controlled trial
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Douglas Xavier-Santos, Egidio Dorea Lima, Andréa Name Colado Simão, Raquel Bedani, Susana Marta Isay Saad

    This study aimed to evaluate the impact of a synbiotic diet mousse containing Lactobacillus acidophilus La-5 and the prebiotics inulin and fructooligosaccharides on anthropometric and blood pressure measurements, biochemical, inflammatory, haematological, and immunological parameters of volunteers with metabolic syndrome (MetS). In a randomized, double-blind, placebo-controlled trial, forty-five volunteers with MetS were assigned into two groups, each receiving 40 g/day of: synbiotic diet mousse (SDM) (n = 23) and placebo diet mousse (PDM) without pro- and prebiotics (n = 22). All the evaluated parameters were measured at the beginning and after 8 weeks of intervention. The daily intake of SDM and PDM led to significant reductions of total cholesterol and HDL-cholesterol, as well as of immunoglobulins (A and M), and interleukin-1β in both groups (p < .05). These results suggest that the presence of the probiotic and prebiotic ingredients in the diet mousse did not show any additional effects on the parameters evaluated in volunteers with MetS.

    更新日期:2017-12-22
  • Cyanidin-3-glucoside attenuates high-fat and high-fructose diet-induced obesity by promoting the thermogenic capacity of brown adipose tissue
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Yilin You, Xue Han, Jielong Guo, Yu Guo, Manwen Yin, Guojie Liu, Weidong Huang, Jicheng Zhan

    Obesity results from a sustained positive energy balance, occurring when energy intake exceeds energy expenditure. One promising therapeutic strategy to mitigate obesity is the promotion of thermogenesis of brown adipose tissue (BAT) to increase energy expenditure. Cyanidin-3-glucoside (C3G) is an anthocyanin compound widely distributed in human diets. In this study, researchers studied the effect and mechanism of C3G on the prevention and treatment of high-fat and high-fructose diet (HFFD) induced obesity. The study shows that C3G enhances energy expenditure and thermogenic capacity of BAT, protecting mice against HFFD obesity. Further, C3G increases expression of UCP1 and other thermogenic genes in inguinal white adipose tissue (iWAT), as well as in BAT. Results demonstrate that C3G promotes the heat production of BAT and iWAT by increasing mitochondrial biogenesis and function. These findings reveal that C3G activates BAT, which may provide a safe, effective approach to prevent and treat diet-induced obesity.

    更新日期:2017-12-22
  • Oat β-glucan inhibits adipogenesis and hepatic steatosis in high fat diet-induced hyperlipidemic mice via AMPK signaling
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Bo Liu, Tao Yang, Yi Luo, Linna Zeng, Limin Shi, Chengxi Wei, Ying Nie, Yu Cheng, Qinlu Lin, Feijun Luo
    更新日期:2017-12-22
  • The intake of red raspberry fruit is inversely related to cardiac risk factors associated with metabolic syndrome
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Ara Kirakosyan, E. Mitchell Seymour, Nicholas Kondoleon, Enrique Gutierrez, Janet Wolforth, Steven Bolling

    The effect of red raspberry fruit (RSP) was assessed in obesity-prone, Zucker Fatty rats as a model of cardiometabolic risk. RSP reduced fasting triglycerides and fasting glucose but did not appear to affect fasting insulin, low-density lipoprotein, or body weight gain. RSP did significantly reduce heart rate relative to time-matched CON rats. Noteworthy, RSP reduced left ventricular enlargement and wall thickening as measured by echocardiography, without impacting ejection fraction. Cardiac tissue was also evaluated for relative gene expression of key genes impacted in non-insulin-dependent diabetes mellitus (NIDDM). RSP upregulated the expression of myocardial adiponectin receptor 1 and apolipoprotein E, which may impact plasma cholesterol and triglyceride homeostasis. The lipoprotein lipase (Lpl) gene was down-regulated. On the contrary, RSP did not alter PPAR and NF-kB-related mRNA in heart tissue, but did alter nicotinamide phosphoribosyltransferase (Nampt) mRNA. RSP intake impacted cardiometabolic pathophysiology in this model, and molecular mechanisms deserve further study.

    更新日期:2017-12-22
  • Immunomodulatory effect of structurally-characterized mushroom sclerotial polysaccharides isolated from Polyporus rhinocerus on human monoctyes THP-1
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Chaoran Liu, Man Wing Choi, Xiaojie Li, Peter C.K. Cheung

    Two high molecular weight (MW larger than 788 kDa) mushroom polysaccharides extracted by hot water (PRW) and micronized sonication-assisted cold alkali (mPRSon), were isolated from the sclerotia of Polyporus rhinocerus. PRW was a polysaccharide-protein complex with a highly branched (degree of branching DB 0.60) β-D-mannoglucan while mPRSon was a hyper-branched β-glucan (DB 0.85). PRW could bind to complement receptor 3 (CR3) and significantly induced THP-1 differentiation evidenced by cell morphology and enhanced phagocytic activity. A significant increase in the expression of surface markers including CD14, CD11b and HLA-DR as well as enhanced production of cytokines including IL-8, RANTES, GRO, MCP-1, MCP-2 and IL-6 were observed on THP-1 cells treated with PRW. In contrast, mPRSon could not either activate the Dectin-1 signaling or induce the THP-1 differentiation. High MW and DB mushroom sclerotial polysaccharide which has a structure of heteroglycan and protein is more immunopotent than pure homoglycan.

    更新日期:2017-12-22
  • Retention and pre-colon bioaccessibility of oleuropein in starchy food matrices, and the effect of microencapsulation by using inulin
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-22
    Camila Pacheco, Estefanía González, Paz Robert, Javier Parada

    Oleuropein is a phenolic compound that is present in fruits and olive tree leaves, which has shown enormous health benefits. This study aimed to assess the effects of the baking and boiling cooking methods and the inclusion of extract of olive leaf and inulin microparticles on oleuropein retention and bioaccessibility in a food matrix. Retention was measured after cooking, and bioaccessibility was measured in cooked samples subjected to in vitro digestion. Our findings showed that oven cooking generated matrices that possess oleuropein retention 15% higher than those presented by food cooked in boiling water, while bioaccessibility at small intestine conditions was 27.5% lower when microparticles, rather than an extract in the starchy matrix, were included, which proves the benefits of using inulin microcapsules to enhance the amount of oleuropein that reaches the colon.

    更新日期:2017-12-22
  • In vitro bioavailability of chlorophyll pigments from edible seaweeds
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-20
    Kewei Chen, María Roca
    更新日期:2017-12-21
  • Evaluation of in silico approach for prediction of presence of opioid peptides in wheat
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-20
    Swati Garg, Vasso Apostolopoulos, Kulmira Nurgali, Vijay Kumar Mishra

    Opioid like morphine and codeine are used for the management of pain, but are associated with serious side-effects limiting their use. Wheat gluten proteins were assessed for the presence of opioid peptides on the basis of tyrosine and proline within their sequence. Eleven peptides were identified and occurrence of predicted sequences or their structural motifs were analysed using BIOPEP database and ranked using PeptideRanker. Based on higher peptide ranking, three sequences YPG, YYPG and YIPP were selected for determination of opioid activity by cAMP assay against µ and κ opioid receptors. Three peptides inhibited the production of cAMP to varied degree with EC50 values of YPG, YYPG and YIPP were 5.3 mM, 1.5 mM and 2.9 mM for µ-opioid receptor, and 1.9 mM, 1.2 mM and 3.2 mM for κ-opioid receptor, respectively. The study showed that in silico approach can be used for the prediction of opioid peptides from gluten.

    更新日期:2017-12-21
  • Preliminary characterization and anti-hyperglycemic activity of a pectic polysaccharide from okra (Abelmoschus esculentus (L.) Moench)
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-19
    Tao Zhang, Jialin Xiang, Guobo Zheng, Renqing Yan, Xun Min

    Okra is widely used as vegetable, food ingredient, and traditional medicine in China for various applications. The main healthy properties are accepted to originate from the high polysaccharide content of okra. In this study, a homogenous pectic polysaccharide WOP-2 was extracted, isolated, and purified from okra by DEAE-cellulose and Sepharose CL-6B column, and its molecular weight was estimated to be 580 kDa. Monosaccharide composition was analyzed to be Rha (21.4%), GalA (34.9%), Gal (29.6%), GlcA (4.5%), Glc (5.9%), and Ara (3.7%) by HPLC with PMP derivatization. Combined with NMR analysis, WOP-2 was elucidated to be a rhamnogalacturonan I backbone with type-II arabinogalactan side-chains substituted partly at O-4 of Rhap. WOP-2 exhibits significant anti-hyperglycemic activity on STZ-induced diabetic mice by inhibiting the lipid peroxidation chain reaction probably. Overall, these results provide new insight into structure–activity relationships of polysaccharide from okra and provide impetus towards the development of polysaccharide-based therapeutics on diabetes.

    更新日期:2017-12-20
  • Anti-gastrointestinal cancer activity of cyclodextrin-encapsulated propolis
    J. Funct. Foods (IF 3.144) Pub Date : 2017-12-18
    Owen Catchpole, Kevin Mitchell, Stephen Bloor, Paul Davis, Amanda Suddes

    New Zealand propolis resin and tinctures are rich in compounds that have in vitro anti-gastrointestinal cancer activity. However, propolis tincture has restricted acceptability for human consumption due to pungency in taste and aroma. We have formulated New Zealand propolis into cyclodextrin complexes (CD) that resolve these acceptability issues, and carried out in vitro bioactivity testing of these complexes using human anti-gastrointestinal cancer, anti-inflammatory and anti-oxidant assays. Demonstration of encapsulation was performed by physical, enzymic and chemical measurements. The New Zealand propolis γCD, αCD, and βCD complexes inhibited the proliferation of 4 human gastro-intestinal cancer cell lines, with the extent of inhibition increasing with increasing exposure time. The complexes were also strongly anti-inflammatory in vitro with respect to the cytokine TNF-α, and showed strong lipid anti-oxidant activity. The bioassay results give a strong first indication of beneficial gastro-intestinal health potential of New Zealand propolis – cyclodextrin complexes.

    更新日期:2017-12-19
Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
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